ROBERT R CLARKE

Summary

Affiliation: Georgetown University
Country: USA

Publications

  1. pmc The Role of Interferon Regulatory Factor-1 (IRF1) in Overcoming Antiestrogen Resistance in the Treatment of Breast Cancer
    J L Schwartz
    Georgetown University Medical Center, W401 Research Building, 3970 Reservoir Road, NW, Washington, DC 20057, USA
    Int J Breast Cancer 2011:912102. 2011
  2. pmc Genome-wide identification of significant aberrations in cancer genome
    Xiguo Yuan
    School of Computer Science and Technology, Xidian University, Xi an, P R China
    BMC Genomics 13:342. 2012
  3. pmc GX15-070 (obatoclax) induces apoptosis and inhibits cathepsin D- and L-mediated autophagosomal lysis in antiestrogen-resistant breast cancer cells
    Jessica L Schwartz-Roberts
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, DC 20057, USA
    Mol Cancer Ther 12:448-59. 2013
  4. pmc Endoplasmic reticulum stress, the unfolded protein response, autophagy, and the integrated regulation of breast cancer cell fate
    Robert Clarke
    Department of Oncology, Georgetown University School of Medicine, Washington, DC 20057, USA
    Cancer Res 72:1321-31. 2012
  5. pmc Identifying cancer biomarkers by network-constrained support vector machines
    Li Chen
    Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA, USA
    BMC Syst Biol 5:161. 2011
  6. pmc Reverse engineering module networks by PSO-RNN hybrid modeling
    Yuji Zhang
    Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA
    BMC Genomics 10:S15. 2009
  7. pmc AIB1 gene amplification and the instability of polyQ encoding sequence in breast cancer cell lines
    Lee Jun C Wong
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    BMC Cancer 6:111. 2006
  8. pmc Motif-guided sparse decomposition of gene expression data for regulatory module identification
    Ting Gong
    Bradley Department of Electrical and Computer Engineering, Virginia Tech, Arlington, VA 22203, USA
    BMC Bioinformatics 12:82. 2011
  9. pmc Motif-directed network component analysis for regulatory network inference
    Chen Wang
    Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA, USA
    BMC Bioinformatics 9:S21. 2008
  10. pmc Knowledge-guided gene ranking by coordinative component analysis
    Chen Wang
    Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA, USA
    BMC Bioinformatics 11:162. 2010

Research Grants

  1. Endocrine resistance in breast cancer
    Robert Clarke; Fiscal Year: 2009
  2. Molecular Analysis of Human Breast Cancer
    Robert Clarke; Fiscal Year: 2007
  3. Molecular Analysis of Human Breast Cancer
    Robert Clarke; Fiscal Year: 2006
  4. Molecular Analysis of Human Breast Cancer
    Robert Clarke; Fiscal Year: 2005
  5. Molecular Analysis of Human Breast Cancer
    Robert Clarke; Fiscal Year: 2004
  6. Molecular Analysis of Human Breast Cancer
    Robert Clarke; Fiscal Year: 2003
  7. ESTROGEN INDUCED PROGRESSION IN BREAST CANCER
    Robert Clarke; Fiscal Year: 2001
  8. ESTROGEN INDUCED PROGRESSION IN BREAST CANCER
    Robert Clarke; Fiscal Year: 2000
  9. ESTROGEN-INDUCED PROGRESSION IN HUMAN BREAST CANCER
    Robert Clarke; Fiscal Year: 1993
  10. ESTROGEN-INDUCED PROGRESSION IN HUMAN BREAST CANCER
    Robert Clarke; Fiscal Year: 1992

