I Brook

Summary

Affiliation: Georgetown University
Country: USA

Publications

  1. ncbi request reprint Microbiology and antimicrobial management of sinusitis
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    J Laryngol Otol 119:251-8. 2005
  2. doi request reprint A physician's experience as a cancer of the neck patient
    Itzhak Brook
    Georgetown University School of Medicine, NW, Washington, DC 20016, USA
    Surg Oncol 19:188-92. 2010
  3. ncbi request reprint Clindamycin and quinolone therapy for Bacillus anthracis Sterne infection in 60Co-gamma-photon-irradiated and sham-irradiated mice
    I Brook
    Scientific Research Department, Armed Forces Radiobiology Research Institute, 8901 Wisconsin Avenue, Bethesda, MD 20889 5603, USA
    J Antimicrob Chemother 56:1074-80. 2005
  4. ncbi request reprint Overcoming penicillin failures in the treatment of Group A streptococcal pharyngo-tonsillitis
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington DC, USA
    Int J Pediatr Otorhinolaryngol 71:1501-8. 2007
  5. doi request reprint Current concepts in the management of Clostridium tetani infection
    Itzhak Brook
    Georgetown University School of Medicine, 4431 Albemarle Street NW, Washington, DC 20016, USA
    Expert Rev Anti Infect Ther 6:327-36. 2008
  6. ncbi request reprint Microbiology of infected hemangiomas in children
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, 4431 Albemarle Street NW, Washington, DC 20016, USA
    Pediatr Dermatol 21:113-6. 2004
  7. ncbi request reprint Microbiology and management of intra-abdominal infections in children
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington DC, United States of America
    Pediatr Int 45:123-9. 2003
  8. ncbi request reprint Cephalosporins in overcoming beta-lactamase-producing bacteria and preservation of the interfering bacteria in the treatment of otitis, sinusitis and tonsillitis
    Itzhak Brook
    Georgetown University School of Medicine, Department of Pediatrics, 4431 Albemarle Street NW, Washington, DC 20016, USA
    Expert Rev Anti Infect Ther 5:939-50. 2007
  9. ncbi request reprint Acute and chronic bacterial sinusitis
    Itzhak Brook
    Department of Pediatrics and Medicine, Georgetown University School of Medicine, 4431 Albemarle St NW, Washington, DC 20016, USA
    Infect Dis Clin North Am 21:427-48, vii. 2007
  10. ncbi request reprint Microbiology and management of soft tissue and muscle infections
    Itzhak Brook
    Georgetown University, Schools of Medicine, 4431 Albemarle St NW, Washington, DC 20016, USA
    Int J Surg 6:328-38. 2008

Detail Information

Publications157 found, 100 shown here

  1. ncbi request reprint Microbiology and antimicrobial management of sinusitis
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    J Laryngol Otol 119:251-8. 2005
    ..The antimicrobials that are the most effective in management of chronic sinusitis are amoxycillinclavulanate, clindamycin and the combination of metronidazole and a penicillin...
  2. doi request reprint A physician's experience as a cancer of the neck patient
    Itzhak Brook
    Georgetown University School of Medicine, NW, Washington, DC 20016, USA
    Surg Oncol 19:188-92. 2010
    ..During this difficult and challenging time, a proficient, competent, compassionate and caring approach that understands what the patient is experiencing should be practiced...
  3. ncbi request reprint Clindamycin and quinolone therapy for Bacillus anthracis Sterne infection in 60Co-gamma-photon-irradiated and sham-irradiated mice
    I Brook
    Scientific Research Department, Armed Forces Radiobiology Research Institute, 8901 Wisconsin Avenue, Bethesda, MD 20889 5603, USA
    J Antimicrob Chemother 56:1074-80. 2005
    ..anthracis Sterne spores. Clindamycin has in vitro activity against B. anthracis and inhibits the production of toxin from other species, although no direct evidence exists that production of B. anthracis toxin is inhibited...
  4. ncbi request reprint Overcoming penicillin failures in the treatment of Group A streptococcal pharyngo-tonsillitis
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington DC, USA
    Int J Pediatr Otorhinolaryngol 71:1501-8. 2007
    ..The use of antimicrobials that can overcome and modulate these phenomena and achieve better cure of the infection is described...
  5. doi request reprint Current concepts in the management of Clostridium tetani infection
    Itzhak Brook
    Georgetown University School of Medicine, 4431 Albemarle Street NW, Washington, DC 20016, USA
    Expert Rev Anti Infect Ther 6:327-36. 2008
    ..The disease can be prevented by immunization with tetanal toxoid and appropriate wound care...
  6. ncbi request reprint Microbiology of infected hemangiomas in children
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, 4431 Albemarle Street NW, Washington, DC 20016, USA
    Pediatr Dermatol 21:113-6. 2004
    ..The polymicrobial etiology of secondarily infected hemangiomas and the association of bacterial flora with the anatomic site of the lesions is thereby demonstrated...
