I Brook

Summary

Affiliation: Georgetown University
Country: USA

Publications

  1. ncbi request reprint Microbiology and antimicrobial management of sinusitis
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    J Laryngol Otol 119:251-8. 2005
  2. doi request reprint The effects of antimicrobials and exposure to smoking on bacterial interference in the upper respiratory tract of children
    Itzhak Brook
    Department of Pediatrics, Georgetown University, Washington, DC, USA Electronic address
    Int J Pediatr Otorhinolaryngol 78:179-85. 2014
  3. pmc Antianaerobic antimicrobials: spectrum and susceptibility testing
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine Washington, DC, USA
    Clin Microbiol Rev 26:526-46. 2013
  4. doi request reprint Fusobacterial infections in children
    Itzhak Brook
    Departments of Pediatrics and Medicine, Georgetown University School of Medicine, 4431 Albemarle St NW, Washington, DC, 20016, USA
    Curr Infect Dis Rep 15:288-94. 2013
  5. doi request reprint Penicillin failure in the treatment of streptococcal pharyngo-tonsillitis
    Itzhak Brook
    Department of Pediatrics and Medicine, Georgetown University School of Medicine, 4431 Albemarle St NW, Washington, DC, 20016, USA
    Curr Infect Dis Rep 15:232-5. 2013
  6. doi request reprint Acute sinusitis in children
    Itzhak Brook
    Department of Pediatrics and Medicine, Georgetown University School of Medicine, Washington, DC 20016, USA
    Pediatr Clin North Am 60:409-24. 2013
  7. doi request reprint Anaerobic bacteria in upper respiratory tract and head and neck infections: microbiology and treatment
    Itzhak Brook
    Departments of Pediatrics and Medicine, Georgetown University School of Medicine, Washington, DC 20016, USA
    Anaerobe 18:214-20. 2012
  8. ncbi request reprint Effect of telithromycin and azithromycin on nasopharyngeal bacterial flora in patients with acute maxillary sinusitis
    Itzhak Brook
    Department of Pediatrics and Medicine, Georgetown University School of Medicine, Washington, DC, USA
    Arch Otolaryngol Head Neck Surg 132:442-5. 2006
  9. ncbi request reprint Infected neonatal cephalohematomas caused by anaerobic bacteria
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    J Perinat Med 33:255-8. 2005
  10. ncbi request reprint Frequency of recovery of pathogens causing acute maxillary sinusitis in adults before and after introduction of vaccination of children with the 7-valent pneumococcal vaccine
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine and Alachua General and North Florida Regional Hospitals, Gainesville, Florida, USA
    J Med Microbiol 55:943-6. 2006

Detail Information

Publications130 found, 100 shown here

  1. ncbi request reprint Microbiology and antimicrobial management of sinusitis
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    J Laryngol Otol 119:251-8. 2005
    ..The antimicrobials that are the most effective in management of chronic sinusitis are amoxycillinclavulanate, clindamycin and the combination of metronidazole and a penicillin...
  2. doi request reprint The effects of antimicrobials and exposure to smoking on bacterial interference in the upper respiratory tract of children
    Itzhak Brook
    Department of Pediatrics, Georgetown University, Washington, DC, USA Electronic address
    Int J Pediatr Otorhinolaryngol 78:179-85. 2014
    ....
  3. pmc Antianaerobic antimicrobials: spectrum and susceptibility testing
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine Washington, DC, USA
    Clin Microbiol Rev 26:526-46. 2013
    ..The spectrum of efficacy, antimicrobial resistance mechanisms, and resistance patterns against these agents are described...
  4. doi request reprint Fusobacterial infections in children
    Itzhak Brook
    Departments of Pediatrics and Medicine, Georgetown University School of Medicine, 4431 Albemarle St NW, Washington, DC, 20016, USA
    Curr Infect Dis Rep 15:288-94. 2013
    ..This review describes the clinical spectrum of fusobacterial infection in children and their management...
  5. doi request reprint Penicillin failure in the treatment of streptococcal pharyngo-tonsillitis
    Itzhak Brook
    Department of Pediatrics and Medicine, Georgetown University School of Medicine, 4431 Albemarle St NW, Washington, DC, 20016, USA
    Curr Infect Dis Rep 15:232-5. 2013
    ..In treatment of recurrent and chronic PT, the administration of clindamycin or amoxicillin-clavulanatecan eradicates both aerobic and anaerobic BLPB, as well as GABHS...
  6. doi request reprint Acute sinusitis in children
    Itzhak Brook
    Department of Pediatrics and Medicine, Georgetown University School of Medicine, Washington, DC 20016, USA
    Pediatr Clin North Am 60:409-24. 2013
    ..Isolation of the causative agents should be considered in those who failed the initial treatment. In addition to antibiotics, adjuvant therapies and surgery may be used in the management of acute bacterial rhinosinusitis...
