Ibolja Cernak

Summary

Affiliation: Georgetown University
Country: USA

Publications

  1. ncbi request reprint Activation of cyclo-oxygenase-2 contributes to motor and cognitive dysfunction following diffuse traumatic brain injury in rats
    I Cernak
    Department of Physiology and Pharmacology, James Cook University, Townsville, Queensland, Australia
    Clin Exp Pharmacol Physiol 28:922-5. 2001
  2. ncbi request reprint The pathobiology of moderate diffuse traumatic brain injury as identified using a new experimental model of injury in rats
    Ibolja Cernak
    Department of Neuroscience, Georgetown University, Washington, DC 20057 1464, USA
    Neurobiol Dis 17:29-43. 2004
  3. pmc Animal models of head trauma
    Ibolja Cernak
    Department of Neuroscience, Georgetown University Medical Center, Washington, D C 20057, USA
    NeuroRx 2:410-22. 2005
  4. ncbi request reprint The "dark side" of endocannabinoids: a neurotoxic role for anandamide
    Ibolja Cernak
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20057, USA
    J Cereb Blood Flow Metab 24:564-78. 2004
  5. ncbi request reprint Role of the cell cycle in the pathobiology of central nervous system trauma
    Ibolja Cernak
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20057, USA
    Cell Cycle 4:1286-93. 2005
  6. ncbi request reprint Neuroprotective and nootropic actions of a novel cyclized dipeptide after controlled cortical impact injury in mice
    Alan I Faden
    Department of Neuroscience, Georgetown University Medical Center, 3970 Reservoir Road NW, Room EP 12, Washington, DC 20057, USA
    J Cereb Blood Flow Metab 23:355-63. 2003
  7. ncbi request reprint Novel small peptides with neuroprotective and nootropic properties
    Alan I Faden
    Department of Neuroscience, Georgetown University Medical Center, Washington, D C 20057, USA
    J Alzheimers Dis 6:S93-7. 2004
  8. ncbi request reprint Neuroprotective effects of novel small peptides in vitro and after brain injury
    Alan I Faden
    Laboratory for the Study of CNS Injury, Department of Neuroscience, Georgetown University Medical Center, 3970 Reservoir Rd, NW, Research Bld, Room EP04, Washington, DC 20057, USA
    Neuropharmacology 49:410-24. 2005
  9. pmc Cell cycle inhibition provides neuroprotection and reduces glial proliferation and scar formation after traumatic brain injury
    Simone Di Giovanni
    Department of Neuroscience, Georgetown University School of Medicine, 3900 Reservoir Road NW, Washington, DC 20057, USA
    Proc Natl Acad Sci U S A 102:8333-8. 2005
  10. ncbi request reprint Novel diketopiperazine enhances motor and cognitive recovery after traumatic brain injury in rats and shows neuroprotection in vitro and in vivo
    Alan I Faden
    Department of Neuroscience, Georgetown University Medical Center, 3970 Reservoir Road NW, Room EP 12, Washington, DC 20057, USA
    J Cereb Blood Flow Metab 23:342-54. 2003

