Kenneth Kellar

Summary

Affiliation: Georgetown University
Country: USA

Publications

  1. pmc Chronic sazetidine-A at behaviorally active doses does not increase nicotinic cholinergic receptors in rodent brain
    G Patrick Hussmann
    Department of Pharmacology and Physiology, Georgetown University School of Medicine, 3900 Reservoir Road, NW, Washington, DC 20057, USA
    J Pharmacol Exp Ther 343:441-50. 2012
  2. pmc A new radioligand binding assay to measure the concentration of drugs in rodent brain ex vivo
    G Patrick Hussmann
    Department of Pharmacology and Physiology, Georgetown University School of Medicine, Medical Dental Building, 3900 Reservoir Road, NW, Washington, DC 20057, USA
    J Pharmacol Exp Ther 343:434-40. 2012
  3. pmc Overcoming inhibitions
    Kenneth J Kellar
    Department of Pharmacology, Georgetown University School of Medicine, Washington, DC 20057, USA
    Proc Natl Acad Sci U S A 103:13263-4. 2006
  4. doi request reprint Rat neuronal nicotinic acetylcholine receptors containing alpha7 subunit: pharmacological properties of ligand binding and function
    Yingxian Xiao
    Department of Pharmacology, Georgetown University School of Medicine, Washington, DC 20057, USA
    Acta Pharmacol Sin 30:842-50. 2009
  5. ncbi request reprint Deletion of the GABA(A) receptor alpha1 subunit increases tonic GABA(A) receptor current: a role for GABA uptake transporters
    Pavel I Ortinski
    Department of Physiology and Biophysics, Georgetown University School of Medicine, Washington, DC 20007, USA
    J Neurosci 26:9323-31. 2006
  6. ncbi request reprint The comparative pharmacology and up-regulation of rat neuronal nicotinic receptor subtype binding sites stably expressed in transfected mammalian cells
    Yingxian Xiao
    Department of Pharmacology, Georgetown University School of Medicine, Washington, DC 20057 2195, USA
    J Pharmacol Exp Ther 310:98-107. 2004
  7. ncbi request reprint Nicotinic cholinergic receptors in the rat retina: simple and mixed heteromeric subtypes
    Andrea M Marritt
    Department of Pharmacology, Georgetown University School of Medicine, Washington, DC 20057, USA
    Mol Pharmacol 68:1656-68. 2005
  8. ncbi request reprint Pharmacology of the agonist binding sites of rat neuronal nicotinic receptor subtypes expressed in HEK 293 cells
    Yingxian Xiao
    Department of Pharmacology, Georgetown University School of Medicine, Washington, DC 20057, USA
    Bioorg Med Chem Lett 14:1845-8. 2004
  9. ncbi request reprint Novel pyridyl ring C5 substituted analogues of epibatidine and 3-(1-methyl-2(S)-pyrrolidinylmethoxy)pyridine (A-84543) as highly selective agents for neuronal nicotinic acetylcholine receptors containing beta2 subunits
    Zhi Liang Wei
    Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612, USA
    J Med Chem 48:1721-4. 2005
  10. ncbi request reprint Synthesis and pharmacological characterization of bivalent ligands of epibatidine at neuronal nicotinic acetylcholine receptors
    Zhi Liang Wei
    Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 S Wood Street, Chicago, IL 60612, USA
    Bioorg Med Chem Lett 14:1855-8. 2004

Collaborators

  • David C Perry
  • Stefano Vicini
  • J McIntosh
  • Galya R Abdrakhmanova
  • ALAN PAUL KOZIKOWSKI
  • Yingxian Xiao
  • G Patrick Hussmann
  • Zhi Liang Wei
  • Barry B Wolfe
  • Robert P Yasuda
  • Maryna Baydyuk
  • Jill R Turner
  • Sheela K Chellappan
  • Pavel I Ortinski
  • Andrea M Marritt
  • Amir H Rezvani
  • Julie A Blendy
  • Vanessa Cousins
  • Ermelinda Lomazzo
  • Edward D Levin
  • Rashmi Venkatesh
  • Susan Hernandez
  • Werner Tueckmantel
  • Andrea Barberis
  • Gholam Motamedi
  • John L Musachio
  • Brandon C Cox
  • Pavel A Petukhov
  • Hongbin Yuan
  • Heather E Davis
  • Haizhu Pearl Wang