  7. ncbi request reprint Microbiology and management of intra-abdominal infections in children
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington DC, United States of America
    Pediatr Int 45:123-9. 2003
    ..and Clostridium spp. The treatment of abdominal infection includes surgical correction and drainage, and administration of antimicrobials that are effective against both aerobic and anaerobic micro-organisms...
  8. ncbi request reprint Cephalosporins in overcoming beta-lactamase-producing bacteria and preservation of the interfering bacteria in the treatment of otitis, sinusitis and tonsillitis
    Itzhak Brook
    Georgetown University School of Medicine, Department of Pediatrics, 4431 Albemarle Street NW, Washington, DC 20016, USA
    Expert Rev Anti Infect Ther 5:939-50. 2007
    ..The use of some of the cephalosporins that are able to overcome the effect of BLPB and preserve the beneficial interfering bacteria can overcome and modulate these phenomena and achieve better cure of URTIs...
  9. ncbi request reprint Acute and chronic bacterial sinusitis
    Itzhak Brook
    Department of Pediatrics and Medicine, Georgetown University School of Medicine, 4431 Albemarle St NW, Washington, DC 20016, USA
    Infect Dis Clin North Am 21:427-48, vii. 2007
    ..This article discusses the microbiology and pathogenesis of acute and chronic bacterial sinusitis. The role anaerobic bacterial in chronic and recurrent sinusitis is emphasized, and appropriate antimicrobial regimens are discussed...
  10. ncbi request reprint Microbiology and management of soft tissue and muscle infections
    Itzhak Brook
    Georgetown University, Schools of Medicine, 4431 Albemarle St NW, Washington, DC 20016, USA
    Int J Surg 6:328-38. 2008
    ..The infections can progress rapidly and early recognition and proper medical and surgical management is the cornerstone of therapy...
  11. ncbi request reprint Microbiology and antimicrobial treatment of orbital and intracranial complications of sinusitis in children and their management
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, 4431 Albemarle Street NW, Washington, DC 20016, USA
    Int J Pediatr Otorhinolaryngol 73:1183-6. 2009
    ..Early recognition and appropriate surgical and medical therapy are essential to ensure recovery...
  12. ncbi request reprint Treatment of anaerobic infection
    Itzhak Brook
    Georgetown University School of Medicine, Department of Pediatrics, 4431 Albemarle St NW, Washington, DC 20016, USA
    Expert Rev Anti Infect Ther 5:991-1006. 2007
    ....
  13. ncbi request reprint Bacteriology of acute and chronic frontal sinusitis
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Arch Otolaryngol Head Neck Surg 128:583-5. 2002
    ..The predominant anaerobes included Prevotella species (8), Peptostreptococcus species (6), and Fusobacterium species (4). These findings illustrate the microbiologic features of acute and chronic frontal sinusitis...
  14. doi request reprint Increase in the frequency of recovery of meticillin-resistant Staphylococcus aureus in acute and chronic maxillary sinusitis
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    J Med Microbiol 57:1015-7. 2008
    ..05). These data illustrate that a significant increase occurred in the rate of recovery of MRSA in patients with acute and chronic maxillary sinusitis over the periods studied...
  15. ncbi request reprint Microbial dynamics of purulent nasopharyngitis in children
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, 4431 Albemarle Street NW, Washington, DC 20016, USA
    Int J Pediatr Otorhinolaryngol 67:1047-53. 2003
    ..Controversy exists regarding the management of NPT as no conclusive evidence exists to date that the administration of antimicrobials will shorten the illness...
  16. ncbi request reprint Microbiology and management of infected neck cysts
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    J Oral Maxillofac Surg 63:392-5. 2005
    ..To review and describe the microbiology, diagnosis, and management of infected neck cysts...
  17. ncbi request reprint The increased risk of community-acquired methicillin-resistant Staphylococcus aureus in neck infections in young children
    Itzhak Brook
    4431 Albemarle St NW, Washington, DC, 20016, USA
    Curr Infect Dis Rep 14:119-20. 2012
    ..Clindamycin resistance was detected in 8% (4/49) of all community-acquired MRSA isolates. The study illustrates significant differences in age and location of neck space infections as they relate to isolation of S. aureus...
  18. ncbi request reprint Microbiology and principles of antimicrobial therapy for head and neck infections
    Itzhak Brook
    Department of Pediatrics and Medicine, Georgetown University School of Medicine, 4431 Albemarle St NW, Washington, DC 20016, USA
    Infect Dis Clin North Am 21:355-91, vi. 2007
    ..This article summarizes the aerobic and anaerobic microbiology of selected acute and chronic infections of the head and neck and the approaches to antimicrobial therapy...
