R D Higgins

Summary

Affiliation: Georgetown University
Country: USA

Publications

  1. ncbi Antenatal dexamethasone and decreased severity of retinopathy of prematurity
    R D Higgins
    Department of Pediatrics, New York University Medical Center and Bellevue Hospital Center, New York City, USA
    Arch Ophthalmol 116:601-5. 1998
  2. ncbi Hyperoxia stimulates endothelin-1 secretion from endothelial cells; modulation by captopril and nifedipine
    R D Higgins
    Georgetown University Medical Center, Department of Pediatrics, Washington, DC 20007, USA
    Curr Eye Res 17:487-93. 1998
  3. ncbi Diltiazem reduces retinal neovascularization in a mouse model of oxygen induced retinopathy
    R D Higgins
    Department of Pediatrics, Georgetown University Medical Center, Washington, DC 20007, USA
    Curr Eye Res 18:20-7. 1999
  4. ncbi Squalamine improves retinal neovascularization
    R D Higgins
    Department of Pediatrics, Georgetown University Medical Center, Washington, DC 20007, USA
    Invest Ophthalmol Vis Sci 41:1507-12. 2000
  5. ncbi Somatostatin analogs inhibit neonatal retinal neovascularization
    Rosemary D Higgins
    Department of Pediatrics, Division of Neonatology, Georgetown University Children s Medical Center, 3800 Reservoir Road, NW M3400, Washington, DC, 20007, USA
    Exp Eye Res 74:553-9. 2002
  6. ncbi Lack of effect of gender on retinopathy in the mouse
    R D Higgins
    Department of Paediatrics, Georgetown University Children s Medical Center, Washington, DC 20007, USA
    Clin Experiment Ophthalmol 29:323-6. 2001
  7. ncbi Dexamethasone alters TNF-alpha expression in retinopathy
    P Yossuck
    Department of Pediatrics, Division of Neonatology, Georgetown University Children's Medical Center, Washington, DC 20007, USA
    Mol Genet Metab 72:164-7. 2001
  8. ncbi Captopril improves retinal neovascularization via endothelin-1
    M Tadesse
    Georgetown University Children's Medical Center, Department of Pediatrics, Division of Neonatology, 3800 Reservoir Road NW, Washington, DC 20007, USA
    Invest Ophthalmol Vis Sci 42:1867-72. 2001
  9. ncbi Impact of postnatal corticosteroid use on neurodevelopment at 18 to 22 months' adjusted age: effects of dose, timing, and risk of bronchopulmonary dysplasia in extremely low birth weight infants
    Deanne Wilson-Costello
    Rainbow Babies and Children s Hospital, Division of Neonatology, 11100 Euclid Ave, Cleveland, OH 44106, USA
    Pediatrics 123:e430-7. 2009
  10. ncbi Ibuprofen improves oxygen-induced retinopathy in a mouse model
    Jotishna Sharma
    Department of Pediatrics, Division of Neonatology, Georgetown University Children's Medical Center, Washington, DC, USA
    Curr Eye Res 27:309-14. 2003

