Research Topics
Species | John M LachinSummaryAffiliation: George Washington University Country: USA Publications
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Publications
Power of the Mantel-Haenszel and other tests for discrete or grouped time-to-event data under a chained binomial modelJohn M Lachin
The Biostatistics Center, Departments of Epidemiology and Biostatistics, and Statistics, The George Washington University, 6110 Executive Boulevard, Suite 750, Rockville, MD 20852, USA
Stat Med 32:220-9. 2013....
Sample size requirements for studies of treatment effects on beta-cell function in newly diagnosed type 1 diabetesJohn M Lachin
The Biostatistics Center, The George Washington University, Rockville, Maryland, United States of America
PLoS ONE 6:e26471. 2011..These results provide the information needed to accurately evaluate the sample size for studies of new agents to preserve C-peptide levels in newly diagnosed type 1 diabetes...- Renal function in type 2 diabetes with rosiglitazone, metformin, and glyburide monotherapyJohn M Lachin
The Biostatistics Center, The George Washington University, Rockville, MD 20852, USA
Clin J Am Soc Nephrol 6:1032-40. 2011..Herein, we examine differences in albumin excretion, renal function (estimated GFR), and BP over 5 years between treatment groups... - Factors associated with diabetes onset during metformin versus placebo therapy in the diabetes prevention programJohn M Lachin
d, Diabetes Prevention Program Coordinating Center, The Biostatistics Center, George Washington University, 6110 Executive Blvd, Suite 750, Rockville, MD 20852, USA
Diabetes 56:1153-9. 2007.... - Comparison of urinary albumin-creatinine ratio and albumin excretion rate in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications studyNaji Younes
Biostatistics Center, George Washington University, 6110 Executive Boulevard, Suite 700, Rockville, MD 20852 USA
Clin J Am Soc Nephrol 5:1235-42. 2010..The objective of this study was to compare random urine albumin-creatinine ratio (ACR) with timed urine albumin excretion rate (AER) in patients with type 1 diabetes... - Effect of glycemic exposure on the risk of microvascular complications in the diabetes control and complications trial--revisitedJohn M Lachin
The Biostatistics Center, The George Washington University, Rockville, MD 20852, USA
Diabetes 57:995-1001. 2008.... 
The hemoglobin glycation index is not an independent predictor of the risk of microvascular complications in the Diabetes Control and Complications TrialJohn M Lachin
The Biostatistics Center, George Washington University, Rockville, MD 20852, USA
Diabetes 56:1913-21. 2007..The HGI should not be used to estimate risk of complications or to guide therapy...- TCF7L2 polymorphism, weight loss and proinsulin:insulin ratio in the diabetes prevention programJeanne M McCaffery
The Biostatistics Center, The George Washington University, Rockville, Maryland, United States of America
PLoS ONE 6:e21518. 2011..Here we sought to test whether these effects were apparent in high-risk individuals and modify treatment responses... - Effect of weight loss with lifestyle intervention on risk of diabetesRichard F Hamman
Diabetes Prevention Program Coordinating Center, The Biostatistics Center, George Washington University, 6110 Executive Blvd, Suite 750, Rockville, MD 20852, USA
Diabetes Care 29:2102-7. 2006..We explored the contribution of changes in weight, diet, and physical activity on the risk of developing diabetes among ILS participants... - A composite design for transition from a preliminary to a full-scale studyJohn M Lachin
The Biostatistics Center, Department of Epidemiology and Biostatistics, The George Washington University, 6110 Executive Boulevard, Suite 750, Rockville, MD 20852, USA
Stat Med 26:5014-32. 2007..We also discuss the practical considerations in the implementation of the design... - Mixed-meal tolerance test versus glucagon stimulation test for the assessment of beta-cell function in therapeutic trials in type 1 diabetesCarla J Greenbaum
TrialNet Publications, The Biostatistics Center, Rockville, Maryland, USA
Diabetes Care 31:1966-71. 2008..The Type 1 Diabetes TrialNet Research Group and the European C-peptide Trial (ECPT) Study Group conducted parallel randomized studies to compare the sensitivity, reproducibility, and tolerability of these procedures... - Differences in A1C by race and ethnicity among patients with impaired glucose tolerance in the Diabetes Prevention ProgramWilliam H Herman
Department of Internal Medicine and Epidemiology, University of Michigan Health System, Ann Arbor, Michigan, USA
Diabetes Care 30:2453-7. 2007..We sought to examine racial and ethnic differences in A1C in individuals with impaired glucose tolerance (IGT)... - Group sequential large sample T2-like chi2 tests for multivariate observationsJohn M Lachin
The Biostatistics Center, The George Washington University, 6110 Executive Boulevard, Suite 750, Rockville, MD 20852, USA
Stat Med 22:3357-68. 2003..An example is presented using the analysis of repeated cholesterol measurements in a clinical trial... - Conflicts of interest in data monitoring of industry versus publicly financed clinical trialsJohn M Lachin
The Biostatistics Center, Department of Epidemiology and Biostatistics, The George Washington University, Rockville, MD 20857, USA