  19. ncbi request reprint Microbiology and management of infectious gangrene in children
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC 20016, USA
    J Pediatr Orthop 24:587-92. 2004
  20. doi request reprint The impact of smoking on oral and nasopharyngeal bacterial flora
    I Brook
    Department of Pediatrics and Medicine, Georgetown University School of Medicine, Washington, DC 20016, USA
    J Dent Res 90:704-10. 2011
    ..Analysis of the data presented illustrates the adverse effects of direct and indirect exposure to smoking on colonization with potential pathogens...
  21. ncbi request reprint Recovery of interfering and beta-lactamase-producing bacteria from group A beta-haemolytic streptococci carriers and non-carriers
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington DC, USA
    J Med Microbiol 55:1741-4. 2006
    ..A higher rate of recovery of BLPB was observed only in GABHS carriers who were treated with penicillin for GABHS PT...
  22. ncbi request reprint Pseudomembranous colitis in children
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, 4431 Albemarle Street NW, Washington, DC 20016, USA
    J Gastroenterol Hepatol 20:182-6. 2005
    ..Discontinuation of antibiotics and supportive therapy usually lead to resolution of this disorder. Administration of oral vancomycin or other therapeutic regimens may be needed...
  23. ncbi request reprint The role of anaerobic bacteria in tonsillitis
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, 4431 Albemarlr St NW, Washington, DC 20016, USA
    Int J Pediatr Otorhinolaryngol 69:9-19. 2005
    ..Although more studies are needed, these findings support the possible pathogenicity of Gram-negative anaerobic bacilli in tonsillitis...
  24. ncbi request reprint Anaerobic pulmonary infections in children
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Pediatr Emerg Care 20:636-40. 2004
    ..and Bacteroides fragilis group. Management of these infections includes the administration of antimicrobials effective against the anaerobic as well as the aerobic pathogens...
  25. ncbi request reprint Role of anaerobic bacteria in infections following tracheostomy, intubation, or the use of ventilatory tubes in children
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Ann Otol Rhinol Laryngol 113:830-4. 2004
    ..Appropriate management of mixed pulmonary aerobic and anaerobic infections requires the administration of antimicrobials that are effective against both the aerobic and anaerobic components of the infection...
  26. ncbi request reprint Microbiology and management of infected solid tumours
    I Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Eur J Cancer Care (Engl) 16:12-6. 2007
    ..This review describes the microbiology and management of infection in necrotic tumours...
  27. ncbi request reprint Beta-lactamase-producing bacteria in mixed infections
    I Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington DC 20016, USA
    Clin Microbiol Infect 10:777-84. 2004
    ..The in-vitro and in-vivo clinical evidence supporting the role of BLPB in the increasing failure of penicillin to resolve such infections, and the implications of this phenomenon for the management of infections, are discussed...
  28. ncbi request reprint Immune response to Fusobacterium nucleatum and Prevotella intermedia in the sputum of patients with acute exacerbation of chronic bronchitis
    Itzhak Brook
    Naval Medical Center, Bethesda, MD, USA
    Chest 124:832-3. 2003
    ..To assess the role of anaerobic bacteria in acute exacerbation of chronic bronchitis (AECB)...
  29. doi request reprint Current management of upper respiratory tract and head and neck infections
    Itzhak Brook
    Departments of Pediatrics and Medicine, Georgetown University School of Medicine, Washington, DC 20016, USA
    Eur Arch Otorhinolaryngol 266:315-23. 2009
    ..In conclusion, the proper management of these infections requires an accurate clinical and bacteriological diagnosis...
  30. ncbi request reprint Infective endocarditis caused by anaerobic bacteria
    Itzhak Brook
    Department of Pediatrics and Medicine, Georgetown University School of Medicine, Washington, DC, USA
    Arch Cardiovasc Dis 101:665-76. 2008
    ..The mortality rate for patients with anaerobic IE ranges from 21 to 43%. Treatment of anaerobic IE includes the use of antimicrobial effective against these organisms. Surgical intervention may be indicated in some patients...
  31. ncbi request reprint A physician's personal experience as a cancer of the neck patient
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Otolaryngol Head Neck Surg 143:324-6. 2010
    ..The editorial highlights some of the book's features that relate to the important role of head and neck surgeons in the care of patients with cancer...
  32. ncbi request reprint β-Lactamase-Producing Bacteria in Upper Respiratory Tract Infections
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, 4431 Albemarle Street NW, Washington, DC, 20016, USA
    Curr Infect Dis Rep 12:110-7. 2010
    ....
  33. ncbi request reprint Frequency of recovery of pathogens from the nasopharynx of children with acute maxillary sinusitis before and after the introduction of vaccination with the 7-valent pneumococcal vaccine
    Itzhak Brook
    Department of Pediatrics, Georgetown University, School of Medicine, Washington, DC, USA
    Int J Pediatr Otorhinolaryngol 71:575-9. 2007
    ....