Detail Information

Publications24

  1. ncbi request reprint Activation of cyclo-oxygenase-2 contributes to motor and cognitive dysfunction following diffuse traumatic brain injury in rats
    I Cernak
    Department of Physiology and Pharmacology, James Cook University, Townsville, Queensland, Australia
    Clin Exp Pharmacol Physiol 28:922-5. 2001
    ..7. These results implicate the involvement of COX-2 in cognitive and motor dysfunction following diffuse traumatic brain injury...
  2. ncbi request reprint The pathobiology of moderate diffuse traumatic brain injury as identified using a new experimental model of injury in rats
    Ibolja Cernak
    Department of Neuroscience, Georgetown University, Washington, DC 20057 1464, USA
    Neurobiol Dis 17:29-43. 2004
    ..These results show that this model is capable of reproducing major biochemical and neurological changes of diffuse clinical TBI...
  3. pmc Animal models of head trauma
    Ibolja Cernak
    Department of Neuroscience, Georgetown University Medical Center, Washington, D C 20057, USA
    NeuroRx 2:410-22. 2005
    ..Thus, a search continues for new animal models, which would more closely mimic the highly heterogeneous nature of human TBI, and address key factors in treatment optimization...
  4. ncbi request reprint The "dark side" of endocannabinoids: a neurotoxic role for anandamide
    Ibolja Cernak
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20057, USA
    J Cereb Blood Flow Metab 24:564-78. 2004
    ..Thus, anandamide produces neurotoxic effects both in vitro and in vivo through multiple mechanisms independent of the CB1 receptor...
  5. ncbi request reprint Role of the cell cycle in the pathobiology of central nervous system trauma
    Ibolja Cernak
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20057, USA
    Cell Cycle 4:1286-93. 2005
    ....
  6. ncbi request reprint Neuroprotective and nootropic actions of a novel cyclized dipeptide after controlled cortical impact injury in mice
    Alan I Faden
    Department of Neuroscience, Georgetown University Medical Center, 3970 Reservoir Road NW, Room EP 12, Washington, DC 20057, USA
    J Cereb Blood Flow Metab 23:355-63. 2003
    ..In addition, they show that 35b has a relatively wide therapeutic window and improves cognitive function after both acute and chronic injury...
  7. ncbi request reprint Novel small peptides with neuroprotective and nootropic properties
    Alan I Faden
    Department of Neuroscience, Georgetown University Medical Center, Washington, D C 20057, USA
    J Alzheimers Dis 6:S93-7. 2004
    ..Thus, these novel dipeptides have multipotential actions that make them candidates for the treatment of both acute and chronic neurodegeneration...
  8. ncbi request reprint Neuroprotective effects of novel small peptides in vitro and after brain injury
    Alan I Faden
    Laboratory for the Study of CNS Injury, Department of Neuroscience, Georgetown University Medical Center, 3970 Reservoir Rd, NW, Research Bld, Room EP04, Washington, DC 20057, USA
    Neuropharmacology 49:410-24. 2005
    ....
  9. pmc Cell cycle inhibition provides neuroprotection and reduces glial proliferation and scar formation after traumatic brain injury
    Simone Di Giovanni
    Department of Neuroscience, Georgetown University School of Medicine, 3900 Reservoir Road NW, Washington, DC 20057, USA
    Proc Natl Acad Sci U S A 102:8333-8. 2005
    ..The ability of cell cycle inhibition to decrease both neuronal cell death and reactive gliosis after experimental TBI suggests that this treatment approach may be useful clinically...
  10. ncbi request reprint Novel diketopiperazine enhances motor and cognitive recovery after traumatic brain injury in rats and shows neuroprotection in vitro and in vivo
    Alan I Faden
    Department of Neuroscience, Georgetown University Medical Center, 3970 Reservoir Road NW, Room EP 12, Washington, DC 20057, USA
    J Cereb Blood Flow Metab 23:342-54. 2003
    ..Thus, 35b shows none of the typical physiologic actions associated with TRH, but possesses neuroprotective actions in vivo and in vitro, and appears to attenuate both necrotic and apoptotic cell death...
  11. doi request reprint Pathophysiological response to experimental diffuse brain trauma differs as a function of developmental age
    Ibolja Cernak
    Department of Neuroscience, Georgetown University Medical Center, Washington, D C, USA
    Dev Neurosci 32:442-53. 2010
    ..Phosphorus MR spectroscopy showed no significant changes in the brain energy metabolism of immature rats with moderate DTBI, in contrast to significant decreases previously identified in adult animals...
  12. ncbi request reprint Caspase inhibitor z-DEVD-fmk attenuates calpain and necrotic cell death in vitro and after traumatic brain injury
    Susan M Knoblach
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20057, USA
    J Cereb Blood Flow Metab 24:1119-32. 2004
    ..These data suggest that neuroprotection by z-DEVD-fmk may, in part, reflect inhibition of calpain-related necrotic cell death...
  13. ncbi request reprint Gene expression profile changes are commonly modulated across models and species after traumatic brain injury
    Joanne E Natale
