Research Topics
| Jacqueline JonklaasSummaryAffiliation: Georgetown University Country: USA Publications
Research Grants
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Detail Information
Publications
Tandem mass spectrometry as a novel tool for elucidating pituitary-thyroid relationshipsJacqueline Jonklaas
Division of Endocrinology, Georgetown University Medical Center, Washington, District of Columbia 20007, USA
Thyroid 18:1303-11. 2008..Our objective was to determine the performance of liquid chromatography-tandem mass spectrometry (LC-MS/MS) in documenting both group and individual relationships between thyroid hormone and thyroid-stimulating hormone (TSH) concentrations...
Sex and age differences in levothyroxine dosage requirementJacqueline Jonklaas
Division of Endocrinology, Georgetown University Medical Center, Washington, DC 20007, USA
Endocr Pract 16:71-9. 2010..To examine the performance of weight-based formulae for estimating the levothyroxine dosage requirement in athyreotic patients and to determine whether formula performance is affected by age, sex, or menstrual status...- Correlations of free thyroid hormones measured by tandem mass spectrometry and immunoassay with thyroid-stimulating hormone across 4 patient populationsJacqueline Jonklaas
Division of Endocrinology, Georgetown University Medical Center, Washington, DC 20007, USA
Clin Chem 55:1380-8. 2009..Our study was designed to compare free thyroid hormone measurements performed with immunoassay and LC-MS/MS... - Endogenous thyrotropin and triiodothyronine concentrations in individuals with thyroid cancerJacqueline Jonklaas
Division of Endocrinology, Georgetown University Medical Center, Washington, District of Columbia 20007, USA
Thyroid 18:943-52. 2008..We also sought to determine whether thyroid hormone levels were lower in the patients with malignancy... - Triiodothyronine levels in athyreotic individuals during levothyroxine therapyJacqueline Jonklaas
Division of Endocrinology, Georgetown University Medical Center, Washington, DC, USA
JAMA 299:769-77. 2008..However, trials evaluating therapy with combined LT4 and T3 have failed to demonstrate any consistent advantage of combination therapy... 
Role of radioactive iodine for adjuvant therapy and treatment of metastasesJacqueline Jonklaas
Division of Endocrinology and Metabolism, Georgetown University Medical Center, Washington, DC 20007, USA
J Natl Compr Canc Netw 5:631-40. 2007..Stimulation of the expression of the sodium iodide symporter, or its introduction de novo into nonthyroid cells, is promising in treating poorly differentiated thyroid cancer and nonthyroid malignancies, respectively...- Outcomes of patients with differentiated thyroid carcinoma following initial therapyJacqueline Jonklaas
Georgetown University Medical Center, Washington, DC 20007, USA
Thyroid 16:1229-42. 2006..We were unable to show any impact, positive or negative, of specific therapies in stage I patients... - Use of steroid profiles in determining the cause of adrenal insufficiencyJennifer P Holst
Center for Diabetes and Endocrinology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Steroids 72:71-84. 2007..The study objective was to determine whether a steroid profile, created by simultaneous measurement of 10 steroid hormones by tandem mass spectrometry, would help determine the cause of adrenal insufficiency... - Changes in steroid concentrations with the timing of corticotropin stimulation testing in participants with adrenal sufficiencyJacqueline Jonklaas
Division of Endocrinology, Georgetown University Medical Center, Washington, DC 20007, USA
Endocr Pract 18:66-75. 2012..To determine whether the time of day at which corticotropin stimulation testing is performed influences the steroid concentrations observed in persons with normal adrenal function... - Radioiodine treatment of metastatic thyroid cancer: relative efficacy and side effect profile of preparation by thyroid hormone withdrawal versus recombinant human thyrotropinJoanna Klubo-Gwiezdzinska
Division of Endocrinology, Department of Medicine, Washington Hospital Center, Washington, District of Columbia 20010 2910, USA
Thyroid 22:310-7. 2012..The aim of our study was to compare the relative efficacy and side effect profile of rhTSH versus THW preparation for RAI therapy of metastatic DTC... - The magnitude of increased levothyroxine requirements in hypothyroid pregnant women depends upon the etiology of the hypothyroidismJennifer A Loh
Division of Endocrinology, Washington Hospital Center, Washington, District of Columbia 20010, USA
Thyroid 19:269-75. 2009..We hypothesized that dosage requirements during pregnancy might differ depending upon the nature of the underlying hypothyroidism... - Age and the thyrotropin response to hypothyroxinemiaRebecca Over
Division of Endocrinology, Georgetown University Medical Center, Suite 232, Building D, and Washington Hospital Center, 4000 Reservoir Road, NW, Washington, DC 20007, USA
J Clin Endocrinol Metab 95:3675-83. 2010..Some studies suggest altered pituitary functioning and TSH production with aging... - Thyroid medications during pregnancyThien-Giang Bach-Huynh
Division of Endocrinology and Metabolism, Georgetown University, Suite 232, Bldg. D, 4000 Reservoir Road, NW, Washington, DC 20007, USA
Ther Drug Monit 28:431-41. 2006..There is limited data about the role and safety of oral contrast agents, iodine, amiodarone, and perchlorate. Radioiodine therapy is contradicted during pregnancy... - Efficacy of dosimetric versus empiric prescribed activity of 131I for therapy of differentiated thyroid cancerJoanna Klubo-Gwiezdzinska
Division of Nuclear Medicine, Washington Hospital Center, Washington, DC 20010 2910, USA
