J E Freedman
Affiliation: Georgetown University
- Deficient platelet-derived nitric oxide and enhanced hemostasis in mice lacking the NOSIII geneJ E Freedman
Department of Pharmacology, Georgetown University Medical Center, Washington, DC 20007, USA
Circ Res 84:1416-21. 1999..These data suggest that the lack of platelet-derived NO alters in vivo hemostatic response by increasing platelet recruitment. Thus, these data support a role for platelet-derived NO production in the regulation of hemostasis...
- alpha-Tocopherol and protein kinase C inhibition enhance platelet-derived nitric oxide releaseJ E Freedman
Department of Pharmacology, Georgetown University Medical Center, Washington, D C 20007, USA
FASEB J 14:2377-9. 2000..Thus, a-tocopherol appears to enhance platelet NO release both in vitro and in vivo through antioxidant- and PKC-dependent mechanisms...
- Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide releaseJ E Freedman
Departments of Pharmacology and Medicine, Georgetown University Medical Center, Washington, DC 20007, USA
Circulation 103:2792-8. 2001..Acute cardiac events are also associated with decreased platelet-derived nitric oxide (NO) release. In this study, the effects of PGJ and PGJ-derived flavonoids on platelet function and platelet NO production were determined...
- Vitamin E inhibition of platelet aggregation is independent of antioxidant activityJ E Freedman
Department of Pharmacology, Georgetown University Medical Center, Washington, DC, USA
J Nutr 131:374S-7S. 2001..Moreover, the platelet inhibitory activity of vitamin E was independent of its antioxidant action because platelet inhibition was still observed with isoforms of vitamin E that were devoid of antioxidant activity...
- Pharmacological control of platelet functionP Clutton
Departments of Pharmacology and Medicine, Georgetown University Medical Center, Washington, DC, USA
Pharmacol Res 44:255-64. 2001..Future development in receptor pathway inhibitors also includes glycoprotein Ib/IX as well as the potential use of platelet signaling pathway inhibitors...
- Soluble adhesion molecules and unstable coronary artery diseaseC Parker
Departments of Pharmacology and Medicine, Med-Dent Bldg. Rm. NE 403, Georgetown University Medical Center, 3900 Reservoir Road, Washington, DC 20007, USA
Atherosclerosis 156:417-24. 2001..In addition, the beneficial effects of alpha-tocopherol in patients with cardiovascular disease may be related to inhibition of platelet function...
- Nitric oxide and its relationship to thrombotic disordersJ E Freedman
The Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, 715 Albany Street, W507, Boston, MA 02118, USA
J Thromb Haemost 1:1183-8. 2003..Diseases including atrial fibrillation and coronary atherothrombotic disease have been associated with impaired NO release or decrease in NO bioavailability...
- Heparin reacts with and inactivates nitric oxideG R Upchurch
Whitaker Cardiovascular Institute, Evans Department of Medicine, Boston University School of Medicine, MA 02118, USA
J Cardiovasc Pharmacol Ther 6:163-73. 2001....