Robert Glazer

Summary

Affiliation: Georgetown University
Country: USA

Publications

  1. pmc The chemopreventive effect of mifepristone on mammary tumorigenesis is associated with an anti-invasive and anti-inflammatory gene signature
    Hongyan Yuan
    Department of Oncology, Georgetown University Medical Center, Washington, DC 20007, USA
    Cancer Prev Res (Phila) 5:754-64. 2012
  2. pmc Musashi1 regulates breast tumor cell proliferation and is a prognostic indicator of poor survival
    Xiao Yang Wang
    Department of Oncology, Georgetown University, and Lombardi Comprehensive Cancer Center, Washington, DC 20007, USA
    Mol Cancer 9:221. 2010
  3. pmc Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors
    Jason I Herschkowitz
    Lineberger Comprehensive Cancer Center
    Genome Biol 8:R76. 2007
  4. pmc 3-phosphoinositide-dependent protein kinase-1 (PDK1) promotes invasion and activation of matrix metalloproteinases
    Zhihui Xie
    Department of Oncology, Georgetown University School of Medicine, and Lombardi Comprehensive Cancer Center, Washington, DC, USA
    BMC Cancer 6:77. 2006
  5. ncbi request reprint Mammary stem and progenitor cell regulation
    Robert I Glazer
    Department of Oncology, Georgetown University Medical Center, and Lombardi Comprehensive Cancer Center, Washington, DC 20007, USA
    Cancer Biomark 3:171-81. 2007
  6. pmc Stem cell antigen-1 deficiency enhances the chemopreventive effect of peroxisome proliferator-activated receptorĪ³ activation
    Hongyan Yuan
    Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20007, USA
    Cancer Prev Res (Phila) 5:51-60. 2012
  7. pmc Musashi1: a stem cell marker no longer in search of a function
    Robert I Glazer
    Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20007, USA
    Cell Cycle 7:2635-9. 2008
  8. pmc Musashi1 modulates mammary progenitor cell expansion through proliferin-mediated activation of the Wnt and Notch pathways
    Xiao Yang Wang
    Department of Oncology, Georgetown University, and Lombardi Comprehensive Cancer Center, Washington, DC 20007, USA
    Mol Cell Biol 28:3589-99. 2008
  9. ncbi request reprint Transformation of mammary epithelial cells by 3-phosphoinositide- dependent protein kinase-1 activates beta-catenin and c-Myc, and down-regulates caveolin-1
    Zhihui Xie
    Department of Oncology, Georgetown University School of Medicine, Washington, DC 20057, USA
    Cancer Res 63:5370-5. 2003
  10. ncbi request reprint Transformation of mammary epithelial cells by 3-phosphoinositide-dependent protein kinase-1 (PDK1) is associated with the induction of protein kinase Calpha
    Xiao Zeng
    Department of Pharmacology, Lombardi Cancer Center, Georgetown University School of Medicine, Washington, DC 20007, USA
    Cancer Res 62:3538-43. 2002

Research Grants

  1. PDK1 and PPARdelta Signaling in Mammary Tumorigenesis
    Robert Glazer; Fiscal Year: 2009
  2. PDK1 and PPAR-delta Signaling in Mammary Tumorigenesis
    Robert Glazer; Fiscal Year: 2007
  3. AKT PROTOONCOGENE IN BREAST CANCER
    Robert Glazer; Fiscal Year: 2003
  4. Structure Based Discovery of AKT Inhibitors
    Robert Glazer; Fiscal Year: 2003
  5. PDK1 and PPARdelta Signaling in Mammary Tumorigenesis
    Robert I Glazer; Fiscal Year: 2010

Collaborators

  • Xiaoyang Wang
  • H Okano
  • Yuzhi Yin
  • Hongyan Yuan
  • Levy Kopelovich
  • Xiao Zeng
  • Zhihui Xie
  • Geeta Upadhyay
  • Zhi Liang Wei
  • Jason I Herschkowitz
  • Ke Liang
  • Renkui Bai
  • Alan P Kozikowski
  • Scott Ackler
  • Jin Lu
  • Karl Simin
  • Charles M Perou
  • Igor Mikaelian
  • Terry van Dyke
  • Priscilla A Furth
  • Gary A Churchill
  • Karen E Rasmussen
  • Roy Bastein
  • Michael G Backlund
  • Laundette P Jones
  • Zhiyuan Hu
  • Shahin Assefnia
  • Andrey I Khramtsov
  • Subhashini Chandrasekharan
  • Jerry Usary
  • John Quackenbush
  • Victor J Weigman
  • Philip S Bernard
  • Olufunmilayo I Olopade
  • Jeffrey E Green
  • Juan P Palazzo
  • Powel H Brown
  • Chenguang Wang
  • Richard G Pestell
  • Gordon B Mills
  • Mahadev Rao
  • Xinqun Li
  • Nagarajan Pattabiraman
  • Yang Lu
  • Zhen Fan
  • Luis E Dettin
  • Robert G Russell
  • Levy Kopleovich
  • Eugene A Volpe
  • Joaquim Cabral Teixeira
  • Fero Bizik
  • Mark Mercola
  • Timothy M Willson
  • Pavel A Petukhov
  • Todd Waldman
  • Michael D Johnson
  • Christopher Tobias
  • Hangmin Xu
  • Shakeel Ahmad