  34. ncbi request reprint Effects of amoxicillin and cefdinir on nasopharyngeal bacterial flora
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Arch Otolaryngol Head Neck Surg 131:785-7. 2005
    ..To compare the effects of cefdinir (14 mg/kg per day) and amoxicillin (90 mg/kg per day) antimicrobial therapy on the nasopharyngeal flora of children with acute otitis media...
  35. doi request reprint Ventilation of neck breathers undergoing a diagnostic procedure or surgery
    Itzhak Brook
    Department of Pediatrics and Medicine, Georgetown University School of Medicine, Washington, DC 20016, USA
    Anesth Analg 114:1318-22. 2012
    ..Methods to improve the care are discussed. Educating medical personnel about these issues can improve the care of neck breathers...
  36. ncbi request reprint Microbiology and management of endodontic infections in children
    Itzhak Brook
    Georgetown University School of Medicine, Washington DC, USA
    J Clin Pediatr Dent 28:13-7. 2003
    ..These agents include amoxicillin-clavulanate, clindamycin or the combination of metronidazole plus amoxicillin or a macrolide...
  37. ncbi request reprint Chronic sinusitis in children and adults: role of bacteria and antimicrobial management
    Itzhak Brook
    Georgetown University School of Medicine, 4431 Albemarle Street NW, Washington, DC 20016, USA
    Curr Allergy Asthma Rep 5:482-90. 2005
    ..The choice of antimicrobial agent in chronic sinusitis should provide coverage for the usual pathogens in acute sinusitis as well as beta-lactamase-producing aerobic and anaerobic organisms...
  38. doi request reprint Eating again: a physician's personal experience after laryngectomy
    Itzhak Brook
    Department of Pediatrics and Medicine, Georgetown University School of Medicine, Washington, DC, USA
    Nutr Cancer 64:635-6. 2012
    ..These include the effects of radiation treatment and surgery, which create functional and anatomical changes that make swallowing difficult...
  39. ncbi request reprint Antimicrobial resistance in the nasopharyngeal flora of children with acute maxillary sinusitis and maxillary sinusitis recurring after amoxicillin therapy
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, 4431 Albemarle St NW, Washington, DC 20016, USA
    J Antimicrob Chemother 53:399-402. 2004
    ..To investigate the antimicrobial susceptibility of the organisms isolated from the nasopharynx of children who present with acute maxillary sinusitis (AMS) or maxillary sinusitis that recurred (RMS) after amoxicillin therapy...
  40. ncbi request reprint Urinary tract and genito-urinary suppurative infections due to anaerobic bacteria
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington DC 20016, USA
    Int J Urol 11:133-41. 2004
    ..Percutaneous drainage, open surgical drainage or nephectomy might be indicated for abscesses...
  41. doi request reprint Recovery of aerobic and anaerobic bacteria in sinus fungal ball
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Otolaryngol Head Neck Surg 145:851-2. 2011
    ..This study demonstrates the recovery of polymicrobial aerobic-anaerobic flora in the sinuses of patients with fungus ball...
  42. ncbi request reprint Microbiology and antimicrobial management of sinusitis
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, 4431 Albemarle Street NW, Washington, DC 20016, USA
    Otolaryngol Clin North Am 37:253-66, v-vi. 2004
    ..This article summarizes the current information regarding the microbiology of all forms of sinusitis and approaches to antimicrobial therapy...
  43. pmc Microbiology and management of myositis
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, 4431 Albemarle St NW, Washington, DC 20016, USA
    Int Orthop 28:257-60. 2004
    ..Intensive surgical and medical therapy that includes the administration of intravenous fluids and antimicrobial therapy is an essential element in management of muscle infection...
  44. ncbi request reprint Microbiology of intracranial abscesses and their associated sinusitis
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Arch Otolaryngol Head Neck Surg 131:1017-9. 2005
    ..To evaluate the organisms recovered from infected sinuses and associated intracranial abscesses (IAs)...
  45. ncbi request reprint Effect of amoxicillin or clindamycin on the adenoids bacterial flora
    Itzhak Brook
    Department of Pediatrics, Georgetown University, USA
    Otolaryngol Head Neck Surg 129:5-10. 2003
    ..They were divided into 3 groups of 15 each to receive either no therapy (control) or 10 days of therapy with Am or C. Core adenoid tissues was quantitatively cultured for aerobic and anaerobic bacteria...
  46. pmc Bacteriology of acute and chronic ethmoid sinusitis
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, 4431 Albemarle St NW, Washington, DC 20016, USA
    J Clin Microbiol 43:3479-80. 2005
    ..Twenty-seven aerobes and 41 anaerobes were found in isolates from patients with chronic sinusitis. The predominant isolates were anaerobic gram-negative bacilli and Peptostreptococcus spp...
  47. doi request reprint Effects of exposure to smoking on the microbial flora of children and their parents
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, 4431 Albemarle St NW, Washington, DC 20016, United States
    Int J Pediatr Otorhinolaryngol 74:447-50. 2010
    ..These studies illustrate the adverse effects of direct and indirect exposure to smoking on colonization with potential pathogens...
