Kamal Datta

Summary

Affiliation: Georgetown University
Country: USA

Publications

  1. ncbi request reprint Radiation persistently promoted oxidative stress, activated mTOR via PI3K/Akt, and downregulated autophagy pathway in mouse intestine
    Kamal Datta
    Department of Biochemistry and Molecular and Cellular Biology, Georgetown University, Washington, DC 20057, USA Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA Electronic address
    Int J Biochem Cell Biol 57:167-76. 2014
  2. pmc Heavy ion radiation exposure triggered higher intestinal tumor frequency and greater β-catenin activation than γ radiation in APC(Min/+) mice
    Kamal Datta
    Department of Biochemistry and Molecular and Cell Biology and Lombardi Comprehensives Cancer Center, Georgetown University, Washington, DC, USA
    PLoS ONE 8:e59295. 2013
  3. pmc Exposure to heavy ion radiation induces persistent oxidative stress in mouse intestine
    Kamal Datta
    Department of Biochemistry and Molecular and Cell Biology, Georgetown University Medical Center, Lombardi Comprehensive Cancer Center, Washington, DC, United States of America
    PLoS ONE 7:e42224. 2012
  4. pmc Accelerated hematopoietic toxicity by high energy (56)Fe radiation
    Kamal Datta
    Department of Biochemistry and Molecular and Cell Biology and Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057 1468, USA
    Int J Radiat Biol 88:213-22. 2012
  5. ncbi request reprint Gamma tocotrienol, a potent radioprotector, preferentially upregulates expression of anti-apoptotic genes to promote intestinal cell survival
    Shubhankar Suman
    Department of Biochemistry and Molecular and Cell Biology, Georgetown University Medical Center and Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA
    Food Chem Toxicol 60:488-96. 2013
  6. pmc Relative biological effectiveness of 12C and 28Si radiation in C57BL/6J mice
    Shubhankar Suman
    Department of Biochemistry and Molecular and Cell Biology, Lombardi Comprehensive Cancer Center, Georgetown University, Room E504 Research Building, 3970 Reservoir Rd, NW, Washington, DC 20057 1468, USA
    Radiat Environ Biophys 51:303-9. 2012
  7. pmc Therapeutic and space radiation exposure of mouse brain causes impaired DNA repair response and premature senescence by chronic oxidant production
    Shubhankar Suman
    Department of Biochemistry and Molecular and Cell Biology, Georgetown University Medical Center, Washington, DC 20057, USA
    Aging (Albany NY) 5:607-22. 2013
  8. pmc Sex-dependent differences in intestinal tumorigenesis induced in Apc1638N/+ mice by exposure to γ rays
    Daniela Trani
    Department of Biochemistry and Molecular and Cellular Biology, Georgetown University, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, District of Columbia 20057, USA
    Int J Radiat Oncol Biol Phys 85:223-9. 2013
  9. ncbi request reprint Radioprotective effects of ON 01210.Na upon oral administration
    Shubhankar Suman
    Department of Biochemistry and Molecular and Cellular Biology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057 1468, USA
    J Radiat Res 53:368-76. 2012
  10. pmc Exposure to ionizing radiation induced persistent gene expression changes in mouse mammary gland
    Kamal Datta
    Department of Biochemistry and Molecular and Cellular Biology, Georgetown University, 3970 Reservoir Rd, Washington, DC, NW 20057 1468, USA
    Radiat Oncol 7:205. 2012