  7. doi request reprint Anaerobic bacteria in upper respiratory tract and head and neck infections: microbiology and treatment
    Itzhak Brook
    Departments of Pediatrics and Medicine, Georgetown University School of Medicine, Washington, DC 20016, USA
    Anaerobe 18:214-20. 2012
    ..The recovery from these infections depends on prompt and proper medical and when indicated also surgical management...
  8. ncbi request reprint Effect of telithromycin and azithromycin on nasopharyngeal bacterial flora in patients with acute maxillary sinusitis
    Itzhak Brook
    Department of Pediatrics and Medicine, Georgetown University School of Medicine, Washington, DC, USA
    Arch Otolaryngol Head Neck Surg 132:442-5. 2006
    ..The growing resistance of Streptococcus pneumoniae to penicillin and macrolides brought about the development of a new class of antibiotics-the ketolides-that are effective against resistant pneumococci...
  9. ncbi request reprint Infected neonatal cephalohematomas caused by anaerobic bacteria
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    J Perinat Med 33:255-8. 2005
    ..To present the microbiological and clinical features of six children with infected cephalohematomas (IC) caused by anaerobic bacteria...
  10. ncbi request reprint Frequency of recovery of pathogens causing acute maxillary sinusitis in adults before and after introduction of vaccination of children with the 7-valent pneumococcal vaccine
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine and Alachua General and North Florida Regional Hospitals, Gainesville, Florida, USA
    J Med Microbiol 55:943-6. 2006
    ..These data illustrate that a significant shift occurred in the causative pathogens of acute maxillary sinusitis in adults in the 5 years after the introduction of vaccination of children with the PCV7 compared to the previous 4 years...
  11. pmc Clinical review: bacteremia caused by anaerobic bacteria in children
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Crit Care 6:205-11. 2002
    ..The early recognition of anaerobic bacteremia and administration of appropriate antimicrobial and surgical therapy play a significant role in preventing mortality and morbidity in pediatric patients...
  12. ncbi request reprint Anaerobic bacteria in upper respiratory tract and other head and neck infections
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Ann Otol Rhinol Laryngol 111:430-40. 2002
    ..Because anaerobic bacteria generally are recovered mixed with aerobic organisms, the choice of appropriate antimicrobial agents should provide for adequate coverage of both types of pathogens...
  13. ncbi request reprint Increased recovery of Moraxella catarrhalis and Haemophilus influenzae in association with group A beta-haemolytic streptococci in healthy children and those with pharyngo-tonsillitis
    Itzhak Brook
    Department of Pediatrics, Georgetown University, School of Medicine, Washington, DC, USA
    J Med Microbiol 55:989-92. 2006
    ..This study demonstrates an association between the recovery of GABHS and H. influenzae and M. catarrhalis from pharyngo-tonsillar cultures of patients with APT and M. catarrhalis from pharyngo-tonsillar cultures of healthy children...
  14. ncbi request reprint The role of anaerobic bacteria in mediastinitis
    Itzhak Brook
    Georgetown University School of Medicine, Washington, DC 20016, USA
    Drugs 66:315-20. 2006
    ..Selection of antibacterials for the treatment of mediastinitis is determined by bacteriological studies...
  15. ncbi request reprint The role of bacteria in chronic rhinosinusitis
    Itzhak Brook
    Department of Pediatrics and Medicine, Georgetown University School of Medicine, 4431 Albemarle Street Northwest, Washington, DC 20016, USA
    Otolaryngol Clin North Am 38:1171-92. 2005
    ..The bacterial pathogens in acute sinusitis are S. pneumoniae, H. influenzae, and M. catarrhalis, while anaerobic bacteria and S. aureus predominant in CRS...
  16. ncbi request reprint Ocular infections due to anaerobic bacteria
    I Brook
    Georgetown University School of Medicine, Washington, DC, USA
    Int Ophthalmol 24:269-77. 2001
    ..Propionibacterium spp., Prevotella spp., and Fusobacterium spp. This review describes the microbiology, diagnosis and management of ocular infections due to anaerobic bacteria in children...
  17. ncbi request reprint Prevotella intermedia meningitis associated with cerebrospinal fluid leakage in an adolescent
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Pediatr Infect Dis J 22:751-3. 2003
  18. ncbi request reprint Microbiology of polymicrobial abscesses and implications for therapy
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, 4431 Albemarle Street NW, Washington, DC 20016, USA
    J Antimicrob Chemother 50:805-10. 2002
    ..Appropriate management of these mixed aerobic and anaerobic infections may also require the administration of antimicrobials that are effective against both the aerobic and anaerobic components of the infections...
  19. ncbi request reprint Acute and chronic frontal sinusitis
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Curr Opin Pulm Med 9:171-4. 2003
    ..Surgery is indicated to treat patients with acute and chronic sinusitis and their complications. Several surgical procedures were recently evaluated, and these are briefly reviewed...