Stat Med 23:1519-21. 2004..However, the Guidance should heighten the awareness of all investigators in public trials to the potential for the appearance of conflicts and to the need for full and open participation in the management of dualities of interest... - A review of methods for futility stopping based on conditional powerJohn M Lachin
The Biostatistics Center, Department of Epidemiology and Biostatistics, The George Washington University, Rockville, MD 20852, USA
Stat Med 24:2747-64. 2005..The implementation in conjunction with a group sequential analysis for effectiveness is also described... - Antidepressant medicine use and risk of developing diabetes during the diabetes prevention program and diabetes prevention program outcomes studyRichard R Rubin
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Diabetes Care 33:2549-51. 2010..To assess the association between antidepressant medicine use and risk of developing diabetes during the Diabetes Prevention Program (DPP) and Diabetes Prevention Program Outcomes Study (DPPOS)... - Futility interim monitoring with control of type I and II error probabilities using the interim Z-value or confidence limitJohn M Lachin
The Biostatistics Center, Departments of Epidemiology and Biostatistics, and Statistics, The George Washington University, Rockville 20852, MD, USA
Clin Trials 6:565-73. 2009..Each such assumption will yield a different conditional power value... - Operating characteristics of sample size re-estimation with futility stopping based on conditional powerJohn M Lachin
The Biostatistics Center, Department of Epidemiology and Biostatistics and Statistics, The George Washington University, Rockville, MD 20852, USA
Stat Med 25:3348-65. 2006..Sample size re-estimation procedures should be used with caution and the impact on the overall type II error probability should be assessed... - Parametric survival models for interval-censored data with time-dependent covariatesYvonne H Sparling
The Biostatistics Center, Department of Biostatistics and Epidemiology, School of Public Health and Health Services, The George Washington University, Rockville, MD 20852, USA
Biostatistics 7:599-614. 2006.... - Power and sample size evaluation for the Cochran-Mantel-Haenszel mean score (Wilcoxon rank sum) test and the Cochran-Armitage test for trendJohn M Lachin
The Biostatistics Center, Departments of Epidemiology and Biostatistics and Statistics, The George Washington University, Rockville, MD, 20852, USA
Stat Med 30:3057-66. 2011..Herein, it is shown that the power of the test is a function of the slope of the response probabilities over the ordinal scores assigned to the groups that yields simple expressions for the power of the test... - Costs associated with the primary prevention of type 2 diabetes mellitus in the diabetes prevention programWilliam H Hernan
The Diabetes Prevention Program Coordinating Center, Biostatistics Center, George Washington University, Rockville, Maryland 20852, USA
Diabetes Care 26:36-47. 2003..To describe the costs of the Diabetes Prevention Program (DPP) interventions to prevent or delay type 2 diabetes... - Relation between carotid intima-media thickness and left ventricular mass in type 1 diabetes mellitus (from the Epidemiology of Diabetes Interventions and Complications [EDIC] Study)Harjit Chahal
Department of Radiology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
Am J Cardiol 110:1534-40. 2012..Furthermore, the relation observed between LV mass and cIMT was stronger in patients with shorter duration of DM. In conclusion, cIMT was an independent predictor of larger LV mass in a well-characterized population with type 1 DM... - Maximum information designsJohn M Lachin
The Biostatistics Center, Department of Epidemiology and Biostatistics, The George Washington University, Rockville, Maryland 20852, USA
Clin Trials 2:453-64. 2005..Thus, the actual information to be accrued and the associated level of power are random variables with sample variation... - Sample size evaluation for a multiply matched case-control study using the score test from a conditional logistic (discrete Cox PH) regression modelJohn M Lachin
Department of Epidemiology and Biostatistics, The Biostatistics Center, The George Washington University, Rockville, MD 20852, USA
Stat Med 27:2509-23. 2008..Examples are presented for a nested case-control study and a multiply matched case-control study... - Reduction in the incidence of type 2 diabetes with lifestyle intervention or metforminWilliam C Knowler
Diabetes Prevention Program Coordinating Center, Biostatistics Center, George Washington University, 6110 Executive Blvd, Suite 750, Rockville, MD 20852, USA
N Engl J Med 346:393-403. 2002..9 would have to receive metformin. CONCLUSIONS: Lifestyle changes and treatment with metformin both reduced the incidence of diabetes in persons at high risk. The lifestyle intervention was more effective than metformin... - The role of measurement reliability in clinical trialsJohn M Lachin
The Biostatistics Center, Departments of Epidemiology and Biostatistics and Statistics, The George Washington University, Rockville, MD 20852, USA
Clin Trials 1:553-66. 2004.... - A tribute to Samuel W. GreenhouseJohn M Lachin
The Biostatistics Center, The George Washington University, USA
Stat Med 22:3267-76. 2003