Research Topics
Genomes and Genes
| Yuntao WuSummaryAffiliation: George Mason University Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
Gene transcription in HIV infectionYuntao Wu
Laboratory of Molecular Biology, National Institute of Mental Health, 36 Convent Drive, Bethesda, MD 20892-4034, USA
Microbes Infect 5:1023-7. 2003..HIV also possesses the unusual capacity to transcribe from non-integrated DNA...
Early transcription from nonintegrated DNA in human immunodeficiency virus infectionYuntao Wu
Laboratory of Molecular Biology, National Institute of Mental Health, Bethesda, Maryland 20892-4034, USA
J Virol 77:10376-82. 2003..This restriction of protein expression was due in part to inadequate Rev function, since expression of Rev in trans resulted in the expression of the late structural gene gag by nonintegrated HIV DNA...- The second chance story of HIV-1 DNA: Unintegrated? Not a problem!Yuntao Wu
Department of Molecular and Microbiology, George Mason University, Manassas, VA 20110, USA
Retrovirology 5:61. 2008..This new mode of HIV-1 replication has numerous implications for the function of unintegrated viral DNA and its application as a therapeutic vector... - Chemokine control of HIV-1 infection: beyond a binding competitionYuntao Wu
Department of Molecular and Microbiology, George Mason University, Manassas, VA 20110, USA
Retrovirology 7:86. 2010..This new study suggests that a diverse group of chemokines may also affect HIV infection through synergistic or antagonistic interaction with the viral coreceptor signaling pathways... - Chemokine coreceptor signaling in HIV-1 infection and pathogenesisYuntao Wu
Department of Molecular and Microbiology, George Mason University, Manassas, Virginia, USA
PLoS Pathog 5:e1000520. 2009..In this review, we summarize past and present studies on HIV coreceptor signaling. We also discuss possible roles of coreceptor signaling in facilitating viral infection and pathogenesis... - The co-receptor signaling model of HIV-1 pathogenesis in peripheral CD4 T cellsYuntao Wu
Department of Molecular and Microbiology, George Mason University, Manassas, VA 20110, USA
Retrovirology 6:41. 2009..I also suggest that the gradual evolution and emergence of this subpopulation are largely responsible for the slow depletion of peripheral CD4 T cells... - Cofilin activation in peripheral CD4 T cells of HIV-1 infected patients: a pilot studyYuntao Wu
Department of Molecular and Microbiology, George Mason University, Manassas, VA, 20110, USA
Retrovirology 5:95. 2008..HIV-1-mediated aberrant activation of cofilin may also lead to abnormalities in T cell migration and activation that could contribute to viral pathogenesis... - Rev-dependent lentiviral expression vectorYuntao Wu
Section on Molecular Virology, Laboratory of Cellular and Molecular Regulation, NIMH, Bethesda, MD 20892 4483, USA
Retrovirology 4:12. 2007..Enhancements in specificity would increase opportunities for expression vector use in detection of HIV as well as in experimental gene expression in HIV-infected cells... - HIV-1 gene expression: lessons from provirus and non-integrated DNAYuntao Wu
Center for Biodefense, Department of Molecular and Microbiology, George Mason University, Manassas, VA 20110, USA
Retrovirology 1:13. 2004.... - LIM kinase 1 modulates cortical actin and CXCR4 cycling and is activated by HIV-1 to initiate viral infectionPaul J Vorster
Department of Molecular and Microbiology, George Mason University, Manassas, Virginia 20110, USA
J Biol Chem 286:12554-64. 2011..Taken together, our results suggest that HIV hijacks LIMK to control the cortical actin dynamics for the initiation of viral infection of CD4 T cells... - HIV envelope-CXCR4 signaling activates cofilin to overcome cortical actin restriction in resting CD4 T cellsAlyson Yoder
Department of Molecular and Microbiology, George Mason University, Manassas, VA 20110, USA
Cell 134:782-92. 2008..Conversely, induction of active cofilin greatly facilitates it. These findings shed light on viral exploitation of cellular machinery in resting T cells, where chemokine receptor signaling becomes obligatory... - The HIV envelope but not VSV glycoprotein is capable of mediating HIV latent infection of resting CD4 T cellsDongyang Yu
Department of Molecular and Microbiology, George Mason University, Manassas, Virginia, USA
PLoS Pathog 5:e1000633. 2009..These results also call for caution on the endocytotic entry model of HIV-1, and on data interpretation where the VSV-G-pseudotyped HIV was used for identifying HIV restriction factors in resting T cells... - A dichotomy in cortical actin and chemotactic actin activity between human memory and naive T cells contributes to their differential susceptibility to HIV-1 infectionWeifeng Wang
National Center for Biodefense and Infectious Diseases, Department of Molecular and Microbiology, George Mason University, Manassas, Virginia 20110, USA
J Biol Chem 287:35455-69. 2012..These results suggest a key role of chemotactic actin activity in facilitating HIV-1 latent infection of these T cell subsets... - Selective killing of HIV-1-positive macrophages and T cells by the Rev-dependent lentivirus carrying anthrolysin O from Bacillus anthracisJessica Young
Department of Molecular and Microbiology, George Mason University, Manassas, VA 20110, USA
Retrovirology 5:36. 2008.... - Human macrophages support persistent transcription from unintegrated HIV-1 DNAJeremy Kelly
Department of Molecular and Microbiology, George Mason University, Manassas, Virginia 20110, USA
Virology 372:300-12. 2008..One viral early gene product Nef was measurably synthesized. We also find that independent of integration, the HIV infection process in macrophages leads to generation of numerous chemokines... - Rev-dependent indicator T cell lineYuntao Wu
Section on Molecular Virology, Laboratory of Cellular and Molecular Regulation, NIMH, Bethesda, MD, USA
Curr HIV Res 5:394-402. 2007..The line is able to complete TCID50 assays in 3-5 days, and appears sensitive to both CCR5- and CXCR4-utilizing viruses... 
