Affiliation: Georgetown University
- ..Furthermore, a recent paper describing the immune phenotype of 5-HT deficient mice is discussed. ..
- Phan T, Ton H, Chen Y, Basha M, Ahern G. Sex-dependent expression of TRPV1 in bladder arterioles. Am J Physiol Renal Physiol. 2016;311:F1063-F1073 pubmed publisher..TRPV1 may therefore play an important role in regulating the microcirculation of the female bladder, and this effect may be of significance during inflammatory conditions. ..
- Ton H, Phan T, Abramyan A, Shi L, Ahern G. Identification of a putative binding site critical for general anesthetic activation of TRPA1. Proc Natl Acad Sci U S A. 2017;114:3762-3767 pubmed publisher..These data may provide a structural basis for designing drugs to counter the noxious and vasorelaxant properties of general anesthetics and may prove useful in understanding effects of anesthetics on related ion channels. ..
- Ahern G. Activation of TRPV1 by the satiety factor oleoylethanolamide. J Biol Chem. 2003;278:30429-34 pubmed..Thus, TRPV1 represents a potential target for OEA and may contribute to the excitatory action of OEA on sensory nerves. ..