John L Casey

Summary

Affiliation: Georgetown University
Country: USA

Publications

  1. ncbi request reprint RNA editing in hepatitis delta virus
    J L Casey
    Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC, USA
    Curr Top Microbiol Immunol 307:67-89. 2006
  2. pmc RNA editing in hepatitis delta virus genotype III requires a branched double-hairpin RNA structure
    John L Casey
    Division of Molecular Virology and Immunology, Georgetown University Medical Center, Rockville, Maryland 20850, USA
    J Virol 76:7385-97. 2002
  3. pmc Control of ADAR1 editing of hepatitis delta virus RNAs
    John L Casey
    Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC, USA
    Curr Top Microbiol Immunol 353:123-43. 2012
  4. ncbi request reprint The woodchuck model of HDV infection
    J L Casey
    Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC 20007, USA
    Curr Top Microbiol Immunol 307:211-25. 2006
  5. pmc Genetic changes in hepatitis delta virus from acutely and chronically infected woodchucks
    John L Casey
    Department of Microbiology and Immunology, Georgetown University Medical Center, 3900 Reservoir Road NW, Washington, DC 20007, USA
    J Virol 80:6469-77. 2006
  6. pmc Clevudine inhibits hepatitis delta virus viremia: a pilot study of chronically infected woodchucks
    John Casey
    Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC 20057, USA
    Antimicrob Agents Chemother 49:4396-9. 2005
  7. pmc The fraction of RNA that folds into the correct branched secondary structure determines hepatitis delta virus type 3 RNA editing levels
    Sarah D Linnstaedt
    Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC 20007, USA
    RNA 15:1177-87. 2009
  8. pmc Inhibition of hepatitis delta virus RNA editing by short inhibitory RNA-mediated knockdown of ADAR1 but not ADAR2 expression
    Geetha C Jayan
    Division of Molecular Virology and Immunology, Georgetown University Medical Center, Rockville, Maryland 20850, USA
    J Virol 76:12399-404. 2002
  9. pmc Differential inhibition of RNA editing in hepatitis delta virus genotype III by the short and long forms of hepatitis delta antigen
    Qiufang Cheng
    Department of Microbiology and Immunology, Georgetown University Medical Center, 3900 Reservoir Road NW, Washington, D C 20007 2197, USA
    J Virol 77:7786-95. 2003
  10. pmc Effects of conserved RNA secondary structures on hepatitis delta virus genotype I RNA editing, replication, and virus production
    Geetha C Jayan
    Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC 20007, USA
    J Virol 79:11187-93. 2005

Research Grants

  1. HEPATITIS DELTA VIRUS RNA EDITING
    John Casey; Fiscal Year: 2002
  2. HEPATITIS DELTA VIRUS RNA EDITING
    John Casey; Fiscal Year: 2007