J Clin Endocrinol Metab 96:3217-25. 2011..The prescribed activity of (131)I can be determined using two approaches: 1) empiric prescribed activity of (131)I (E-Rx); and 2) dosimetry-based prescribed activity of (131)I (D-Rx)... - Tandem mass spectrometry improves the accuracy of free thyroxine measurements during pregnancyNatasa Kahric Janicic
Division of Endocrinology, Georgetown University Medical Center, Washington, DC, USA
Thyroid 17:303-11. 2007..The objective of this study was to characterize the performance of a novel tandem mass spectrometric assay for free thyroxine during the physiologic conditions of pregnancy... - Levothyroxine replacement doses are affected by gender and weight, but not ageMadhuri Devdhar
Division of Endocrinology and Metabolism, Georgetown University Medical Center, Washington, District of Columbia 20007, USA
Thyroid 21:821-7. 2011..Our objective was to determine whether gender, menstrual status, and ideal BW (IBW) also affect the LT(4) dose required to achieve a serum TSH within the normal range... - Weight changes in euthyroid patients undergoing thyroidectomyJacqueline Jonklaas
Division of Endocrinology, Georgetown University Medical Center, Washington, District of Columbia 20007, USA
Thyroid 21:1343-51. 2011..We wished to determine whether recently thyroidectomized euthyroid patients gained more weight over 1 year than matched euthyroid patients with preexisting hypothyroidism... - Timing of levothyroxine administration affects serum thyrotropin concentrationThien Giang Bach-Huynh
Division of Endocrinology, Georgetown University Medical Center, Washington, DC 20007, USA
J Clin Endocrinol Metab 94:3905-12. 2009..Patients treated with levothyroxine typically ingest it in a fasting state to prevent food impairing its absorption. The serum thyrotropin concentration is the therapeutic index of levothyroxine action... - Age modifies the response to recombinant human thyrotropinRebecca Over
Division of Endocrinology, Georgetown University Medical Center, Washington, District of Columbia 20007, USA
Thyroid 20:1377-84. 2010..We wished to test the hypothesis that TSH concentrations achieved after rhTSH injection are influenced by age... - Potential use of recombinant human thyrotropin in the treatment of distant metastases in patients with differentiated thyroid cancerJoanna Klubo-Gwiezdzinska
Division of Endocrinology, Department of Medicine, Washington Hospital Center, Washington, DC 20010, USA
Endocr Pract 19:139-48. 2013..The goal of this review is to present current data on the relative efficacy and side effects profile of rhTSH-aided versus THW-aided RAI therapy for the treatment of patients with distant metastases of DTC... - Utility of PET/neck MRI digital fusion images in the management of recurrent or persistent thyroid cancerLaura Seiboth
Endocrine Medicine Section, Washington Hospital Center, Georgetown University Medical Center, Washington, DC 20010, USA
Thyroid 18:103-11. 2008..We define standard imaging as a neck sonogram, 131I scan, computed tomography, and MRI... - Radioiodine therapy for thyroid cancer and hyperthyroidism in patients with end-stage renal disease on hemodialysisJennifer P Holst
Georgetown University Washington Hospital Center, Washington, DC, USA
Thyroid 15:1321-31. 2005..Using a multidisciplinary approach and special precautions, (131)I therapy can be administered safely and effectively for patients with thyroid cancer or hyperthyroidism who are receiving hemodialysis... - Intravenous methimazole in the treatment of refractory hyperthyroidismSteven P Hodak
Georgetown University Hospital, Division of Endocrinology and Metabolism, Washington, DC 20007, USA
Thyroid 16:691-5. 2006..CONCLUSION: Two cases of hyperthyroidism successfully treated with a preparation of intravenous MMI are described... - Thyroid nodulesGeanina Popoveniuc
Division of Endocrinology, Georgetown University Medical Center, Washington, DC 20007, USA
Med Clin North Am 96:329-49. 2012..Thyroid cancer discovered during pregnancy is also discussed... - The measurement of free thyroxine by isotope dilution tandem mass spectrometrySteven J Soldin
Bioanalytical Core Laboratory, Georgetown Clinical Research Center, Georgetown University, Washington, DC 20007 2197, USA
Clin Chim Acta 358:113-8. 2005..We developed a rapid, reliable free T4 method employing isotope dilution tandem mass spectrometry and compared our results with both the analogue (direct) free T4 and equilibrium dialysis procedures... - Transient Graves' hyperthyroidism during pregnancy in a patient with Hashimoto's hypothyroidismRui Lu
Division of Endocrinology and Metabolism, Georgetown University Hospital, Washington, DC 20007, USA
Thyroid 15:725-9. 2005..This interesting case is presented, along with a discussion of how the expression of autoimmune thyroid disease may be altered during pregnancy... - Cushing's syndrome during pregnancy: personal experience and review of the literatureJohn R Lindsay
Reproductive Biology and Medicine Branch, National Institute for Child Health and Human Development, National Institutes of Health, Building 10, CRC, Room 1-3140, 10 Center Drive, Bethesda, Maryland 20892-1109, USA
J Clin Endocrinol Metab 90:3077-83. 2005..It is likely that earlier recognition and treatment would improve outcome. There is a need for development of criteria for interpretation of diagnostic tests and increased consideration of CS in pregnancy...
Research Grants
- Mentored Patient-Oriented Research Career Development AwardJacqueline Jonklaas; Fiscal Year: 2006..A new sustained release product, which results in steady triiodothyronine levels, will furnish more physiologic replacement. This will be tested against treatment with levothyroxine, and levothyroxine and triiodothyronine. ..