Collaborators

Detail Information

Publications48

  1. pmc The Role of Interferon Regulatory Factor-1 (IRF1) in Overcoming Antiestrogen Resistance in the Treatment of Breast Cancer
    J L Schwartz
    Georgetown University Medical Center, W401 Research Building, 3970 Reservoir Road, NW, Washington, DC 20057, USA
    Int J Breast Cancer 2011:912102. 2011
    ..By understanding IRF1 signaling in the context of endocrine responsiveness, we may be able to develop novel therapeutic strategies and better predict how patients will respond to endocrine therapy...
  2. pmc Genome-wide identification of significant aberrations in cancer genome
    Xiguo Yuan
    School of Computer Science and Technology, Xidian University, Xi an, P R China
    BMC Genomics 13:342. 2012
    ....
  3. pmc GX15-070 (obatoclax) induces apoptosis and inhibits cathepsin D- and L-mediated autophagosomal lysis in antiestrogen-resistant breast cancer cells
    Jessica L Schwartz-Roberts
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, DC 20057, USA
    Mol Cancer Ther 12:448-59. 2013
    ..Our data highlight a new mechanism of GX15-070-induced cell death that could be used to design novel therapeutic interventions for antiestrogen resistant breast cancer...
  4. pmc Endoplasmic reticulum stress, the unfolded protein response, autophagy, and the integrated regulation of breast cancer cell fate
    Robert Clarke
    Department of Oncology, Georgetown University School of Medicine, Washington, DC 20057, USA
    Cancer Res 72:1321-31. 2012
    ..Central topologic features of the signaling network that integrate cell-fate regulation and decision execution are discussed...
  5. pmc Identifying cancer biomarkers by network-constrained support vector machines
    Li Chen
    Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA, USA
    BMC Syst Biol 5:161. 2011
    ..Nonetheless, the variables in multivariable classifiers should synergistically interact to produce more effective classifiers than individual biomarkers...
  6. pmc Reverse engineering module networks by PSO-RNN hybrid modeling
    Yuji Zhang
    Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA
    BMC Genomics 10:S15. 2009
    ....
  7. pmc AIB1 gene amplification and the instability of polyQ encoding sequence in breast cancer cell lines
    Lee Jun C Wong
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    BMC Cancer 6:111. 2006
    ..The purpose of this study is to investigate the sequence variation of poly Q encoding region in breast cancer cell lines at single molecule level, and to determine if the sequence variation is related to AIB1 gene amplification...
  8. pmc Motif-guided sparse decomposition of gene expression data for regulatory module identification
    Ting Gong
    Bradley Department of Electrical and Computer Engineering, Virginia Tech, Arlington, VA 22203, USA
    BMC Bioinformatics 12:82. 2011
    ..However, traditional gene clustering often yields unsatisfactory results for regulatory module identification because the resulting gene clusters are co-expressed but not necessarily co-regulated...
  9. pmc Motif-directed network component analysis for regulatory network inference
    Chen Wang
    Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA, USA
    BMC Bioinformatics 9:S21. 2008
    ..We propose a new approach, motif-directed NCA (mNCA), to integrate motif information and gene expression data to infer regulatory networks...
  10. pmc Knowledge-guided gene ranking by coordinative component analysis
    Chen Wang
    Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA, USA
    BMC Bioinformatics 11:162. 2010
    ..However, current integration strategies are often heuristic and fail to incorporate fully the true interplay between biological knowledge and gene expression data...
  11. pmc Network motif-based identification of transcription factor-target gene relationships by integrating multi-source biological data
    Yuji Zhang
    Lombardi Comprehensive Cancer Center, Georgetown University, 4000 Reservoir Rd, Washington, DC, USA
    BMC Bioinformatics 9:203. 2008
    ..The data include time course gene expression profiles, genome-wide location analysis data, binding sequence data, and gene ontology (GO) information...
  12. pmc Knowledge-guided multi-scale independent component analysis for biomarker identification
    Li Chen
    Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA, USA
    BMC Bioinformatics 9:416. 2008
    ..In this paper, we develop a novel strategy, namely knowledge-guided multi-scale independent component analysis (ICA), to first infer regulatory signals and then identify biologically relevant biomarkers from microarray data...
  13. pmc caBIG VISDA: modeling, visualization, and discovery for cluster analysis of genomic data
    Yitan Zhu
    Department of Electrical and Computer Engineering, Virginia Polytechnic and State University, Arlington, VA 22203, USA
    BMC Bioinformatics 9:383. 2008
    ....
