M Jung

Summary

Affiliation: Georgetown University
Country: USA

Publications

  1. pmc Involvement of P-glycoprotein and multidrug resistance associated protein 1 on the transepithelial transport of a mercaptoacetamide-based histone-deacetylase inhibitor in Caco-2 cells
    Zacharoula Konsoula
    Department of Radiation Medicine, Lombardi Cancer Center, Georgetown University Medical Center, Washington, DC 20057 1482, USA
    Biol Pharm Bull 32:74-8. 2009
  2. pmc Human fibroblasts for large-scale "omics" investigations of ATM gene function
    Mira Jung
    Department of Radiation Medicine, Georgetown University Medical Center, Washington, DC 20057, USA
    Adv Exp Med Biol 720:181-90. 2011
  3. ncbi request reprint Novel HDAC inhibitors with radiosensitizing properties
    Mira Jung
    Department of Radiation Medicine, Georgetown University Medical Center, Washington, DC 20057, USA
    Radiat Res 163:488-93. 2005
  4. doi request reprint Combining radiation therapy with interstitial radiation-inducible TNF-α expression for locoregional cancer treatment
    M Jung
    Division of Radiation Research, Department of Radiation Medicine, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057 1482, USA
    Cancer Gene Ther 18:189-95. 2011
  5. ncbi request reprint Interstitial gene delivery in human xenograft prostate tumors using titanium metal seeds
    Mira Jung
    Department of Radiation Medicine, Division of Radiation Research, Georgetown University Medical Center, Research Building, Suite E211, Box 571482, Washington, DC 20057 1482, USA
    Mol Cancer Ther 3:655-9. 2004
  6. ncbi request reprint Ionizing radiation-induced apoptosis in ataxia-telangiectasia fibroblasts. Roles of caspase-9 and cellular inhibitor of apoptosis protein-1
    Y Zhang
    Department of Radiation Medicine, Division of Radiation Research, Vincent T. Lombardi Cancer Center, Georgetown University School of Medicine, Washington, D. C. 20007, USA
    J Biol Chem 276:28842-8. 2001
  7. ncbi request reprint Sensing of ionizing radiation-induced DNA damage by ATM through interaction with histone deacetylase
    G D Kim
    Department of Radiation Medicine, Division of Radiation Research, Vincent T Lombardi Cancer Center, Georgetown University Medical Center, Washington, D C 20007, USA
    J Biol Chem 274:31127-30. 1999
  8. ncbi request reprint Expression of a dominant negative I kappa B-alpha modulates hypersensitivity of ataxia telangiectasia fibroblasts to streptonigrin-induced apoptosis
    M Jung
    Department of Radiation Medicine, Georgetown University Medical Center, Washington, D C, USA
    Radiat Oncol Investig 5:265-8. 1997
  9. ncbi request reprint Role of ATM in oxidative stress-mediated c-Jun phosphorylation in response to ionizing radiation and CdCl2
    S A Lee
    Department of Radiation Medicine, Georgetown University Medical Center, Washington, D C 20007 2197, USA
    J Biol Chem 276:11783-90. 2001
  10. ncbi request reprint p53-Independent tumorigenic progression of human prostate cells
    P Ramsamooj
    Department of Radiation Medicine, Georgetown University, Washington, D C, USA
    Radiat Oncol Investig 5:269-74. 1997

