Research Topics

Genomes and Genes


V Craig Jordan


Affiliation: Georgetown University
Country: USA


  1. Jordan V, Obiorah I, Fan P, Kim H, Ariazi E, Cunliffe H, et al. The St. Gallen Prize Lecture 2011: evolution of long-term adjuvant anti-hormone therapy: consequences and opportunities. Breast. 2011;20 Suppl 3:S1-11 pubmed publisher
  2. Craig Jordan V, McDaniel R, Agboke F, Maximov P. The evolution of nonsteroidal antiestrogens to become selective estrogen receptor modulators. Steroids. 2014;90:3-12 pubmed publisher
    ..This article charts the origins of the current path for progress in women's health with SERMs. ..
  3. Fan P, Agboke F, Cunliffe H, Ramos P, Jordan V. A molecular model for the mechanism of acquired tamoxifen resistance in breast cancer. Eur J Cancer. 2014;50:2866-76 pubmed publisher
    ..Importantly, it provides a rationale that membrane-associated pathways may be valuable therapeutic targets for tamoxifen resistant patients in clinic. ..
  4. Fan P, Cunliffe H, Griffith O, Agboke F, Ramos P, Gray J, et al. Identification of gene regulation patterns underlying both oestrogen- and tamoxifen-stimulated cell growth through global gene expression profiling in breast cancer cells. Eur J Cancer. 2014;50:2877-86 pubmed publisher
    ..Membrane-associated signalling is critical for 4-OHT-stimulated cell growth in MCF-7:PF cells. This study provides a rationale for the further investigation of target therapy for tamoxifen resistant patients. ..
  5. Jordan V. Linking estrogen-induced apoptosis with decreases in mortality following long-term adjuvant tamoxifen therapy. J Natl Cancer Inst. 2014;106: pubmed publisher
  6. Sweeney E, Fan P, Jordan V. Molecular modulation of estrogen-induced apoptosis by synthetic progestins in hormone replacement therapy: an insight into the women's health initiative study. Cancer Res. 2014;74:7060-8 pubmed publisher
    ..Therefore, perhaps other approved progestins (e.g., NETA) should be considered as alternatives to MPA. ..
  7. Maximov P, McDaniel R, Fernandes D, Bhatta P, Korostyshevskiy V, Curpan R, et al. Pharmacological relevance of endoxifen in a laboratory simulation of breast cancer in postmenopausal patients. J Natl Cancer Inst. 2014;106: pubmed publisher
    ..Endoxifen is of supportive importance for the therapeutic effect of tamoxifen in a postmenopausal setting. ..
  8. Fan P, Agboke F, McDaniel R, Sweeney E, Zou X, Creswell K, et al. Inhibition of c-Src blocks oestrogen-induced apoptosis and restores oestrogen-stimulated growth in long-term oestrogen-deprived breast cancer cells. Eur J Cancer. 2014;50:457-68 pubmed publisher
    ..Caution must be exercised when considering c-Src inhibitors in clinical trials following the development of acquired resistance to aromatase inhibitors, especially in the presence of the patient's own oestrogen. ..