Yuntao Wu

Summary

Affiliation: George Mason University
Country: USA

Publications

  1. ncbi request reprint Gene transcription in HIV infection
    Yuntao Wu
    Laboratory of Molecular Biology, National Institute of Mental Health, 36 Convent Drive, Bethesda, MD 20892 4034, USA
    Microbes Infect 5:1023-7. 2003
  2. pmc Early transcription from nonintegrated DNA in human immunodeficiency virus infection
    Yuntao Wu
    Laboratory of Molecular Biology, National Institute of Mental Health, Bethesda, Maryland 20892 4034, USA
    J Virol 77:10376-82. 2003
  3. pmc The second chance story of HIV-1 DNA: Unintegrated? Not a problem!
    Yuntao Wu
    Department of Molecular and Microbiology, George Mason University, Manassas, VA 20110, USA
    Retrovirology 5:61. 2008
  4. pmc Chemokine control of HIV-1 infection: beyond a binding competition
    Yuntao Wu
    Department of Molecular and Microbiology, George Mason University, Manassas, VA 20110, USA
    Retrovirology 7:86. 2010
  5. pmc The HIV envelope but not VSV glycoprotein is capable of mediating HIV latent infection of resting CD4 T cells
    Dongyang Yu
    Department of Molecular and Microbiology, George Mason University, Manassas, Virginia, USA
    PLoS Pathog 5:e1000633. 2009
  6. pmc Development of a nonintegrating Rev-dependent lentiviral vector carrying diphtheria toxin A chain and human TRAF6 to target HIV reservoirs
    Z Wang
    Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Harvard University, Boston, MA, USA
    Gene Ther 17:1063-76. 2010
  7. pmc Involvement of LIM kinase 1 in actin polarization in human CD4 T cells
    Xuehua Xu
    Chemotaxis Signal Section Laboratory of Immunogenetics National Institute of Allergy and Infectious Disease NIH Rockville, MD USA
    Commun Integr Biol 5:381-3. 2012
  8. pmc Genistein interferes with SDF-1- and HIV-mediated actin dynamics and inhibits HIV infection of resting CD4 T cells
    Jia Guo
    National Center for Biodefense and Infectious Diseases, Department of Molecular and Microbiology, George Mason University, Manassas VA 20110, USA
    Retrovirology 10:62. 2013
  9. pmc Inhibition of HIV replication in vitro by clinical immunosuppressants and chemotherapeutic agents
    Todd Hawley
    National Center for Biodefense and Infectious Diseases, Department of Molecular and Microbiology, George Mason University, 10900, University Boulevard, Manassas, VA, USA
    Cell Biosci 3:22. 2013
  10. pmc Chemokine coreceptor signaling in HIV-1 infection and pathogenesis
    Yuntao Wu
    Department of Molecular and Microbiology, George Mason University, Manassas, Virginia, USA
    PLoS Pathog 5:e1000520. 2009