Collaborators

Detail Information

Publications20

  1. ncbi Antenatal dexamethasone and decreased severity of retinopathy of prematurity
    R D Higgins
    Department of Pediatrics, New York University Medical Center and Bellevue Hospital Center, New York City, USA
    Arch Ophthalmol 116:601-5. 1998
    ..To assess risk factors associated with the development of retinopathy of prematurity (ROP) in an urban population...
  2. ncbi Hyperoxia stimulates endothelin-1 secretion from endothelial cells; modulation by captopril and nifedipine
    R D Higgins
    Georgetown University Medical Center, Department of Pediatrics, Washington, DC 20007, USA
    Curr Eye Res 17:487-93. 1998
    ..Premature birth results in a relative systemic hyperoxia, compared to the in utero oxygen milieu. We tested the hypothesis that hyperoxia increases ET-1 expression as a possible mechanism for vasoconstriction in the retinal vasculature...
  3. ncbi Diltiazem reduces retinal neovascularization in a mouse model of oxygen induced retinopathy
    R D Higgins
    Department of Pediatrics, Georgetown University Medical Center, Washington, DC 20007, USA
    Curr Eye Res 18:20-7. 1999
    ....
  4. ncbi Squalamine improves retinal neovascularization
    R D Higgins
    Department of Pediatrics, Georgetown University Medical Center, Washington, DC 20007, USA
    Invest Ophthalmol Vis Sci 41:1507-12. 2000
    ..The effect of squalamine, an antiangiogenic amino sterol, on oxygen-induced retinopathy (OIR) was assessed in a mouse model...
  5. ncbi Somatostatin analogs inhibit neonatal retinal neovascularization
    Rosemary D Higgins
    Department of Pediatrics, Division of Neonatology, Georgetown University Children s Medical Center, 3800 Reservoir Road, NW M3400, Washington, DC, 20007, USA
    Exp Eye Res 74:553-9. 2002
    ..Growth as measured by animal weight was unaffected by either treatment. Woc4D and octreotide inhibited retinal neovascularization in an equally effective manner in the mouse model of oxygen induced retinopathy...
  6. ncbi Lack of effect of gender on retinopathy in the mouse
    R D Higgins
    Department of Paediatrics, Georgetown University Children s Medical Center, Washington, DC 20007, USA
    Clin Experiment Ophthalmol 29:323-6. 2001
    ..The reported effect of gender on retinopathy of prematurity has been controversial. The goal of this study was to determine the effect of gender on oxygen-induced retinopathy in a mouse model...
  7. ncbi Dexamethasone alters TNF-alpha expression in retinopathy
    P Yossuck
    Department of Pediatrics, Division of Neonatology, Georgetown University Children's Medical Center, Washington, DC 20007, USA
    Mol Genet Metab 72:164-7. 2001
    ..It increased markedly during the vasoproliferative phase and was suppressed by dexamethasone. Modulation of TNF-alpha expression may provide a potential site of action for future therapeutic targets...
  8. ncbi Captopril improves retinal neovascularization via endothelin-1
    M Tadesse
    Georgetown University Children's Medical Center, Department of Pediatrics, Division of Neonatology, 3800 Reservoir Road NW, Washington, DC 20007, USA
    Invest Ophthalmol Vis Sci 42:1867-72. 2001
    ..ET-1 expression is increased from P7 to P17, altered by hyperoxic exposure and relative hypoxic recovery and modulated by captopril in a mouse model of OIR...
  9. ncbi Impact of postnatal corticosteroid use on neurodevelopment at 18 to 22 months' adjusted age: effects of dose, timing, and risk of bronchopulmonary dysplasia in extremely low birth weight infants
    Deanne Wilson-Costello
    Rainbow Babies and Children s Hospital, Division of Neonatology, 11100 Euclid Ave, Cleveland, OH 44106, USA
    Pediatrics 123:e430-7. 2009
    ....
  10. ncbi Ibuprofen improves oxygen-induced retinopathy in a mouse model
    Jotishna Sharma
    Department of Pediatrics, Division of Neonatology, Georgetown University Children's Medical Center, Washington, DC, USA
    Curr Eye Res 27:309-14. 2003
    ..005. Ibuprofen did not affect the growth of the animals. CONCLUSION: Ibuprofen improves oxygen-induced retinopathy when administered concurrently with the injury phase without affecting the normal retinal development of the animals...
