Research Topics
| Radoslav GoldmanSummaryAffiliation: Georgetown University Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
Detection of hepatocellular carcinoma using glycomic analysisRadoslav Goldman
Department of Oncology, Georgetown University, Washington, District of Columbia 20057 1469, USA
Clin Cancer Res 15:1808-13. 2009..The objective of our study was to quantitatively assess N-glycans originating from serum glycoproteins as alternative markers for the detection of HCC...- MS/MS library facilitated MRM quantification of native peptides prepared by denaturing ultrafiltrationJuraj Lenco
Georgetown University, Department of Oncology, Lombardi Comprehensive Cancer Center, 3970 Reservoir Rd NW, Washington, DC 20057, USA
Proteome Sci 10:7. 2012..The added value of the workflow is demonstrated in the development of a triplex LC-MRM MS assay used for quantification of peptides potentially associated with the progression of liver disease to hepatocellular carcinoma... - A simplified immunoprecipitation method for quantitatively measuring antibody responses in clinical sera samples by using mammalian-produced Renilla luciferase-antigen fusion proteinsPeter D Burbelo
Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University Medical Center, Washington, DC 20057, USA
BMC Biotechnol 5:22. 2005.... - Candidate markers for the detection of hepatocellular carcinoma in low-molecular weight fraction of serumRadoslav Goldman
Georgetown University, Lombardi Comprehensive Cancer Center, 3970 Reservoir Road Northwest, Washington, DC 20057, USA
Carcinogenesis 28:2149-53. 2007..Further evaluation of these marker candidates for the diagnosis of HCC is needed... - Analysis of MALDI-TOF mass spectrometry data for discovery of peptide and glycan biomarkers of hepatocellular carcinomaHabtom W Ressom
Georgetown University, Lombardi Comprehensive Cancer Center, Washington, DC, USA
J Proteome Res 7:603-10. 2008..Further evaluation is needed to examine the potential clinical utility of the candidate peptide and glycan markers identified in this study... - Integrated peptide and glycan biomarker discovery using MALDI-TOF mass spectrometryRency S Varghese
Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA
Conf Proc IEEE Eng Med Biol Soc 2008:3791-4. 2008..The performance of these markers is evaluated in terms of their ability to distinguish HCC cases from patients with CLD in a blinded validation set... 
Ant colony optimization for biomarker identification from MALDI-TOF mass spectraHabtom W Ressom
Lombardi Comprehensive Cancer Center, Georgetown Univ, Washington, DC, USA
Conf Proc IEEE Eng Med Biol Soc 1:4560-3. 2006..The results indicate that the MALDI-TOF technology could provide the means to discover novel biomarkers for HCC...- Peptides in low molecular weight fraction of serum associated with hepatocellular carcinomaYanming An
Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, 3970 Reservoir Road NW, Washington, DC 20057, USA
Dis Markers 29:11-20. 2010..These peptides could potentially serve as markers of HCC following additional validation studies; however, association of similar peptides with other diseases and cancers dictates a very cautious approach... - Identification of N-glycan serum markers associated with hepatocellular carcinoma from mass spectrometry dataZhiqun Tang
Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA
J Proteome Res 9:104-12. 2010..The method of this study is significant in deriving consistent, accurate, and biological significant glycan marker candidates for hepatocellular carcinoma diagnosis... - Enrichment of low molecular weight fraction of serum for MS analysis of peptides associated with hepatocellular carcinomaEduard Orvisky
Georgetown University, Department of Oncology, Lombardi Comprehensive Cancer Center, Washington, DC 20057-1469, USA
Proteomics 6:2895-902. 2006..This study shows that enrichment of the low molecular weight fraction of serum facilitates an efficient discovery of peptides that could serve as biomarkers for detection of HCC as well as other diseases... - Semi-automated identification of N-Glycopeptides by hydrophilic interaction chromatography, nano-reverse-phase LC-MS/MS, and glycan database searchPetr Pompach
Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, 3970 Reservoir Road NW, Washington, DC 20057 1465, United States
J Proteome Res 11:1728-40. 2012..The optimized workflow, coupled with GlycoPeptideSearch, is expected to make high-throughput semiautomated glycopeptide identification feasible for a wide range of users... - Acrolein-derived DNA adduct formation in human colon cancer cells: its role in apoptosis induction by docosahexaenoic acidJishen Pan
Lombardi Comprehensive Cancer Center, Georgetown University, 3800 Reservoir Road NW, Washington, DC 20057, USA
Chem Res Toxicol 22:798-806. 2009..Taken together, these results demonstrate the parallel relationships between Acr-dG level and apoptosis in HT-29 cells, suggesting that the formation of Acr-dG in cellular DNA may contribute to apoptosis induced by DHA... - Analysis of mass spectral serum profiles for biomarker selectionHabtom W Ressom
Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA
Bioinformatics 21:4039-45. 2005..We present low-level methods for the processing of mass spectral data and a machine learning method that combines support vector machines, with particle swarm optimization for biomarker selection... - Utilization of metabolomics to identify serum biomarkers for hepatocellular carcinoma in patients with liver cirrhosisHabtom W Ressom
Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA
Anal Chim Acta 743:90-100. 2012..Our work shows that metabolomic profiling is a promising tool to identify candidate metabolic biomarkers for early detection of HCC cases in high risk population of cirrhotic patients... - Proteome-wide analysis of single-nucleotide variations in the N-glycosylation sequon of human genesRaja Mazumder
Department of Biochemistry and Molecular Biology, George Washington University Medical Center, Washington, DC, USA
PLoS ONE 7:e36212. 2012.... - Quantification of DNA repair capacity in whole blood of patients with head and neck cancer and healthy donors by comet assayDaniel T Saha
Georgetown University, Department of Oncology, Washington, DC 20057, USA
Mutat Res 650:55-62. 2008..Additional method optimization would be helpful to improve the assay for a large population screening... 