  14. pmc Cannibalism, cell survival, and endocrine resistance in breast cancer
    Robert Clarke
    Department of Oncology, W405A Research Building, Georgetown University Medical Center, 3970 Reservoir Road NW, Washington, DC 20057, USA
    Breast Cancer Res 13:311. 2011
    ....
  15. ncbi Multidrug resistance/P-glycoprotein and breast cancer: review and meta-analysis
    Robert Clarke
    Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA
    Semin Oncol 32:S9-15. 2005
    ..Future studies should also take into account the potentially multifactorial nature of multidrug resistance...
  16. pmc Gene network signaling in hormone responsiveness modifies apoptosis and autophagy in breast cancer cells
    Robert Clarke
    Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, DC 20057, USA
    J Steroid Biochem Mol Biol 114:8-20. 2009
    ..Signaling proceeds through BCL2 gene family members and BECN1 ultimately to regulate cell fate...
  17. ncbi Antiestrogen resistance in breast cancer and the role of estrogen receptor signaling
    Robert Clarke
    Department of Oncology and Vincent T Lombardi Cancer Center, Georgetown University School of Medicine, 3970 Reservoir Road NW, Washington, DC 20057, USA
    Oncogene 22:7316-39. 2003
    ..The network also may involve signaling through ras and MAPK, implicating crosstalk with growth factors and cytokines. Ultimately, signaling affects the expression/function of the proliferation and/or apoptotic machineries...
  18. ncbi Association of interferon regulatory factor-1, nucleophosmin, nuclear factor-kappaB, and cyclic AMP response element binding with acquired resistance to Faslodex (ICI 182,780)
    Zhiping Gu
    Vincent T Lombardi Cancer Center and Department of Oncology, Georgetown University School of Medicine, Washington, DC 20007, USA
    Cancer Res 62:3428-37. 2002
    ..Thus, some breast cancer cells may survive antiestrogen treatment by bypassing specific growth inhibitory signals induced by antagonist-occupied estrogen receptors...
  19. ncbi Human X-box binding protein-1 confers both estrogen independence and antiestrogen resistance in breast cancer cell lines
    Bianca P Gomez
    Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, 3970 Reservoir Rd, NW, Washington, DC 20057, USA
    FASEB J 21:4013-27. 2007
    ..XBP1 and/or the UPR may be a useful molecular target for the development of novel predictive and therapeutic strategies in breast cancer...
  20. pmc BCL2 and CASP8 regulation by NF-kappaB differentially affect mitochondrial function and cell fate in antiestrogen-sensitive and -resistant breast cancer cells
    Ruchi Nehra
    Department of Oncology, Georgetown University School of Medicine, Washington, DC 20057, USA
    FASEB J 24:2040-55. 2010
    ....
  21. ncbi The nuclear factor kappa B inhibitor parthenolide restores ICI 182,780 (Faslodex; fulvestrant)-induced apoptosis in antiestrogen-resistant breast cancer cells
    Rebecca B Riggins
    Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Room W405A Research Building, 3970 Reservoir Road Northwest, Washington, DC 20057, USA
    Mol Cancer Ther 4:33-41. 2005
    ..Because parthenolide has shown safety in Phase I clinical trials, these findings have direct clinical relevance and provide support for the design of clinical studies combining antiestrogens and parthenolide in ER-positive breast cancer...
  22. ncbi interferon regulatory factor-1 mediates the proapoptotic but not cell cycle arrest effects of the steroidal antiestrogen ICI 182,780 (faslodex, fulvestrant)
    Kerrie B Bouker
    Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, District of Columbia 20007, USA
    Cancer Res 64:4030-9. 2004
    ..These data identify a novel mechanism of antiestrogen resistance and implicate IRF-1 as a key component in signaling some ER-mediated effects on apoptosis/cell survival...
  23. pmc IFNgamma restores breast cancer sensitivity to fulvestrant by regulating STAT1, IFN regulatory factor 1, NF-kappaB, BCL2 family members, and signaling to caspase-dependent apoptosis
    Yanxia Ning
    Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, DC 20057, USA
    Mol Cancer Ther 9:1274-85. 2010
    ..These observations support the exploration of clinical trials combining antiestrogens and compounds that can induce IRF1, such as IFNgamma, for the treatment of some ER-positive breast cancers...
  24. ncbi Expression patterns among interferon regulatory factor-1, human X-box binding protein-1, nuclear factor kappa B, nucleophosmin, estrogen receptor-alpha and progesterone receptor proteins in breast cancer tissue microarrays
    Yuelin Zhu
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA
    Int J Oncol 28:67-76. 2006
    ..018) is observed. An inverse correlation exists between IRF-1n and NFkappaB (p=0.034). All four proteins are detected in breast tumors and their expression patterns support their role(s) in a key signaling network...
  25. pmc ERRgamma mediates tamoxifen resistance in novel models of invasive lobular breast cancer