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Gene transcription in HIV infection
    Yuntao Wu
    Laboratory of Molecular Biology, National Institute of Mental Health, 36 Convent Drive, Bethesda, MD 20892 4034, USA
    Microbes Infect 5:1023-7. 2003
    ..HIV also possesses the unusual capacity to transcribe from non-integrated DNA...
  2. pmc Early transcription from nonintegrated DNA in human immunodeficiency virus infection
    Yuntao Wu
    Laboratory of Molecular Biology, National Institute of Mental Health, Bethesda, Maryland 20892 4034, USA
    J Virol 77:10376-82. 2003
    ..This restriction of protein expression was due in part to inadequate Rev function, since expression of Rev in trans resulted in the expression of the late structural gene gag by nonintegrated HIV DNA...
  3. pmc The second chance story of HIV-1 DNA: Unintegrated? Not a problem!
    Yuntao Wu
    Department of Molecular and Microbiology, George Mason University, Manassas, VA 20110, USA
    Retrovirology 5:61. 2008
    ..This new mode of HIV-1 replication has numerous implications for the function of unintegrated viral DNA and its application as a therapeutic vector...
  4. pmc Chemokine control of HIV-1 infection: beyond a binding competition
    Yuntao Wu
    Department of Molecular and Microbiology, George Mason University, Manassas, VA 20110, USA
    Retrovirology 7:86. 2010
    ..This new study suggests that a diverse group of chemokines may also affect HIV infection through synergistic or antagonistic interaction with the viral coreceptor signaling pathways...
  5. pmc The HIV envelope but not VSV glycoprotein is capable of mediating HIV latent infection of resting CD4 T cells
    Dongyang Yu
    Department of Molecular and Microbiology, George Mason University, Manassas, Virginia, USA
    PLoS Pathog 5:e1000633. 2009
    ..These results also call for caution on the endocytotic entry model of HIV-1, and on data interpretation where the VSV-G-pseudotyped HIV was used for identifying HIV restriction factors in resting T cells...
  6. pmc Development of a nonintegrating Rev-dependent lentiviral vector carrying diphtheria toxin A chain and human TRAF6 to target HIV reservoirs
    Z Wang
    Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Harvard University, Boston, MA, USA
    Gene Ther 17:1063-76. 2010
    ..This allowed us to manufacture the first high-titer NIRD lentiviral particles carrying DT-A to target HIV-positive cells...
  7. pmc Involvement of LIM kinase 1 in actin polarization in human CD4 T cells
    Xuehua Xu
    Chemotaxis Signal Section Laboratory of Immunogenetics National Institute of Allergy and Infectious Disease NIH Rockville, MD USA
    Commun Integr Biol 5:381-3. 2012
    ..The inhibition of HIV-1 infection by LIMK1 knockdown may also result from the decrease of actin-rich membrane protrusions that may be preferred viral entry sites in T cells...
  8. pmc Genistein interferes with SDF-1- and HIV-mediated actin dynamics and inhibits HIV infection of resting CD4 T cells
    Jia Guo
    National Center for Biodefense and Infectious Diseases, Department of Molecular and Microbiology, George Mason University, Manassas VA 20110, USA
    Retrovirology 10:62. 2013
    ..To determine whether inhibiting SDF-1-mediated chemotactic activity can also inhibit HIV infection, we screened several inhibitors known to reduce SDF-1-mediated chemotaxis of T cells...
  9. pmc Inhibition of HIV replication in vitro by clinical immunosuppressants and chemotherapeutic agents
    Todd Hawley
    National Center for Biodefense and Infectious Diseases, Department of Molecular and Microbiology, George Mason University, 10900, University Boulevard, Manassas, VA, USA
    Cell Biosci 3:22. 2013
    ..However, the precise role of the coinciding medical interventions in diminishing detectable HIV reservoirs remains unstudied...
  10. pmc Chemokine coreceptor signaling in HIV-1 infection and pathogenesis
    Yuntao Wu
    Department of Molecular and Microbiology, George Mason University, Manassas, Virginia, USA
    PLoS Pathog 5:e1000520. 2009
    ..In this review, we summarize past and present studies on HIV coreceptor signaling. We also discuss possible roles of coreceptor signaling in facilitating viral infection and pathogenesis...
  11. pmc HIV-1 gene expression: lessons from provirus and non-integrated DNA
    Yuntao Wu
    Center for Biodefense, Department of Molecular and Microbiology, George Mason University, Manassas, VA 20110, USA
    Retrovirology 1:13. 2004
    ....
  12. pmc The co-receptor signaling model of HIV-1 pathogenesis in peripheral CD4 T cells
    Yuntao Wu
    Department of Molecular and Microbiology, George Mason University, Manassas, VA 20110, USA
    Retrovirology 6:41. 2009
    ..I also suggest that the gradual evolution and emergence of this subpopulation are largely responsible for the slow depletion of peripheral CD4 T cells...
  13. pmc Cofilin activation in peripheral CD4 T cells of HIV-1 infected patients: a pilot study
    Yuntao Wu