Detail Information

Publications16

  1. pmc The chemopreventive effect of mifepristone on mammary tumorigenesis is associated with an anti-invasive and anti-inflammatory gene signature
    Hongyan Yuan
    Department of Oncology, Georgetown University Medical Center, Washington, DC 20007, USA
    Cancer Prev Res (Phila) 5:754-64. 2012
    ..These results suggest that the chemopreventive activity of mifepristone in WT mice correlates with a specific gene expression signature that is associated with multiple nuclear receptor signaling pathways...
  2. pmc Musashi1 regulates breast tumor cell proliferation and is a prognostic indicator of poor survival
    Xiao Yang Wang
    Department of Oncology, Georgetown University, and Lombardi Comprehensive Cancer Center, Washington, DC 20007, USA
    Mol Cancer 9:221. 2010
    ..It is unknown how Msi1 relates to other breast cancer markers, whether it denotes tumor initiating cells (TICs), and how it affects gene expression and tumor cell survival in breast cancer cells...
  3. pmc Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors
    Jason I Herschkowitz
    Lineberger Comprehensive Cancer Center
    Genome Biol 8:R76. 2007
    ..To address this need, we characterized mammary tumor gene expression profiles from 13 different murine models using DNA microarrays and compared the resulting data to those from human breast tumors...
  4. pmc 3-phosphoinositide-dependent protein kinase-1 (PDK1) promotes invasion and activation of matrix metalloproteinases
    Zhihui Xie
    Department of Oncology, Georgetown University School of Medicine, and Lombardi Comprehensive Cancer Center, Washington, DC, USA
    BMC Cancer 6:77. 2006
    ..These properties correlate with induction of MMP-2 activity, increased MT1-MMP expression and a unique gene expression profile...
  5. ncbi request reprint Mammary stem and progenitor cell regulation
    Robert I Glazer
    Department of Oncology, Georgetown University Medical Center, and Lombardi Comprehensive Cancer Center, Washington, DC 20007, USA
    Cancer Biomark 3:171-81. 2007
    ..Lastly, we present the utility of modulating stem cell self-renewal through the use of inhibitors of the Notch and Wnt pathways...
  6. pmc Stem cell antigen-1 deficiency enhances the chemopreventive effect of peroxisome proliferator-activated receptorĪ³ activation
    Hongyan Yuan
    Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20007, USA
    Cancer Prev Res (Phila) 5:51-60. 2012
    ..These data implicate Sca-1 as a negative regulator of the tumor suppressor effects of PPARĪ³...
  7. pmc Musashi1: a stem cell marker no longer in search of a function
    Robert I Glazer
    Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20007, USA
    Cell Cycle 7:2635-9. 2008
    ..Identification of PLF1 as an effector of these pathways in the absence of the DKK3 tumor suppressor provides a new avenue for investigating differences between normal and malignant tissues, and potentially targeting tumor stem cells...
  8. pmc Musashi1 modulates mammary progenitor cell expansion through proliferin-mediated activation of the Wnt and Notch pathways
    Xiao Yang Wang
    Department of Oncology, Georgetown University, and Lombardi Comprehensive Cancer Center, Washington, DC 20007, USA
    Mol Cell Biol 28:3589-99. 2008
    ..These results identify Msi1 as a key determinant of the mammary lineage through its ability to coordinate cell cycle entry and activate the Notch and Wnt pathways by a novel autocrine process involving PLF1 and DKK3...
  9. ncbi request reprint Transformation of mammary epithelial cells by 3-phosphoinositide- dependent protein kinase-1 activates beta-catenin and c-Myc, and down-regulates caveolin-1
    Zhihui Xie
    Department of Oncology, Georgetown University School of Medicine, Washington, DC 20057, USA
    Cancer Res 63:5370-5. 2003
    ..Therefore, it appears that a concomitant gain of c-myc function and a loss or reduction of caveolin-1 are major determinants of PDK1- and PKCalpha-mediated mammary oncogenesis...
  10. ncbi request reprint Transformation of mammary epithelial cells by 3-phosphoinositide-dependent protein kinase-1 (PDK1) is associated with the induction of protein kinase Calpha
    Xiao Zeng
    Department of Pharmacology, Lombardi Cancer Center, Georgetown University School of Medicine, Washington, DC 20007, USA