  11. ncbi Neuropeptide Y expression in a mouse model of oxygen-induced retinopathy
    Helen Z Yoon
    Department of Pediatrics, Division of Neonatology, Georgetown University Children's Medical Center, Washington, DC 20007, USA
    Clin Experiment Ophthalmol 30:424-9. 2002
    ..Alteration in the production of NPY and the NPY Y2 receptor may be avenues for potential modification in the development of retinopathy...
  12. ncbi Outcomes of safety and effectiveness in a multicenter randomized, controlled trial of whole-body hypothermia for neonatal hypoxic-ischemic encephalopathy
    Seetha Shankaran
    Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan, USA
    Pediatrics 122:e791-8. 2008
    ..Whole-body hypothermia reduced the frequency of death or moderate/severe disabilities in neonates with hypoxic-ischemic encephalopathy in a randomized, controlled multicenter trial...
  13. ncbi Association between urinary lactate to creatinine ratio and neurodevelopmental outcome in term infants with hypoxic-ischemic encephalopathy
    William Oh
    Department of Pediatrics, Warren Alpert Medical School of Brown University, Providence, RI, USA
    J Pediatr 153:375-8. 2008
    ..To assess the association between urinary lactate to creatinine ratio (ULCR) and neurodevelopmental outcome in term infants with hypoxic ischemic encephalopathy and examine the effect of hypothermia on the change in ULCR...
  14. ncbi Neurodevelopmental outcomes of premature infants with severe respiratory failure enrolled in a randomized controlled trial of inhaled nitric oxide
    Susan R Hintz
    NICHD Neonatal Research Network
    J Pediatr 151:16-22, 22.e1-3. 2007
    ....
  15. ncbi Predicting outcomes of neonates diagnosed with hypoxemic-ischemic encephalopathy
    Namasivayam Ambalavanan
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35249, USA
    Pediatrics 118:2084-93. 2006
    ..The goals were to identify predictor variables and to develop scoring systems and classification trees to predict death/disability or death in infants with hypoxic-ischemic encephalopathy...
  16. ncbi Hypoxic ischemic encephalopathy and hypothermia: a critical look
    Rosemary D Higgins
    Pregnancy and Perinatology Branch, Center for Developmental Biology and Perinatal Medicine, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA
    Obstet Gynecol 106:1385-7. 2005
    ..Therapeutic hypothermia offers a potentially promising therapy for hypoxic ischemic encephalopathy. Hypothermia for encephalopathy should be considered an evolving therapy because of lack of long-term safety and efficacy data...
  17. ncbi Inhaled nitric oxide for premature infants with severe respiratory failure
    Krisa P Van Meurs
    Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, Calif 94304, USA
    N Engl J Med 353:13-22. 2005
    ..We conducted a multicenter, randomized, blinded, controlled trial to determine whether inhaled nitric oxide reduced the rate of death or bronchopulmonary dysplasia in such infants...
  18. ncbi Neuropeptide Y and Y2-receptor are involved in development of diabetic retinopathy and retinal neovascularization
    Markku Koulu
    Department of Pharmacology and Clinical Pharmacology, University of Turku, Turku, Finland
    Ann Med 36:232-40. 2004
    ..In addition, we investigated the role of the NPY Y2-receptor as a putative mediator of angiogenic NPY signaling in the retina...
  19. ncbi Regression of retinopathy by squalamine in a mouse model
    Rosemary D Higgins
    Department of Pediatrics, Georgetown University, Wshington, DC 20007, USA
    Pediatr Res 56:144-9. 2004
    ..Further, squalamine given late in the course of OIR improves retinopathy by inducing regression of retinal neovessels and abrogating invasion of new vessels beyond the inner-limiting membrane of the retina...
  20. ncbi Captopril and vascular endothelial growth factor in a mouse model of retinopathy
    Rosemary D Higgins
    Department of Pediatrics, Division of Neonatology, Georgetown University Children s Medical Center, Washington, DC, USA
    Curr Eye Res 27:123-9. 2003
    ..The objective of this study was to determine the effect of captopril, an angiotensin converting enzyme (ACE) inhibitor, on retinal VEGF, VEGF-R1, and VEGF-R2 expression in a mouse model of oxygen induced retinopathy (OIR)...