Collaborators

  • Y Zhang
  • ALAN PAUL KOZIKOWSKI
  • Anatoly Dritschilo
  • Bin Chen
  • D S Rosenthal
  • Amrita K Cheema
  • S Varghese
  • A Kondratyev
  • Y H Choi
  • P Ramsamooj
  • M E Smulson
  • Habtom Ressom
  • Johng S Rhim
  • Jong Seog Ahn
  • ERIC M VERDIN
  • Steven P Zielske
  • Tae You Kim
  • Bo Yeon Kim
  • Zacharoula Konsoula
  • Osong Kwon
  • Sun Ok Kim
  • Sung A Lee
  • Min Soo Kim
  • Gun Do Kim
  • Zhang Zhi Hu
  • Olga A Timofeeva
  • S Agbor-Enoh
  • Alfredo Velena
  • Roula Konsoula
  • Stefan Schafer
  • Long He
  • Rajshree R Mewani
  • Mukesh K Nyati
  • Won Keun Oh
  • Kyoung M Kim
  • Irina Trofimova
  • C M Simbulan-Rosenthal
  • S A Lee
  • Anton Wellstein
  • Anna T Riegel
  • Hongzhan Huang
  • Cathy H Wu
  • Youngmi Ji
  • C Seudieu
  • Bhaskar V S Kallakury
  • Rency S Varghese
  • E Davidson
  • Kan Wang
  • Milton L Brown
  • Hong Cao
  • Xueping Zhang
  • Wolfgang Sippl
  • Sonja Schlimme
  • Ralf Ficner
  • Achim Dickmanns
  • G D Kim
  • Elena Eliseeva
  • Anja Strasser
  • Andreas Schwienhorst
  • Laura Saunders
  • Eun Young Bae
  • KiHwan Bae
  • A Moon
  • Myung Sun Lee
  • Kyoung A Kim
  • Aquilur Rahman
  • Usha N Kasid
  • Malika T Danner
  • Sooryanarayana Varambally
  • Felix Y Feng
  • Aarif Ahsan
  • Hee Sik Kim
  • Prafulla C Gokhale
  • Sung Lee
  • Cheorl Ho Kim
  • Divya Maheshwari
  • Christine E Canman
  • Ryong Ha
  • Mats Ljungman
  • Vinay A Arora
  • Song Tian
  • Jong Wan Kim
  • Arul M Chinnaiyan
  • Theresa D Carr
  • Patrick Y Chun
  • Kyong A Kim
  • Mary A Davis
  • Bihua Li
  • Theodore S Lawrence
  • Beom Seok Kim

