John M Lachin

Summary

Affiliation: George Washington University
Country: USA

Publications

  1. pmc Update on cardiovascular outcomes at 30 years of the diabetes control and complications trial/epidemiology of diabetes interventions and complications study
    John M Lachin
    Corresponding author John M Lachin
    Diabetes Care 37:39-43. 2014
  2. pmc Power of the Mantel-Haenszel and other tests for discrete or grouped time-to-event data under a chained binomial model
    John M Lachin
    The Biostatistics Center, Departments of Epidemiology and Biostatistics, and Statistics, The George Washington University, 6110 Executive Boulevard, Suite 750, Rockville, MD 20852, USA
    Stat Med 32:220-9. 2013
  3. pmc Sample size requirements for studies of treatment effects on beta-cell function in newly diagnosed type 1 diabetes
    John M Lachin
    The Biostatistics Center, The George Washington University, Rockville, Maryland, United States of America
    PLoS ONE 6:e26471. 2011
  4. pmc Renal function in type 2 diabetes with rosiglitazone, metformin, and glyburide monotherapy
    John M Lachin
    The Biostatistics Center, The George Washington University, Rockville, MD 20852, USA
    Clin J Am Soc Nephrol 6:1032-40. 2011
  5. pmc Factors associated with diabetes onset during metformin versus placebo therapy in the diabetes prevention program
    John M Lachin
    d, Diabetes Prevention Program Coordinating Center, The Biostatistics Center, George Washington University, 6110 Executive Blvd, Suite 750, Rockville, MD 20852, USA
    Diabetes 56:1153-9. 2007
  6. pmc Comparison of urinary albumin-creatinine ratio and albumin excretion rate in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications study
    Naji Younes
    Biostatistics Center, George Washington University, 6110 Executive Boulevard, Suite 700, Rockville, MD 20852 USA
    Clin J Am Soc Nephrol 5:1235-42. 2010
  7. doi Effect of glycemic exposure on the risk of microvascular complications in the diabetes control and complications trial--revisited
    John M Lachin
    The Biostatistics Center, The George Washington University, Rockville, MD 20852, USA
    Diabetes 57:995-1001. 2008
  8. pmc Aortic distensibility in type 1 diabetes
    Evrim B Turkbey
    Radiology and Imaging Sciences, National Institutes of Health Clinical Center, National Institute of Biomedical Imaging and Bioengineering, Bethesda, Maryland, USA
    Diabetes Care 36:2380-7. 2013
  9. ncbi The hemoglobin glycation index is not an independent predictor of the risk of microvascular complications in the Diabetes Control and Complications Trial
    John M Lachin
    The Biostatistics Center, George Washington University, Rockville, MD 20852, USA
    Diabetes 56:1913-21. 2007
  10. pmc TCF7L2 polymorphism, weight loss and proinsulin:insulin ratio in the diabetes prevention program
    Jeanne M McCaffery
    The Biostatistics Center, The George Washington University, Rockville, Maryland, United States of America
    PLoS ONE 6:e21518. 2011