    Rebecca B Riggins
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, District of Columbia 20057, USA
    Cancer Res 68:8908-17. 2008
    ..These data support a role for ERRgamma/AP1 signaling in the development of TAM resistance and suggest that expression of ERRgamma may be a marker of poor TAM response...
  26. ncbi Block principal component analysis with application to gene microarray data classification
    Aiyi Liu
    Biostatistics Unit, Lombardi Cancer Center, Georgetown University Medical Center, 3800 Reservoir Road, NW, Washington, DC 20007, USA
    Stat Med 21:3465-74. 2002
    ..The method is illustrated with the well-known National Cancer Institute database of 60 human cancer cell lines data (NCI60) of gene microarray expressions, in the context of classification of cancer cell lines...
  27. pmc Classification algorithms for phenotype prediction in genomics and proteomics
    Habtom W Ressom
    Lombardi Comprehensive Cancer Center, 3970 Reservoir Rd NW, Washington, DC 20057, USA
    Front Biosci 13:691-708. 2008
    ..The selected features are presented to a classifier for phenotype prediction...
  28. ncbi Do estrogens always increase breast cancer risk?
    Leena Hilakivi-Clarke
    Lombardi Cancer Center and Department of Oncology, Georgetown University, Room W405, 3970 Reservoir Road NW, Washington, DC 20007, USA
    J Steroid Biochem Mol Biol 80:163-74. 2002
    ..We further propose that the timing of estrogenic exposures may play at least as important a role in affecting breast cancer risk as life-time exposure...
  29. ncbi Development and validation of a method for using breast core needle biopsies for gene expression microarray analyses
    Matthew Ellis
    Department of Oncology, Georgetown University School of Medicine, Washington, DC 20007, USA
    Clin Cancer Res 8:1155-66. 2002
    ..We wished to develop optimal tissue acquisition, processing, and analysis procedures for exploring the gene expression profiles of breast core needle biopsies representing cancer and noncancer tissues...
  30. ncbi Dietary modulation of pregnancy estrogen levels and breast cancer risk among female rat offspring
    Leena Hilakivi-Clarke
    Department of Oncology, Lombardi Cancer Center, Washington, DC 20007, USA
    Clin Cancer Res 8:3601-10. 2002
    ....
  31. ncbi Estrogen receptor alpha positive breast tumors and breast cancer cell lines share similarities in their transcriptome data structures
    Yuelin Zhu
    Lombardi Comprehensive Cancer Center and Departments of Oncology, Georgetown University School of Medicine, Washington, DC, USA
    Int J Oncol 29:1581-9. 2006
    ....
  32. ncbi Antiestrogens, aromatase inhibitors, and apoptosis in breast cancer
    Rebecca B Riggins
    Department of Oncology and Physiology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA
    Vitam Horm 71:201-37. 2005
    ..Finally, we discuss the evidence supporting a role for apoptotic defects in acquired and de novo antiestrogen resistance...
  33. ncbi Mechanisms mediating the effects of prepubertal (n-3) polyunsaturated fatty acid diet on breast cancer risk in rats
    Leena Hilakivi-Clarke
    Department of Oncology, Georgetown University Medical Center, Washington, DC 20057, USA
    J Nutr 135:2946S-2952S. 2005
    ....
  34. ncbi C-7 analogues of progesterone as potent inhibitors of the P-glycoprotein efflux pump
    Fabio Leonessa
    Department of Oncology and Lombardi Cancer Center, Georgetown University School of Medicine, 3970 Reservoir Road Northwest, Washington, DC 20007, USA
    J Med Chem 45:390-8. 2002
    ..These data identify C-7-substituted progesterone analogues and 5, in particular, as rationally designed antiPgp compounds worthy of further evaluation/development...
  35. ncbi Evaluation of gene expression profile of keratinocytes in response to JP-8 jet fuel
    Luis A Espinoza
    Department of Biochemistry and Molecular Biology, Georgetown University School of Medicine, Washington, DC 20057, USA
    Toxicol Appl Pharmacol 200:93-102. 2004
    ..Gene expression data from these studies can be used to build accurate predictive models that separate different molecular profiles. The data establish the use and effectiveness of these approaches for future prospective studies...
  36. ncbi Cadmium mimics the in vivo effects of estrogen in the uterus and mammary gland
    Michael D Johnson
    Department of Oncology, Lombardi Cancer Center, Georgetown University, Washington, DC 20007, USA
    Nat Med 9:1081-4. 2003
    ..In utero exposure to the metal also mimicked the effects of estrogens. Female offspring experienced an earlier onset of puberty and an increase in the epithelial area and the number of terminal end buds in the mammary gland...
  37. pmc The role of X-box binding protein-1 in tumorigenicity
    Ayesha N Shajahan
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, D C, USA
    Drug News Perspect 22:241-6. 2009
    ..Furthermore, combining inhibitors of XBP-1 with other anti-UPR drugs may enhance the activity of some antineoplastic therapies...