Detail Information

Publications34

  1. pmc Involvement of P-glycoprotein and multidrug resistance associated protein 1 on the transepithelial transport of a mercaptoacetamide-based histone-deacetylase inhibitor in Caco-2 cells
    Zacharoula Konsoula
    Department of Radiation Medicine, Lombardi Cancer Center, Georgetown University Medical Center, Washington, DC 20057 1482, USA
    Biol Pharm Bull 32:74-8. 2009
    ..4x10(-6) cm/s). The results suggest that P-gp and MRP1 transporters are capable of mediating the efflux of W2 and might play a significant role in its oral absorption...
  2. pmc Human fibroblasts for large-scale "omics" investigations of ATM gene function
    Mira Jung
    Department of Radiation Medicine, Georgetown University Medical Center, Washington, DC 20057, USA
    Adv Exp Med Biol 720:181-90. 2011
    ..We present here a summary of the derivation and characterization of cells comprising this model cell system and review applications of this model to systems analysis of ATM functions...
  3. ncbi request reprint Novel HDAC inhibitors with radiosensitizing properties
    Mira Jung
    Department of Radiation Medicine, Georgetown University Medical Center, Washington, DC 20057, USA
    Radiat Res 163:488-93. 2005
    ..The data support the further investigation of these HDAC inhibitors for use as sensitizing agents with potential for clinical application...
  4. doi request reprint Combining radiation therapy with interstitial radiation-inducible TNF-α expression for locoregional cancer treatment
    M Jung
    Division of Radiation Research, Department of Radiation Medicine, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057 1482, USA
    Cancer Gene Ther 18:189-95. 2011
    ....
  5. ncbi request reprint Interstitial gene delivery in human xenograft prostate tumors using titanium metal seeds
    Mira Jung
    Department of Radiation Medicine, Division of Radiation Research, Georgetown University Medical Center, Research Building, Suite E211, Box 571482, Washington, DC 20057 1482, USA
    Mol Cancer Ther 3:655-9. 2004
    ..The expression of TNF-alpha resulted in tumor growth delay of a human prostate cancer xenograft. These results demonstrate the feasibility of applying interstitial delivery of gene expressing vectors for the treatment of human cancers...
  6. ncbi request reprint Ionizing radiation-induced apoptosis in ataxia-telangiectasia fibroblasts. Roles of caspase-9 and cellular inhibitor of apoptosis protein-1
    Y Zhang
    Department of Radiation Medicine, Division of Radiation Research, Vincent T. Lombardi Cancer Center, Georgetown University School of Medicine, Washington, D. C. 20007, USA
    J Biol Chem 276:28842-8. 2001
    ..These results indicate that the extent of IR-induced apoptosis in different AT cell lines is inversely related to the abundance of c-IAP-1 and directly related to the extent of activation of caspases-3 and 9...
  7. ncbi request reprint Sensing of ionizing radiation-induced DNA damage by ATM through interaction with histone deacetylase
    G D Kim
    Department of Radiation Medicine, Division of Radiation Research, Vincent T Lombardi Cancer Center, Georgetown University Medical Center, Washington, D C 20007, USA
    J Biol Chem 274:31127-30. 1999
    ..These results suggest a previously unanticipated role for ATM in the modification of chromatin components in response to ionizing radiation...
  8. ncbi request reprint Expression of a dominant negative I kappa B-alpha modulates hypersensitivity of ataxia telangiectasia fibroblasts to streptonigrin-induced apoptosis
    M Jung
    Department of Radiation Medicine, Georgetown University Medical Center, Washington, D C, USA
    Radiat Oncol Investig 5:265-8. 1997
    ..These data indicate that the mechanisms underlying apoptosis induction by streptonigrin are modulated by regulation of NF-kappa B...
  9. ncbi request reprint Role of ATM in oxidative stress-mediated c-Jun phosphorylation in response to ionizing radiation and CdCl2
    S A Lee
    Department of Radiation Medicine, Georgetown University Medical Center, Washington, D C 20007 2197, USA
    J Biol Chem 276:11783-90. 2001
    ..Our data suggest that ATM contributes to oxidative stress-mediated signaling that leads to c-Jun phosphorylation by acting as a sensor of ionizing radiation-induced oxidative stress and by modulating intracellular redox homeostasis...
  10. ncbi request reprint p53-Independent tumorigenic progression of human prostate cells
    P Ramsamooj
    Department of Radiation Medicine, Georgetown University, Washington, D C, USA
    Radiat Oncol Investig 5:269-74. 1997
    ..These results suggest that the progression of 267B1 cells from nontumorigenic to tumorigenic involves p53-independent processes...
  11. ncbi request reprint NF-kappa B signaling pathway as a target for human tumor radiosensitization
    M Jung
    Department of Radiation Medicine, Georgetown University Medical Center, Washington, DC 20007-2197, USA
    Semin Radiat Oncol 11:346-51. 2001
    ..Therefore, we hypothesize that the signaling pathway involving ATM/NF-kappa B/I kappa B offers attractive potential molecular targets for radiation sensitization in strategies to enhance the therapeutic ratio in cancer treatment...
