BARBARA BREGMAN

Summary

Affiliation: Georgetown University
Country: USA

Publications

  1. ncbi request reprint Transplants and neurotrophic factors increase regeneration and recovery of function after spinal cord injury
    Barbara S Bregman
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20007, USA
    Prog Brain Res 137:257-73. 2002
  2. ncbi request reprint Differences in cytokine gene expression profile between acute and secondary injury in adult rat spinal cord
    Masaya Nakamura
    Department of Neuroscience, Georgetown University Medical Center, 3970 Reservoir Road, NW, Washington, DC 20007, USA
    Exp Neurol 184:313-25. 2003
  3. ncbi request reprint Neuronal plasticity after spinal cord injury: identification of a gene cluster driving neurite outgrowth
    Simone Di Giovanni
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC, USA
    FASEB J 19:153-4. 2005
  4. ncbi request reprint Delayed intervention with transplants and neurotrophic factors supports recovery of forelimb function after cervical spinal cord injury in adult rats
    James V Lynskey
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20007, USA
    J Neurotrauma 23:617-34. 2006
  5. ncbi request reprint Neutralization of ciliary neurotrophic factor reduces astrocyte production from transplanted neural stem cells and promotes regeneration of corticospinal tract fibers in spinal cord injury
    Ken Ishii
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC, USA
    J Neurosci Res 84:1669-81. 2006
  6. pmc Degradation of chondroitin sulfate proteoglycans potentiates transplant-mediated axonal remodeling and functional recovery after spinal cord injury in adult rats
    Byung G Kim
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20007, USA
    J Comp Neurol 497:182-98. 2006
  7. pmc Activity-based therapies to promote forelimb use after a cervical spinal cord injury
    Haining Dai
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20007, USA
    J Neurotrauma 26:1719-32. 2009
  8. ncbi request reprint Remodeling of synaptic structures in the motor cortex following spinal cord injury
    Byung G Kim
    Department of Neuroscience, NRB Rm EP 04, Georgetown University Medical Center, 3970 Reservoir Rd, NW, Washington, DC 20007, USA
    Exp Neurol 198:401-15. 2006
  9. ncbi request reprint MICAL flavoprotein monooxygenases: expression during neural development and following spinal cord injuries in the rat
    R Jeroen Pasterkamp
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mol Cell Neurosci 31:52-69. 2006
  10. ncbi request reprint Delayed transplantation with exogenous neurotrophin administration enhances plasticity of corticofugal projections after spinal cord injury
    Dmitri E Iarikov
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20007, USA
    J Neurotrauma 24:690-702. 2007

Research Grants

  1. Spinal cord injury: plasticity and recovery of function
    Barbara S Bregman; Fiscal Year: 2010
  2. RECOVERY OF FUNCTION AFTER SPINAL CORD INJURY
    BARBARA BREGMAN; Fiscal Year: 2004
  3. RECOVERY OF FUNCTION AFTER SPINAL CORD INJURY
    BARBARA BREGMAN; Fiscal Year: 2003
  4. RECOVERY OF FUNCTION AFTER SPINAL CORD INJURY
    BARBARA BREGMAN; Fiscal Year: 2002
  5. SPINAL CORD REGENERATION IN NEONATES AND ADULTS
    BARBARA BREGMAN; Fiscal Year: 2002
  6. SPINAL CORD REGENERATION IN NEONATES AND ADULTS
    BARBARA BREGMAN; Fiscal Year: 2001
  7. SPINAL CORD REGENERATION IN NEONATES AND ADULTS
    BARBARA BREGMAN; Fiscal Year: 2000
  8. SPINAL CORD REGENERATION IN NEONATES AND ADULTS
    BARBARA BREGMAN; Fiscal Year: 2000
  9. RECOVERY OF FUNCTION AFTER SPINAL CORD INJURY
    BARBARA BREGMAN; Fiscal Year: 2000
  10. RECOVERY OF FUNCTION AFTER SPINAL CORD INJURY
    BARBARA BREGMAN; Fiscal Year: 2005