  38. pmc The properties of high-dimensional data spaces: implications for exploring gene and protein expression data
    Robert Clarke
    Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, 3970 Reservoir Road NW, Washington, DC 20057, USA
    Nat Rev Cancer 8:37-49. 2008
    ..From the perspective of translational science, this Review discusses the properties of high-dimensional data spaces that arise in genomic and proteomic studies and the challenges they can pose for data analysis and interpretation...
  39. ncbi Interferon regulatory factor-1 (IRF-1) exhibits tumor suppressor activities in breast cancer associated with caspase activation and induction of apoptosis
    Kerrie B Bouker
    Lombardi Comprehensive Cancer Center and Department of Oncology, Georgetown University School of Medicine, 3970 Reservoir Road NW, Washington, DC 20057, USA
    Carcinogenesis 26:1527-35. 2005
    ..03). These data establish a functional role for IRF-1 in the growth suppression of breast cancer cells and strongly implicate IRF-1 as a tumor suppressor gene in breast cancer that acts, independent of p53, to control apoptosis...
  40. ncbi Functionally active estrogen receptor isoform profiles in the breast tumors of African American women are different from the profiles in breast tumors of Caucasian women
    Indra Poola
    Department of Anatomy, Howard University School of Medicine, Washington, DC 20059, USA
    Cancer 94:615-23. 2002
    ..The molecular factors responsible for these tumor characteristics are mostly unknown...
  41. ncbi The proapoptotic molecule BLID interacts with Bcl-XL and its downregulation in breast cancer correlates with poor disease-free and overall survival
    Constantinos G Broustas
    Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, District of Columbia 20057, USA
    Clin Cancer Res 16:2939-48. 2010
    ..BLID is a BH3-like motif containing apoptotic member of the Bcl-2 family of proteins. This study was designed to investigate the mechanism of BLID-induced apoptosis and to assess the significance of BLID expression in breast cancer...
  42. pmc Orphan nuclear receptors in breast cancer pathogenesis and therapeutic response
    Rebecca B Riggins
    Lombardi Comprehensive Cancer Center and Department of Oncology Department of Physiology and Biophysics, Georgetown University School of Medicine, 3970 Reservoir Road NW, Washington, DC 20057, USA
    Endocr Relat Cancer 17:R213-31. 2010
    ..We also propose that a clearer understanding of the function of orphan nuclear receptors in mammary gland development and normal mammary tissues could significantly improve our ability to diagnose, treat, and prevent breast cancer...
  43. pmc Frequent loss of heterozygosity at the interferon regulatory factor-1 gene locus in breast cancer
    Luciane R Cavalli
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, DC 20057, USA
    Breast Cancer Res Treat 121:227-31. 2010
    ..00; P = 0.003; n = 273 cases) and risk of death (OR = 4.18; P = 0.004; n = 191 cases). Our findings strongly imply a tumor suppressor role for the IRF1 gene in breast cancer...
  44. ncbi Caveolin-1 tyrosine phosphorylation enhances paclitaxel-mediated cytotoxicity
    Ayesha N Shajahan
    Department of Oncology, Lombardi Comprehensive Cancer Center, and Departments of Physiology and Biophysics, Georgetown University, College of Medicine, Washington, D C 20057, USA
    J Biol Chem 282:5934-43. 2007
    ..Collectively, our findings underscore the importance of CAV1 phosphorylation in apoptosis and suggest that events that negate CAV1 tyrosine phosphorylation may contribute to anti-microtubule drug resistance...
  45. ncbi The A4396G polymorphism in interferon regulatory factor 1 is frequently expressed in breast cancer cell lines
    Kerrie B Bouker
    Lombardi Comprehensive Cancer Center and Department of Oncology, Georgetown University School of Medicine, Washington, DC 20057, USA
    Cancer Genet Cytogenet 175:61-4. 2007
    ..001), leading to a significant difference in genotype distribution between these populations (P = 0.002)...
  46. ncbi Iterative normalization of cDNA microarray data
    Yue Wang
    Department of Electrical Engineering and Computer Science, The Catholic University of America, Washington, DC 20064, USA
    IEEE Trans Inf Technol Biomed 6:29-37. 2002
    ..In this way, the two processes bootstrap one another. We evaluate the technique on real microarray data from breast cancer cell lines and complement the experiment with a data cluster visualization study...
  47. ncbi Inferring network interactions using recurrent neural networks and swarm intelligence
    Habtom W Ressom
    Dept of Biostat, Bioinf, and Biomath, Georgetown Univ, Washington, DC 20057, USA
    Conf Proc IEEE Eng Med Biol Soc 1:4241-4. 2006
    ..The results indicate that the algorithm has a promising potential to infer complex interactions such as gene regulatory networks from time-series gene expression data...