Detail Information

Publications31

  1. pmc Update on cardiovascular outcomes at 30 years of the diabetes control and complications trial/epidemiology of diabetes interventions and complications study
    John M Lachin
    Corresponding author John M Lachin
    Diabetes Care 37:39-43. 2014
    ..CONCLUSIONS DCCT INT and the attendant 6.5 years of lower HbA1c had long-term salutary effects on the development and progression of atherosclerosis and cardiovascular disease during the subsequent follow-up during EDIC. ..
  2. pmc Power of the Mantel-Haenszel and other tests for discrete or grouped time-to-event data under a chained binomial model
    John M Lachin
    The Biostatistics Center, Departments of Epidemiology and Biostatistics, and Statistics, The George Washington University, 6110 Executive Boulevard, Suite 750, Rockville, MD 20852, USA
    Stat Med 32:220-9. 2013
    ....
  3. pmc Sample size requirements for studies of treatment effects on beta-cell function in newly diagnosed type 1 diabetes
    John M Lachin
    The Biostatistics Center, The George Washington University, Rockville, Maryland, United States of America
    PLoS ONE 6:e26471. 2011
    ..These results provide the information needed to accurately evaluate the sample size for studies of new agents to preserve C-peptide levels in newly diagnosed type 1 diabetes...
  4. pmc Renal function in type 2 diabetes with rosiglitazone, metformin, and glyburide monotherapy
    John M Lachin
    The Biostatistics Center, The George Washington University, Rockville, MD 20852, USA
    Clin J Am Soc Nephrol 6:1032-40. 2011
    ..Herein, we examine differences in albumin excretion, renal function (estimated GFR), and BP over 5 years between treatment groups...
  5. pmc Factors associated with diabetes onset during metformin versus placebo therapy in the diabetes prevention program
    John M Lachin
    d, Diabetes Prevention Program Coordinating Center, The Biostatistics Center, George Washington University, 6110 Executive Blvd, Suite 750, Rockville, MD 20852, USA
    Diabetes 56:1153-9. 2007
    ....
  6. pmc Comparison of urinary albumin-creatinine ratio and albumin excretion rate in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications study
    Naji Younes
    Biostatistics Center, George Washington University, 6110 Executive Boulevard, Suite 700, Rockville, MD 20852 USA
    Clin J Am Soc Nephrol 5:1235-42. 2010
    ..The objective of this study was to compare random urine albumin-creatinine ratio (ACR) with timed urine albumin excretion rate (AER) in patients with type 1 diabetes...
  7. doi Effect of glycemic exposure on the risk of microvascular complications in the diabetes control and complications trial--revisited
    John M Lachin
    The Biostatistics Center, The George Washington University, Rockville, MD 20852, USA
    Diabetes 57:995-1001. 2008
    ....
  8. pmc Aortic distensibility in type 1 diabetes
    Evrim B Turkbey
    Radiology and Imaging Sciences, National Institutes of Health Clinical Center, National Institute of Biomedical Imaging and Bioengineering, Bethesda, Maryland, USA
    Diabetes Care 36:2380-7. 2013
    ..To evaluate the relationship between long-term glycemia, traditional cardiovascular disease (CVD) risk factors, and ascending aortic stiffness in type 1 diabetes...
  9. ncbi The hemoglobin glycation index is not an independent predictor of the risk of microvascular complications in the Diabetes Control and Complications Trial
    John M Lachin
    The Biostatistics Center, George Washington University, Rockville, MD 20852, USA
    Diabetes 56:1913-21. 2007
    ..The HGI should not be used to estimate risk of complications or to guide therapy...
  10. pmc TCF7L2 polymorphism, weight loss and proinsulin:insulin ratio in the diabetes prevention program
    Jeanne M McCaffery
    The Biostatistics Center, The George Washington University, Rockville, Maryland, United States of America
    PLoS ONE 6:e21518. 2011
    ..Here we sought to test whether these effects were apparent in high-risk individuals and modify treatment responses...
  11. ncbi Operating characteristics of sample size re-estimation with futility stopping based on conditional power
    John M Lachin
    The Biostatistics Center, Department of Epidemiology and Biostatistics and Statistics, The George Washington University, Rockville, MD 20852, USA
    Stat Med 25:3348-65. 2006
    ..Sample size re-estimation procedures should be used with caution and the impact on the overall type II error probability should be assessed...
  12. ncbi Parametric survival models for interval-censored data with time-dependent covariates
    Yvonne H Sparling
    The Biostatistics Center, Department of Biostatistics and Epidemiology, School of Public Health and Health Services, The George Washington University, Rockville, MD 20852, USA
    Biostatistics 7:599-614. 2006
    ....
  13. pmc Effect of weight loss with lifestyle intervention on risk of diabetes
    Richard F Hamman
    Diabetes Prevention Program Coordinating Center, The Biostatistics Center, George Washington University, 6110 Executive Blvd, Suite 750, Rockville, MD 20852, USA
    Diabetes Care 29:2102-7. 2006
    ..We explored the contribution of changes in weight, diet, and physical activity on the risk of developing diabetes among ILS participants...
  14. doi Impact of C-peptide preservation on metabolic and clinical outcomes in the Diabetes Control and Complications Trial
    John M Lachin
    The Biostatistics Center, The George Washington University, Rockville, MD
    Diabetes 63:739-48. 2014
    ..While preservation of stimulated C-peptide at ≥0.2 nmol/L has clinically beneficial outcomes, so also does an increase in the concentration of C-peptide across the range of values. ..
  15. doi Power and sample size evaluation for the Cochran-Mantel-Haenszel mean score (Wilcoxon rank sum) test and the Cochran-Armitage test for trend
    John M Lachin
    The Biostatistics Center, Departments of Epidemiology and Biostatistics and Statistics, The George Washington University, Rockville, MD, 20852, USA
    Stat Med 30:3057-66. 2011
    ..Herein, it is shown that the power of the test is a function of the slope of the response probabilities over the ordinal scores assigned to the groups that yields simple expressions for the power of the test...
