Robert Glazer

Summary

Affiliation: Georgetown University
Country: USA

Publications

  1. pmc Musashi1 as a potential therapeutic target and diagnostic marker for lung cancer
    Xiao Yang Wang
    Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Oncotarget 4:739-50. 2013
  2. pmc Drug-targeted inhibition of peroxisome proliferator-activated receptor-gamma enhances the chemopreventive effect of anti-estrogen therapy
    Hongyan Yuan
    Department of Oncology, Georgetown University School of Medicine, and Lombardi Comprehensive Cancer Center, Washington, DC, USA
    Oncotarget 3:345-56. 2012
  3. pmc Induction of metastatic gastric cancer by peroxisome proliferator-activated receptorδ activation
    Claire B Pollock
    Department of Oncology, Lombardi Comprehensive Cancer Center, Washington, DC 20057, USA
    PPAR Res 2010:571783. 2010
  4. pmc PPARδ activation acts cooperatively with 3-phosphoinositide-dependent protein kinase-1 to enhance mammary tumorigenesis
    Claire B Pollock
    Department of Oncology, Georgetown University Medical Center, Washington, DC, United States of America
    PLoS ONE 6:e16215. 2011
  5. pmc PPARgamma and PPARdelta as Modulators of Neoplasia and Cell Fate
    Robert I Glazer
    Department of Oncology and Lombardi Comprehensive Cancer Center, School of Medicine, Georgetown University, 3970 Reservoir Road, NW, Washington, DC 20007, USA
    PPAR Res 2008:247379. 2008
  6. pmc The chemopreventive effect of mifepristone on mammary tumorigenesis is associated with an anti-invasive and anti-inflammatory gene signature
    Hongyan Yuan
    Department of Oncology, Georgetown University Medical Center, Washington, DC 20007, USA
    Cancer Prev Res (Phila) 5:754-64. 2012
  7. pmc Musashi1 regulates breast tumor cell proliferation and is a prognostic indicator of poor survival
    Xiao Yang Wang
    Department of Oncology, Georgetown University, and Lombardi Comprehensive Cancer Center, Washington, DC 20007, USA
    Mol Cancer 9:221. 2010
  8. pmc Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors
    Jason I Herschkowitz
    Lineberger Comprehensive Cancer Center
    Genome Biol 8:R76. 2007
  9. pmc 3-phosphoinositide-dependent protein kinase-1 (PDK1) promotes invasion and activation of matrix metalloproteinases
    Zhihui Xie
    Department of Oncology, Georgetown University School of Medicine, and Lombardi Comprehensive Cancer Center, Washington, DC, USA
    BMC Cancer 6:77. 2006
  10. pmc Musashi1: a stem cell marker no longer in search of a function
    Robert I Glazer
    Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20007, USA
    Cell Cycle 7:2635-9. 2008

Research Grants

  1. AKT PROTOONCOGENE IN BREAST CANCER
    Robert Glazer; Fiscal Year: 2001
  2. AKT PROTOONCOGENE IN BREAST CANCER
    Robert Glazer; Fiscal Year: 2000
  3. PDK1 and PPARdelta Signaling in Mammary Tumorigenesis
    Robert Glazer; Fiscal Year: 2009
  4. PDK1 and PPAR-delta Signaling in Mammary Tumorigenesis
    Robert Glazer; Fiscal Year: 2007
  5. PDK1 and PPARdelta Signaling in Mammary Tumorigenesis
    Robert Glazer; Fiscal Year: 2006
  6. AKT PROTOONCOGENE IN BREAST CANCER
    Robert Glazer; Fiscal Year: 2003
  7. Structure Based Discovery of AKT Inhibitors
    Robert Glazer; Fiscal Year: 2003
  8. AKT PROTOONCOGENE IN BREAST CANCER
    Robert Glazer; Fiscal Year: 2002
  9. PDK1 and PPARdelta Signaling in Mammary Tumorigenesis
    Robert I Glazer; Fiscal Year: 2010

