J E Freedman

Summary

Affiliation: Georgetown University
Country: USA

Publications

  1. ncbi request reprint Deficient platelet-derived nitric oxide and enhanced hemostasis in mice lacking the NOSIII gene
    J E Freedman
    Department of Pharmacology, Georgetown University Medical Center, Washington, DC 20007, USA
    Circ Res 84:1416-21. 1999
  2. ncbi request reprint alpha-Tocopherol and protein kinase C inhibition enhance platelet-derived nitric oxide release
    J E Freedman
    Department of Pharmacology, Georgetown University Medical Center, Washington, D C 20007, USA
    FASEB J 14:2377-9. 2000
  3. ncbi request reprint Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release
    J E Freedman
    Departments of Pharmacology and Medicine, Georgetown University Medical Center, Washington, DC 20007, USA
    Circulation 103:2792-8. 2001
  4. ncbi request reprint Vitamin E inhibition of platelet aggregation is independent of antioxidant activity
    J E Freedman
    Department of Pharmacology, Georgetown University Medical Center, Washington, DC, USA
    J Nutr 131:374S-7S. 2001
  5. ncbi request reprint Pharmacological control of platelet function
    P Clutton
    Departments of Pharmacology and Medicine, Georgetown University Medical Center, Washington, DC, USA
    Pharmacol Res 44:255-64. 2001
  6. ncbi request reprint Soluble adhesion molecules and unstable coronary artery disease
    C Parker
    Departments of Pharmacology and Medicine, Med-Dent Bldg. Rm. NE 403, Georgetown University Medical Center, 3900 Reservoir Road, Washington, DC 20007, USA
    Atherosclerosis 156:417-24. 2001
  7. ncbi request reprint Nitric oxide and its relationship to thrombotic disorders
    J E Freedman
    The Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, 715 Albany Street, W507, Boston, MA 02118, USA
    J Thromb Haemost 1:1183-8. 2003
  8. ncbi request reprint Heparin reacts with and inactivates nitric oxide
    G R Upchurch
    Whitaker Cardiovascular Institute, Evans Department of Medicine, Boston University School of Medicine, MA 02118, USA
    J Cardiovasc Pharmacol Ther 6:163-73. 2001

Collaborators

Detail Information

Publications8

  1. ncbi request reprint Deficient platelet-derived nitric oxide and enhanced hemostasis in mice lacking the NOSIII gene
    J E Freedman
    Department of Pharmacology, Georgetown University Medical Center, Washington, DC 20007, USA
    Circ Res 84:1416-21. 1999
    ..These data suggest that the lack of platelet-derived NO alters in vivo hemostatic response by increasing platelet recruitment. Thus, these data support a role for platelet-derived NO production in the regulation of hemostasis...
  2. ncbi request reprint alpha-Tocopherol and protein kinase C inhibition enhance platelet-derived nitric oxide release
    J E Freedman
    Department of Pharmacology, Georgetown University Medical Center, Washington, D C 20007, USA
    FASEB J 14:2377-9. 2000
    ..Thus, a-tocopherol appears to enhance platelet NO release both in vitro and in vivo through antioxidant- and PKC-dependent mechanisms...
  3. ncbi request reprint Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release
    J E Freedman
    Departments of Pharmacology and Medicine, Georgetown University Medical Center, Washington, DC 20007, USA
    Circulation 103:2792-8. 2001
    ..Acute cardiac events are also associated with decreased platelet-derived nitric oxide (NO) release. In this study, the effects of PGJ and PGJ-derived flavonoids on platelet function and platelet NO production were determined...
  4. ncbi request reprint Vitamin E inhibition of platelet aggregation is independent of antioxidant activity
    J E Freedman
    Department of Pharmacology, Georgetown University Medical Center, Washington, DC, USA
    J Nutr 131:374S-7S. 2001
    ..Moreover, the platelet inhibitory activity of vitamin E was independent of its antioxidant action because platelet inhibition was still observed with isoforms of vitamin E that were devoid of antioxidant activity...
  5. ncbi request reprint Pharmacological control of platelet function
    P Clutton
    Departments of Pharmacology and Medicine, Georgetown University Medical Center, Washington, DC, USA
    Pharmacol Res 44:255-64. 2001
    ..Future development in receptor pathway inhibitors also includes glycoprotein Ib/IX as well as the potential use of platelet signaling pathway inhibitors...
  6. ncbi request reprint Soluble adhesion molecules and unstable coronary artery disease
    C Parker
    Departments of Pharmacology and Medicine, Med-Dent Bldg. Rm. NE 403, Georgetown University Medical Center, 3900 Reservoir Road, Washington, DC 20007, USA
    Atherosclerosis 156:417-24. 2001
    ..In addition, the beneficial effects of alpha-tocopherol in patients with cardiovascular disease may be related to inhibition of platelet function...
  7. ncbi request reprint Nitric oxide and its relationship to thrombotic disorders
    J E Freedman
    The Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, 715 Albany Street, W507, Boston, MA 02118, USA
    J Thromb Haemost 1:1183-8. 2003
    ..Diseases including atrial fibrillation and coronary atherothrombotic disease have been associated with impaired NO release or decrease in NO bioavailability...
  8. ncbi request reprint Heparin reacts with and inactivates nitric oxide
    G R Upchurch
    Whitaker Cardiovascular Institute, Evans Department of Medicine, Boston University School of Medicine, MA 02118, USA
    J Cardiovasc Pharmacol Ther 6:163-73. 2001
    ....