  16. ncbi A composite design for transition from a preliminary to a full-scale study
    John M Lachin
    The Biostatistics Center, Department of Epidemiology and Biostatistics, The George Washington University, 6110 Executive Boulevard, Suite 750, Rockville, MD 20852, USA
    Stat Med 26:5014-32. 2007
    ..We also discuss the practical considerations in the implementation of the design...
  17. pmc Mixed-meal tolerance test versus glucagon stimulation test for the assessment of beta-cell function in therapeutic trials in type 1 diabetes
    Carla J Greenbaum
    TrialNet Publications, The Biostatistics Center, Rockville, Maryland, USA
    Diabetes Care 31:1966-71. 2008
    ..The Type 1 Diabetes TrialNet Research Group and the European C-peptide Trial (ECPT) Study Group conducted parallel randomized studies to compare the sensitivity, reproducibility, and tolerability of these procedures...
  18. pmc Differences in A1C by race and ethnicity among patients with impaired glucose tolerance in the Diabetes Prevention Program
    William H Herman
    Department of Internal Medicine and Epidemiology, University of Michigan Health System, Ann Arbor, Michigan, USA
    Diabetes Care 30:2453-7. 2007
    ..We sought to examine racial and ethnic differences in A1C in individuals with impaired glucose tolerance (IGT)...
  19. ncbi Conflicts of interest in data monitoring of industry versus publicly financed clinical trials
    John M Lachin
    The Biostatistics Center, Department of Epidemiology and Biostatistics, The George Washington University, Rockville, MD 20857, USA
    Stat Med 23:1519-21. 2004
    ..However, the Guidance should heighten the awareness of all investigators in public trials to the potential for the appearance of conflicts and to the need for full and open participation in the management of dualities of interest...
  20. pmc Antidepressant medicine use and risk of developing diabetes during the diabetes prevention program and diabetes prevention program outcomes study
    Richard R Rubin
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Diabetes Care 33:2549-51. 2010
    ..To assess the association between antidepressant medicine use and risk of developing diabetes during the Diabetes Prevention Program (DPP) and Diabetes Prevention Program Outcomes Study (DPPOS)...
  21. pmc Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
    William C Knowler
    Diabetes Prevention Program Coordinating Center, Biostatistics Center, George Washington University, 6110 Executive Blvd, Suite 750, Rockville, MD 20852, USA
    N Engl J Med 346:393-403. 2002
    ..We hypothesized that modifying these factors with a lifestyle-intervention program or the administration of metformin would prevent or delay the development of diabetes...
  22. ncbi Maximum information designs
    John M Lachin
    The Biostatistics Center, Department of Epidemiology and Biostatistics, The George Washington University, Rockville, Maryland 20852, USA
    Clin Trials 2:453-64. 2005
    ..Thus, the actual information to be accrued and the associated level of power are random variables with sample variation...
  23. ncbi A review of methods for futility stopping based on conditional power
    John M Lachin
    The Biostatistics Center, Department of Epidemiology and Biostatistics, The George Washington University, Rockville, MD 20852, USA
    Stat Med 24:2747-64. 2005
    ..The implementation in conjunction with a group sequential analysis for effectiveness is also described...
  24. doi Futility interim monitoring with control of type I and II error probabilities using the interim Z-value or confidence limit
    John M Lachin
    The Biostatistics Center, Departments of Epidemiology and Biostatistics, and Statistics, The George Washington University, Rockville 20852, MD, USA
    Clin Trials 6:565-73. 2009
    ..Each such assumption will yield a different conditional power value...
  25. pmc Costs associated with the primary prevention of type 2 diabetes mellitus in the diabetes prevention program
    William H Hernan
    The Diabetes Prevention Program Coordinating Center, Biostatistics Center, George Washington University, Rockville, Maryland 20852, USA
    Diabetes Care 26:36-47. 2003
    ..To describe the costs of the Diabetes Prevention Program (DPP) interventions to prevent or delay type 2 diabetes...
  26. ncbi The role of measurement reliability in clinical trials
    John M Lachin
    The Biostatistics Center, Departments of Epidemiology and Biostatistics and Statistics, The George Washington University, Rockville, MD 20852, USA
    Clin Trials 1:553-66. 2004
    ....
  27. pmc Relation between carotid intima-media thickness and left ventricular mass in type 1 diabetes mellitus (from the Epidemiology of Diabetes Interventions and Complications [EDIC] Study)
    Harjit Chahal
    Department of Radiology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Am J Cardiol 110:1534-40. 2012
    ..Furthermore, the relation observed between LV mass and cIMT was stronger in patients with shorter duration of DM. In conclusion, cIMT was an independent predictor of larger LV mass in a well-characterized population with type 1 DM...
  28. pmc Sample size evaluation for a multiply matched case-control study using the score test from a conditional logistic (discrete Cox PH) regression model
    John M Lachin
    Department of Epidemiology and Biostatistics, The Biostatistics Center, The George Washington University, Rockville, MD 20852, USA
    Stat Med 27:2509-23. 2008
    ..Examples are presented for a nested case-control study and a multiply matched case-control study...
  29. ncbi A tribute to Samuel W. Greenhouse
    John M Lachin
    The Biostatistics Center, The George Washington University, USA
    Stat Med 22:3267-76. 2003
  30. ncbi Group sequential large sample T2-like chi2 tests for multivariate observations
    John M Lachin
    The Biostatistics Center, The George Washington University, 6110 Executive Boulevard, Suite 750, Rockville, MD 20852, USA
    Stat Med 22:3357-68. 2003
    ..An example is presented using the analysis of repeated cholesterol measurements in a clinical trial...