  48. ncbi request reprint Microbiology and management of abdominal infections
    Itzhak Brook
    Schools of Medicine, Georgetown University, 4431 Albemarle St NW, Washington, DC 20016, USA
    Dig Dis Sci 53:2585-91. 2008
    ..and Clostridium spp. The treatment of abdominal infection includes surgical correction and drainage of pus and administration of antimicrobials effective against both the aerobic and anaerobic pathogens...
  49. doi request reprint Failure to eradicate streptococci and beta-lactamase producing bacteria
    Itzhak Brook
    Department of Pediatrics, Georgetown University, Schools of Medicine, Washington, DC, USA
    Acta Paediatr 97:193-5. 2008
    ....
  50. doi request reprint The role of anaerobic bacteria in chronic suppurative otitis media in children: implications for medical therapy
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, 4431 Albemarle St NW, Washington, DC 20016, USA
    Anaerobe 14:297-300. 2008
    ..The medical therapy of CSOM should be directed at the eradication of the pathogenic aerobic and anaerobic organisms...
  51. doi request reprint Microbiology of sinusitis
    Itzhak Brook
    Georgetown University School of Medicine, Washington DC, USA
    Proc Am Thorac Soc 8:90-100. 2011
    ..The microbiology of sinusitis is influenced by the previous antimicrobial therapy, vaccinations, and the presence of normal flora capable of interfering with the growth of pathogens...
  52. ncbi request reprint Suppurative parotitis caused by anaerobic bacteria in newborns
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Pediatr Infect Dis J 21:81-2. 2002
    ..Peptostreptococcus intermedius and Prevotella melaninogenica were isolated from one child and Prevotella intermedia from the other patient. Complete recovery occurred after 4 weeks of antimicrobial therapy...
  53. ncbi request reprint Discrepancies in the recovery of bacteria from multiple sinuses in acute and chronic sinusitis
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, 4431 Albemarle St NW, Washington, DC 20016, USA
    J Med Microbiol 53:879-85. 2004
    ..These findings illustrate that there are differences in the distribution of organisms in single patients who suffer from infections in multiple sinuses and emphasize the importance of obtaining cultures from all infected sinuses...
  54. ncbi request reprint Anaerobic infections in children
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Microbes Infect 4:1271-80. 2002
    ..Because anaerobes are generally recovered mixed with aerobic organisms, the choice of antimicrobial agents should provide coverage of both types of pathogens...
  55. doi request reprint The bacteriology of salivary gland infections
    Itzhak Brook
    Georgetown University School of Medicine, 4431 Albemarle Street NW, Washington, DC 20016, USA
    Oral Maxillofac Surg Clin North Am 21:269-74. 2009
    ..Mycobacterium tuberculosis and atypical mycobacteria are rare causes of infection. The choice of antibiotics should be guided by identification of the etiologic agent...
  56. ncbi request reprint Increased antimicrobial resistance in organisms recovered from otitis media with effusion
    Itzhak Brook
    Department of Paediatrics of Georgetown and George Washington University, School of Medicine, Washington DC, USA
    J Laryngol Otol 117:449-53. 2003
    ..The data illustrate the relationship between resistance to the antimicrobials given to children and their recovery from the middle ear of patients with OME...
  57. ncbi request reprint The effects of antimicrobials and exposure to smoking on bacterial interference in the upper respiratory tract of children
    Itzhak Brook
    Department of Pediatrics, Georgetown University, Washington, DC, USA Electronic address
    Int J Pediatr Otorhinolaryngol 78:179-85. 2014
    ....
  58. pmc Antianaerobic antimicrobials: spectrum and susceptibility testing
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine Washington, DC, USA
    Clin Microbiol Rev 26:526-46. 2013
    ..The spectrum of efficacy, antimicrobial resistance mechanisms, and resistance patterns against these agents are described...
  59. doi request reprint Fusobacterial infections in children
    Itzhak Brook
    Departments of Pediatrics and Medicine, Georgetown University School of Medicine, 4431 Albemarle St NW, Washington, DC, 20016, USA
    Curr Infect Dis Rep 15:288-94. 2013
    ..This review describes the clinical spectrum of fusobacterial infection in children and their management...
  60. doi request reprint Penicillin failure in the treatment of streptococcal pharyngo-tonsillitis
    Itzhak Brook
    Department of Pediatrics and Medicine, Georgetown University School of Medicine, 4431 Albemarle St NW, Washington, DC, 20016, USA
    Curr Infect Dis Rep 15:232-5. 2013
    ..In treatment of recurrent and chronic PT, the administration of clindamycin or amoxicillin-clavulanatecan eradicates both aerobic and anaerobic BLPB, as well as GABHS...