Collaborators

  • Levy Kopelovich
  • Xin Li
  • Xiao Yang Wang
  • Hideyuki Okano
  • Laodong Li
  • R Ilona Linnoila
  • Zhihui Xie
  • Hongyan Yuan
  • Yuzhi Yin
  • Claire B Pollock
  • Xiao Zeng
  • Jin Lu
  • Geeta Upadhyay
  • Zhi Liang Wei
  • Chris Albanese
  • Jason I Herschkowitz
  • Ke Liang
  • Alan P Kozikowski
  • Scott Ackler
  • Sruthi King
  • Philip L Martin
  • Olga Rodriguez
  • Karl Simin
  • Charles M Perou
  • Igor Mikaelian
  • Terry van Dyke
  • Karen E Rasmussen
  • Roy Bastein
  • Subhashini Chandrasekharan
  • Olufunmilayo I Olopade
  • Jeffrey E Green
  • Juan P Palazzo
  • Priscilla A Furth
  • Gary A Churchill
  • Michael G Backlund
  • Laundette P Jones
  • Zhiyuan Hu
  • Shahin Assefnia
  • Andrey I Khramtsov
  • Jerry Usary
  • John Quackenbush
  • Victor J Weigman
  • Philip S Bernard
  • Powel H Brown
  • Yang Lu
  • Zhen Fan
  • Chenguang Wang
  • Richard G Pestell
  • Gordon B Mills
  • Mahadev Rao
  • Nagarajan Pattabiraman
  • Robert G Russell
  • Renkui Bai
  • Luis E Dettin
  • Levy Kopleovich
  • Fero Bizik
  • Mark Mercola
  • Timothy M Willson
  • Eugene A Volpe
  • Joaquim Cabral Teixeira
  • Pavel A Petukhov
  • Christopher Tobias
  • Hangmin Xu
  • Shakeel Ahmad
  • Michael D Johnson