Site-specific Glycoforms of Haptoglobin in Liver Cirrhosis and Hepatocellular CarcinomaPetr Pompach
Department of Oncology, Georgetown University, Washington, D C 20057
Mol Cell Proteomics 12:1281-93. 2013..The presence of multiply fucosylated Lewis Y glycoforms of haptoglobin in the disease context could have important functional implications...- The role of protein binding in induction of apoptosis by phenethyl isothiocyanate and sulforaphane in human non-small lung cancer cellsLixin Mi
Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia 20057, USA
Cancer Res 67:6409-16. 2007..Because PEITC is a stronger inducer of apoptosis than SFN, these results indicate that direct covalent binding to cellular proteins is an important early event in the induction of apoptosis by the ITCs... - Urinary estrogen metabolites and prostate cancer risk: a pilot studyOurania Kosti
Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia 20057, USA
Prostate 71:507-16. 2011..The aim of this pilot study was to evaluate urinary estrogen metabolites as a biomarker of prostate cancer risk... - Structure-based Comparative Analysis and Prediction of N-linked Glycosylation Sites in Evolutionarily Distant EukaryotesPhuc Vinh Nguyen Lam
Life Sciences Department, Paris Diderot University, Paris 75013, France Department of Biochemistry and Molecular Biology, George Washington University Medical Center, Washington, DC 20037, USA
Genomics Proteomics Bioinformatics 11:96-104. 2013..The tool, Structure Feature Analysis Tool (SFAT), is freely available to the public at http://hive.biochemistry.gwu.edu/tools/sfat... - Decreased risk of squamous cell carcinoma of the head and neck in users of nonsteroidal anti-inflammatory drugsNeda Ahmadi
Department of Otolaryngology Head and Neck Surgery, Georgetown University Hospital, Washington, DC 20007, USA
Int J Otolaryngol 2010:424161. 2010..This study provides evidence for a significant reduction in the risk of developing HNSCC in users of NSAIDs, and specifically aspirin users... - Food mutagensRadoslav Goldman
Lombardi Cancer Center, Georgetown University Medical Center, Washington, DC, USA
J Nutr 133:965S-973S. 2003..This article reviews the role of food mutagens in mutagenesis and carcinogenesis and how their effects are modified by heritable traits and discusses how to identify and evaluate the effects of food mutagens... - A sensitive immunofluorescence assay for detection of p53 protein in the sputumZumei Feng
Department of Oncology, Lombardi Cancer Center, Georgetown University Medical Center, Washington, DC, USA
Methods Mol Med 75:389-95. 2003
Research Grants
- Glycans in Hepatocellular CarcinomaRadoslav Goldman; Fiscal Year: 2009..The identified sugars could be used to screen high risk populations for early signs of liver cancer; to design and test new chemoprevention strategies; and to follow disease progression after treatment. ..
- Effects of smoking on ERb and AHR pathway in human lungRadoslav Goldman; Fiscal Year: 2004..The grant would provide critical support for this pilot study, whose results will lead to refined hypotheses testable in future research. ..
- Proteomic Analysis of Serum in Liver CancerRadoslav Goldman; Fiscal Year: 2007..Identification of the P/P is expected to generate new hypotheses for targeted disease management. ..
- Optimization of enrichment for MALDI TOF/TOF identification of cancer biomarkersRadoslav Goldman; Fiscal Year: 2007..Identification of the P/P is expected to generate new hypotheses for targeted disease management. ..
- Proteomic Analysis of Serum in Liver CancerRadoslav Goldman; Fiscal Year: 2009..Identification of the P/P is expected to generate new hypotheses for targeted disease management. ..
- Proteomic Analysis of Serum in Liver CancerRadoslav Goldman; Fiscal Year: 2010..Identification of the P/P is expected to generate new hypotheses for targeted disease management. ..
- Glycans in Hepatocellular CarcinomaRadoslav Goldman; Fiscal Year: 2010..The identified sugars could be used to screen high risk populations for early signs of liver cancer;to design and test new chemoprevention strategies;and to follow disease progression after treatment. ..