  61. doi request reprint Acute sinusitis in children
    Itzhak Brook
    Department of Pediatrics and Medicine, Georgetown University School of Medicine, Washington, DC 20016, USA
    Pediatr Clin North Am 60:409-24. 2013
    ..Isolation of the causative agents should be considered in those who failed the initial treatment. In addition to antibiotics, adjuvant therapies and surgery may be used in the management of acute bacterial rhinosinusitis...
  62. ncbi request reprint Anaerobic bacteria in upper respiratory tract and head and neck infections: microbiology and treatment
    Itzhak Brook
    Departments of Pediatrics and Medicine, Georgetown University School of Medicine, Washington, DC 20016, USA
    Anaerobe 18:214-20. 2012
    ..The recovery from these infections depends on prompt and proper medical and when indicated also surgical management...
  63. doi request reprint Antimicrobial treatment of anaerobic infections
    Itzhak Brook
    Georgetown University School of Medicine, Department of Pediatrics, 4431 Albemarle St NW, Washington DC 20016, USA
    Expert Opin Pharmacother 12:1691-707. 2011
    ..Anaerobic infections can occur at all body sites, including the central nervous system, oral cavity, head and neck, chest, abdomen, pelvis, skin and soft tissues...
  64. ncbi request reprint Frequency of recovery of pathogens causing acute maxillary sinusitis in adults before and after introduction of vaccination of children with the 7-valent pneumococcal vaccine
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine and Alachua General and North Florida Regional Hospitals, Gainesville, Florida, USA
    J Med Microbiol 55:943-6. 2006
    ..These data illustrate that a significant shift occurred in the causative pathogens of acute maxillary sinusitis in adults in the 5 years after the introduction of vaccination of children with the PCV7 compared to the previous 4 years...
  65. doi request reprint Pericarditis caused by anaerobic bacteria
    Itzhak Brook
    Department of Pediatrics and Medicine, Georgetown University School of Medicine, Washington, DC 20016, USA
    Int J Antimicrob Agents 33:297-300. 2009
    ..Identification of pathogens and determination of their antimicrobial susceptibility and beta-lactamase production are essential for adequate selection of antibiotic therapy effective against these organisms...
  66. ncbi request reprint Management of human and animal bite wound infection: an overview
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, 4431 Albemarle Street NW, Washington DC 20016, USA
    Curr Infect Dis Rep 11:389-95. 2009
    ..Wound management includes administering local care and using proper antimicrobial therapy when needed...
  67. ncbi request reprint The role of anaerobic bacteria in bacteremia
    Itzhak Brook
    Georgetown University School of Medicine, 4431 Albemarle St NW, Washington, DC 20016, USA
    Anaerobe 16:183-9. 2010
    ..Early recognition and appropriate treatment of these infections are of great clinical importance...
  68. doi request reprint Rate of eradication of group A beta-hemolytic streptococci in children with pharyngo-tonsillitis by amoxicillin and cefdinir
    Itzhak Brook
    Department of Pediatrics, Georgetown University, Schools of Medicine, Washington, DC 20016, USA
    Int J Pediatr Otorhinolaryngol 73:757-9. 2009
    ..This study investigated the effect of amoxicillin and cefdinir therapies on the rate of eradication of GABHS from the tonsils of children with acute pharyngo-tonsillitis (PT)...
  69. ncbi request reprint Isolation of methicillin resistant Staphylococcus aureus from the surface and core of tonsils in children
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Int J Pediatr Otorhinolaryngol 70:2099-102. 2006
    ..This study investigated the rate of recovery of MRSA as well as other aerobic organisms from tonsils that were removed because of recurrent GABHS infection...
  70. ncbi request reprint The role of bacterial interference in otitis, sinusitis and tonsillitis
    Itzhak Brook
    Department of Pediatrics, Georgetown University, USA
    Otolaryngol Head Neck Surg 133:139-46. 2005
    ....
  71. ncbi request reprint Increased recovery of Moraxella catarrhalis and Haemophilus influenzae in association with group A beta-haemolytic streptococci in healthy children and those with pharyngo-tonsillitis
    Itzhak Brook
    Department of Pediatrics, Georgetown University, School of Medicine, Washington, DC, USA
    J Med Microbiol 55:989-92. 2006
    ..This study demonstrates an association between the recovery of GABHS and H. influenzae and M. catarrhalis from pharyngo-tonsillar cultures of patients with APT and M. catarrhalis from pharyngo-tonsillar cultures of healthy children...
  72. ncbi request reprint In vitro effects of penicillin and telithromycin on the expression of Streptococcus pneumoniae capsule
    Itzhak Brook
    Department of Pediatrics and Medicine, Georgetown University and George Washington University, Schools of Medicine, Washington, DC, USA
    J Antimicrob Chemother 58:678-9. 2006
    ..To evaluate the effects of subinhibitory concentrations of penicillin and telithromycin on capsular formation by Streptococcus pneumoniae...
