Research Topics
Genomes and Genes | John L CaseySummaryAffiliation: Georgetown University Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
RNA editing in hepatitis delta virusJ L Casey
Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC, USA
Curr Top Microbiol Immunol 307:67-89. 2006..This review covers the mechanisms of RNA editing in the HDV replication cycle and the regulatory mechanisms by which HDV controls editing...
RNA editing in hepatitis delta virus genotype III requires a branched double-hairpin RNA structureJohn L Casey
Division of Molecular Virology and Immunology, Georgetown University Medical Center, Rockville, Maryland 20850, USA
J Virol 76:7385-97. 2002..The different mechanisms of editing in genotypes I and III underscore their functional differences and may be related to pathogenic differences as well...- Control of ADAR1 editing of hepatitis delta virus RNAsJohn L Casey
Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC, USA
Curr Top Microbiol Immunol 353:123-43. 2012..This review will cover the mechanisms of editing at the amber/W site and the means by which the virus controls it in these two genotypes... - The woodchuck model of HDV infectionJ L Casey
Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC 20007, USA
Curr Top Microbiol Immunol 307:211-25. 2006.... - Genetic changes in hepatitis delta virus from acutely and chronically infected woodchucksJohn L Casey
Department of Microbiology and Immunology, Georgetown University Medical Center, 3900 Reservoir Road NW, Washington, DC 20007, USA
J Virol 80:6469-77. 2006..Chronic HDV infection in woodchucks may result from a delayed and weak immune response that is limited to a small number of epitopes on HDAg... - Clevudine inhibits hepatitis delta virus viremia: a pilot study of chronically infected woodchucksJohn Casey
Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC 20057, USA
Antimicrob Agents Chemother 49:4396-9. 2005.... - The fraction of RNA that folds into the correct branched secondary structure determines hepatitis delta virus type 3 RNA editing levelsSarah D Linnstaedt
Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC 20007, USA
RNA 15:1177-87. 2009.... - Inhibition of hepatitis delta virus RNA editing by short inhibitory RNA-mediated knockdown of ADAR1 but not ADAR2 expressionGeetha C Jayan
Division of Molecular Virology and Immunology, Georgetown University Medical Center, Rockville, Maryland 20850, USA
J Virol 76:12399-404. 2002..We conclude that ADAR1 is primarily responsible for editing HDV RNA at the amber/W site during HDV infection... - Differential inhibition of RNA editing in hepatitis delta virus genotype III by the short and long forms of hepatitis delta antigenQiufang Cheng
Department of Microbiology and Immunology, Georgetown University Medical Center, 3900 Reservoir Road NW, Washington, D.C. 20007-2197, USA
J Virol 77:7786-95. 2003..These results are consistent with regulation of amber/W editing in HDV genotype III by a negative-feedback mechanism due to differential interactions between structural elements in the HDV genotype III RNA and the two forms of HDAg... - Effects of conserved RNA secondary structures on hepatitis delta virus genotype I RNA editing, replication, and virus productionGeetha C Jayan
Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC 20007, USA
J Virol 79:11187-93. 2005..Therefore, it appears that the conserved RNA secondary structure around the HDV genotype I amber/W site has been selected not for the highest editing efficiency but for optimal viral replication and secretion... - Increased RNA editing and inhibition of hepatitis delta virus replication by high-level expression of ADAR1 and ADAR2Geetha C Jayan
Division of Molecular Virology and Immunology, Georgetown University Medical Center, Rockville, Maryland 20850, USA
J Virol 76:3819-27. 2002..Our results indicate that HDV requires highly regulated and selective editing and that the level of ADAR expression can play an important role: overexpression of ADARs inhibits HDV RNA replication and compromises virus viability... - The role of a metastable RNA secondary structure in hepatitis delta virus genotype III RNA editingSarah D Linnstaedt
Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC 20057, USA
RNA 12:1521-33. 2006.... - RNA editing of the human herpesvirus 8 kaposin transcript eliminates its transforming activity and is induced during lytic replicationSharon Z Gandy
Department of Microbiology and Immunology, Georgetown University Medical Center, 3900 Reservoir Rd, NW, Washington, DC 20007, USA
J Virol 81:13544-51. 2007.... - Hepatitis delta antigen requires a minimum length of the hepatitis delta virus unbranched rod RNA structure for bindingDawn A Defenbaugh
Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC 20007, USA
J Virol 83:4548-56. 2009..The results are consistent with a model in which HDAg binds HDV unbranched rod RNA as multimers of fixed size rather than as individual subunits... - Multimerization of hepatitis delta antigen is a critical determinant of RNA binding specificityBrian C Lin
Department of Microbiology and Immunology, Georgetown University Medical Center, 3900 Reservoir Rd, NW, Washington, DC 20007, USA
J Virol 84:1406-13. 2010..The results confirm the previous proposal that HDAg binds as a large multimer and demonstrate that the multimer is a critical determinant of the structure of the HDV RNP... - RNA editing and its control in hepatitis delta virus replicationRenxiang Chen
Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC 20007, USA E Mails R C S D L
Viruses 2:131-46. 2010..The virus' use of host RNA editing activity to produce two functionally distinct forms of HDAg is a particularly good example of this reliance. This review covers the mechanisms and control of RNA editing in the HDV replication cycle... - In vivo antiviral efficacy of prenylation inhibitors against hepatitis delta virusBruno B Bordier
Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Palo Alto, California 94305, USA
J Clin Invest 112:407-14. 2003..These results provide the first preclinical data supporting the in vivo efficacy of prenylation inhibition as a novel antiviral therapy with potential application to HDV and a wide variety of other viruses... - A prenylation inhibitor prevents production of infectious hepatitis delta virus particlesBruno B Bordier
Division of Gastroenterology and Hepatology, Stanford University School of Medicine, 269 Campus Drive, Palo Alto, CA 94305-5187, USA
J Virol 76:10465-72. 2002..Farnesyltransferase inhibitors thus represent an attractive potential class of novel antiviral agents for use against HDV, including the genotypes associated with most severe disease...
Research Grants
- HEPATITIS DELTA VIRUS RNA EDITINGJohn Casey; Fiscal Year: 2002..These aims will be addressed by a combination of approaches, including site- directed mutagenesis, analysis in vitro of editing and RNA-protein interactions, and evaluation of editing and its consequences in transfected cells. ..
- HEPATITIS DELTA VIRUS RNA EDITINGJohn Casey; Fiscal Year: 2007....