Research Grants17

  1. Endocrine resistance in breast cancer
    Robert Clarke; Fiscal Year: 2009
    ....
  2. Molecular Analysis of Human Breast Cancer
    Robert Clarke; Fiscal Year: 2007
    ..AIM 4: We will use tissue arrays (multiple cores from archival tissues arrayed on glass slides) to validate and optimize the performance of these classifiers in a retrospective prognostic study of human breast tumors. ..
  3. Molecular Analysis of Human Breast Cancer
    Robert Clarke; Fiscal Year: 2006
    ..AIM 4: We will use tissue arrays (multiple cores from archival tissues arrayed on glass slides) to validate and optimize the performance of these classifiers in a retrospective prognostic study of human breast tumors. ..
  4. Molecular Analysis of Human Breast Cancer
    Robert Clarke; Fiscal Year: 2005
    ..AIM 4: We will use tissue arrays (multiple cores from archival tissues arrayed on glass slides) to validate and optimize the performance of these classifiers in a retrospective prognostic study of human breast tumors. ..
  5. Molecular Analysis of Human Breast Cancer
    Robert Clarke; Fiscal Year: 2004
    ..AIM 4: We will use tissue arrays (multiple cores from archival tissues arrayed on glass slides) to validate and optimize the performance of these classifiers in a retrospective prognostic study of human breast tumors. ..
  6. Molecular Analysis of Human Breast Cancer
    Robert Clarke; Fiscal Year: 2003
    ..AIM 4: We will use tissue arrays (multiple cores from archival tissues arrayed on glass slides) to validate and optimize the performance of these classifiers in a retrospective prognostic study of human breast tumors. ..
  7. ESTROGEN INDUCED PROGRESSION IN BREAST CANCER
    Robert Clarke; Fiscal Year: 2001
    ....
  8. ESTROGEN INDUCED PROGRESSION IN BREAST CANCER
    Robert Clarke; Fiscal Year: 2000
    ....
  9. ESTROGEN-INDUCED PROGRESSION IN HUMAN BREAST CANCER
    Robert Clarke; Fiscal Year: 1993
    ....
  10. ESTROGEN-INDUCED PROGRESSION IN HUMAN BREAST CANCER
    Robert Clarke; Fiscal Year: 1992
    ....
  11. ESTROGEN INDUCED PROGRESSION IN BREAST CANCER
    Robert Clarke; Fiscal Year: 1999
    ....
  12. Endocrine resistance in breast cancer
    ROBERT R CLARKE; Fiscal Year: 2010
    ....