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Transplants and neurotrophic factors increase regeneration and recovery of function after spinal cord injury
    Barbara S Bregman
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20007, USA
    Prog Brain Res 137:257-73. 2002
    ....
  2. ncbi request reprint Differences in cytokine gene expression profile between acute and secondary injury in adult rat spinal cord
    Masaya Nakamura
    Department of Neuroscience, Georgetown University Medical Center, 3970 Reservoir Road, NW, Washington, DC 20007, USA
    Exp Neurol 184:313-25. 2003
    ....
  3. ncbi request reprint Neuronal plasticity after spinal cord injury: identification of a gene cluster driving neurite outgrowth
    Simone Di Giovanni
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC, USA
    FASEB J 19:153-4. 2005
    ..Finally, in vitro transfection experiments in primary dorsal root ganglion cells showed that cluster members act synergistically to drive neurite outgrowth...
  4. ncbi request reprint Delayed intervention with transplants and neurotrophic factors supports recovery of forelimb function after cervical spinal cord injury in adult rats
    James V Lynskey
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20007, USA
    J Neurotrauma 23:617-34. 2006
    ..Plasticity of both spared and axotomized descending pathways likely contributes to the functional recovery observed...
  5. ncbi request reprint Neutralization of ciliary neurotrophic factor reduces astrocyte production from transplanted neural stem cells and promotes regeneration of corticospinal tract fibers in spinal cord injury
    Ken Ishii
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC, USA
    J Neurosci Res 84:1669-81. 2006
    ..We suggest that the blocking of CNTF at the beginning of SCI provides a more favorable environment for the differentiation of transplanted NSC and the regeneration of host axons...
  6. pmc Degradation of chondroitin sulfate proteoglycans potentiates transplant-mediated axonal remodeling and functional recovery after spinal cord injury in adult rats
    Byung G Kim
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20007, USA
    J Comp Neurol 497:182-98. 2006
    ....
  7. pmc Activity-based therapies to promote forelimb use after a cervical spinal cord injury
    Haining Dai
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20007, USA
    J Neurotrauma 26:1719-32. 2009
    ..These studies suggest that rehabilitating forelimb function after spinal cord injury will require separate strategies for descending and segmental pathways...
  8. ncbi request reprint Remodeling of synaptic structures in the motor cortex following spinal cord injury
    Byung G Kim
    Department of Neuroscience, NRB Rm EP 04, Georgetown University Medical Center, 3970 Reservoir Rd, NW, Washington, DC 20007, USA
    Exp Neurol 198:401-15. 2006
    ..Elongation of dendritic spines may indicate a more immature and modifiable pattern of synaptic connectivity in the motor cortex being reorganized following SCI...
  9. ncbi request reprint MICAL flavoprotein monooxygenases: expression during neural development and following spinal cord injuries in the rat
    R Jeroen Pasterkamp
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mol Cell Neurosci 31:52-69. 2006
    ..These results implicate MICALs in neuronal regeneration and support the possibility of employing EGCG to attenuate Sema3-mediated axon repulsion in the injured spinal cord...
  10. ncbi request reprint Delayed transplantation with exogenous neurotrophin administration enhances plasticity of corticofugal projections after spinal cord injury
    Dmitri E Iarikov
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20007, USA
    J Neurotrauma 24:690-702. 2007
    ..Targeting anatomical plasticity of corticofugal projections may be a promising strategy to enhance functional recovery following incomplete SCI...
  11. pmc Modulation of dendritic spine remodeling in the motor cortex following spinal cord injury: effects of environmental enrichment and combinatorial treatment with transplants and neurotrophin-3
    Byung G Kim
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20007, USA
    J Comp Neurol 508:473-86. 2008
    ..We suggest that synaptic remodeling processes in the motor cortex can be targeted for an intervention to enhance functional recovery after SCI...
  12. pmc In vivo quantum dot labeling of mammalian stem and progenitor cells
    Jonathan R Slotkin
    Department of Neuroscience, Georgetown University School of Medicine, Washington, DC, USA
    Dev Dyn 236:3393-401. 2007
    ..These studies reveal that QDs can be effectively used to label mammalian NSPCs in vivo and will be useful for studies of in vivo fate mapping, cellular migration, and NSPC differentiation during mammalian development...
  13. pmc The phosphodiesterase inhibitor rolipram delivered after a spinal cord lesion promotes axonal regeneration and functional recovery
    Elena Nikulina
    Biology Department, Hunter College, City University of New York, New York, NY 10024, USA
    Proc Natl Acad Sci U S A 101:8786-90. 2004
    ..c., as well as post-injury, it is a strong candidate as a useful therapy subsequent to spinal cord injury...
  14. ncbi request reprint Spinal axon regeneration induced by elevation of cyclic AMP
    Jin Qiu
    Biology Department, Hunter College, City University of New York, 695 Park Avenue, New York, NY 10021, USA
    Neuron 34:895-903. 2002
    ..Importantly, DRG injection of db-cAMP results in extensive regeneration of dorsal column axons lesioned 1 week later. These results may be relevant to developing therapies for spinal cord injury...