  20. ncbi request reprint The role of bacterial interference in otitis, sinusitis and tonsillitis
    Itzhak Brook
    Department of Pediatrics, Georgetown University, USA
    Otolaryngol Head Neck Surg 133:139-46. 2005
    ....
  21. ncbi request reprint Effects of antimicrobial therapy on the microbial flora of the adenoids
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, 4431 Albemarle St NW, Washington, DC 20016, USA
    J Antimicrob Chemother 51:1331-7. 2003
    ....
  22. ncbi request reprint Microbiology and management of deep facial infections and Lemierre syndrome
    Itzhak Brook
    Georgetown University School of Medicine, Washington, D C, USA
    ORL J Otorhinolaryngol Relat Spec 65:117-20. 2003
    ..Management includes surgical drainage and antimicrobial therapy...
  23. ncbi request reprint Isolation of methicillin resistant Staphylococcus aureus from the surface and core of tonsils in children
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Int J Pediatr Otorhinolaryngol 70:2099-102. 2006
    ..This study investigated the rate of recovery of MRSA as well as other aerobic organisms from tonsils that were removed because of recurrent GABHS infection...
  24. ncbi request reprint Effect of amoxicillin and co-amoxiclav on the aerobic and anaerobic nasopharyngeal flora
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    J Antimicrob Chemother 49:689-92. 2002
    ..005). This study illustrates the greater ability of AMC, compared with AMX, to reduce the number of potential nasopharyngeal pathogens and penicillin-resistant bacteria in children with AOM...
  25. doi request reprint Antimicrobial treatment of anaerobic infections
    Itzhak Brook
    Georgetown University School of Medicine, Department of Pediatrics, 4431 Albemarle St NW, Washington DC 20016, USA
    Expert Opin Pharmacother 12:1691-707. 2011
    ..Anaerobic infections can occur at all body sites, including the central nervous system, oral cavity, head and neck, chest, abdomen, pelvis, skin and soft tissues...
  26. ncbi request reprint Endocarditis due to anaerobic bacteria
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Cardiology 98:1-5. 2002
    ..The mortality rate for patients with anaerobes endocarditis is 21-43%. Treatment of endocarditis involving anaerobic bacteria includes the use of antibiotic therapy effective against these organisms...
  27. doi request reprint The role of anaerobic bacteria in bacteremia
    Itzhak Brook
    Georgetown University School of Medicine, 4431 Albemarle St NW, Washington, DC 20016, USA
    Anaerobe 16:183-9. 2010
    ..Early recognition and appropriate treatment of these infections are of great clinical importance...
  28. ncbi request reprint Intra-abdominal, retroperitoneal, and visceral abscesses in children
    I Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC 20016, USA
    Eur J Pediatr Surg 14:265-73. 2004
    ..Fusobacterium spp., and Clostridium spp. The treatment of intraabdominal abscesses includes drainage, surgical correction of pathology, and administration of antimicrobials effective against both aerobic and anaerobic microorganisms...
  29. ncbi request reprint Use of oral cephalosporins in the treatment of acute otitis media in children
    Itzhak Brook
    Department of Pediatrics, School of Medicine, Georgetown University, 4431 Albemarle St NW, Washington, DC 20016, USA
    Int J Antimicrob Agents 24:18-23. 2004
    ....
  30. doi request reprint Rate of eradication of group A beta-hemolytic streptococci in children with pharyngo-tonsillitis by amoxicillin and cefdinir
    Itzhak Brook
    Department of Pediatrics, Georgetown University, Schools of Medicine, Washington, DC 20016, USA
    Int J Pediatr Otorhinolaryngol 73:757-9. 2009
    ..This study investigated the effect of amoxicillin and cefdinir therapies on the rate of eradication of GABHS from the tonsils of children with acute pharyngo-tonsillitis (PT)...
  31. ncbi request reprint Antimicrobial resistance in the nasopharyngeal flora of children with acute otitis media and otitis media recurring after amoxicillin therapy
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, 4431 Albemarle St NW, Washington DC 20016, USA
    J Med Microbiol 54:83-5. 2005
    ..025). These data illustrate the higher recovery rate of antimicrobial-resistant Streptococcus pneumoniae and H. influenzae from the nasopharynx of children who had otitis media that recurred after amoxicillin therapy than those with AOM...
  32. doi request reprint Pericarditis caused by anaerobic bacteria
    Itzhak Brook
    Department of Pediatrics and Medicine, Georgetown University School of Medicine, Washington, DC 20016, USA
    Int J Antimicrob Agents 33:297-300. 2009
    ..Identification of pathogens and determination of their antimicrobial susceptibility and beta-lactamase production are essential for adequate selection of antibiotic therapy effective against these organisms...
