Patrick A Forcelli

Summary

Affiliation: Georgetown University
Country: USA

Publications

  1. pmc Neonatal exposure to antiepileptic drugs disrupts striatal synaptic development
    Patrick A Forcelli
    Interdisciplinary Program in Neuroscience, Georgetown University, School of Medicine, Washington, DC, USA
    Ann Neurol 72:363-72. 2012
  2. pmc Ventral pallidum mediates amygdala-evoked deficits in prepulse inhibition
    Patrick A Forcelli
    Department of Pharmacology and Physiology, Georgetown University, New Research Building, W214, 3970 Reservoir Road Northwest, Washington, DC 20007, USA
    Behav Neurosci 126:290-300. 2012
  3. pmc Pattern of antiepileptic drug-induced cell death in limbic regions of the neonatal rat brain
    Patrick A Forcelli
    Interdisciplinary Program in Neuroscience, Georgetown University, Washington, District of Columbia, USA
    Epilepsia 52:e207-11. 2011
  4. pmc Effects of neonatal antiepileptic drug exposure on cognitive, emotional, and motor function in adult rats
    Patrick A Forcelli
    Department of Pharmacology and Physiology, Georgetown University Medical Center, Washington, DC 20057, USA
    J Pharmacol Exp Ther 340:558-66. 2012
  5. pmc Transient inactivation of basolateral amygdala during selective satiation disrupts reinforcer devaluation in rats
    Elizabeth A West
    Department of Pharmacology and Physiology, Georgetown University Medical Center, Washington, DC 20007, USA
    Behav Neurosci 126:563-74. 2012
  6. pmc Defense-like behaviors evoked by pharmacological disinhibition of the superior colliculus in the primate
    Jacqueline T Desjardin
    Department of Pharmacology and Physiology, Georgetown University Medical Center, Washington, DC 20007, USA
    J Neurosci 33:150-5. 2013
  7. pmc Superior colliculus mediates cervical dystonia evoked by inhibition of the substantia nigra pars reticulata
    Angela L Holmes
    Department of Pharmacology and Physiology, Georgetown University Medical Center, Washington, DC 20007, USA
    J Neurosci 32:13326-32. 2012
  8. pmc Therapeutic strategies to avoid long-term adverse outcomes of neonatal antiepileptic drug exposure
    Patrick A Forcelli
    Department of Pharmacology, Georgetown University, Washington, District of Columbia 20057, USA
    Epilepsia 51:18-23. 2010
  9. doi request reprint Anticonvulsant effect of retigabine during postnatal development in rats
    Patrick A Forcelli
    Department of Pharmacology and Physiology, Georgetown University Medical Center, Washington, DC 20007, United States
    Epilepsy Res 101:135-40. 2012
  10. pmc Early postnatal exposure of rats to lamotrigine, but not phenytoin, reduces seizure threshold in adulthood
    Patrick A Forcelli
    Interdisciplinary Program in Neuroscience, Georgetown University, Washington, District of Columbia, USA
    Epilepsia 52:e20-2. 2011