Research Grants41

  1. Spinal cord injury: plasticity and recovery of function
    Barbara S Bregman; Fiscal Year: 2010
    ..abstract_text> ..
  2. RECOVERY OF FUNCTION AFTER SPINAL CORD INJURY
    BARBARA BREGMAN; Fiscal Year: 2004
    ..abstract_text> ..
  3. RECOVERY OF FUNCTION AFTER SPINAL CORD INJURY
    BARBARA BREGMAN; Fiscal Year: 2003
    ..abstract_text> ..
  4. RECOVERY OF FUNCTION AFTER SPINAL CORD INJURY
    BARBARA BREGMAN; Fiscal Year: 2002
    ..abstract_text> ..
  5. SPINAL CORD REGENERATION IN NEONATES AND ADULTS
    BARBARA BREGMAN; Fiscal Year: 2002
    ....
  6. SPINAL CORD REGENERATION IN NEONATES AND ADULTS
    BARBARA BREGMAN; Fiscal Year: 2001
    ....
  7. SPINAL CORD REGENERATION IN NEONATES AND ADULTS
    BARBARA BREGMAN; Fiscal Year: 2000
    ....
  8. SPINAL CORD REGENERATION IN NEONATES AND ADULTS
    BARBARA BREGMAN; Fiscal Year: 2000
    ....
  9. RECOVERY OF FUNCTION AFTER SPINAL CORD INJURY
    BARBARA BREGMAN; Fiscal Year: 2000
    ..In this proposal, the effects of these treatments will be examined in adult rats with spinal cord injury, examing 1) acute thoracic, 2) acute cervical, and 3) chronic cervical injury, evaluating both anatomical and behavioral recovery. ..
  10. RECOVERY OF FUNCTION AFTER SPINAL CORD INJURY
    BARBARA BREGMAN; Fiscal Year: 2005
    ..abstract_text> ..
  11. Spinal cord injury: plasticity and recovery of function
    BARBARA BREGMAN; Fiscal Year: 2006
    ....
  12. Spinal cord injury: plasticity and recovery of function
    BARBARA BREGMAN; Fiscal Year: 2009
    ..abstract_text> ..
  13. National Capital Area Rehibiliation Research Network
    BARBARA BREGMAN; Fiscal Year: 2007
    ....
  14. TRAINING IN RECOVERY OF FUNCTION AFTER CNS INJURY
    BARBARA BREGMAN; Fiscal Year: 2007
    ....
  15. Spinal cord injury: plasticity and recovery of function
    BARBARA BREGMAN; Fiscal Year: 2007
    ....
  16. RECOVERY OF FUNCTION AFTER SPINAL CORD INJURY
    BARBARA BREGMAN; Fiscal Year: 2006
    ..abstract_text> ..
  17. RECOVERY OF FUNCTION AFTER SPINAL CORD INJURY
    BARBARA BREGMAN; Fiscal Year: 1999
    ..In this proposal, the effects of these treatments will be examined in adult rats with spinal cord injury, examing 1) acute thoracic, 2) acute cervical, and 3) chronic cervical injury, evaluating both anatomical and behavioral recovery. ..
  18. RECOVERY OF FUNCTION AFTER SPINAL CORD INJURY
    BARBARA BREGMAN; Fiscal Year: 1991
  19. RECOVERY OF FUNCTION AFTER SPINAL CORD INJURY
    BARBARA BREGMAN; Fiscal Year: 1990
  20. RECOVERY OF FUNCTION AFTER SPINAL CORD INJURY
    BARBARA BREGMAN; Fiscal Year: 1999
    ..In this proposal, the effects of these treatments will be examined in adult rats with spinal cord injury, examing 1) acute thoracic, 2) acute cervical, and 3) chronic cervical injury, evaluating both anatomical and behavioral recovery. ..
  21. SPINAL CORD REGENERATION IN NEONATES AND ADULTS
    BARBARA BREGMAN; Fiscal Year: 1999
    ....
  22. RECOVERY OF FUNCTION AFTER SPINAL CORD INJURY
    BARBARA BREGMAN; Fiscal Year: 1993
    ....
  23. CNS REGENERATION IN NEONATALS AND ADULTS
    BARBARA BREGMAN; Fiscal Year: 1993
    ....
  24. CNS REGENERATION IN NEONATALS AND ADULTS
    BARBARA BREGMAN; Fiscal Year: 1992
    ....
  25. CNS REGENERATION IN NEONATALS AND ADULTS
    BARBARA BREGMAN; Fiscal Year: 1991
    ....
  26. CNS REGENERATION IN NEONATALS AND ADULTS
    BARBARA BREGMAN; Fiscal Year: 1990
    ....