  33. ncbi request reprint Bacteriology of chronic maxillary sinusitis associated with nasal polyposis
    Itzhak Brook
    Department of Pediatrics, Otolaryngology and Infectious Diseases, Navy Hospital, Bethesda, MD, USA
    J Med Microbiol 54:595-7. 2005
    ..being predominant. These findings illustrate for the first time the presence of polymicrobial aerobic-anaerobic flora in patients with chronic maxillary sinusitis who had nasal polyposis...
  34. ncbi request reprint Tetanus in children
    Itzhak Brook
    Georgetown University School of Medicine, Department of Pediatrics, Washington, DC, USA
    Pediatr Emerg Care 20:48-51. 2004
  35. ncbi request reprint Management of human and animal bite wound infection: an overview
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, 4431 Albemarle Street NW, Washington DC 20016, USA
    Curr Infect Dis Rep 11:389-95. 2009
    ..Wound management includes administering local care and using proper antimicrobial therapy when needed...
  36. ncbi request reprint In vitro effects of penicillin and telithromycin on the expression of Streptococcus pneumoniae capsule
    Itzhak Brook
    Department of Pediatrics and Medicine, Georgetown University and George Washington University, Schools of Medicine, Washington, DC, USA
    J Antimicrob Chemother 58:678-9. 2006
    ..To evaluate the effects of subinhibitory concentrations of penicillin and telithromycin on capsular formation by Streptococcus pneumoniae...
  37. ncbi request reprint Microbiology and management of peritonsillar, retropharyngeal, and parapharyngeal abscesses
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC 20016, USA
    J Oral Maxillofac Surg 62:1545-50. 2004
    ..Death can occur from aspiration, airway obstruction, erosion into major blood vessels, or extension to the mediastinum...
  38. ncbi request reprint Recovery of potential pathogens and interfering bacteria in the nasopharynx of smokers and nonsmokers
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Chest 127:2072-5. 2005
    ....
  39. ncbi request reprint Long-term effects on the nasopharyngeal flora of children following antimicrobial therapy of acute otitis media with cefdinir or amoxycillin-clavulanate
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington DC 20016, USA
    J Med Microbiol 54:553-6. 2005
    ..In contrast, utilization of a broad-spectrum antimicrobial is associated with prolonged absence of inhibitory organisms and rapid recolonization with pathogens...
  40. ncbi request reprint Recovery of anaerobic bacteria from wounds after lawn-mower injuries
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Pediatr Emerg Care 21:109-10. 2005
    ..This report illustrates the recovery of anaerobic bacteria from children that had wound infection after lawn-mower injury...
  41. ncbi request reprint Microbiology of acute and chronic maxillary sinusitis associated with an odontogenic origin
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Laryngoscope 115:823-5. 2005
    ..To study the microbiology of sinusitis associated with odontogenic origin...
  42. ncbi request reprint Management of anaerobic infection
    Itzhak Brook
    Expert Rev Anti Infect Ther 2:153-8. 2004
    ..The more suitable agents include penicillins, cephalosporins, carbapenems, chloramphenicol, clindamycin, metronidazole, macrolides, glycopeptides, tetracyclines and quinolones...
  43. ncbi request reprint Recovery of potential pathogens and interfering bacteria in the nasopharynx of otitis media-prone children and their smoking and nonsmoking parents
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Arch Otolaryngol Head Neck Surg 131:509-12. 2005
    ....
  44. pmc The role of beta-lactamase-producing-bacteria in mixed infections
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    BMC Infect Dis 9:202. 2009
    ....
  45. doi request reprint Bacteriology of spontaneously draining acute otitis media in children before and after the introduction of pneumococcal vaccination
    Itzhak Brook
    Department of Pediatrics Georgetown, University School of Medicine, Washington, DC, USA
    Pediatr Infect Dis J 28:640-2. 2009
    ..05) in the latter period...
  46. doi request reprint The effects of treatment of acute otitis media with a low dose vs a high dose of amoxicillin on the nasopharyngeal flora
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Arch Otolaryngol Head Neck Surg 135:458-61. 2009
    ..To compare the effects on the nasopharyngeal flora of therapy of acute otitis media in children with either a low dose or a high dose of amoxicillin...
  47. doi request reprint Actinomycosis: diagnosis and management
    Itzhak Brook
    Department of Pediatrics and Medicine, Georgetown University School of Medicine, Washington, DC 20016, USA
    South Med J 101:1019-23. 2008
    ..Prolonged antimicrobial therapy with penicillin has typically been recommended for patients with all clinical forms of actinomycosis to prevent disease recrudescence...
  48. ncbi request reprint The role of anaerobic bacteria in cutaneous and soft tissue abscesses and infected cysts
    Itzhak Brook
    Schools of Medicine, Georgetown University, 4431 Albemarle Street NW, Washington, DC 20016, USA
    Anaerobe 13:171-7. 2007
    ..The infections can progress rapidly and early recognition and proper medical and surgical management is the cornerstone of therapy...
