Edward P Gelmann

Summary

Affiliation: Georgetown University
Country: USA

Publications

  1. ncbi request reprint Searching for the gatekeeper oncogene of prostate cancer
    Edward P Gelmann
    Department of Oncology, Lombardi Cancer Center, Georgetown University School of Medicine, 3800 Reservoir Rd NW, 20007 2197, Washington, DC, USA
    Crit Rev Oncol Hematol 46:S11-20. 2003
  2. ncbi request reprint Occurrence of NKX3.1 C154T polymorphism in men with and without prostate cancer and studies of its effect on protein function
    Edward P Gelmann
    Department of Oncology, Lombardi Cancer Center, Georgetown University School of Medicine, Washington, DC 20007 2197, USA
    Cancer Res 62:2654-9. 2002
  3. ncbi request reprint Expression of genes and proteins specific for prostate cancer
    Edward P Gelmann
    Department of Oncology, Lombardi Cancer Center, Georgetown University, Washington, DC 20057, USA
    J Urol 172:S23-6; discussion S26-7. 2004
  4. ncbi request reprint Expression of NKX3.1 in normal and malignant tissues
    Edward P Gelmann
    Department of Oncology, Lombardi Cancer Center, Georgetown University School of Medicine, Washington, District of Columbia 20007 2197, USA
    Prostate 55:111-7. 2003
  5. pmc NKX3.1 activates expression of insulin-like growth factor binding protein-3 to mediate insulin-like growth factor-I signaling and cell proliferation
    Erin Muhlbradt
    Lombardi Comprehensive Cancer Center, Washington, District of Columbia, USA
    Cancer Res 69:2615-22. 2009
  6. ncbi request reprint NKX3.1 homeodomain protein binds to topoisomerase I and enhances its activity
    Cai Bowen
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia 20007 2197, USA
    Cancer Res 67:455-64. 2007
  7. ncbi request reprint Antiandrogen effects of mifepristone on coactivator and corepressor interactions with the androgen receptor
    Liang Nian Song
    Department of Oncology, Lombardi Cancer Center, Georgetown University, 3800 Reservoir Road, Northwest, Washington, D C 20057, USA
    Mol Endocrinol 18:70-85. 2004
  8. ncbi request reprint Physical and functional interactions between the prostate suppressor homeoprotein NKX3.1 and serum response factor
    Jeong Ho Ju
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, 3800 Reservoir Road, NW, Washington, DC 20007, USA
    J Mol Biol 360:989-99. 2006
  9. ncbi request reprint Effect of homeodomain protein NKX3.1 R52C polymorphism on prostate gland size
    Elizabeth Rodriguez Ortner
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20007 2197, USA
    Urology 67:311-5. 2006
  10. ncbi request reprint Activation of signal transducer and activator of transcription-5 in prostate cancer predicts early recurrence
    Hongzhen Li
    Department of Oncology and Biostatistics Unit, Lombardi Comprehensive Cancer Center, Georgetown, University Medical Center, Washington, District of Columbia 20057, USA
    Clin Cancer Res 11:5863-8. 2005