Chemokine receptor signaling and HIV infectionYuntao Wu
Department of Molecular and Microbiology, George Mason University, Manassas, VA, USA
Methods Mol Biol 571:309-19. 2009..Activation of cofilin promotes the cortical actin dynamics that are critical for viral intracellular migration across the static cortical actin barrier in resting T cells...- Measurement of human immunodeficiency virus type 1 preintegration transcription by using Rev-dependent Rev-CEM cells reveals a sizable transcribing DNA population comparable to that from proviral templatesSubashini R Iyer
Department of Molecular and Microbiology, George Mason University, 10900 University Boulevard, Manassas, VA 20110, USA
J Virol 83:8662-73. 2009..Our results also suggest that a nonintegrating lentiviral vector can be as effective as an integrating vector in directing gene expression in nondividing cells, with the proper choice of an internal promoter... - The trinity of the cortical actin in the initiation of HIV-1 infectionMark Spear
National Center for Biodefense and Infectious Diseases, Department of Molecular and Microbiology, George Mason University, Manassas, VA 20110, USA
Retrovirology 9:45. 2012..It is the purpose of this review to examine, in detail, the manifestation of viral dependence on the actin cytoskeleton, and present a model of how HIV utilizes actin dynamics to initiate infection... - Endogenous TGF-beta activation by reactive oxygen species is key to Foxp3 induction in TCR-stimulated and HIV-1-infected human CD4+CD25- T cellsShoba Amarnath
Mucosal Immunology Unit, OIIB, NIDCR, NIH, Bethesda, MD 20895, USA
Retrovirology 4:57. 2007..We also explored the effects of TGF-beta on HIV-1 infection mediated induction of human Tregs since recent evidence has suggested that HIV-1 infection may also impact the generation of Tregs in infected patients... - Spinoculation triggers dynamic actin and cofilin activity that facilitates HIV-1 infection of transformed and resting CD4 T cellsJia Guo
Department of Molecular and Microbiology, George Mason University, VA 20110, USA
J Virol 85:9824-33. 2011..Our results also indicate that caution needs to be taken in data interpretation when cells are spinoculated; some of the spin-induced cellular permissiveness may be beyond the natural capacity of an infecting virus... - HIV gp120 is an aberrant chemoattractant for blood resting CD4 T cellsJia Guo
National Center for Biodefense and Infectious Diseases, Department of Molecular and Microbiology, George Mason University, Manassas, VA 20110, USA
Curr HIV Res 10:636-42. 2012..These results suggest that gp120 does not act like a typical chemoattractant, although it triggers actin dynamics to facilitate HIV infection... - Control of the differentiation of regulatory T cells and T(H)17 cells by the DNA-binding inhibitor Id3Takashi Maruyama
Mucosal Immunology Unit, Oral Infection and Immunity Branch, National Institutes of Health, Bethesda, Maryland, USA
Nat Immunol 12:86-95. 2011..Therefore, a network of factors acts in a TGF-β-dependent manner to control Foxp3 expression and inhibit the development of T(H)17 cells... - Effects of microtubule modulators on HIV-1 infection of transformed and resting CD4 T cellsAlyson Yoder
Department of Molecular and Microbiology, George Mason University, 10900 University Blvd, Manassas, VA 20110, USA
J Virol 85:3020-4. 2011..Although these drugs disrupted microtubule integrity, almost no inhibition of HIV-1 infection was observed. Our results do not appear to support an essential role for microtubules in the initiation of HIV infection of CD4 T cells... - The BET bromodomain inhibitor JQ1 activates HIV latency through antagonizing Brd4 inhibition of Tat-transactivationZichong Li
Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
Nucleic Acids Res 41:277-87. 2013.... - No single homologous repeat region is essential for DNA replication of the baculovirus Autographa californica multiple nucleopolyhedrovirusEric B Carstens
Department of Microbiology and Immunology, Queen s University, Kingston, ON K7L 3N6, Canada
J Gen Virol 88:114-22. 2007..The functional significance of multiple origin regions is still unclear...
Research Grants
- Targeting Brain Macrophages by a novel lentiviral vectorYuntao Wu; Fiscal Year: 2006..abstract_text> ..
- Determine the Transcriptional Activity of Non-integrated HIV-1 DNAYuntao Wu; Fiscal Year: 2007..Additionally, non-integrated viral DNA could serve as clinical markers for disease progression in certain situation. ..
- Regulation of Cofilin in HIV-1 Infection of Human CD4 T CellsYuntao Wu; Fiscal Year: 2010..These mechanisms are very important to understand viral pathogenesis and will help to identify novel therapeutic targets to treat HIV-1 infection. ..