Collaborators

Detail Information

Publications18

  1. ncbi request reprint RNA editing in hepatitis delta virus
    J L Casey
    Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC, USA
    Curr Top Microbiol Immunol 307:67-89. 2006
    ..This review covers the mechanisms of RNA editing in the HDV replication cycle and the regulatory mechanisms by which HDV controls editing...
  2. pmc RNA editing in hepatitis delta virus genotype III requires a branched double-hairpin RNA structure
    John L Casey
    Division of Molecular Virology and Immunology, Georgetown University Medical Center, Rockville, Maryland 20850, USA
    J Virol 76:7385-97. 2002
    ..The different mechanisms of editing in genotypes I and III underscore their functional differences and may be related to pathogenic differences as well...
  3. pmc Control of ADAR1 editing of hepatitis delta virus RNAs
    John L Casey
    Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC, USA
    Curr Top Microbiol Immunol 353:123-43. 2012
    ..This review will cover the mechanisms of editing at the amber/W site and the means by which the virus controls it in these two genotypes...
  4. ncbi request reprint The woodchuck model of HDV infection
    J L Casey
    Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC 20007, USA
    Curr Top Microbiol Immunol 307:211-25. 2006
    ....
  5. pmc Genetic changes in hepatitis delta virus from acutely and chronically infected woodchucks
    John L Casey
    Department of Microbiology and Immunology, Georgetown University Medical Center, 3900 Reservoir Road NW, Washington, DC 20007, USA
    J Virol 80:6469-77. 2006
    ..Chronic HDV infection in woodchucks may result from a delayed and weak immune response that is limited to a small number of epitopes on HDAg...
  6. pmc Clevudine inhibits hepatitis delta virus viremia: a pilot study of chronically infected woodchucks
    John Casey
    Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC 20057, USA
    Antimicrob Agents Chemother 49:4396-9. 2005
    ....
  7. pmc The fraction of RNA that folds into the correct branched secondary structure determines hepatitis delta virus type 3 RNA editing levels
    Sarah D Linnstaedt
    Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC 20007, USA
    RNA 15:1177-87. 2009
    ....
  8. pmc Inhibition of hepatitis delta virus RNA editing by short inhibitory RNA-mediated knockdown of ADAR1 but not ADAR2 expression
    Geetha C Jayan
    Division of Molecular Virology and Immunology, Georgetown University Medical Center, Rockville, Maryland 20850, USA
    J Virol 76:12399-404. 2002
    ..We conclude that ADAR1 is primarily responsible for editing HDV RNA at the amber/W site during HDV infection...
  9. pmc Differential inhibition of RNA editing in hepatitis delta virus genotype III by the short and long forms of hepatitis delta antigen
    Qiufang Cheng
    Department of Microbiology and Immunology, Georgetown University Medical Center, 3900 Reservoir Road NW, Washington, D C 20007 2197, USA
    J Virol 77:7786-95. 2003
    ..These results are consistent with regulation of amber/W editing in HDV genotype III by a negative-feedback mechanism due to differential interactions between structural elements in the HDV genotype III RNA and the two forms of HDAg...
  10. pmc Effects of conserved RNA secondary structures on hepatitis delta virus genotype I RNA editing, replication, and virus production
    Geetha C Jayan
    Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC 20007, USA
    J Virol 79:11187-93. 2005
    ..Therefore, it appears that the conserved RNA secondary structure around the HDV genotype I amber/W site has been selected not for the highest editing efficiency but for optimal viral replication and secretion...
  11. pmc Increased RNA editing and inhibition of hepatitis delta virus replication by high-level expression of ADAR1 and ADAR2
    Geetha C Jayan
    Division of Molecular Virology and Immunology, Georgetown University Medical Center, Rockville, Maryland 20850, USA
    J Virol 76:3819-27. 2002
    ..Our results indicate that HDV requires highly regulated and selective editing and that the level of ADAR expression can play an important role: overexpression of ADARs inhibits HDV RNA replication and compromises virus viability...
  12. pmc The role of a metastable RNA secondary structure in hepatitis delta virus genotype III RNA editing
    Sarah D Linnstaedt
    Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC 20057, USA
    RNA 12:1521-33. 2006
    ....
  13. pmc RNA editing of the human herpesvirus 8 kaposin transcript eliminates its transforming activity and is induced during lytic replication
    Sharon Z Gandy
    Department of Microbiology and Immunology, Georgetown University Medical Center, 3900 Reservoir Rd, NW, Washington, DC 20007, USA
    J Virol 81:13544-51. 2007
    ....
  14. pmc Hepatitis delta antigen requires a minimum length of the hepatitis delta virus unbranched rod RNA structure for binding
    Dawn A Defenbaugh
    Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC 20007, USA
    J Virol 83:4548-56. 2009
    ..The results are consistent with a model in which HDAg binds HDV unbranched rod RNA as multimers of fixed size rather than as individual subunits...
  15. pmc Multimerization of hepatitis delta antigen is a critical determinant of RNA binding specificity
    Brian C Lin
    Department of Microbiology and Immunology, Georgetown University Medical Center, 3900 Reservoir Rd, NW, Washington, DC 20007, USA
    J Virol 84:1406-13. 2010
    ..The results confirm the previous proposal that HDAg binds as a large multimer and demonstrate that the multimer is a critical determinant of the structure of the HDV RNP...
  16. pmc RNA editing and its control in hepatitis delta virus replication
    Renxiang Chen
    Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC 20007, USA E Mails R C S D L
    Viruses 2:131-46. 2010
    ..The virus' use of host RNA editing activity to produce two functionally distinct forms of HDAg is a particularly good example of this reliance. This review covers the mechanisms and control of RNA editing in the HDV replication cycle...
  17. pmc In vivo antiviral efficacy of prenylation inhibitors against hepatitis delta virus
    Bruno B Bordier
    Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Palo Alto, California 94305, USA
    J Clin Invest 112:407-14. 2003
    ..These results provide the first preclinical data supporting the in vivo efficacy of prenylation inhibition as a novel antiviral therapy with potential application to HDV and a wide variety of other viruses...
  18. pmc A prenylation inhibitor prevents production of infectious hepatitis delta virus particles
    Bruno B Bordier
    Division of Gastroenterology and Hepatology, Stanford University School of Medicine, 269 Campus Drive, Palo Alto, CA 94305 5187, USA
    J Virol 76:10465-72. 2002
    ..Farnesyltransferase inhibitors thus represent an attractive potential class of novel antiviral agents for use against HDV, including the genotypes associated with most severe disease...

Research Grants9

  1. HEPATITIS DELTA VIRUS RNA EDITING
    John Casey; Fiscal Year: 2002
    ..These aims will be addressed by a combination of approaches, including site- directed mutagenesis, analysis in vitro of editing and RNA-protein interactions, and evaluation of editing and its consequences in transfected cells. ..
  2. HEPATITIS DELTA VIRUS RNA EDITING
    John Casey; Fiscal Year: 2007
    ....