    Department of Molecular and Microbiology, George Mason University, Manassas, VA, 20110, USA
    Retrovirology 5:95. 2008
    ..HIV-1-mediated aberrant activation of cofilin may also lead to abnormalities in T cell migration and activation that could contribute to viral pathogenesis...
  14. pmc Rev-dependent lentiviral expression vector
    Yuntao Wu
    Section on Molecular Virology, Laboratory of Cellular and Molecular Regulation, NIMH, Bethesda, MD 20892 4483, USA
    Retrovirology 4:12. 2007
    ..Enhancements in specificity would increase opportunities for expression vector use in detection of HIV as well as in experimental gene expression in HIV-infected cells...
  15. pmc HIV envelope-CXCR4 signaling activates cofilin to overcome cortical actin restriction in resting CD4 T cells
    Alyson Yoder
    Department of Molecular and Microbiology, George Mason University, Manassas, VA 20110, USA
    Cell 134:782-92. 2008
    ..Conversely, induction of active cofilin greatly facilitates it. These findings shed light on viral exploitation of cellular machinery in resting T cells, where chemokine receptor signaling becomes obligatory...
  16. pmc LIM kinase 1 modulates cortical actin and CXCR4 cycling and is activated by HIV-1 to initiate viral infection
    Paul J Vorster
    Department of Molecular and Microbiology, George Mason University, Manassas, Virginia 20110, USA
    J Biol Chem 286:12554-64. 2011
    ..Taken together, our results suggest that HIV hijacks LIMK to control the cortical actin dynamics for the initiation of viral infection of CD4 T cells...
  17. pmc Selective killing of HIV-1-positive macrophages and T cells by the Rev-dependent lentivirus carrying anthrolysin O from Bacillus anthracis
    Jessica Young
    Department of Molecular and Microbiology, George Mason University, Manassas, VA 20110, USA
    Retrovirology 5:36. 2008
    ....
  18. pmc HIV-1 triggers WAVE2 phosphorylation in primary CD4 T cells and macrophages, mediating Arp2/3-dependent nuclear migration
    Mark Spear
    From the National Center for Biodefense and Infectious Diseases, Department of Molecular and Microbiology, George Mason University, Manassas, Virginia 20110
    J Biol Chem 289:6949-59. 2014
    ..Our results suggest that Arp2/3 and the upstream regulator, WAVE2, are essential co-factors hijacked by HIV for intracellular migration, and may serve as novel targets to prevent HIV transmission. ..
  19. pmc A dichotomy in cortical actin and chemotactic actin activity between human memory and naive T cells contributes to their differential susceptibility to HIV-1 infection
    Weifeng Wang
    National Center for Biodefense and Infectious Diseases, Department of Molecular and Microbiology, George Mason University, Manassas, Virginia 20110, USA
    J Biol Chem 287:35455-69. 2012
    ..These results suggest a key role of chemotactic actin activity in facilitating HIV-1 latent infection of these T cell subsets...
  20. pmc Human macrophages support persistent transcription from unintegrated HIV-1 DNA
    Jeremy Kelly
    Department of Molecular and Microbiology, George Mason University, Manassas, Virginia 20110, USA
    Virology 372:300-12. 2008
    ..One viral early gene product Nef was measurably synthesized. We also find that independent of integration, the HIV infection process in macrophages leads to generation of numerous chemokines...
  21. pmc Rev-dependent indicator T cell line
    Yuntao Wu
    Section on Molecular Virology, Laboratory of Cellular and Molecular Regulation, NIMH, Bethesda, MD, USA
    Curr HIV Res 5:394-402. 2007
    ..The line is able to complete TCID50 assays in 3-5 days, and appears sensitive to both CCR5- and CXCR4-utilizing viruses...
  22. doi request reprint Chemokine receptor signaling and HIV infection
    Yuntao Wu
    Department of Molecular and Microbiology, George Mason University, Manassas, VA, USA
    Methods Mol Biol 571:309-19. 2009
    ..Activation of cofilin promotes the cortical actin dynamics that are critical for viral intracellular migration across the static cortical actin barrier in resting T cells...
  23. pmc Measurement of human immunodeficiency virus type 1 preintegration transcription by using Rev-dependent Rev-CEM cells reveals a sizable transcribing DNA population comparable to that from proviral templates
    Subashini R Iyer
    Department of Molecular and Microbiology, George Mason University, 10900 University Boulevard, Manassas, VA 20110, USA
    J Virol 83:8662-73. 2009
    ..Our results also suggest that a nonintegrating lentiviral vector can be as effective as an integrating vector in directing gene expression in nondividing cells, with the proper choice of an internal promoter...
  24. pmc Novel anti-HIV therapeutics targeting chemokine receptors and actin regulatory pathways
    Mark Spear
    National Center for Biodefense and Infectious Diseases, Department of Molecular and Microbiology, George Mason University, Manassas, VA, USA
    Immunol Rev 256:300-12. 2013