Detail Information

Publications22

  1. pmc Musashi1 as a potential therapeutic target and diagnostic marker for lung cancer
    Xiao Yang Wang
    Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Oncotarget 4:739-50. 2013
    ..Thus, Msi1 is a sensitive and specific diagnostic marker for all lung cancer subtypes. ..
  2. pmc Drug-targeted inhibition of peroxisome proliferator-activated receptor-gamma enhances the chemopreventive effect of anti-estrogen therapy
    Hongyan Yuan
    Department of Oncology, Georgetown University School of Medicine, and Lombardi Comprehensive Cancer Center, Washington, DC, USA
    Oncotarget 3:345-56. 2012
    ..These findings suggest that it may be possible to pharmacologically influence the responsiveness of tumors to anti-estrogen therapy...
  3. pmc Induction of metastatic gastric cancer by peroxisome proliferator-activated receptorδ activation
    Claire B Pollock
    Department of Oncology, Lombardi Comprehensive Cancer Center, Washington, DC 20057, USA
    PPAR Res 2010:571783. 2010
    ..The rapid development of metastatic gastric tumors in this model will be useful for evaluating preventive and therapeutic interventions in this disease...
  4. pmc PPARδ activation acts cooperatively with 3-phosphoinositide-dependent protein kinase-1 to enhance mammary tumorigenesis
    Claire B Pollock
    Department of Oncology, Georgetown University Medical Center, Washington, DC, United States of America
    PLoS ONE 6:e16215. 2011
    ..These results reveal that PPARδ activation elicits a distinct metabolic and metabolomic profile in tumors that is in part related to PDK1 and AKT signaling...
  5. pmc PPARgamma and PPARdelta as Modulators of Neoplasia and Cell Fate
    Robert I Glazer
    Department of Oncology and Lombardi Comprehensive Cancer Center, School of Medicine, Georgetown University, 3970 Reservoir Road, NW, Washington, DC 20007, USA
    PPAR Res 2008:247379. 2008
    ..This review discusses the role of PPARgamma and PPARdelta agonists as modulators of these processes...
  6. pmc The chemopreventive effect of mifepristone on mammary tumorigenesis is associated with an anti-invasive and anti-inflammatory gene signature
    Hongyan Yuan
    Department of Oncology, Georgetown University Medical Center, Washington, DC 20007, USA
    Cancer Prev Res (Phila) 5:754-64. 2012
    ..These results suggest that the chemopreventive activity of mifepristone in WT mice correlates with a specific gene expression signature that is associated with multiple nuclear receptor signaling pathways...
  7. pmc Musashi1 regulates breast tumor cell proliferation and is a prognostic indicator of poor survival
    Xiao Yang Wang
    Department of Oncology, Georgetown University, and Lombardi Comprehensive Cancer Center, Washington, DC 20007, USA
    Mol Cancer 9:221. 2010
    ..It is unknown how Msi1 relates to other breast cancer markers, whether it denotes tumor initiating cells (TICs), and how it affects gene expression and tumor cell survival in breast cancer cells...
  8. pmc Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors
    Jason I Herschkowitz
    Lineberger Comprehensive Cancer Center
    Genome Biol 8:R76. 2007
    ..To address this need, we characterized mammary tumor gene expression profiles from 13 different murine models using DNA microarrays and compared the resulting data to those from human breast tumors...
  9. pmc 3-phosphoinositide-dependent protein kinase-1 (PDK1) promotes invasion and activation of matrix metalloproteinases
    Zhihui Xie
    Department of Oncology, Georgetown University School of Medicine, and Lombardi Comprehensive Cancer Center, Washington, DC, USA
    BMC Cancer 6:77. 2006
    ..These properties correlate with induction of MMP-2 activity, increased MT1-MMP expression and a unique gene expression profile...
  10. pmc Musashi1: a stem cell marker no longer in search of a function
    Robert I Glazer
    Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20007, USA
    Cell Cycle 7:2635-9. 2008
    ..Identification of PLF1 as an effector of these pathways in the absence of the DKK3 tumor suppressor provides a new avenue for investigating differences between normal and malignant tissues, and potentially targeting tumor stem cells...
  11. pmc Stem cell antigen-1 deficiency enhances the chemopreventive effect of peroxisome proliferator-activated receptorγ activation
    Hongyan Yuan
    Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20007, USA
    Cancer Prev Res (Phila) 5:51-60. 2012
    ..These data implicate Sca-1 as a negative regulator of the tumor suppressor effects of PPARγ...
  12. ncbi request reprint Mammary stem and progenitor cell regulation
    Robert I Glazer
    Department of Oncology, Georgetown University Medical Center, and Lombardi Comprehensive Cancer Center, Washington, DC 20007, USA
    Cancer Biomark 3:171-81. 2007
    ..Lastly, we present the utility of modulating stem cell self-renewal through the use of inhibitors of the Notch and Wnt pathways...
  13. pmc Musashi1 modulates mammary progenitor cell expansion through proliferin-mediated activation of the Wnt and Notch pathways
    Xiao Yang Wang
    Department of Oncology, Georgetown University, and Lombardi Comprehensive Cancer Center, Washington, DC 20007, USA
    Mol Cell Biol 28:3589-99. 2008
    ..These results identify Msi1 as a key determinant of the mammary lineage through its ability to coordinate cell cycle entry and activate the Notch and Wnt pathways by a novel autocrine process involving PLF1 and DKK3...
  14. ncbi request reprint Transformation of mammary epithelial cells by 3-phosphoinositide- dependent protein kinase-1 activates beta-catenin and c-Myc, and down-regulates caveolin-1
    Zhihui Xie
    Department of Oncology, Georgetown University School of Medicine, Washington, DC 20057, USA
    Cancer Res 63:5370-5. 2003
    ..Therefore, it appears that a concomitant gain of c-myc function and a loss or reduction of caveolin-1 are major determinants of PDK1- and PKCalpha-mediated mammary oncogenesis...
  15. ncbi request reprint Transformation of mammary epithelial cells by 3-phosphoinositide-dependent protein kinase-1 (PDK1) is associated with the induction of protein kinase Calpha
    Xiao Zeng
    Department of Pharmacology, Lombardi Cancer Center, Georgetown University School of Medicine, Washington, DC 20007, USA
    Cancer Res 62:3538-43. 2002
    ..These results suggest that activation of PDK1 can lead to mammary tumorigenesis, in part through PKCalpha, and that PDK1 expression may be an important target in human breast cancer...
  16. ncbi request reprint Delayed mammary gland involution in MMTV-AKT1 transgenic mice
    Scott Ackler
    Department of Pharmacology, Georgetown University School of Medicine and Lombardi Cancer Center, Washington, DC 20007, USA
    Oncogene 21:198-206. 2002
    ..These data suggest that AKT1 is involved in cell survival in the lactating and involuting mammary gland, but that overexpression of AKT1 alone is insufficient to induce transformation...
  17. ncbi request reprint Peroxisome proliferator-activated receptor delta and gamma agonists differentially alter tumor differentiation and progression during mammary carcinogenesis
    Yuzhi Yin
    Department of Oncology, Georgetown University, Washington, District of Columbia 20057, USA
    Cancer Res 65:3950-7. 2005
    ..These results indicate that PPARdelta and PPARgamma agonists produce diverse, yet profound effects on mammary tumorigenesis that give rise to distinctive histopathologic patterns of tumor differentiation and tumor development...
  18. pmc Inhibition of peroxisome proliferator-activated receptor gamma increases estrogen receptor-dependent tumor specification
    Yuzhi Yin
    Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia 20007, USA
    Cancer Res 69:687-94. 2009
    ..These results reveal important new insights into the previously unrecognized role of PPARgamma in the specification of mammary lineage and the development of ER(+) tumors...
  19. ncbi request reprint 3-phosphoinositide-dependent protein kinase-1 activates the peroxisome proliferator-activated receptor-gamma and promotes adipocyte differentiation
    Yuzhi Yin
    Georgetown University School of Medicine, Washington, D C 20007, USA
    Mol Endocrinol 20:268-78. 2006
    ..These results suggest that PDK1 can function as a PPARgamma1 coactivator independently of its catalytic activity and establishes an important mechanistic link between adipocyte differentiation and the insulin signaling pathway...
  20. ncbi request reprint Differential roles of phosphoinositide-dependent protein kinase-1 and akt1 expression and phosphorylation in breast cancer cell resistance to Paclitaxel, Doxorubicin, and gemcitabine
    Ke Liang
    Department of Experimental Therapeutics, Unit 036, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Pharmacol 70:1045-52. 2006
    ..Our findings show that PDK1 may be a superior alternative to Akt1 as a target for sensitizing breast cancer cells to chemotherapeutic agents, particularly gemcitabine...
  21. ncbi request reprint Isoxazolyl-serine-based agonists of peroxisome proliferator-activated receptor: design, synthesis, and effects on cardiomyocyte differentiation
    Zhi Liang Wei
    USA Stem Cell and Regeneration Program, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Am Chem Soc 126:16714-5. 2004
    ..Notably, the known PPARalpha, gamma, and delta agonists tested, e.g., fenofibrate, rosiglitazone, and GW501516, were inactive in this assay...