Collaborators

Detail Information

Publications15

  1. pmc Neonatal exposure to antiepileptic drugs disrupts striatal synaptic development
    Patrick A Forcelli
    Interdisciplinary Program in Neuroscience, Georgetown University, School of Medicine, Washington, DC, USA
    Ann Neurol 72:363-72. 2012
    ..The functional significance of the preclinical neurotoxicity has been questioned due to the absence of evidence for functional impairment associated with drug-induced developmental apoptosis...
  2. pmc Ventral pallidum mediates amygdala-evoked deficits in prepulse inhibition
    Patrick A Forcelli
    Department of Pharmacology and Physiology, Georgetown University, New Research Building, W214, 3970 Reservoir Road Northwest, Washington, DC 20007, USA
    Behav Neurosci 126:290-300. 2012
    ..We unilaterally inactivated BLA with concurrent inactivation of VP and found that VP inactivation blocked BLA-evoked deficits in PPI. We suggest that BLA inactivation disrupts PPI through disinhibition of VP...
  3. pmc Pattern of antiepileptic drug-induced cell death in limbic regions of the neonatal rat brain
    Patrick A Forcelli
    Interdisciplinary Program in Neuroscience, Georgetown University, Washington, District of Columbia, USA
    Epilepsia 52:e207-11. 2011
    ..These findings raise the possibility that AED exposure in infancy may contribute to adverse neuropsychiatric outcomes later in life...
  4. pmc Effects of neonatal antiepileptic drug exposure on cognitive, emotional, and motor function in adult rats
    Patrick A Forcelli
    Department of Pharmacology and Physiology, Georgetown University Medical Center, Washington, DC 20057, USA
    J Pharmacol Exp Ther 340:558-66. 2012
    ..Our findings suggest that a history of AED therapy during development must be considered as a variable when assessing later-life cognitive and psychiatric outcomes...
  5. pmc Transient inactivation of basolateral amygdala during selective satiation disrupts reinforcer devaluation in rats
    Elizabeth A West
    Department of Pharmacology and Physiology, Georgetown University Medical Center, Washington, DC 20007, USA
    Behav Neurosci 126:563-74. 2012
    ..Our results are the first to describe the contribution of rat BLA to specific components of reinforcer devaluation and are the first to show impairment in reinforcer devaluation following transient inactivation in the rat...
  6. pmc Defense-like behaviors evoked by pharmacological disinhibition of the superior colliculus in the primate
    Jacqueline T Desjardin
    Department of Pharmacology and Physiology, Georgetown University Medical Center, Washington, DC 20007, USA
    J Neurosci 33:150-5. 2013
    ..Our data provide the first evidence for induction of defense-like behaviors by activation of DLSC in monkeys, suggesting that the role of DLSC in responding to threats is conserved across species...
  7. pmc Superior colliculus mediates cervical dystonia evoked by inhibition of the substantia nigra pars reticulata
    Angela L Holmes
    Department of Pharmacology and Physiology, Georgetown University Medical Center, Washington, DC 20007, USA
    J Neurosci 32:13326-32. 2012
    ....
  8. pmc Therapeutic strategies to avoid long-term adverse outcomes of neonatal antiepileptic drug exposure
    Patrick A Forcelli
    Department of Pharmacology, Georgetown University, Washington, District of Columbia 20057, USA
    Epilepsia 51:18-23. 2010
    ..In addition, our findings identify early exposure to certain AEDs as an important potential risk factor contributing to psychiatric and neurologic abnormalities later in life...
  9. doi request reprint Anticonvulsant effect of retigabine during postnatal development in rats
    Patrick A Forcelli
    Department of Pharmacology and Physiology, Georgetown University Medical Center, Washington, DC 20007, United States
    Epilepsy Res 101:135-40. 2012
    ..These findings allow a direct comparison between retigabine and previously studied antiepileptic drugs against PTZ seizures during development, and provide the first report of the effective dose range of retigabine in neonatal animals...
  10. pmc Early postnatal exposure of rats to lamotrigine, but not phenytoin, reduces seizure threshold in adulthood
    Patrick A Forcelli
    Interdisciplinary Program in Neuroscience, Georgetown University, Washington, District of Columbia, USA
    Epilepsia 52:e20-2. 2011
    ....
  11. doi request reprint Correction to forcelli et Al. (2012)
    Patrick A Forcelli
    Interdisciplinary Program in Neuroscience, Georgetown University
    Behav Neurosci 127:399. 2013
    ..We suggest that BLA inactivation disrupts PPI through disinhibition of VP. (PsycINFO Database Record (c) 2013 APA, all rights reserved)...
  12. pmc Differential effects of serotonin-specific and excitotoxic lesions of OFC on conditioned reinforcer devaluation and extinction in rats
    Elizabeth A West
    Department of Pharmacology and Physiology, Georgetown University Medical Center, Washington, DC 20007, United States Interdisciplinary Program in Neuroscience, Georgetown University Medical Center, Washington, DC 20007, United States Electronic address
    Behav Brain Res 246:10-4. 2013
    ..Our results are the first to demonstrate that serotonin in OFC is necessary for reinforcer devaluation, but not extinction...
  13. pmc A visual, position-independent instrumental reinforcer devaluation task for rats
    Elizabeth A West
    Interdisciplinary Program in Neuroscience, Georgetown University, 3970 Reservoir Rd NW, Washington, DC 20007, United States
    J Neurosci Methods 194:297-304. 2011
    ..Discrimination of the visual cues is not aided by spatial cues, thereby eliminating a major difference between the instrumental tasks used in rats and the task used in monkeys...
  14. doi request reprint Topography of dyskinesias and torticollis evoked by inhibition of substantia nigra pars reticulata
    David Dybdal
    Department of Pharmacology and Physiology, Georgetown University Medical Center, Washington, DC 20007, USA
    Mov Disord 28:460-8. 2013
    ..These abnormalities are symptoms of dystonia, Huntington's disease, and iatrogenic dyskinesias, suggesting that these conditions may result, in part, from a loss of function in SNpr efferent projections...
  15. pmc Histocompatibility and in vivo signal throughput for PEDOT, PEDOP, P3MT, and polycarbazole electrodes
    Patrick A Forcelli
    Department of Pharmacology and Physiology, Georgetown University, Washington, District of Columbia 20057, USA
    J Biomed Mater Res A 100:3455-62. 2012
    ..These results suggest that CP electrodes may present viable alternatives to the metal electrodes that are currently in use...