BARBARA BREGMANSummaryAffiliation: Georgetown University Country: USA Publications
Research Grants
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Publications
Transplants and neurotrophic factors increase regeneration and recovery of function after spinal cord injuryBarbara S Bregman
Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20007, USA
Prog Brain Res 137:257-73. 2002....- Differences in cytokine gene expression profile between acute and secondary injury in adult rat spinal cordMasaya Nakamura
Department of Neuroscience, Georgetown University Medical Center, 3970 Reservoir Road, NW, Washington, DC 20007, USA
Exp Neurol 184:313-25. 2003.... - Neuronal plasticity after spinal cord injury: identification of a gene cluster driving neurite outgrowthSimone Di Giovanni
Department of Neuroscience, Georgetown University Medical Center, Washington, DC, USA
FASEB J 19:153-4. 2005..Finally, in vitro transfection experiments in primary dorsal root ganglion cells showed that cluster members act synergistically to drive neurite outgrowth... - Delayed intervention with transplants and neurotrophic factors supports recovery of forelimb function after cervical spinal cord injury in adult ratsJames V Lynskey
Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20007, USA
J Neurotrauma 23:617-34. 2006..Plasticity of both spared and axotomized descending pathways likely contributes to the functional recovery observed... - Neutralization of ciliary neurotrophic factor reduces astrocyte production from transplanted neural stem cells and promotes regeneration of corticospinal tract fibers in spinal cord injuryKen Ishii
Department of Neuroscience, Georgetown University Medical Center, Washington, DC, USA
J Neurosci Res 84:1669-81. 2006..We suggest that the blocking of CNTF at the beginning of SCI provides a more favorable environment for the differentiation of transplanted NSC and the regeneration of host axons... 
Degradation of chondroitin sulfate proteoglycans potentiates transplant-mediated axonal remodeling and functional recovery after spinal cord injury in adult ratsByung G Kim
Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20007, USA
J Comp Neurol 497:182-98. 2006....- Activity-based therapies to promote forelimb use after a cervical spinal cord injuryHaining Dai
Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20007, USA
J Neurotrauma 26:1719-32. 2009..These studies suggest that rehabilitating forelimb function after spinal cord injury will require separate strategies for descending and segmental pathways... - Remodeling of synaptic structures in the motor cortex following spinal cord injuryByung G Kim
Department of Neuroscience, NRB Rm EP-04, Georgetown University Medical Center, 3970 Reservoir Rd, NW, Washington, DC 20007, USA
Exp Neurol 198:401-15. 2006..Elongation of dendritic spines may indicate a more immature and modifiable pattern of synaptic connectivity in the motor cortex being reorganized following SCI... - MICAL flavoprotein monooxygenases: expression during neural development and following spinal cord injuries in the ratR Jeroen Pasterkamp
Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Mol Cell Neurosci 31:52-69. 2006..These results implicate MICALs in neuronal regeneration and support the possibility of employing EGCG to attenuate Sema3-mediated axon repulsion in the injured spinal cord... - Delayed transplantation with exogenous neurotrophin administration enhances plasticity of corticofugal projections after spinal cord injuryDmitri E Iarikov
Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20007, USA
J Neurotrauma 24:690-702. 2007..Targeting anatomical plasticity of corticofugal projections may be a promising strategy to enhance functional recovery following incomplete SCI... - Modulation of dendritic spine remodeling in the motor cortex following spinal cord injury: effects of environmental enrichment and combinatorial treatment with transplants and neurotrophin-3Byung G Kim
Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20007, USA
J Comp Neurol 508:473-86. 2008..We suggest that synaptic remodeling processes in the motor cortex can be targeted for an intervention to enhance functional recovery after SCI... - In vivo quantum dot labeling of mammalian stem and progenitor cellsJonathan R Slotkin
Department of Neuroscience, Georgetown University School of Medicine, Washington, DC, USA
Dev Dyn 236:3393-401. 2007..These studies reveal that QDs can be effectively used to label mammalian NSPCs in vivo and will be useful for studies of in vivo fate mapping, cellular migration, and NSPC differentiation during mammalian development... - The phosphodiesterase inhibitor rolipram delivered after a spinal cord lesion promotes axonal regeneration and functional recoveryElena Nikulina
Biology Department, Hunter College, City University of New York, New York, NY 10024, USA
Proc Natl Acad Sci U S A 101:8786-90. 2004..c., as well as post-injury, it is a strong candidate as a useful therapy subsequent to spinal cord injury... - Spinal axon regeneration induced by elevation of cyclic AMPJin Qiu
Biology Department, Hunter College, City University of New York, 695 Park Avenue, New York, NY 10021, USA
Neuron 34:895-903. 2002..Importantly, DRG injection of db-cAMP results in extensive regeneration of dorsal column axons lesioned 1 week later. These results may be relevant to developing therapies for spinal cord injury...
Research Grants
- Spinal cord injury: plasticity and recovery of functionBarbara S Bregman; Fiscal Year: 2010..abstract_text> ..
- SPINAL CORD REGENERATION IN NEONATES AND ADULTSBARBARA BREGMAN; Fiscal Year: 2002....
- RECOVERY OF FUNCTION AFTER SPINAL CORD INJURYBARBARA BREGMAN; Fiscal Year: 2000..In this proposal, the effects of these treatments will be examined in adult rats with spinal cord injury, examing 1) acute thoracic, 2) acute cervical, and 3) chronic cervical injury, evaluating both anatomical and behavioral recovery. ..
- National Capital Area Rehibiliation Research NetworkBARBARA BREGMAN; Fiscal Year: 2007....
- TRAINING IN RECOVERY OF FUNCTION AFTER CNS INJURYBARBARA BREGMAN; Fiscal Year: 2007....
- Spinal cord injury: plasticity and recovery of functionBARBARA BREGMAN; Fiscal Year: 2007....
- RECOVERY OF FUNCTION AFTER SPINAL CORD INJURYBARBARA BREGMAN; Fiscal Year: 2006..abstract_text> ..
- RECOVERY OF FUNCTION AFTER SPINAL CORD INJURYBARBARA BREGMAN; Fiscal Year: 1991
- RECOVERY OF FUNCTION AFTER SPINAL CORD INJURYBARBARA BREGMAN; Fiscal Year: 1993....
- CNS REGENERATION IN NEONATALS AND ADULTSBARBARA BREGMAN; Fiscal Year: 1993....