  49. ncbi request reprint Current issues in the management of acute bacterial sinusitis in children
    Itzhak Brook
    Department of Pediatrics, Georgetown University, Schools of Medicine, 4431 Albemarle St NW, Washington, DC 20016, USA
    Int J Pediatr Otorhinolaryngol 71:1653-61. 2007
    ..To review and summarize recent challenges in the microbiology and treatment of acute bacterial sinusitis (ABS), one of the most common infectious diseases in the pediatric community...
  50. ncbi request reprint Infant botulism
    I Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC 20016, USA
    J Perinatol 27:175-80. 2007
    ..Management includes meticulous supportive intensive care that may include mechanical ventilation and administration of human botulinum immunoglobulin in severe cases...
  51. ncbi request reprint Effect of smoking cessation on the microbial flora
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC 20016, USA
    Arch Otolaryngol Head Neck Surg 133:135-8. 2007
    ..To determine the effect of smoking cessation on the frequency of recovery of potential pathogens and aerobic and anaerobic interfering bacteria in the nasopharynges of smokers...
  52. ncbi request reprint Bacteriology of chronic sinusitis and acute exacerbation of chronic sinusitis
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC 20016, USA
    Arch Otolaryngol Head Neck Surg 132:1099-101. 2006
    ..To establish the microbiological characteristics of acute exacerbation of chronic sinusitis (AECS)...
  53. doi request reprint Treatment modalities for bacterial rhinosinusitis
    Itzhak Brook
    Department of Pediatrics and Medicine, Georgetown University School of Medicine, Washington, DC 20016, USA
    Expert Opin Pharmacother 11:755-69. 2010
    ..Accurate diagnosis of rhinosinusitis depends upon clinical assessment. Isolation of the causative agents must be considered in cases failing initial treatment...
  54. pmc Recovery of interfering bacteria in the nasopharynx following antimicrobial therapy of acute maxillary sinusitis with telithromycin or amoxicillin-clavulanate
    Itzhak Brook
    Georgetown University School of Medicine, Washington, DC 20016, USA
    Antimicrob Agents Chemother 49:4793-4. 2005
    ..However, the number of interfering Prevotella spp. declined more significantly after amoxicillin-clavulanate treatment...
  55. pmc Efficacy of penicillin versus cefdinir in eradication of group A streptococci and tonsillar flora
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington DC, USA
    Antimicrob Agents Chemother 49:4787-8. 2005
    ..01) patients. Inhibiting alpha-hemolytic streptococci were isolated less often from penicillin-treated patients than from cefdinir-treated patients...
  56. ncbi request reprint Eradication of pathogens from the nasopharynx after therapy of acute maxillary sinusitis with low- or high-dose amoxicillin/clavulanic acid
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine and Alachua General and North Florida Regional Hospitals, Gainesville, FL, USA
    Int J Antimicrob Agents 26:416-9. 2005
    ..These data illustrate the superiority of 4.0 g/day amoxicillin/clavulanic acid compared with 1.5 g/day amoxicillin/clavulanic acid in the eradication of S. pneumoniae from the nasopharynx...
  57. ncbi request reprint A pooled comparison of cefdinir and penicillin in the treatment of group a beta-hemolytic streptococcal pharyngotonsillitis
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Clin Ther 27:1266-73. 2005
    ..This pooled analysis compared the clinical cure and bacterial eradication rates achieved by cefdinir and penicillin in the treatment of group A beta-hemolytic streptococcal (GABHS) pharngotonsillitis...
  58. doi request reprint A physician as a cancer of the neck patient: getting irradiated
    Itzhak Brook
    Georgetown University School of Medicine, 4431 Albemarle St NW, Washington, DC 20016, USA
    Support Care Cancer 19:1061-4. 2011
    ..It is also my hope that health care professionals who care for these patients will gain insight into what their patients experience and feel so that they would be able to better assist them during this difficult time...
  59. pmc Eradication of Streptococcus pneumoniae in the nasopharyngeal flora of children with acute otitis media after amoxicillin-clavulanate therapy
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, D C 20016, USA
    Antimicrob Agents Chemother 48:1419-21. 2004
    ..The number of Streptococcus pneumoniae isolates in the 45-mg/kg group was reduced from 12 to 6 and was reduced from 14 to 1 (P = 0.0261) in the 90-mg/kg group...
  60. ncbi request reprint Microbiology and management of polymicrobial female genital tract infections in adolescents
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    J Pediatr Adolesc Gynecol 15:217-26. 2002
    ..Treatment regimens must provide antimicrobial coverage for N gonorrhoeae, C trachomatis, anaerobes, streptococci, and gram-negative facultative bacteria...