  12. pmc Omics-based molecular target and biomarker identification
    Zhang Zhi Hu
    Lombardi Cancer Center, Georgetown University, Washington, DC, USA
    Methods Mol Biol 719:547-71. 2011
    ..We describe a downstream workflow and procedures for functional analysis that focus on biological pathways, from which molecular targets can be derived and proposed for experimental validation...
  13. ncbi request reprint ATM gene product phosphorylates I kappa B-alpha
    M Jung
    Department of Radiation Medicine, Vincent T Lombardi Cancer Center, Georgetown University Medical Center, Washington, DC 20007, USA
    Cancer Res 57:24-7. 1997
    ..However, we did not observe a phosphatidyl-3 kinase or a DNA-dependent protein kinase function by ATM immunoprecipitates. These data support a protein kinase activity for ATM and suggest a role in NF-kappa B activation...
  14. ncbi request reprint Overexpression of Rb and E2F-1 in ataxia-telangiectasia lymphocytes
    S Varghese
    Department of Radiation Medicine, Georgetown University Medical School, Washington, DC 20007, USA
    Arch Pharm Res 21:640-4. 1998
    ..The data suggests that abnormalities in the function of Rb and E2F-1 proteins may also be responsible for the failure of AT cells to arrest in the G1/S checkpoint in response to DNA damage...
  15. pmc Poly(ADP-ribosyl)ation of p53 in vitro and in vivo modulates binding to its DNA consensus sequence
    C M Simbulan-Rosenthal
    Department of Biochemistry and Molecular Biology, Georgetown University School of Medicine, Washington, DC 20007, USA
    Neoplasia 3:179-88. 2001
    ....
  16. pmc Novel inhibitor of Plasmodium histone deacetylase that cures P. berghei-infected mice
    S Agbor-Enoh
    Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, Washington, DC 20057, USA
    Antimicrob Agents Chemother 53:1727-34. 2009
    ..These potential drugs improved survival and completely and irreversibly suppressed parasitemia in P. berghei-infected mice...
  17. ncbi request reprint Enhancement of radiation sensitivity of human squamous carcinoma cells by histone deacetylase inhibitors
    Yin Zhang
    Department of Radiation Medicine, Georgetown University School of Medicine, Washington, DC 20057, USA
    Radiat Res 161:667-74. 2004
    ..Taken together, these results implicate G(1) arrest and inhibition of DNA synthesis in the mechanisms underlying radiation sensitization by trichostatin A and support the use of HDAC inhibitors for targeting radioresistant cancers...
  18. ncbi request reprint The p65 subunit of nuclear factor-kappaB is a molecular target for radiation sensitization of human squamous carcinoma cells
    Kyoung M Kim
    Department of Radiation Medicine, Division of Radiation Research, Georgetown University, Research Building, Suite E211, Box 571482, Washington, DC 20057 1482, USA
    Mol Cancer Ther 3:693-8. 2004
    ..The NH(2)-terminal region of p65 is thus a potential molecular target for disruption of NF-kappaB activation and sensitization of tumors to radiotherapy...
  19. ncbi request reprint Rational design and development of radiation-sensitizing histone deacetylase inhibitors
    Mira Jung
    Department of Radiation Medicine, Georgetown University Medical Center, The Research Building, Room E202, Box 571482, 3970 Reservoir Road NW, Washington, DC 20057 1482, USA
    Chem Biodivers 2:1452-61. 2005
    ..Cell-type specificities in radiation-sensitizing properties have been observed. Mechanisms underlying specificity are under investigation...
  20. ncbi request reprint The nucleoside analog sangivamycin induces apoptotic cell death in breast carcinoma MCF7/adriamycin-resistant cells via protein kinase Cdelta and JNK activation
    Sung A Lee
    Department of Radiation Medicine, Georgetown University Medical Center, Washington, DC 20057 1482, USA
    J Biol Chem 282:15271-83. 2007
    ..Taken together, our data suggest that sangivamycin induces mitochondria-mediated apoptotic cell death of MCF7/ADR cells via activation of JNK in a protein kinase Cdelta-dependent manner...
  21. pmc Enhanced expression of SOS1 is detected in prostate cancer epithelial cells from African-American men
    Olga A Timofeeva
    Vincent T Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, DC 20057, USA
    Int J Oncol 35:751-60. 2009
    ....
  22. ncbi request reprint Gene therapy for prostate cancer by targeting poly(ADP-ribose) polymerase
    Irina Trofimova
    Department of Radiation Medicine, Georgetown University Medical Center, Washington, DC 20007, USA
    Cancer Res 62:6879-83. 2002
    ..These results provide proof-of-principle for a novel therapeutic strategy for the treatment of prostate cancer...
  23. pmc Pharmacokinetics-pharmacodynamics and antitumor activity of mercaptoacetamide-based histone deacetylase inhibitors
    Zacharoula Konsoula
    Division of Radiation Biology, Department of Radiation Medicine, The Research Building, Room E 211, Georgetown University School of Medicine, Box 571482, 3970 Reservoir Road, Northwest, Washington, DC 20057 1482, USA