    Cancer Res 62:3538-43. 2002
    ..These results suggest that activation of PDK1 can lead to mammary tumorigenesis, in part through PKCalpha, and that PDK1 expression may be an important target in human breast cancer...
  11. pmc Inhibition of peroxisome proliferator-activated receptor gamma increases estrogen receptor-dependent tumor specification
    Yuzhi Yin
    Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia 20007, USA
    Cancer Res 69:687-94. 2009
    ..These results reveal important new insights into the previously unrecognized role of PPARgamma in the specification of mammary lineage and the development of ER(+) tumors...
  12. ncbi request reprint Delayed mammary gland involution in MMTV-AKT1 transgenic mice
    Scott Ackler
    Department of Pharmacology, Georgetown University School of Medicine and Lombardi Cancer Center, Washington, DC 20007, USA
    Oncogene 21:198-206. 2002
    ..These data suggest that AKT1 is involved in cell survival in the lactating and involuting mammary gland, but that overexpression of AKT1 alone is insufficient to induce transformation...
  13. ncbi request reprint 3-phosphoinositide-dependent protein kinase-1 activates the peroxisome proliferator-activated receptor-gamma and promotes adipocyte differentiation
    Yuzhi Yin
    Georgetown University School of Medicine, Washington, D C 20007, USA
    Mol Endocrinol 20:268-78. 2006
    ..These results suggest that PDK1 can function as a PPARgamma1 coactivator independently of its catalytic activity and establishes an important mechanistic link between adipocyte differentiation and the insulin signaling pathway...
  14. ncbi request reprint Peroxisome proliferator-activated receptor delta and gamma agonists differentially alter tumor differentiation and progression during mammary carcinogenesis
    Yuzhi Yin
    Department of Oncology, Georgetown University, Washington, District of Columbia 20057, USA
    Cancer Res 65:3950-7. 2005
    ..These results indicate that PPARdelta and PPARgamma agonists produce diverse, yet profound effects on mammary tumorigenesis that give rise to distinctive histopathologic patterns of tumor differentiation and tumor development...
  15. ncbi request reprint Differential roles of phosphoinositide-dependent protein kinase-1 and akt1 expression and phosphorylation in breast cancer cell resistance to Paclitaxel, Doxorubicin, and gemcitabine
    Ke Liang
    Department of Experimental Therapeutics, Unit 036, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Pharmacol 70:1045-52. 2006
    ..Our findings show that PDK1 may be a superior alternative to Akt1 as a target for sensitizing breast cancer cells to chemotherapeutic agents, particularly gemcitabine...
  16. ncbi request reprint Isoxazolyl-serine-based agonists of peroxisome proliferator-activated receptor: design, synthesis, and effects on cardiomyocyte differentiation
    Zhi Liang Wei
    USA Stem Cell and Regeneration Program, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Am Chem Soc 126:16714-5. 2004
    ..Notably, the known PPARalpha, gamma, and delta agonists tested, e.g., fenofibrate, rosiglitazone, and GW501516, were inactive in this assay...

Research Grants10

  1. PDK1 and PPARdelta Signaling in Mammary Tumorigenesis
    Robert Glazer; Fiscal Year: 2009
    ..The influence of PDK1 and PPARtf transaene expression on Sca-1 M mammary stem cells will also be evaluated. ..
  2. PDK1 and PPAR-delta Signaling in Mammary Tumorigenesis
    Robert Glazer; Fiscal Year: 2007
    ..The influence of PDK1 and PPARd transgene expression on Sca-1 (+) mammary stem cells will also be evaluated. ..
  3. AKT PROTOONCOGENE IN BREAST CANCER
    Robert Glazer; Fiscal Year: 2003
    ..abstract_text> ..
  4. Structure Based Discovery of AKT Inhibitors
    Robert Glazer; Fiscal Year: 2003
    ..Modeling of active structures to the AKT1 AH domain binding pocket will be used in an iterative manner to guide compound synthesis as well as to suggest possible compound libraries to be created using combinatorial chemistry methods. ..
  5. PDK1 and PPARdelta Signaling in Mammary Tumorigenesis
    Robert I Glazer; Fiscal Year: 2010
    ..The influence of PDK1 and PPARtf transaene expression on Sca-1 M mammary stem cells will also be evaluated. ..