Kimberly R Byrnes

Summary

Affiliation: Georgetown University
Country: USA

Publications

  1. ncbi request reprint Photobiomodulation improves cutaneous wound healing in an animal model of type II diabetes
    Kimberly R Byrnes
    Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Photomed Laser Surg 22:281-90. 2004
  2. pmc Metabotropic glutamate receptor 5 activation inhibits microglial associated inflammation and neurotoxicity
    Kimberly R Byrnes
    Department of Neuroscience, Georgetown University Medical Center, 3970 Reservoir Road N W, Washington, DC 20057, USA
    Glia 57:550-60. 2009
  3. ncbi request reprint Light promotes regeneration and functional recovery and alters the immune response after spinal cord injury
    Kimberly R Byrnes
    Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Lasers Surg Med 36:171-85. 2005
  4. ncbi request reprint Low power laser irradiation alters gene expression of olfactory ensheathing cells in vitro
    Kimberly R Byrnes
    Department of Neuroscience, Georgetown University, 3970 Reservoir Road NW, Washington, DC 20057, USA
    Lasers Surg Med 37:161-71. 2005
  5. pmc Activation of metabotropic glutamate receptor 5 improves recovery after spinal cord injury in rodents
    Kimberly R Byrnes
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC, USA
    Ann Neurol 66:63-74. 2009
  6. ncbi request reprint Expression of two temporally distinct microglia-related gene clusters after spinal cord injury
    Kimberly R Byrnes
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20057, USA
    Glia 53:420-33. 2006
  7. ncbi request reprint Role of cell cycle proteins in CNS injury
    Kimberly R Byrnes
    Department of Neuroscience, Georgetown University Medical Center, Room EP16A, New Research Building, 3970 Reservoir Rd, NW, Washington, DC 20057, USA
    Neurochem Res 32:1799-807. 2007
  8. ncbi request reprint Cell cycle activation contributes to post-mitotic cell death and secondary damage after spinal cord injury
    Kimberly R Byrnes
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20057, USA
    Brain 130:2977-92. 2007
  9. pmc Metabotropic glutamate receptors as targets for multipotential treatment of neurological disorders
    Kimberly R Byrnes
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20057, USA
    Neurotherapeutics 6:94-107. 2009
  10. pmc Activation of metabotropic glutamate receptor 5 modulates microglial reactivity and neurotoxicity by inhibiting NADPH oxidase
    David J Loane
    Department of Neuroscience, Georgetown University Medical Center, Washington, D C 20057, USA
    J Biol Chem 284:15629-39. 2009