  61. ncbi request reprint Microbiology of recurrent acute rhinosinusitis
    Itzhak Brook
    Department of Pediatrics, Georgetown University, Washington, DC, USA
    Laryngoscope 114:129-31. 2004
    ..We undertook to evaluate the microbiology of recurrent acute rhinosinusitis...
  62. ncbi request reprint Secondary bacterial infections complicating skin lesions
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    J Med Microbiol 51:808-12. 2002
    ..These organisms probably reached these sites from the oral cavity, where they are part of the normal flora. This review highlights the polymicrobial aerobic-anaerobic microbiology of secondarily infected skin lesions...
  63. ncbi request reprint The prophylaxis and treatment of anthrax
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Int J Antimicrob Agents 20:320-5. 2002
    ..Other agents with in vitro activity are also suggested for be use in conjunction with ciprofloxacin or doxycycline include rifampciin, vancomycin, imipenem, chloramphenicol, penicillin and ampicillin, clindamycin, and clarithromycin...
  64. ncbi request reprint Antibacterial therapy for acute group a streptococcal pharyngotonsillitis: short-course versus traditional 10-day oral regimens
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Paediatr Drugs 4:747-54. 2002
    ..In conclusion, short courses of amoxicillin, cephalosporins, and macrolides provide superior or equal efficacy to a 10-day course of penicillin therapy in the treatment of GABHS pharyngotonsillitis...
  65. ncbi request reprint Antibiotic resistance of oral anaerobic bacteria and their effect on the management of upper respiratory tract and head and neck infections
    Itzhak Brook
    Georgetown University School of Medicine, Washington, DC, USA
    Semin Respir Infect 17:195-203. 2002
    ..Because anaerobes generally are isolated mixed with aerobic organisms, therapy should provide for adequate coverage of both types of pathogens...
  66. ncbi request reprint Pericarditis due to anaerobic bacteria
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Cardiology 97:55-8. 2002
    ..Treatment of pericarditis involving anaerobic bacteria includes the use of antibiotic therapy effective against these organisms...
  67. doi request reprint Role of methicillin-resistant Staphylococcus aureus in head and neck infections
    I Brook
    Departments of Pediatrics and Medicine, Georgetown University School of Medicine, Washington DC, USA
    J Laryngol Otol 123:1301-7. 2009
    ....
  68. ncbi request reprint Microbiology and management of human and animal bite wound infections
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, 4431 Albemarle Street, NW, Washington, DC, USA
    Prim Care 30:25-39, v. 2003
    ..Wound management includes the administration of proper local care and the use of proper antimicrobial agents when needed...
  69. ncbi request reprint Acute bacterial suppurative parotitis: microbiology and management
    Itzhak Brook
    Georgetown University School of Medicine, Washington, DC, USA
    J Craniofac Surg 14:37-40. 2003
    ..The choice of antimicrobial depends on the etiologic agent. Maintenance of good oral hygiene, adequate hydration, and early and proper therapy of bacterial infection of the oropharynx may reduce the occurrence of suppurative parotitis...
  70. ncbi request reprint Management of group A beta-hemolytic streptococcal pharyngotonsillitis in children
    Itzhak Brook
    Georgetown University School of Medicine, Washington, DC, USA
    J Fam Pract 55:S1-11; quiz S12. 2006
    ....
  71. ncbi request reprint Microbiology of acute sinusitis of odontogenic origin presenting with periorbital cellulitis in children
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Ann Otol Rhinol Laryngol 116:386-8. 2007
    ..This study was undertaken to evaluate the aerobic and anaerobic microbiology of acute maxillary sinusitis of odontogenic origin presenting with periodontal infection in children...
  72. ncbi request reprint Management of human and animal bite wounds: an overview
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Adv Skin Wound Care 18:197-203. 2005
    ..Wound management includes proper local care and, when needed, antimicrobial therapy...
  73. ncbi request reprint Susceptibility of irradiated mice to Bacillus anthracis sterne by the intratracheal route of infection
    I Brook
    Radiation Medicine Department, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889-5603, USA
    J Med Microbiol 50:702-11. 2001
    ..anthracis was observed above 4 Gy. The lethal toxin of B. anthracis may enhance the emergence of polymicrobial infection with B. anthracis and enteric micro-organisms...
  74. ncbi request reprint Clindamycin in dentistry: more than just effective prophylaxis for endocarditis?
    Itzhak Brook
    Georgetown University School of Medicine, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 100:550-8. 2005
    ..This review discusses the microbiologic and clinical evidence supporting the efficacy and safety of clindamycin for the successful management of dental infections...
  75. ncbi request reprint Recovery of potential pathogens in the nasopharynx of healthy and otitis media-prone children and their smoking and nonsmoking parents
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Ann Otol Rhinol Laryngol 117:727-30. 2008
    ..This study investigated the frequency of isolation of potential pathogens in the nasopharynx of healthy and otitis media-prone (OMP) children and their smoking or nonsmoking parents...