Detail Information

Publications11

  1. pmc Chronic sazetidine-A at behaviorally active doses does not increase nicotinic cholinergic receptors in rodent brain
    G Patrick Hussmann
    Department of Pharmacology and Physiology, Georgetown University School of Medicine, 3900 Reservoir Road, NW, Washington, DC 20057, USA
    J Pharmacol Exp Ther 343:441-50. 2012
    ....
  2. pmc A new radioligand binding assay to measure the concentration of drugs in rodent brain ex vivo
    G Patrick Hussmann
    Department of Pharmacology and Physiology, Georgetown University School of Medicine, Medical Dental Building, 3900 Reservoir Road, NW, Washington, DC 20057, USA
    J Pharmacol Exp Ther 343:434-40. 2012
    ..It is important to note that the method described here to measure sazetidine-A in brain should be generalizable to other drugs acting at any receptor that can be reliably measured with a radiolabeled ligand...
  3. pmc Overcoming inhibitions
    Kenneth J Kellar
    Department of Pharmacology, Georgetown University School of Medicine, Washington, DC 20057, USA
    Proc Natl Acad Sci U S A 103:13263-4. 2006
  4. doi request reprint Rat neuronal nicotinic acetylcholine receptors containing alpha7 subunit: pharmacological properties of ligand binding and function
    Yingxian Xiao
    Department of Pharmacology, Georgetown University School of Medicine, Washington, DC 20057, USA
    Acta Pharmacol Sin 30:842-50. 2009
    ....
  5. ncbi request reprint Deletion of the GABA(A) receptor alpha1 subunit increases tonic GABA(A) receptor current: a role for GABA uptake transporters
    Pavel I Ortinski
    Department of Physiology and Biophysics, Georgetown University School of Medicine, Washington, DC 20007, USA
    J Neurosci 26:9323-31. 2006
    ....
  6. ncbi request reprint The comparative pharmacology and up-regulation of rat neuronal nicotinic receptor subtype binding sites stably expressed in transfected mammalian cells
    Yingxian Xiao
    Department of Pharmacology, Georgetown University School of Medicine, Washington, DC 20057 2195, USA
    J Pharmacol Exp Ther 310:98-107. 2004
    ....
  7. ncbi request reprint Nicotinic cholinergic receptors in the rat retina: simple and mixed heteromeric subtypes
    Andrea M Marritt
    Department of Pharmacology, Georgetown University School of Medicine, Washington, DC 20057, USA
    Mol Pharmacol 68:1656-68. 2005
    ....
  8. ncbi request reprint Pharmacology of the agonist binding sites of rat neuronal nicotinic receptor subtypes expressed in HEK 293 cells
    Yingxian Xiao
    Department of Pharmacology, Georgetown University School of Medicine, Washington, DC 20057, USA
    Bioorg Med Chem Lett 14:1845-8. 2004
    ....
  9. ncbi request reprint Novel pyridyl ring C5 substituted analogues of epibatidine and 3-(1-methyl-2(S)-pyrrolidinylmethoxy)pyridine (A-84543) as highly selective agents for neuronal nicotinic acetylcholine receptors containing beta2 subunits
    Zhi Liang Wei
    Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612, USA
    J Med Chem 48:1721-4. 2005
    ..Our data indicate that the extracellular domains of the nAChRs are sufficiently different to allow for the design of novel ligands with high affinity and selectivity for the nAChR subtypes...
  10. ncbi request reprint Synthesis and pharmacological characterization of bivalent ligands of epibatidine at neuronal nicotinic acetylcholine receptors
    Zhi Liang Wei
    Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 S Wood Street, Chicago, IL 60612, USA
    Bioorg Med Chem Lett 14:1855-8. 2004
    ..In contrast to epibatidine, these bivalent ligands are weak partial agonists at the alpha3beta4 nAChR as shown by functional assays...
  11. pmc Synthesis and pharmacological evaluation of novel 9- and 10-substituted cytisine derivatives. Nicotinic ligands of enhanced subtype selectivity
    Sheela K Chellappan
    Drug Discovery Program, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Illinois 60612, USA
    J Med Chem 49:2673-6. 2006
    ..The 9-vinyl derivative was found to have a very similar agonist activity profile to that of cytisine...

Research Grants10

  1. Pharmacology and Regulation of Nicotinic Receptor Subtypes
    Kenneth Kellar; Fiscal Year: 2009
    ....
  2. Pharmacology and Regulation of Nicotinic Receptor Subtypes
    Kenneth Kellar; Fiscal Year: 2007
    ..abstract_text> ..
  3. NICOTINIC RECEPTORS AUTONOMIC GANGLIA AND ADRENAL GLAND
    Kenneth Kellar; Fiscal Year: 2005
    ....
  4. Pharmacology and Regulation of Nicotinic Receptor Subtypes
    Kenneth J Kellar; Fiscal Year: 2010
    ....