Genomes and Genes


Monique L van Hoek


Affiliation: George Mason University
Country: USA


  1. Chung M, Dean S, van Hoek M. Acyl carrier protein is a bacterial cytoplasmic target of cationic antimicrobial peptide LL-37. Biochem J. 2015;470:243-53 pubmed publisher
    ..Our findings highlight a novel mechanism of antimicrobial activity of this peptide and document a previously unexplored target of α-helical CAMPs. ..
  2. Dean S, Chung M, van Hoek M. Burkholderia Diffusible Signal Factor Signals to Francisella novicida To Disperse Biofilm and Increase Siderophore Production. Appl Environ Microbiol. 2015;81:7057-66 pubmed publisher
    ..Overall, this study suggests that in response to the interspecies DSF signal, F. novicida can alter its gene expression and regulate its biofilm formation. ..
  3. Kaushal A, Gupta K, van Hoek M. Characterization of Cimex lectularius (bedbug) defensin peptide and its antimicrobial activity against human skin microflora. Biochem Biophys Res Commun. 2016;470:955-60 pubmed publisher
    ..CL-defensin was also effective against M. luteus and C. renale in high-salt (MIC) conditions. Our studies indicate that CL-defensin functions by depolarization and pore-formation in the bacterial cytoplasmic membrane. ..
  4. Kaushal A, Gupta K, Shah R, van Hoek M. Antimicrobial activity of mosquito cecropin peptides against Francisella. Dev Comp Immunol. 2016;63:171-80 pubmed publisher
    ..Thus, it is possible that antimicrobial peptides may play a role in the inability of mosquitoes to establish an effective natural transmission of tularemia. ..
  5. Pierson T, Learmonth Pierson S, Pinto D, van Hoek M. Cigarette smoke extract induces differential expression levels of beta-defensin peptides in human alveolar epithelial cells. Tob Induc Dis. 2013;11:10 pubmed publisher
    ..Establishing differential ?-defensin expression following CSE treatment will add to our understanding of the molecular response of the lung alveolar epithelium to cigarette smoke exposure. ..
  6. Ulrey R, Barksdale S, Zhou W, van Hoek M. Cranberry proanthocyanidins have anti-biofilm properties against Pseudomonas aeruginosa. BMC Complement Altern Med. 2014;14:499 pubmed publisher
    ..mellonella. Results suggest that A-type proanthocyanidins may be a useful therapeutic against the biofilm-mediated infections caused by P. aeruginosa and should be further tested. ..
  7. Gupta K, Singh S, van Hoek M. Short, Synthetic Cationic Peptides Have Antibacterial Activity against Mycobacterium smegmatis by Forming Pores in Membrane and Synergizing with Antibiotics. Antibiotics (Basel). 2015;4:358-78 pubmed publisher
    ..These studies provide the foundation for the potential development of synthetic cationic antimicrobial peptides with activity against mycobacteria. ..
  8. Propst C, Nwabueze A, Kanev I, Pepin R, Gutting B, Morozov V, et al. Nanoaerosols reduce required effective dose of liposomal levofloxacin against pulmonary murine Francisella tularensis subsp. novicida infection. J Nanobiotechnology. 2016;14:29 pubmed publisher
    ..This could represent a significant advance for the use of expensive therapeutics and lung directed therapies. ..
  9. Barksdale S, Hrifko E, Chung E, van Hoek M. Peptides from American alligator plasma are antimicrobial against multi-drug resistant bacterial pathogens including Acinetobacter baumannii. BMC Microbiol. 2016;16:189 pubmed publisher
    ..Overall, we suggest that Apo5 and Apo6 have a different mode of action than A1P, and that all three peptides make promising candidates for the treatment of drug-resistant bacteria, such as A. baumannii. ..

More Information


  1. Barksdale S, Hrifko E, van Hoek M. Cathelicidin antimicrobial peptide from Alligator mississippiensis has antibacterial activity against multi-drug resistant Acinetobacter baumanii and Klebsiella pneumoniae. Dev Comp Immunol. 2017;70:135-144 pubmed publisher
    ..In addition, due to their activities against MDR bacteria and lack of cytotoxicity, the AM-CATH peptides could be an attractive platform for further development as a potential therapeutic. ..