  73. ncbi request reprint The role of anaerobic bacteria in mediastinitis
    Itzhak Brook
    Georgetown University School of Medicine, Washington, DC 20016, USA
    Drugs 66:315-20. 2006
    ..Selection of antibacterials for the treatment of mediastinitis is determined by bacteriological studies...
  74. ncbi request reprint The role of bacteria in chronic rhinosinusitis
    Itzhak Brook
    Department of Pediatrics and Medicine, Georgetown University School of Medicine, 4431 Albemarle Street Northwest, Washington, DC 20016, USA
    Otolaryngol Clin North Am 38:1171-92. 2005
    ..The bacterial pathogens in acute sinusitis are S. pneumoniae, H. influenzae, and M. catarrhalis, while anaerobic bacteria and S. aureus predominant in CRS...
  75. ncbi request reprint Effect of telithromycin and azithromycin on nasopharyngeal bacterial flora in patients with acute maxillary sinusitis
    Itzhak Brook
    Department of Pediatrics and Medicine, Georgetown University School of Medicine, Washington, DC, USA
    Arch Otolaryngol Head Neck Surg 132:442-5. 2006
    ..The growing resistance of Streptococcus pneumoniae to penicillin and macrolides brought about the development of a new class of antibiotics-the ketolides-that are effective against resistant pneumococci...
  76. ncbi request reprint Infected neonatal cephalohematomas caused by anaerobic bacteria
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    J Perinat Med 33:255-8. 2005
    ..To present the microbiological and clinical features of six children with infected cephalohematomas (IC) caused by anaerobic bacteria...
  77. ncbi request reprint Bacteriology of chronic maxillary sinusitis associated with nasal polyposis
    Itzhak Brook
    Department of Pediatrics, Otolaryngology and Infectious Diseases, Navy Hospital, Bethesda, MD, USA
    J Med Microbiol 54:595-7. 2005
    ..being predominant. These findings illustrate for the first time the presence of polymicrobial aerobic-anaerobic flora in patients with chronic maxillary sinusitis who had nasal polyposis...
  78. ncbi request reprint Use of oral cephalosporins in the treatment of acute otitis media in children
    Itzhak Brook
    Department of Pediatrics, School of Medicine, Georgetown University, 4431 Albemarle St NW, Washington, DC 20016, USA
    Int J Antimicrob Agents 24:18-23. 2004
    ....
  79. ncbi request reprint Ocular infections due to anaerobic bacteria
    I Brook
    Georgetown University School of Medicine, Washington, DC, USA
    Int Ophthalmol 24:269-77. 2001
    ..Propionibacterium spp., Prevotella spp., and Fusobacterium spp. This review describes the microbiology, diagnosis and management of ocular infections due to anaerobic bacteria in children...
  80. ncbi request reprint Endocarditis due to anaerobic bacteria
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Cardiology 98:1-5. 2002
    ..The mortality rate for patients with anaerobes endocarditis is 21-43%. Treatment of endocarditis involving anaerobic bacteria includes the use of antibiotic therapy effective against these organisms...
  81. ncbi request reprint Prevotella intermedia meningitis associated with cerebrospinal fluid leakage in an adolescent
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Pediatr Infect Dis J 22:751-3. 2003
  82. ncbi request reprint Intra-abdominal, retroperitoneal, and visceral abscesses in children
    I Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC 20016, USA
    Eur J Pediatr Surg 14:265-73. 2004
    ..Fusobacterium spp., and Clostridium spp. The treatment of intraabdominal abscesses includes drainage, surgical correction of pathology, and administration of antimicrobials effective against both aerobic and anaerobic microorganisms...
  83. pmc Clinical review: bacteremia caused by anaerobic bacteria in children
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Crit Care 6:205-11. 2002
    ..The early recognition of anaerobic bacteremia and administration of appropriate antimicrobial and surgical therapy play a significant role in preventing mortality and morbidity in pediatric patients...
  84. ncbi request reprint Tetanus in children
    Itzhak Brook
    Georgetown University School of Medicine, Department of Pediatrics, Washington, DC, USA
    Pediatr Emerg Care 20:48-51. 2004
  85. ncbi request reprint Anaerobic bacteria in upper respiratory tract and other head and neck infections
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Ann Otol Rhinol Laryngol 111:430-40. 2002
    ..Because anaerobic bacteria generally are recovered mixed with aerobic organisms, the choice of appropriate antimicrobial agents should provide for adequate coverage of both types of pathogens...
  86. ncbi request reprint Effect of amoxicillin and co-amoxiclav on the aerobic and anaerobic nasopharyngeal flora
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    J Antimicrob Chemother 49:689-92. 2002
    ..005). This study illustrates the greater ability of AMC, compared with AMX, to reduce the number of potential nasopharyngeal pathogens and penicillin-resistant bacteria in children with AOM...