  76. ncbi request reprint Beta-lactamase-producing bacteria in mixed infections
    I Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington DC 20016, USA
    Clin Microbiol Infect 10:777-84. 2004
    ..The in-vitro and in-vivo clinical evidence supporting the role of BLPB in the increasing failure of penicillin to resolve such infections, and the implications of this phenomenon for the management of infections, are discussed...
  77. ncbi request reprint Microbiology and management of infected solid tumours
    I Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Eur J Cancer Care (Engl) 16:12-6. 2007
    ..This review describes the microbiology and management of infection in necrotic tumours...
  78. doi request reprint The impact of smoking on oral and nasopharyngeal bacterial flora
    I Brook
    Department of Pediatrics and Medicine, Georgetown University School of Medicine, Washington, DC 20016, USA
    J Dent Res 90:704-10. 2011
    ..Analysis of the data presented illustrates the adverse effects of direct and indirect exposure to smoking on colonization with potential pathogens...
  79. ncbi request reprint Clindamycin and quinolone therapy for Bacillus anthracis Sterne infection in 60Co-gamma-photon-irradiated and sham-irradiated mice
    I Brook
    Scientific Research Department, Armed Forces Radiobiology Research Institute, 8901 Wisconsin Avenue, Bethesda, MD 20889 5603, USA
    J Antimicrob Chemother 56:1074-80. 2005
    ..anthracis Sterne spores. Clindamycin has in vitro activity against B. anthracis and inhibits the production of toxin from other species, although no direct evidence exists that production of B. anthracis toxin is inhibited...
  80. ncbi request reprint Recovery of anaerobic bacteria from a glossal abscess in an adolescent
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Pediatr Emerg Care 18:358-9. 2002
    ..The patient recovered following incision and drainage and 14 days of antimicrobial therapy with clindamycin. This report illustrates the recovery of anaerobic bacteria from glossal abscess in an adolescent...
  81. ncbi request reprint The role of anaerobic bacteria in sinusitis
    Itzhak Brook
    Georgetown University School of Medicine, 4431 Albemarle St NW, Washington, DC 20016, USA
    Anaerobe 12:5-12. 2006
    ..These organisms were also recovered in acute sinusitis that was associated with dental infections. The predominant isolates were pigmented Prevotella and Porphyromonas, Fusobacterium and Peptostreptococcus spp...
  82. ncbi request reprint Bacterial infection and antibiotic treatment in chronic rhinosinusitis
    Itzhak Brook
    Georgetown University School of Medicine, Washington, DC, USA
    Clin Allergy Immunol 20:147-62. 2007
    ..In cases where empiric antibiotics have failed, the need for bacterial cultures is even more critical to assure proper treatment and to minimize antibiotic side effects...
  83. ncbi request reprint Effect of antimicrobial therapy with amoxicillin and cefprozil on bacterial interference and beta-lactamase production in the adenoids
    Itzhak Brook
    Department of Pediatrics, Georgetown University, Washington, DC, USA
    Ann Otol Rhinol Laryngol 113:902-5. 2004
    ..This study suggests a potential beneficial effect of using an antimicrobial that selectively spares interfering AHS while inhibiting BLPB...
  84. ncbi request reprint Cephalosporins in overcoming beta-lactamase-producing bacteria and preservation of the interfering bacteria in the treatment of otitis, sinusitis and tonsillitis
    Itzhak Brook
    Georgetown University School of Medicine, Department of Pediatrics, 4431 Albemarle Street NW, Washington, DC 20016, USA
    Expert Rev Anti Infect Ther 5:939-50. 2007
    ..The use of some of the cephalosporins that are able to overcome the effect of BLPB and preserve the beneficial interfering bacteria can overcome and modulate these phenomena and achieve better cure of URTIs...
  85. doi request reprint Failure to eradicate streptococci and beta-lactamase producing bacteria
    Itzhak Brook
    Department of Pediatrics, Georgetown University, Schools of Medicine, Washington, DC, USA
    Acta Paediatr 97:193-5. 2008
    ....
  86. ncbi request reprint Suppurative parotitis caused by anaerobic bacteria in newborns
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Pediatr Infect Dis J 21:81-2. 2002
    ..Peptostreptococcus intermedius and Prevotella melaninogenica were isolated from one child and Prevotella intermedia from the other patient. Complete recovery occurred after 4 weeks of antimicrobial therapy...
  87. ncbi request reprint Role of anaerobic bacteria in infections following tracheostomy, intubation, or the use of ventilatory tubes in children
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Ann Otol Rhinol Laryngol 113:830-4. 2004
    ..Appropriate management of mixed pulmonary aerobic and anaerobic infections requires the administration of antimicrobials that are effective against both the aerobic and anaerobic components of the infection...
