Timothy J Jorgensen

Summary

Affiliation: Georgetown University
Country: USA

Publications

  1. pmc Ionizing radiation does not alter the antitumor activity of herpes simplex virus vector G207 in subcutaneous tumor models of human and murine prostate cancer
    T J Jorgensen
    Department of Radiation Medicine, Lombardi Cancer Center, Georgetown University Medical Center, Washington, DC 20007, USA
    Neoplasia 3:451-6. 2001
  2. pmc Hypothesis-driven candidate gene association studies: practical design and analytical considerations
    Timothy J Jorgensen
    Department of Radiation Medicine, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA
    Am J Epidemiol 170:986-93. 2009
  3. pmc Binding kinetics and activity of human poly(ADP-ribose) polymerase-1 on oligo-deoxyribonucleotide substrates
    Timothy J Jorgensen
    Departments of Radiation Medicine, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA
    J Mol Recognit 22:446-52. 2009
  4. ncbi request reprint Breast cancer risk is not associated with polymorphic forms of xeroderma pigmentosum genes in a cohort of women from Washington County, Maryland
    T J Jorgensen
    Department of Radiation Medicine, Lombardi Comprehensive Cancer Center, Georgetown University, 3970 Reservoir Road, NW, TRB Room E212, Washington, DC 20057, USA
    Breast Cancer Res Treat 101:65-71. 2007
  5. ncbi request reprint Chemosensitization and radiosensitization of human lung and colon cancers by antimitotic agent, ABT-751, in athymic murine xenograft models of subcutaneous tumor growth
    Timothy J Jorgensen
    Department of Radiation Medicine, Lombardi Comprehensive Cancer Center, Georgetown University, 3970 Reservoir Road NW, TRB E212, Washington DC 20057, USA
    Cancer Chemother Pharmacol 59:725-32. 2007
  6. ncbi request reprint Enhancing radiosensitivity: targeting the DNA repair pathways
    Timothy J Jorgensen
    Department of Radiation Medicine, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA
    Cancer Biol Ther 8:665-70. 2009
  7. pmc DNA repair gene variants associated with benign breast disease in high cancer risk women
    Timothy J Jorgensen
    Department of Radiation Medicine, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia, USA
    Cancer Epidemiol Biomarkers Prev 18:346-50. 2009
  8. pmc A population-based study of hedgehog pathway gene variants in relation to the dual risk of basal cell carcinoma plus another cancer
    Timothy J Jorgensen
    Department of Radiation Medicine, Georgetown University School of Medicine, Washington, DC, USA
    Cancer Epidemiol 36:e288-93. 2012
  9. pmc Radiation-induced phosphorylation of Chk1 at S345 is associated with p53-dependent cell cycle arrest pathways
    Hui Tian
    Department of Radiation Medicine, Lombardi Cancer Center, Georgetown University Medical Center, 3970 Reservoir Road, N W, Washington, DC 20007 2197, USA
    Neoplasia 4:171-80. 2002
  10. pmc Phosphorylation of histone H2A.X as an early marker of neuronal endangerment following seizures in the adult rat brain
    Samantha L Crowe
    Interdisciplinary Program in Neuroscience and Department of Pharmacology, Georgetown University, Washington, DC 20057, USA
    J Neurosci 31:7648-56. 2011