    Mol Cancer Ther 8:2844-51. 2009
    ..Taken together, the results provide a rationale for further investigation of these mercaptoacetamide HDACIs as potent anticancer agents...
  24. pmc In vitro plasma stability, permeability and solubility of mercaptoacetamide histone deacetylase inhibitors
    Roula Konsoula
    Department of Radiation Medicine, Lombardi Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA
    Int J Pharm 361:19-25. 2008
    ..Taken together, these results indicate that the mercaptoacetamide-based HDACIs possess favorable solubility, lipophilicity, permeability and plasma stability features...
  25. ncbi request reprint Attenuated DNA damage repair by trichostatin A through BRCA1 suppression
    Yin Zhang
    Division of Radiation Research, Department of Radiation Medicine, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA
    Radiat Res 168:115-24. 2007
    ..Our data demonstrate for the first time that TSA treatment modulates the radiation-induced DNA damage repair process, in part by suppressing BRCA1 gene expression, suggesting that BRCA1 is one of molecular targets of TSA...
  26. ncbi request reprint Gene expression profile by inhibiting Raf-1 protein kinase in breast cancer cells
    Rajshree R Mewani
    Department of Radiation Medicine, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA
    Int J Mol Med 17:457-63. 2006
    ..Real-time PCR, Northern analysis and Western analysis confirmed the microarray findings. Our study provides insight into Raf-1 related signaling pathways and a model system to identify potential target genes...
  27. ncbi request reprint Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs)
    Stefan Schafer
    Institute of Pharmaceutical Sciences, University of Freiburg, Albertstr 25, 79104 Freiburg, Germany
    Bioorg Med Chem 16:2011-33. 2008
    ..Docking studies were carried out using HDAC1 and HDAC6 protein models. Antiproliferative activity was shown on cancer cells for selected compounds...
  28. ncbi request reprint Ataxia telangiectasia mutated down-regulates phospho-extracellular signal-regulated kinase 1/2 via activation of MKP-1 in response to radiation
    Mukesh K Nyati
    Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Cancer Res 66:11554-9. 2006
    ..These findings show a new function for ATM in the control of mitogenic pathways affecting cell signaling and emphasize the key role of ATM in coordinating the cellular response to DNA damage...
  29. ncbi request reprint NF-kappaB inhibition radiosensitizes Ki-Ras-transformed cells to ionizing radiation
    Bo Yeon Kim
    Laboratory of Cellular Signaling Modulators, Korea Research Institute of Bioscience and Biotechnology KRIBB, Yuseong, Daejeon, 305 333, Korea
    Carcinogenesis 26:1395-403. 2005
    ..All these results suggest an application of blocking NF-kappaB activation pathway to the development of anticancer therapeutics in IR-induced radiotherapy of Ki-Ras-transformed cancer cells...
  30. ncbi request reprint DLC-1, a GTPase-activating protein for Rho, is associated with cell proliferation, morphology, and migration in human hepatocellular carcinoma
    Tai Young Kim
    National Research Laboratory for Cancer Epigenetics, Cancer Research Institute, Seoul National University College of Medicine, Seoul 110 744, Republic of Korea
    Biochem Biophys Res Commun 355:72-7. 2007
    ..These observations suggest that DLC-1 plays important roles in signal transduction pathway regulating cell proliferation, cell morphology, and cell migration by affecting Rho family GTPases and focal adhesion proteins...
  31. ncbi request reprint NF-kappaB inhibition increases chemosensitivity to trichostatin A-induced cell death of Ki-Ras-transformed human prostate epithelial cells
    Osong Kwon
    Laboratory of Cellular Signaling Modulators, Korea Research Institute of Bioscience and Biotechnology KRIBB Yuseong, Daejeon, 305 333, Korea
    Carcinogenesis 27:2258-68. 2006
    ....
  32. ncbi request reprint Transcriptional silencing of the DLC-1 tumor suppressor gene by epigenetic mechanism in gastric cancer cells
    Tai Young Kim
    National Research Laboratory for Cancer Epigenetics, Cancer Research Institute, Seoul National University College of Medicine, Seoul 110 744, Korea
    Oncogene 22:3943-51. 2003
    ..Taken together, the results of our study suggest that the transcriptional silencing of DLC-1, by epigenetic mechanism, may be involved in gastric carcinogenesis...
  33. ncbi request reprint Chemistry and biology of mercaptoacetamides as novel histone deacetylase inhibitors
    Bin Chen
    Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA
    Bioorg Med Chem Lett 15:1389-92. 2005
    ..Their ability to inhibit HDAC activity and their effects on cancer cell growth were investigated. Some compounds exhibit better HDAC inhibitory activity than SAHA...
  34. ncbi request reprint NF-kappaB inhibition enhances caspase-3 degradation of Akt1 and apoptosis in response to camptothecin
    Long He
    Functional Metabolomics Research Center, KRIBB, Daejeon, Yuseong, 305 806, Korea
    Cell Signal 19:1713-21. 2007
    ....