  87. ncbi request reprint Acute and chronic frontal sinusitis
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Curr Opin Pulm Med 9:171-4. 2003
    ..Surgery is indicated to treat patients with acute and chronic sinusitis and their complications. Several surgical procedures were recently evaluated, and these are briefly reviewed...
  88. ncbi request reprint Effects of antimicrobial therapy on the microbial flora of the adenoids
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, 4431 Albemarle St NW, Washington, DC 20016, USA
    J Antimicrob Chemother 51:1331-7. 2003
    ....
  89. ncbi request reprint Microbiology of polymicrobial abscesses and implications for therapy
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, 4431 Albemarle Street NW, Washington, DC 20016, USA
    J Antimicrob Chemother 50:805-10. 2002
    ..Appropriate management of these mixed aerobic and anaerobic infections may also require the administration of antimicrobials that are effective against both the aerobic and anaerobic components of the infections...
  90. ncbi request reprint Microbiology and management of deep facial infections and Lemierre syndrome
    Itzhak Brook
    Georgetown University School of Medicine, Washington, D C, USA
    ORL J Otorhinolaryngol Relat Spec 65:117-20. 2003
    ..Management includes surgical drainage and antimicrobial therapy...
  91. ncbi request reprint Antimicrobial resistance in the nasopharyngeal flora of children with acute otitis media and otitis media recurring after amoxicillin therapy
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, 4431 Albemarle St NW, Washington DC 20016, USA
    J Med Microbiol 54:83-5. 2005
    ..025). These data illustrate the higher recovery rate of antimicrobial-resistant Streptococcus pneumoniae and H. influenzae from the nasopharynx of children who had otitis media that recurred after amoxicillin therapy than those with AOM...
  92. ncbi request reprint Current issues in the management of acute bacterial sinusitis in children
    Itzhak Brook
    Department of Pediatrics, Georgetown University, Schools of Medicine, 4431 Albemarle St NW, Washington, DC 20016, USA
    Int J Pediatr Otorhinolaryngol 71:1653-61. 2007
    ..To review and summarize recent challenges in the microbiology and treatment of acute bacterial sinusitis (ABS), one of the most common infectious diseases in the pediatric community...
  93. ncbi request reprint Secondary bacterial infections complicating skin lesions
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    J Med Microbiol 51:808-12. 2002
    ..These organisms probably reached these sites from the oral cavity, where they are part of the normal flora. This review highlights the polymicrobial aerobic-anaerobic microbiology of secondarily infected skin lesions...
  94. ncbi request reprint The role of anaerobic bacteria in cutaneous and soft tissue abscesses and infected cysts
    Itzhak Brook
    Schools of Medicine, Georgetown University, 4431 Albemarle Street NW, Washington, DC 20016, USA
    Anaerobe 13:171-7. 2007
    ..The infections can progress rapidly and early recognition and proper medical and surgical management is the cornerstone of therapy...
  95. ncbi request reprint Microbiology and management of polymicrobial female genital tract infections in adolescents
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    J Pediatr Adolesc Gynecol 15:217-26. 2002
    ..Treatment regimens must provide antimicrobial coverage for N gonorrhoeae, C trachomatis, anaerobes, streptococci, and gram-negative facultative bacteria...
  96. ncbi request reprint The prophylaxis and treatment of anthrax
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Int J Antimicrob Agents 20:320-5. 2002
    ..Other agents with in vitro activity are also suggested for be use in conjunction with ciprofloxacin or doxycycline include rifampciin, vancomycin, imipenem, chloramphenicol, penicillin and ampicillin, clindamycin, and clarithromycin...
  97. ncbi request reprint Pericarditis due to anaerobic bacteria
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Cardiology 97:55-8. 2002
    ..Treatment of pericarditis involving anaerobic bacteria includes the use of antibiotic therapy effective against these organisms...
  98. doi request reprint Treatment modalities for bacterial rhinosinusitis
    Itzhak Brook
    Department of Pediatrics and Medicine, Georgetown University School of Medicine, Washington, DC 20016, USA
    Expert Opin Pharmacother 11:755-69. 2010
    ..Accurate diagnosis of rhinosinusitis depends upon clinical assessment. Isolation of the causative agents must be considered in cases failing initial treatment...
  99. pmc The role of beta-lactamase-producing-bacteria in mixed infections
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    BMC Infect Dis 9:202. 2009
    ....
  100. ncbi request reprint Role of methicillin-resistant Staphylococcus aureus in head and neck infections
    I Brook
    Departments of Pediatrics and Medicine, Georgetown University School of Medicine, Washington DC, USA
    J Laryngol Otol 123:1301-7. 2009
    ....
  101. ncbi request reprint Bacteriology of spontaneously draining acute otitis media in children before and after the introduction of pneumococcal vaccination
    Itzhak Brook
    Department of Pediatrics Georgetown, University School of Medicine, Washington, DC, USA
    Pediatr Infect Dis J 28:640-2. 2009
    ..05) in the latter period...