Research Grants10

  1. AKT PROTOONCOGENE IN BREAST CANCER
    Robert Glazer; Fiscal Year: 2001
    ..abstract_text> ..
  2. AKT PROTOONCOGENE IN BREAST CANCER
    Robert Glazer; Fiscal Year: 2000
    ..abstract_text> ..
  3. PDK1 and PPARdelta Signaling in Mammary Tumorigenesis
    Robert Glazer; Fiscal Year: 2009
    ..The influence of PDK1 and PPARtf transaene expression on Sca-1 M mammary stem cells will also be evaluated. ..
  4. PDK1 and PPAR-delta Signaling in Mammary Tumorigenesis
    Robert Glazer; Fiscal Year: 2007
    ..The influence of PDK1 and PPARd transgene expression on Sca-1 (+) mammary stem cells will also be evaluated. ..
  5. PDK1 and PPARdelta Signaling in Mammary Tumorigenesis
    Robert Glazer; Fiscal Year: 2006
    ..The influence of PDK1 and PPARd transgene expression on Sca-1 (+) mammary stem cells will also be evaluated. ..
  6. AKT PROTOONCOGENE IN BREAST CANCER
    Robert Glazer; Fiscal Year: 2003
    ..abstract_text> ..
  7. Structure Based Discovery of AKT Inhibitors
    Robert Glazer; Fiscal Year: 2003
    ..Modeling of active structures to the AKT1 AH domain binding pocket will be used in an iterative manner to guide compound synthesis as well as to suggest possible compound libraries to be created using combinatorial chemistry methods. ..
  8. AKT PROTOONCOGENE IN BREAST CANCER
    Robert Glazer; Fiscal Year: 2002
    ..abstract_text> ..
  9. PDK1 and PPARdelta Signaling in Mammary Tumorigenesis
    Robert I Glazer; Fiscal Year: 2010
    ..The influence of PDK1 and PPARtf transaene expression on Sca-1 M mammary stem cells will also be evaluated. ..