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Radiation persistently promoted oxidative stress, activated mTOR via PI3K/Akt, and downregulated autophagy pathway in mouse intestine
    Kamal Datta
    Department of Biochemistry and Molecular and Cellular Biology, Georgetown University, Washington, DC 20057, USA Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA Electronic address
    Int J Biochem Cell Biol 57:167-76. 2014
    ..Radiation-induced promotion of oxidative stress and downregulation of autophagy could work in tandem to alter intestinal functions and have implications for post-radiation chronic gastrointestinal diseases. ..
  2. pmc Heavy ion radiation exposure triggered higher intestinal tumor frequency and greater β-catenin activation than γ radiation in APC(Min/+) mice
    Kamal Datta
    Department of Biochemistry and Molecular and Cell Biology and Lombardi Comprehensives Cancer Center, Georgetown University, Washington, DC, USA
    PLoS ONE 8:e59295. 2013
    ....
  3. pmc Exposure to heavy ion radiation induces persistent oxidative stress in mouse intestine
    Kamal Datta
    Department of Biochemistry and Molecular and Cell Biology, Georgetown University Medical Center, Lombardi Comprehensive Cancer Center, Washington, DC, United States of America
    PLoS ONE 7:e42224. 2012
    ....
  4. pmc Accelerated hematopoietic toxicity by high energy (56)Fe radiation
    Kamal Datta
    Department of Biochemistry and Molecular and Cell Biology and Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057 1468, USA
    Int J Radiat Biol 88:213-22. 2012
    ....
  5. ncbi request reprint Gamma tocotrienol, a potent radioprotector, preferentially upregulates expression of anti-apoptotic genes to promote intestinal cell survival
    Shubhankar Suman
    Department of Biochemistry and Molecular and Cell Biology, Georgetown University Medical Center and Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA
    Food Chem Toxicol 60:488-96. 2013
    ....
  6. pmc Relative biological effectiveness of 12C and 28Si radiation in C57BL/6J mice
    Shubhankar Suman
    Department of Biochemistry and Molecular and Cell Biology, Lombardi Comprehensive Cancer Center, Georgetown University, Room E504 Research Building, 3970 Reservoir Rd, NW, Washington, DC 20057 1468, USA
    Radiat Environ Biophys 51:303-9. 2012
    ..25 Gy) is 1.4 for (28)Si and 0.99 for (12)C. Determination of RBE of (28)Si and (12)C for survival in mice is not only important for space radiation risk estimate studies, but it also has implications for HZE radiation in cancer therapy...
  7. pmc Therapeutic and space radiation exposure of mouse brain causes impaired DNA repair response and premature senescence by chronic oxidant production
    Shubhankar Suman
    Department of Biochemistry and Molecular and Cell Biology, Georgetown University Medical Center, Washington, DC 20057, USA
    Aging (Albany NY) 5:607-22. 2013
    ....
  8. pmc Sex-dependent differences in intestinal tumorigenesis induced in Apc1638N/+ mice by exposure to γ rays
    Daniela Trani
    Department of Biochemistry and Molecular and Cellular Biology, Georgetown University, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, District of Columbia 20057, USA
    Int J Radiat Oncol Biol Phys 85:223-9. 2013
    ....
  9. ncbi request reprint Radioprotective effects of ON 01210.Na upon oral administration
    Shubhankar Suman
    Department of Biochemistry and Molecular and Cellular Biology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057 1468, USA
    J Radiat Res 53:368-76. 2012
    ..Oral administration holds better clinical promise as an effective countermeasure not only for early-responders in a nuclear accident, but also for the at-risk civilian population...
  10. pmc Exposure to ionizing radiation induced persistent gene expression changes in mouse mammary gland
    Kamal Datta
    Department of Biochemistry and Molecular and Cellular Biology, Georgetown University, 3970 Reservoir Rd, Washington, DC, NW 20057 1468, USA
    Radiat Oncol 7:205. 2012
    ..We undertook this study to delineate radiation-induced persistent alterations in gene expression in mouse mammary glands 2-month after radiation exposure...
  11. pmc Administration of ON 01210.Na after exposure to ionizing radiation protects bone marrow cells by attenuating DNA damage response
    Shubhankar Suman
    Department of Biochemistry and Molecular and Cell Biology, Georgetown University Medical Center, Research Building, Room E518, 3970 Reservoir Rd, NW, Washington, DC 20057 1468, USA
    Radiat Oncol 7:6. 2012
    ..Na, a chlorobenzylsulfone derivative, in ameliorating radiation-induced hematopoietic toxicity when administered after exposure to radiation. We also investigate the molecular mechanisms underlying this activity...
  12. ncbi request reprint Wip1 abrogation decreases intestinal tumor frequency in APC(Min/+) mice irrespective of radiation quality
    Shubhankar Suman
    a Department of Biochemistry and Molecular and Cellular Biology and Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057
    Radiat Res 182:345-9. 2014
    ....
  13. pmc Enhanced intestinal tumor multiplicity and grade in vivo after HZE exposure: mouse models for space radiation risk estimates
    Daniela Trani
    Department of Biochemistry and Molecular and Cell Biology and Lombardi Comprehensive Cancer Center, Georgetown University, 3970 Reservoir Rd, NW, Washington, DC 20057 1468, USA
    Radiat Environ Biophys 49:389-96. 2010
    ....
  14. pmc Exposure to ionizing radiation causes long-term increase in serum estradiol and activation of PI3K-Akt signaling pathway in mouse mammary gland
    Shubhankar Suman
    Department of Biochemistry and Molecular and Cellular Biology, Georgetown University, Washington, DC 20057 1468, USA
    Int J Radiat Oncol Biol Phys 84:500-7. 2012
    ..In this study, we investigated the long-term pathophysiologic effects of ionizing radiation at a dose (2 Gy) relevant to fractionated radiotherapy...
  15. pmc Long-term differential changes in mouse intestinal metabolomics after γ and heavy ion radiation exposure
    Amrita K Cheema
    Department of Biochemistry and Molecular and Cellular Biology and Lombardi Comprehensive Cancer Center, Georgetown University, Washington, D C, United States of America
    PLoS ONE 9:e87079. 2014
    ....
  16. pmc An in vitro DNA double-strand break repair assay based on end-joining of defined duplex oligonucleotides
    Kamal Datta
    Department of Biochemistry and Molecular and Cellular Biology, Georgetown University Medical Center, Washington, USA
    Methods Mol Biol 920:485-500. 2012
    ....