    ..We also examine potential pharmacological targets that emerge from this interaction. In addition, we briefly discuss several actin pathway-based anti-HIV drugs that are currently in development or testing...
  25. pmc The trinity of the cortical actin in the initiation of HIV-1 infection
    Mark Spear
    National Center for Biodefense and Infectious Diseases, Department of Molecular and Microbiology, George Mason University, Manassas, VA 20110, USA
    Retrovirology 9:45. 2012
    ..It is the purpose of this review to examine, in detail, the manifestation of viral dependence on the actin cytoskeleton, and present a model of how HIV utilizes actin dynamics to initiate infection...
  26. ncbi request reprint HIV gp120 is an aberrant chemoattractant for blood resting CD4 T cells
    Jia Guo
    National Center for Biodefense and Infectious Diseases, Department of Molecular and Microbiology, George Mason University, Manassas, VA 20110, USA
    Curr HIV Res 10:636-42. 2012
    ..These results suggest that gp120 does not act like a typical chemoattractant, although it triggers actin dynamics to facilitate HIV infection...
  27. pmc Endogenous TGF-beta activation by reactive oxygen species is key to Foxp3 induction in TCR-stimulated and HIV-1-infected human CD4+CD25- T cells
    Shoba Amarnath
    Mucosal Immunology Unit, OIIB, NIDCR, NIH, Bethesda, MD 20895, USA
    Retrovirology 4:57. 2007
    ..We also explored the effects of TGF-beta on HIV-1 infection mediated induction of human Tregs since recent evidence has suggested that HIV-1 infection may also impact the generation of Tregs in infected patients...
  28. pmc Spinoculation triggers dynamic actin and cofilin activity that facilitates HIV-1 infection of transformed and resting CD4 T cells
    Jia Guo
    Department of Molecular and Microbiology, George Mason University, VA 20110, USA
    J Virol 85:9824-33. 2011
    ..Our results also indicate that caution needs to be taken in data interpretation when cells are spinoculated; some of the spin-induced cellular permissiveness may be beyond the natural capacity of an infecting virus...
  29. pmc Effects of microtubule modulators on HIV-1 infection of transformed and resting CD4 T cells
    Alyson Yoder
    Department of Molecular and Microbiology, George Mason University, 10900 University Blvd, Manassas, VA 20110, USA
    J Virol 85:3020-4. 2011
    ..Although these drugs disrupted microtubule integrity, almost no inhibition of HIV-1 infection was observed. Our results do not appear to support an essential role for microtubules in the initiation of HIV infection of CD4 T cells...
  30. pmc Control of the differentiation of regulatory T cells and T(H)17 cells by the DNA-binding inhibitor Id3
    Takashi Maruyama
    Mucosal Immunology Unit, Oral Infection and Immunity Branch, National Institutes of Health, Bethesda, Maryland, USA
    Nat Immunol 12:86-95. 2011
    ..Therefore, a network of factors acts in a TGF-β-dependent manner to control Foxp3 expression and inhibit the development of T(H)17 cells...
  31. ncbi request reprint Viral exploitation of actin: force-generation and scaffolding functions in viral infection
    Mark Spear
    National Center for Biodefense and Infectious Diseases, Department of Molecular and Microbiology, George Mason University, Manassas, VA, 20110, USA
    Virol Sin 29:139-47. 2014
    ..It is the purpose of this review to provide an overview of current research, focusing on the various mechanisms and themes of virus-mediated actin modulation described therein. ..
  32. pmc The BET bromodomain inhibitor JQ1 activates HIV latency through antagonizing Brd4 inhibition of Tat-transactivation
    Zichong Li
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Nucleic Acids Res 41:277-87. 2013
    ....
  33. ncbi request reprint No single homologous repeat region is essential for DNA replication of the baculovirus Autographa californica multiple nucleopolyhedrovirus
    Eric B Carstens
    Department of Microbiology and Immunology, Queen s University, Kingston, ON K7L 3N6, Canada
    J Gen Virol 88:114-22. 2007
    ..The functional significance of multiple origin regions is still unclear...

Research Grants5

  1. Targeting Brain Macrophages by a novel lentiviral vector
    Yuntao Wu; Fiscal Year: 2006
    ..abstract_text> ..
  2. Determine the Transcriptional Activity of Non-integrated HIV-1 DNA
    Yuntao Wu; Fiscal Year: 2007
    ..Additionally, non-integrated viral DNA could serve as clinical markers for disease progression in certain situation. ..
  3. Regulation of Cofilin in HIV-1 Infection of Human CD4 T Cells
    Yuntao Wu; Fiscal Year: 2009
    ..These mechanisms are very important to understand viral pathogenesis and will help to identify novel therapeutic targets to treat HIV-1 infection. ..
  4. Regulation of Cofilin in HIV-1 Infection of Human CD4 T Cells
    Yuntao Wu; Fiscal Year: 2010
    ..These mechanisms are very important to understand viral pathogenesis and will help to identify novel therapeutic targets to treat HIV-1 infection. ..