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Photobiomodulation improves cutaneous wound healing in an animal model of type II diabetes
    Kimberly R Byrnes
    Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Photomed Laser Surg 22:281-90. 2004
    ..We investigated the effects of photobiomodulation (PBM) on cutaneous wound healing in an animal model of type II diabetes, Psammomys obesus (Sand Rats)...
  2. pmc Metabotropic glutamate receptor 5 activation inhibits microglial associated inflammation and neurotoxicity
    Kimberly R Byrnes
    Department of Neuroscience, Georgetown University Medical Center, 3970 Reservoir Road N W, Washington, DC 20057, USA
    Glia 57:550-60. 2009
    ..These data indicate that microglial mGluR5 may represent a novel target for modulating neuroinflammation, an important component of both acute and chronic neurodegenerative disorders...
  3. ncbi request reprint Light promotes regeneration and functional recovery and alters the immune response after spinal cord injury
    Kimberly R Byrnes
    Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Lasers Surg Med 36:171-85. 2005
    ..Photobiomodulation (PBM) has been proposed as a potential therapy for spinal cord injury (SCI). We aimed to demonstrate that 810 nm light can penetrate deep into the body and promote neuronal regeneration and functional recovery...
  4. ncbi request reprint Low power laser irradiation alters gene expression of olfactory ensheathing cells in vitro
    Kimberly R Byrnes
    Department of Neuroscience, Georgetown University, 3970 Reservoir Road NW, Washington, DC 20057, USA
    Lasers Surg Med 37:161-71. 2005
    ..However, neither the combination of these two therapies nor the effect of light on OECs has been reported. The purpose of this study was to determine the effect of light on OEC activity in vitro...
  5. pmc Activation of metabotropic glutamate receptor 5 improves recovery after spinal cord injury in rodents
    Kimberly R Byrnes
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC, USA
    Ann Neurol 66:63-74. 2009
    ..Previously, mGluR5 has been identified on microglia in vitro, but the effects of mGluR5 activation on inflammation in vivo or on recovery after spinal cord injury is unknown...
  6. ncbi request reprint Expression of two temporally distinct microglia-related gene clusters after spinal cord injury
    Kimberly R Byrnes
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20057, USA
    Glia 53:420-33. 2006
    ....
  7. ncbi request reprint Role of cell cycle proteins in CNS injury
    Kimberly R Byrnes
    Department of Neuroscience, Georgetown University Medical Center, Room EP16A, New Research Building, 3970 Reservoir Rd, NW, Washington, DC 20057, USA
    Neurochem Res 32:1799-807. 2007
    ..Here we critically review the role of cell cycle pathways in the pathophysiology of experimental stroke, traumatic brain injury and spinal cord injury, and discuss the potential of cell cycle inhibitors as neuroprotective agents...
  8. ncbi request reprint Cell cycle activation contributes to post-mitotic cell death and secondary damage after spinal cord injury
    Kimberly R Byrnes
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20057, USA
    Brain 130:2977-92. 2007
    ..Thus, flavopiridol treatment improves outcome after SCI by inhibiting cell cycle pathways, resulting in beneficial multifactorial actions on neurons and glia...
  9. pmc Metabotropic glutamate receptors as targets for multipotential treatment of neurological disorders
    Kimberly R Byrnes
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20057, USA
    Neurotherapeutics 6:94-107. 2009
    ..This review examines the multipotential therapeutic utility of mGluR modulation in acute and chronic injury and neurodegeneration...
  10. pmc Activation of metabotropic glutamate receptor 5 modulates microglial reactivity and neurotoxicity by inhibiting NADPH oxidase
    David J Loane
    Department of Neuroscience, Georgetown University Medical Center, Washington, D C 20057, USA
    J Biol Chem 284:15629-39. 2009
    ..These data suggest that mGluR5 represents a novel target for modulating microglial-dependent neuroinflammation, and may have therapeutic relevance for neurological disorders that exhibit microglial-mediated neurodegeneration...
  11. pmc Delayed mGluR5 activation limits neuroinflammation and neurodegeneration after traumatic brain injury
    Kimberly R Byrnes
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC, USA
    J Neuroinflammation 9:43. 2012
    ..Here we examined whether delayed CHPG administration reduces chronic neuroinflammation and associated neurodegeneration after experimental traumatic brain injury in mice...
  12. ncbi request reprint Role of the cell cycle in the pathobiology of central nervous system trauma
    Ibolja Cernak
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20057, USA
    Cell Cycle 4:1286-93. 2005
    ....
  13. pmc Delayed inflammatory mRNA and protein expression after spinal cord injury
    Kimberly R Byrnes
    Department of Neuroscience, Georgetown University Medical Center, NW, Washington, DC 20057, USA
    J Neuroinflammation 8:130. 2011
    ..Here we extend the microarray analysis of these gene clusters up to 6 months post-SCI...
  14. doi request reprint Cell cycle activation and CNS injury
    Bogdan A Stoica
    Department of Neuroscience, Georgetown University School of Medicine, Research Building, Room WG18, 3970 Reservoir Rd, NW, Washington, DC 20057, USA
    Neurotox Res 16:221-37. 2009
    ....
  15. pmc A combined scoring method to assess behavioral recovery after mouse spinal cord injury
    Ahdeah Pajoohesh-Ganji
    Georgetown University, Washington, DC, United States
    Neurosci Res 67:117-25. 2010
    ..These data provide support for use of a combined scoring method to follow motor recovery in mice after contusion SCI...
  16. pmc Characterization of inflammatory gene expression and galectin-3 function after spinal cord injury in mice
    Ahdeah Pajoohesh-Ganji
    Department of Anatomy and Regenerative Biology, The George Washington University Medical Center, 2300 I Street, NW, Washington, DC 20037, USA
    Brain Res 1475:96-105. 2012
    ....
  17. pmc Roscovitine reduces neuronal loss, glial activation, and neurologic deficits after brain trauma
    Genell D Hilton
    Department of Neuroscience, Georgetown University Medical Center, Washington, District of Columbia 20057, USA
    J Cereb Blood Flow Metab 28:1845-59. 2008
    ....
  18. pmc Novel neuroinflammatory targets in the chronically injured spinal cord
    Ahdeah Pajoohesh-Ganji
    Department of Anatomy and Regenerative Biology, The George Washington University, Washington, District of Columbia 20037, USA
    Neurotherapeutics 8:195-205. 2011
    ....
  19. doi request reprint 808 nm wavelength light induces a dose-dependent alteration in microglial polarization and resultant microglial induced neurite growth
    Ramona E von Leden
    Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Jones Bridge Road, Bethesda, Maryland 20814, USA
    Lasers Surg Med 45:253-63. 2013
    ....
  20. ncbi request reprint Quantitation of calcitonin gene-related peptide mRNA and neuronal cell death in facial motor nuclei following axotomy and 633 nm low power laser treatment
    Sara K Snyder
    Laboratory for Receptor Biology and Gene Expression, National Cancer Institute, Bethesda, Maryland 20892, USA
    Lasers Surg Med 31:216-22. 2002
    ..A persistent increase in calcitonin gene-related peptide (CGRP) immunoreactivity in motoneurons may serve as an indicator for regeneration after peripheral nerve injury [Borke et al., J Neurocytol 1993;22:141-153]...
  21. pmc Selective CDK inhibitor limits neuroinflammation and progressive neurodegeneration after brain trauma
    Shruti V Kabadi
    Department of Anesthesiology, Center for Shock, Trauma and Anesthesiology Research, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Cereb Blood Flow Metab 32:137-49. 2012
    ..These findings suggest that CCA contributes to progressive neurodegeneration and related neurologic dysfunction after TBI, likely in part related to its induction of microglial activation...
  22. pmc Neuropathological differences between rats and mice after spinal cord injury
    Kimberly R Byrnes
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC, USA
    J Magn Reson Imaging 32:836-46. 2010
    ..Rats and mice are commonly used to model SCI; however, histology and immunohistochemistry have shown differences in neuropathology between the two species, including cavity formation and scar/inflammatory responses...
  23. pmc Cellular and temporal expression of NADPH oxidase (NOX) isotypes after brain injury
    Sean J Cooney
    Department of Anatomy, Physiology and Genetics, Uniformed Services University, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    J Neuroinflammation 10:155. 2013
    ..However, the cellular and temporal expression profile of these isotypes in the injured and non-injured brain is currently unclear...