Detail Information

Publications38

  1. ncbi request reprint Searching for the gatekeeper oncogene of prostate cancer
    Edward P Gelmann
    Department of Oncology, Lombardi Cancer Center, Georgetown University School of Medicine, 3800 Reservoir Rd NW, 20007 2197, Washington, DC, USA
    Crit Rev Oncol Hematol 46:S11-20. 2003
    ....
  2. ncbi request reprint Occurrence of NKX3.1 C154T polymorphism in men with and without prostate cancer and studies of its effect on protein function
    Edward P Gelmann
    Department of Oncology, Lombardi Cancer Center, Georgetown University School of Medicine, Washington, DC 20007 2197, USA
    Cancer Res 62:2654-9. 2002
    ..1 We conclude that the polymorphic NKX3.1 allele codes for a variant protein with altered DNA binding activity that may affect prostate cancer risk...
  3. ncbi request reprint Expression of genes and proteins specific for prostate cancer
    Edward P Gelmann
    Department of Oncology, Lombardi Cancer Center, Georgetown University, Washington, DC 20057, USA
    J Urol 172:S23-6; discussion S26-7. 2004
    ..We reviewed the pertinent literature and discuss high throughput approaches to the identification of molecular markers characteristic of prostate cancer...
  4. ncbi request reprint Expression of NKX3.1 in normal and malignant tissues
    Edward P Gelmann
    Department of Oncology, Lombardi Cancer Center, Georgetown University School of Medicine, Washington, District of Columbia 20007 2197, USA
    Prostate 55:111-7. 2003
    ..NKX3.1, a member of the NK-class of homeodomain proteins, is expressed primarily in the adult prostate and has growth suppression and differentiating effects in prostate epithelial cells...
  5. pmc NKX3.1 activates expression of insulin-like growth factor binding protein-3 to mediate insulin-like growth factor-I signaling and cell proliferation
    Erin Muhlbradt
    Lombardi Comprehensive Cancer Center, Washington, District of Columbia, USA
    Cancer Res 69:2615-22. 2009
    ..Thus, there is a close relationship in vitro and in vivo between NKX3.1 and IGFBP-3. The growth-suppressive effects of NKX3.1 in prostate cells are mediated, in part, by activation of IGFBP-3 expression...
  6. ncbi request reprint NKX3.1 homeodomain protein binds to topoisomerase I and enhances its activity
    Cai Bowen
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia 20007 2197, USA
    Cancer Res 67:455-64. 2007
    ..This is the first report that a homeodomain protein can modify the activity of Topo I and may have implications for organ-specific DNA replication, transcription, or DNA repair...
  7. ncbi request reprint Antiandrogen effects of mifepristone on coactivator and corepressor interactions with the androgen receptor
    Liang Nian Song
    Department of Oncology, Lombardi Cancer Center, Georgetown University, 3800 Reservoir Road, Northwest, Washington, D C 20057, USA
    Mol Endocrinol 18:70-85. 2004
    ..Mifepristone also antagonized R1881 action on the growth of LNCaP prostate cancer cells...
  8. ncbi request reprint Physical and functional interactions between the prostate suppressor homeoprotein NKX3.1 and serum response factor
    Jeong Ho Ju
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, 3800 Reservoir Road, NW, Washington, DC 20007, USA
    J Mol Biol 360:989-99. 2006
    ..1 and SRF was demonstrated by targeted mutagenesis of an NKX3.1 expression vector in a SMGA reporter assay. The results implicate the NKX3.1 N-terminal region in regulation of transcriptional activity of this tumor suppressor...
  9. ncbi request reprint Effect of homeodomain protein NKX3.1 R52C polymorphism on prostate gland size
    Elizabeth Rodriguez Ortner
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20007 2197, USA
    Urology 67:311-5. 2006
    ..1 prostate homeobox gene. The polymorphism, found in 10% of the population, affects the NKX3.l protein by replacing a cysteine for arginine at amino acid 52 and alters protein phosphorylation and DNA binding...
  10. ncbi request reprint Activation of signal transducer and activator of transcription-5 in prostate cancer predicts early recurrence
    Hongzhen Li
    Department of Oncology and Biostatistics Unit, Lombardi Comprehensive Cancer Center, Georgetown, University Medical Center, Washington, District of Columbia 20057, USA
    Clin Cancer Res 11:5863-8. 2005
    ..Here, we investigated whether activation of Stat5 in prostate cancer was linked to clinical outcome with disease recurrence as end point...
  11. ncbi request reprint Interaction of beta-catenin and TIF2/GRIP1 in transcriptional activation by the androgen receptor
    Liang Nian Song
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20007 2197, USA
    J Biol Chem 280:37853-67. 2005
    ..We propose that beta-catenin may play an integral role in formation of the androgen-receptor transcriptional complex...
  12. pmc Beta-catenin binds to the activation function 2 region of the androgen receptor and modulates the effects of the N-terminal domain and TIF2 on ligand-dependent transcription
    Liang Nian Song
    Department of Oncology, Lombardi Cancer Center, Georgetown University School of Medicine, Washington, D C 20007 2197, USA
    Mol Cell Biol 23:1674-87. 2003
    ..Taken together, the data show that beta-catenin can bind to the androgen receptor LBD and modulate the effects of the androgen receptor NTD and TIF2 on transcription...
