Katherine L Cook
Affiliation: Georgetown University
- Autophagy and endocrine resistance in breast cancerKatherine L Cook
Department of Oncology and Lombardi Comprehensive Cancer Center W405A Research Building, Georgetown University Medical Center, 3970 Reservoir Road NW, Washington, DC 20057, USA
Expert Rev Anticancer Ther 11:1283-94. 2011..In this article, we discuss the complex and occasionally contradictory roles of autophagy in cancer and in resistance to endocrine therapies in breast cancer...
- Glucose-regulated protein 78 controls cross-talk between apoptosis and autophagy to determine antiestrogen responsivenessKatherine L Cook
Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, District of Columbia 20057, USA
Cancer Res 72:3337-49. 2012..Together, our findings reveal a novel role for GRP78 in the integration of cellular signaling pathways including the unfolded protein response, apoptosis, and autophagy to determine cell fate in response to antiestrogen therapy...
- Endoplasmic reticulum stress, the unfolded protein response, autophagy, and the integrated regulation of breast cancer cell fateRobert Clarke
Department of Oncology, Georgetown University School of Medicine, Washington, DC 20057, USA
Cancer Res 72:1321-31. 2012..Central topologic features of the signaling network that integrate cell-fate regulation and decision execution are discussed...