  88. doi request reprint Current management of upper respiratory tract and head and neck infections
    Itzhak Brook
    Departments of Pediatrics and Medicine, Georgetown University School of Medicine, Washington, DC 20016, USA
    Eur Arch Otorhinolaryngol 266:315-23. 2009
    ..In conclusion, the proper management of these infections requires an accurate clinical and bacteriological diagnosis...
  89. doi request reprint A physician's personal experience as a cancer of the neck patient
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Otolaryngol Head Neck Surg 143:324-6. 2010
    ..The editorial highlights some of the book's features that relate to the important role of head and neck surgeons in the care of patients with cancer...
  90. doi request reprint Infective endocarditis caused by anaerobic bacteria
    Itzhak Brook
    Department of Pediatrics and Medicine, Georgetown University School of Medicine, Washington, DC, USA
    Arch Cardiovasc Dis 101:665-76. 2008
    ..The mortality rate for patients with anaerobic IE ranges from 21 to 43%. Treatment of anaerobic IE includes the use of antimicrobial effective against these organisms. Surgical intervention may be indicated in some patients...
  91. doi request reprint The role of anaerobic bacteria in chronic suppurative otitis media in children: implications for medical therapy
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, 4431 Albemarle St NW, Washington, DC 20016, USA
    Anaerobe 14:297-300. 2008
    ..The medical therapy of CSOM should be directed at the eradication of the pathogenic aerobic and anaerobic organisms...
  92. doi request reprint Microbiology and antimicrobial treatment of orbital and intracranial complications of sinusitis in children and their management
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, 4431 Albemarle Street NW, Washington, DC 20016, USA
    Int J Pediatr Otorhinolaryngol 73:1183-6. 2009
    ..Early recognition and appropriate surgical and medical therapy are essential to ensure recovery...
  93. doi request reprint Effects of exposure to smoking on the microbial flora of children and their parents
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, 4431 Albemarle St NW, Washington, DC 20016, United States
    Int J Pediatr Otorhinolaryngol 74:447-50. 2010
    ..These studies illustrate the adverse effects of direct and indirect exposure to smoking on colonization with potential pathogens...
  94. ncbi request reprint Microbiology and management of infectious gangrene in children
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC 20016, USA
    J Pediatr Orthop 24:587-92. 2004
  95. ncbi request reprint Microbiology of infected hemangiomas in children
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, 4431 Albemarle Street NW, Washington, DC 20016, USA
    Pediatr Dermatol 21:113-6. 2004
    ..The polymicrobial etiology of secondarily infected hemangiomas and the association of bacterial flora with the anatomic site of the lesions is thereby demonstrated...
  96. ncbi request reprint Chronic sinusitis in children and adults: role of bacteria and antimicrobial management
    Itzhak Brook
    Georgetown University School of Medicine, 4431 Albemarle Street NW, Washington, DC 20016, USA
    Curr Allergy Asthma Rep 5:482-90. 2005
    ..The choice of antimicrobial agent in chronic sinusitis should provide coverage for the usual pathogens in acute sinusitis as well as beta-lactamase-producing aerobic and anaerobic organisms...
  97. ncbi request reprint Increased antimicrobial resistance in organisms recovered from otitis media with effusion
    Itzhak Brook
    Department of Paediatrics of Georgetown and George Washington University, School of Medicine, Washington DC, USA
    J Laryngol Otol 117:449-53. 2003
    ..The data illustrate the relationship between resistance to the antimicrobials given to children and their recovery from the middle ear of patients with OME...
  98. ncbi request reprint Microbial dynamics of purulent nasopharyngitis in children
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, 4431 Albemarle Street NW, Washington, DC 20016, USA
    Int J Pediatr Otorhinolaryngol 67:1047-53. 2003
    ..Controversy exists regarding the management of NPT as no conclusive evidence exists to date that the administration of antimicrobials will shorten the illness...
  99. ncbi request reprint Immune response to Fusobacterium nucleatum and Prevotella intermedia in the sputum of patients with acute exacerbation of chronic bronchitis
    Itzhak Brook
    Naval Medical Center, Bethesda, MD, USA
    Chest 124:832-3. 2003
    ..To assess the role of anaerobic bacteria in acute exacerbation of chronic bronchitis (AECB)...
  100. ncbi request reprint Antimicrobial resistance in the nasopharyngeal flora of children with acute maxillary sinusitis and maxillary sinusitis recurring after amoxicillin therapy
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, 4431 Albemarle St NW, Washington, DC 20016, USA
    J Antimicrob Chemother 53:399-402. 2004
    ..To investigate the antimicrobial susceptibility of the organisms isolated from the nasopharynx of children who present with acute maxillary sinusitis (AMS) or maxillary sinusitis that recurred (RMS) after amoxicillin therapy...
  101. ncbi request reprint Microbiology and management of infected neck cysts
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    J Oral Maxillofac Surg 63:392-5. 2005
    ..To review and describe the microbiology, diagnosis, and management of infected neck cysts...