  13. ncbi request reprint Targeted therapies for prostate cancer
    Ekatherine Asatiani
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, 3800 Reservoir Road, NW Washington, DC 20007 2197, USA
    Expert Opin Ther Targets 9:283-98. 2005
    ..The interaction of signal kinase inhibitors with androgen ablation and with cytotoxic chemotherapy remains to be explored...
  14. ncbi request reprint Deletion, methylation, and expression of the NKX3.1 suppressor gene in primary human prostate cancer
    Ekatherine Asatiani
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia, USA
    Cancer Res 65:1164-73. 2005
    ..Samples with protein expression below the median level in cancer cells had both NKX3.1 deletion and selective CpG methylation...
  15. ncbi request reprint Molecular biology of prostate-cancer pathogenesis
    Randi L Shand
    Departments of Oncology and Medicine, Lombardi Comprehensive Cancer Center, Georgetown University, 3800 Reservoir Road NW, Washington, DC 20007, USA
    Curr Opin Urol 16:123-31. 2006
    ..The genetic and molecular basis of prostate-cancer pathogenesis is reviewed...
  16. ncbi request reprint P53 gene mutations: case study of a clinical marker for solid tumors
    Minetta C Liu
    Department of Oncology, Lombardi Cancer Center, Georgetown University School of Medicine, Washington, DC 20007, USA
    Semin Oncol 29:246-57. 2002
    ....
  17. ncbi request reprint Retinoblastoma protein-mediated apoptosis after gamma-irradiation
    Cai Bowen
    Department of Medicine, Lombardi Cancer Center, Georgetown University, Washington, DC 20007 2197, USA
    J Biol Chem 277:44969-79. 2002
    ..In addition, p38 MAPK activation occurred independent of RB. ABL kinase, JUN N-terminal kinase, and p38 MAPK activity were all required for RB-mediated DU-145 cell death after gamma-irradiation...
  18. ncbi request reprint The ubiquitin-proteasome pathway and its role in cancer
    Aparna Mani
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, 3800 Reservoir Rd NW, Washington, DC 20007 2197, USA
    J Clin Oncol 23:4776-89. 2005
    ..Further work in this area holds great promise toward our understanding and treatment of a wide range of cancers...
  19. ncbi request reprint Prostate specific antigen changes as related to the initial prostate specific antigen: data from the prostate, lung, colorectal and ovarian cancer screening trial
    E David Crawford
    Department of Urologic Oncology, University of Colorado Health Sciences Center, Denver, Colorado, Washington, DC, USA
    J Urol 175:1286-90; discussion 1290. 2006
    ..A large fraction of screened men have low (less than 2 ng/ml) initial PSA. The yield over time of positive PSA screens (ie more than 4 ng/ml) in these men has not been well characterized in large cohorts in the United States...
  20. ncbi request reprint Role of cadmium in the regulation of AR gene expression and activity
    Mary Beth Martin
    Department of Biochemistry and Molecular Biology, Lombardi Cancer Center, E411 Research Building, 3970 Reservoir Road NW, Washington, D C 20007
    Endocrinology 143:263-75. 2002
    ..97- to 3-fold) and the seminal vesicle complex (approximately 1.5-fold) and increased the expression of the androgen-regulated gene, probasin (27-fold). The in vivo effects were also blocked by an antiandrogen...
  21. pmc Cross-regulation of signaling pathways: an example of nuclear hormone receptors and the canonical Wnt pathway
    Marcy E Beildeck
    Lombardi Comprehensive Cancer Center, Georgetown University, 3970 Reservoir Road, NW, Washington, DC 20057, USA
    Exp Cell Res 316:1763-72. 2010
    ..The aim of this review is to demonstrate the importance of considering pathway cross-talk when predicting functional outcomes of signaling, using nuclear hormone receptor/canonical Wnt pathway cross-talk as an example...
  22. ncbi request reprint Molecular biology of the androgen receptor
    Edward P Gelmann
    Department of Oncology, Lombardi Cancer Center, Georgetown University School of Medicine, 3800 Reservoir Rd NW, Washington, DC 20007 2197, USA
    J Clin Oncol 20:3001-15. 2002
    ..Further understanding of AR action and new strategies to interfere with AR signaling hold promise for improving prostate cancer therapy...
  23. ncbi request reprint 9-Nitrocamptothecin as second line chemotherapy for men with progressive, metastatic, hormone refractory prostate cancer: Results of the CALGB 99901
    Asim Amin
    Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA
    Urol Oncol 22:398-403. 2004
    ..9-nitrocamptothecin (9-NC) a novel, oral camptothecin analogue was tested as second line chemotherapy for patients with progressive hormone refractory prostate cancer...
  24. ncbi request reprint Long-term outcomes after radical prostatectomy performed in a community-based health maintenance organization
    Ying Zhang
    Department of Oncology, Lombardi Cancer Center, Georgetown University, 3800 Reservoir Road NW, Washington, DC 20007, USA
    Cancer 100:300-7. 2004
    ..No long-term analysis has been reported on a series of radical prostatectomies performed in a community-based health maintenance organization...
  25. ncbi request reprint The impact of item order on ratings of cancer risk perception
    Kathryn L Taylor
    Lombardi Cancer Center, Georgetown University, Washington DC 20007 4104, USA
    Cancer Epidemiol Biomarkers Prev 11:654-9. 2002