Research Grants

  1. DNA REPAIR GENE POLYMORPHISMS AND BREAST CANCER RISK
    TIMOTHY JORGENSEN; Fiscal Year: 2003

Collaborators

Detail Information

Publications12

  1. pmc Ionizing radiation does not alter the antitumor activity of herpes simplex virus vector G207 in subcutaneous tumor models of human and murine prostate cancer
    T J Jorgensen
    Department of Radiation Medicine, Lombardi Cancer Center, Georgetown University Medical Center, Washington, DC 20007, USA
    Neoplasia 3:451-6. 2001
    ..We found that individually, either G207 or radiation was effective in delaying tumor growth in these models. However, delivering the treatments simultaneously did not produce an enhanced effect...
  2. pmc Hypothesis-driven candidate gene association studies: practical design and analytical considerations
    Timothy J Jorgensen
    Department of Radiation Medicine, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA
    Am J Epidemiol 170:986-93. 2009
    ..A study design algorithm using the example of DNA repair genes and cancer is presented for purposes of illustration...
  3. pmc Binding kinetics and activity of human poly(ADP-ribose) polymerase-1 on oligo-deoxyribonucleotide substrates
    Timothy J Jorgensen
    Departments of Radiation Medicine, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA
    J Mol Recognit 22:446-52. 2009
    ....
  4. ncbi request reprint Breast cancer risk is not associated with polymorphic forms of xeroderma pigmentosum genes in a cohort of women from Washington County, Maryland
    T J Jorgensen
    Department of Radiation Medicine, Lombardi Comprehensive Cancer Center, Georgetown University, 3970 Reservoir Road, NW, TRB Room E212, Washington, DC 20057, USA
    Breast Cancer Res Treat 101:65-71. 2007
    ..Although mutated XP genes are rare, polymorphic forms with potential functional deficiencies are common, and could pose a significant cancer risk in the general population...
  5. ncbi request reprint Chemosensitization and radiosensitization of human lung and colon cancers by antimitotic agent, ABT-751, in athymic murine xenograft models of subcutaneous tumor growth
    Timothy J Jorgensen
    Department of Radiation Medicine, Lombardi Comprehensive Cancer Center, Georgetown University, 3970 Reservoir Road NW, TRB E212, Washington DC 20057, USA
    Cancer Chemother Pharmacol 59:725-32. 2007
    ..The current studies were conducted to determine whether ABT-751 enhances antitumor activity of standard cytotoxic therapies currently in clinical use...
  6. ncbi request reprint Enhancing radiosensitivity: targeting the DNA repair pathways
    Timothy J Jorgensen
    Department of Radiation Medicine, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA
    Cancer Biol Ther 8:665-70. 2009
    ..The example of PARP1 inhibitor use in BRCA1 and 2 mutated breast cancer therapy is discussed, and future directions and challenges are explored...
  7. pmc DNA repair gene variants associated with benign breast disease in high cancer risk women
    Timothy J Jorgensen
    Department of Radiation Medicine, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia, USA
    Cancer Epidemiol Biomarkers Prev 18:346-50. 2009
    ..68; 95% CI, 1.52-4.66; P(interaction) = 0.02). This study suggests that variant alleles in DNA repair genes may modify BBD risk, a potential intermediate marker of breast cancer risk, particularly among high-risk subgroups...
  8. pmc A population-based study of hedgehog pathway gene variants in relation to the dual risk of basal cell carcinoma plus another cancer
    Timothy J Jorgensen
    Department of Radiation Medicine, Georgetown University School of Medicine, Washington, DC, USA
    Cancer Epidemiol 36:e288-93. 2012
    ..This study tested the hypothesis that hedgehog pathway and pathway-related gene variants contribute to the increased risk of subsequent cancers among those with a history of BCC...
  9. pmc Radiation-induced phosphorylation of Chk1 at S345 is associated with p53-dependent cell cycle arrest pathways
    Hui Tian
    Department of Radiation Medicine, Lombardi Cancer Center, Georgetown University Medical Center, 3970 Reservoir Road, N W, Washington, DC 20007 2197, USA
    Neoplasia 4:171-80. 2002
    ....
  10. pmc Phosphorylation of histone H2A.X as an early marker of neuronal endangerment following seizures in the adult rat brain
    Samantha L Crowe
    Interdisciplinary Program in Neuroscience and Department of Pharmacology, Georgetown University, Washington, DC 20057, USA
    J Neurosci 31:7648-56. 2011
    ..This demonstrates that DNA DSB damage is an especially sensitive indicator of neuronal endangerment and that it is responsive to neuroprotective intervention...
  11. pmc Rapid phosphorylation of histone H2A.X following ionotropic glutamate receptor activation
    Samantha L Crowe
    Interdisciplinary Program in Neuroscience, Georgetown University, Washington, DC, USA
    Eur J Neurosci 23:2351-61. 2006
    ....
  12. pmc Nonmelanoma skin cancer and risk for subsequent malignancy
    Jiping Chen
    Division of Cancer Prevention, National Cancer Institute, Rockville, MD, USA
    J Natl Cancer Inst 100:1215-22. 2008
    ..Individuals with a personal history of nonmelanoma skin cancer (NMSC) may have an increased risk of subsequent noncutaneous malignancies. To test this hypothesis, we carried out a community-based, prospective cohort study...

Research Grants1

  1. DNA REPAIR GENE POLYMORPHISMS AND BREAST CANCER RISK
    TIMOTHY JORGENSEN; Fiscal Year: 2003
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