Katherine L Cook

Summary

Affiliation: Georgetown University
Country: USA

Publications

  1. pmc Autophagy and endocrine resistance in breast cancer
    Katherine L Cook
    Department of Oncology and Lombardi Comprehensive Cancer Center W405A Research Building, Georgetown University Medical Center, 3970 Reservoir Road NW, Washington, DC 20057, USA
    Expert Rev Anticancer Ther 11:1283-94. 2011
  2. pmc GX15-070 (obatoclax) induces apoptosis and inhibits cathepsin D- and L-mediated autophagosomal lysis in antiestrogen-resistant breast cancer cells
    Jessica L Schwartz-Roberts
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, DC 20057, USA
    Mol Cancer Ther 12:448-59. 2013
  3. doi request reprint Targeting GRP78 and antiestrogen resistance in breast cancer
    Katherine L Cook
    Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA
    Future Med Chem 5:1047-57. 2013
  4. pmc Hydroxychloroquine Inhibits Autophagy to Potentiate Antiestrogen Responsiveness in ER+ Breast Cancer
    Katherine L Cook
    Authors Affiliations Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, D C and Department of Pathology, National Cancer Institute, NIH, Bethesda, Maryland
    Clin Cancer Res 20:3222-32. 2014
  5. pmc Glucose-regulated protein 78 controls cross-talk between apoptosis and autophagy to determine antiestrogen responsiveness
    Katherine L Cook
    Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, District of Columbia 20057, USA
    Cancer Res 72:3337-49. 2012
  6. pmc Heat shock 70 kDa protein 5/glucose-regulated protein 78 "AMP"ing up autophagy
    Katherine L Cook
    Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA
    Autophagy 8:1827-9. 2012
  7. pmc Endoplasmic reticulum stress, the unfolded protein response, autophagy, and the integrated regulation of breast cancer cell fate
    Robert Clarke
    Department of Oncology, Georgetown University School of Medicine, Washington, DC 20057, USA
    Cancer Res 72:1321-31. 2012

Collaborators

  • Ayesha N Shajahan
  • Robert Clarke
  • Jessica L Schwartz-Roberts
  • Anni Warri
  • Mones Abu-Asab
  • John J Tyson
  • Yue Wang
  • William T Baumann
  • Rong Hu
  • Caroline O B Facey
  • Iman Tavassoly
  • Jianhua Xuan
  • Jessica L Schwartz

Detail Information

Publications8

  1. pmc Autophagy and endocrine resistance in breast cancer
    Katherine L Cook
    Department of Oncology and Lombardi Comprehensive Cancer Center W405A Research Building, Georgetown University Medical Center, 3970 Reservoir Road NW, Washington, DC 20057, USA
    Expert Rev Anticancer Ther 11:1283-94. 2011
    ..In this article, we discuss the complex and occasionally contradictory roles of autophagy in cancer and in resistance to endocrine therapies in breast cancer...
  2. pmc GX15-070 (obatoclax) induces apoptosis and inhibits cathepsin D- and L-mediated autophagosomal lysis in antiestrogen-resistant breast cancer cells
    Jessica L Schwartz-Roberts
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, DC 20057, USA
    Mol Cancer Ther 12:448-59. 2013
    ..Our data highlight a new mechanism of GX15-070-induced cell death that could be used to design novel therapeutic interventions for antiestrogen resistant breast cancer...
  3. doi request reprint Targeting GRP78 and antiestrogen resistance in breast cancer
    Katherine L Cook
    Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA
    Future Med Chem 5:1047-57. 2013
    ..Recently, various compounds have been reported to affect GRP78 activity and it may be advantageous to combine these drugs with antiestrogens to overcome endocrine therapy resistance...
  4. pmc Hydroxychloroquine Inhibits Autophagy to Potentiate Antiestrogen Responsiveness in ER+ Breast Cancer
    Katherine L Cook
    Authors Affiliations Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, D C and Department of Pathology, National Cancer Institute, NIH, Bethesda, Maryland
    Clin Cancer Res 20:3222-32. 2014
    ..Autophagy has been implicated as a major driver of antiestrogen resistance. We have explored the ability of hydroxychloroquine (HCQ), which inhibits autophagy, to affect antiestrogen responsiveness...
  5. pmc Glucose-regulated protein 78 controls cross-talk between apoptosis and autophagy to determine antiestrogen responsiveness
    Katherine L Cook
    Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, District of Columbia 20057, USA
    Cancer Res 72:3337-49. 2012
    ..Together, our findings reveal a novel role for GRP78 in the integration of cellular signaling pathways including the unfolded protein response, apoptosis, and autophagy to determine cell fate in response to antiestrogen therapy...
  6. pmc Heat shock 70 kDa protein 5/glucose-regulated protein 78 "AMP"ing up autophagy
    Katherine L Cook
    Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA
    Autophagy 8:1827-9. 2012
    ..While several preclinical studies postulate how antiestrogen resistance occurs, for the most part, the molecular mechanism(s) of resistance is unknown...
  7. pmc Endoplasmic reticulum stress, the unfolded protein response, autophagy, and the integrated regulation of breast cancer cell fate
    Robert Clarke
    Department of Oncology, Georgetown University School of Medicine, Washington, DC 20057, USA
    Cancer Res 72:1321-31. 2012
    ..Central topologic features of the signaling network that integrate cell-fate regulation and decision execution are discussed...