    ..Although the use of multiple items may provide more information than when only a single method is used, different conclusions may be reached depending on the context in which an item is assessed...
  26. doi request reprint Complexities of prostate-cancer risk
    Edward P Gelmann
    N Engl J Med 358:961-3. 2008
  27. doi request reprint A phase II study of mifepristone (RU-486) in castration-resistant prostate cancer, with a correlative assessment of androgen-related hormones
    Mary Ellen Taplin
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    BJU Int 101:1084-9. 2008
    ..To evaluate mifepristone (RU-486) in patients with castration-resistant prostate cancer (CRPC), with a correlative assessment of serum androgens and androgen metabolites..
  28. ncbi request reprint Repeat prostate biopsy in the prostate, lung, colorectal and ovarian cancer screening trial
    Paul F Pinsky
    Division of Cancer Prevention, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
    BJU Int 99:775-9. 2007
    ..To determine patterns of repeat prostate biopsy in a cohort of men undergoing prostate cancer screening who have a negative initial biopsy...
  29. doi request reprint Transcription factor Stat5 synergizes with androgen receptor in prostate cancer cells
    Shyh Han Tan
    Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Cancer Res 68:236-48. 2008
    ..The work presented here provides the first evidence of synergy between AR and the prolactin signaling protein Stat5a/b in human prostate cancer cells...
  30. pmc Inflammatory cytokines induce phosphorylation and ubiquitination of prostate suppressor protein NKX3.1
    Mark C Markowski
    Department of Medicine, Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York 10032, USA
    Cancer Res 68:6896-901. 2008
    ..Our data suggest that strategies to inhibit inflammation or to inhibit effector kinases may be useful approaches to prostate cancer prevention...
  31. ncbi request reprint Germ-line mutation of NKX3.1 cosegregates with hereditary prostate cancer and alters the homeodomain structure and function
    S Lilly Zheng
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Cancer Res 66:69-77. 2006
    ..These results suggest that germ-line sequence variants in NKX3.1 may play a role in susceptibility to hereditary prostate cancer and underscore a role for NKX3.1 as a prostate cancer gatekeeper...
  32. pmc Silencing mediator for retinoid and thyroid hormone receptor and nuclear receptor corepressor attenuate transcriptional activation by the beta-catenin-TCF4 complex
    Liang Nian Song
    Department of Medicine, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York 10032, USA
    J Biol Chem 283:25988-99. 2008
    ..These findings demonstrate an important role for corepressors SMRT and NCoR in the regulation of beta-catenin-TCF4-mediated gene transcription...
  33. ncbi request reprint Serum lycopene, other carotenoids, and prostate cancer risk: a nested case-control study in the prostate, lung, colorectal, and ovarian cancer screening trial
    Ulrike Peters
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, P O Box 19024, 1100 Fairview Avenue North M4 B402, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 16:962-8. 2007
    ..This has stimulated extensive laboratory and clinical research, as well as much commercial and public enthusiasm. However, the epidemiologic evidence remains inconclusive...
  34. ncbi request reprint Genome-wide association study of prostate cancer identifies a second risk locus at 8q24
    Meredith Yeager
    SAIC Frederick, National Cancer Institute NCI Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA
    Nat Genet 39:645-9. 2007
    ..We estimate that the population attributable risk of the new locus, marked by rs6983267, is higher than the locus marked by rs1447295 (21% versus 9%)...
  35. ncbi request reprint Tissue microarray analysis reveals prognostic significance of syndecan-1 expression in prostate cancer
    Tobias Zellweger
    Department of Urology, University of Basel, Schonbeinstrasse 40, 4031 Basel, Switzerland
    Prostate 55:20-9. 2003
    ..Here, we have tested several molecular markers on a prostate TMA containing 637 different specimens...
  36. ncbi request reprint Fourth International Conference on Innovations and Challenges in Prostate Cancer: Prevention, Detection and Treatment
    Peter R Carroll
    Department of Urology, University of California School of Medicine, San Francisco 94115 1711, USA
    J Urol 172:S3-5. 2004
  37. ncbi request reprint Prostate Cancer Screening in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial: findings from the initial screening round of a randomized trial
    Gerald L Andriole
    Division of Urologic Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    J Natl Cancer Inst 97:433-8. 2005
    ..We describe the population enrolled in the PLCO trial, their baseline PSA and DRE screening results, and diagnostic follow-up results during the first year of follow-up...
  38. ncbi request reprint Methods for etiologic and early marker investigations in the PLCO trial
    Richard B Hayes
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 8114, Bethesda, MD 20892, USA
    Mutat Res 592:147-54. 2005
    ..g., diet), biochemical, and genetic factors. Early detection studies focus on blood-based biologic markers of early disease. Clinical epidemiology is also an important component of the PLCO trial...