    Research Centers for Genetic Medicine and Neuroscience, Children s National Medical Center, Washington, D C, USA
    J Neurotrauma 20:907-27. 2003
    ..Gene expression profiling across species and models may help identify candidate molecular pathways induced by brain injury, some of which may provide novel targets for therapeutic intervention...
  14. ncbi request reprint Inhibition of cyclooxygenase 2 by nimesulide improves cognitive outcome more than motor outcome following diffuse traumatic brain injury in rats
    Ibolja Cernak
    Department of Neuroscience, Georgetown University, Washington DC, USA
    Exp Brain Res 147:193-9. 2002
    ..We conclude that COX-2 is involved in the development of functional deficits following diffuse TBI, particularly cognitive deficits, and that these can be improved by administration of COX-2 inhibitors...
  15. ncbi request reprint Novel neuroprotective tripeptides and dipeptides
    Alan I Faden
    Department of Neuroscience, Georgetown University Medical Center, 3970 Reservoir Road NW, Research Building, Room EP04, Washington, District of Columbia 20057, USA
    Ann N Y Acad Sci 1053:472-81. 2005
    ..Here, we review these novel tripeptide and dipeptide compounds...
  16. pmc Modulation of ABCA1 by an LXR agonist reduces β-amyloid levels and improves outcome after traumatic brain injury
    David J Loane
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20007, USA
    J Neurotrauma 28:225-36. 2011
    ..T0901317 also limited motor coordination deficits in injured mice and reduced brain lesion volume. These data indicate that activation of LXR can reduce Aβ accumulation after TBI, and is accompanied by improved functional recovery...
  17. ncbi request reprint Human immunodeficiency virus type 1 protein gp120 causes neuronal cell death in the rat brain by activating caspases
    Elio Acquas
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20057, USA
    Neurotox Res 5:605-15. 2004
    ..Few non-neuronal cells exhibited signs of apoptosis. The results of the present study support the notion that gp120 is neurotoxic in vivo and provide evidence that gp120 activates a caspase-dependent apoptotic pathway...
  18. ncbi request reprint Temporal characterisation of pro- and anti-apoptotic mechanisms following diffuse traumatic brain injury in rats
    Ibolja Cernak
    Department of Neuroscience, Georgetown University, Washington, DC, USA
    J Clin Neurosci 9:565-72. 2002
    ..Pharmacological manipulation of this balance may offer a therapeutic approach for preventing cell death and improving outcome after diffuse traumatic brain injury...
  19. ncbi request reprint Effects of daily versus weekly testing and pre-training on the assessment of neurologic impairment following diffuse traumatic brain injury in rats
    Christine O'Connor
    Department of Pathology, University of Adelaide, Adelaide SA, Australia
    J Neurotrauma 20:985-93. 2003
    ..These studies demonstrate that the functional assessment paradigm needs to be considered when quantifying functional deficits following diffuse TBI in rats...
  20. ncbi request reprint Interaction between anesthesia, gender, and functional outcome task following diffuse traumatic brain injury in rats
    Christine A O'Connor
    Department of Pathology, University of Adelaide, Adelaide SA, Australia
    J Neurotrauma 20:533-41. 2003
    ..Isoflurane is particularly protective in females, pentobarbital is deleterious to female outcome, while halothane anesthesia has the least influence on gender-related outcome...
  21. ncbi request reprint Effects of progesterone on neurologic and morphologic outcome following diffuse traumatic brain injury in rats
    Christine A O'Connor
    Discipline of Pathology, University of Adelaide, Adelaide, South Australia 5005, Australia
    Exp Neurol 205:145-53. 2007
    ..We conclude that physiological concentrations of progesterone administered after diffuse TBI confers beneficial effects on morphologic and functional outcome in both ovariectomized female and male animals...
  22. ncbi request reprint Recent advances in neuroprotection for treating traumatic brain injury
    Ibolja Cernak
    Johns Hopkins University Applied Physics Laboratory, Biomedicine Business Area, 11100 Johns Hopkins Road, Laurel, MD 20723 6099, USA
    Expert Opin Investig Drugs 15:1371-81. 2006
    ..In addition, new neurobiological findings and their consequence for novel neuroprotective approaches are discussed...
  23. ncbi request reprint Both estrogen and progesterone attenuate edema formation following diffuse traumatic brain injury in rats
    Christine A O'Connor
    Department of Pathology, University of Adelaide, Adelaide, Australia
    Brain Res 1062:171-4. 2005
    ..We conclude that both hormones may contribute to reduce edema in females after brain injury...
  24. ncbi request reprint A substance P antagonist increases brain intracellular free magnesium concentration after diffuse traumatic brain injury in rats
    Robert Vink
    Department of Pathology, University of Adelaide, Adelaide, SA, Australia
    J Am Coll Nutr 23:538S-540S. 2004
    ..We therefore examined whether a substance P antagonist restores brain intracellular free magnesium concentration following TBI...