J M Krum

Summary

Affiliation: George Washington University
Country: USA

Publications

  1. ncbi request reprint Angiogenic and astroglial responses to vascular endothelial growth factor administration in adult rat brain
    J M Krum
    Department of Anatomy and Cell Biology, The George Washington University Medical Center, Washington, DC 20037, USA
    Neuroscience 110:589-604. 2002
  2. ncbi request reprint Inhibition of endogenous VEGF impedes revascularization and astroglial proliferation: roles for VEGF in brain repair
    Janette M Krum
    Department of Anatomy and Cell Biology, George Washington University Medical Center, Washington, DC 20037, USA
    Exp Neurol 181:241-57. 2003
  3. ncbi request reprint Experimental gliopathy in the adult rat CNS: effect on the blood-spinal cord barrier
    J M Krum
    Department of Anatomy, George Washington University Medical Center, Washington, D C 20037
    Glia 11:354-66. 1994
  4. ncbi request reprint Effect of astroglial degeneration on the blood-brain barrier to protein in neonatal rats
    J M Krum
    Department of Anatomy, George Washington University Medical Center, Washington, DC 20037
    Brain Res Dev Brain Res 74:41-50. 1993
  5. pmc Roles of the endogenous VEGF receptors flt-1 and flk-1 in astroglial and vascular remodeling after brain injury
    Janette M Krum
    Department of Anatomy and Regenerative Biology, The George Washington University Medical Center, 2300 I Street NW, Washington, DC 20037, USA
    Exp Neurol 212:108-17. 2008
  6. ncbi request reprint Astrocyte growth effects of vascular endothelial growth factor (VEGF) application to perinatal neocortical explants: receptor mediation and signal transduction pathways
    Nina Mani
    Department of Anatomy and Cell Biology, Ross Hall 205, The George Washington University Medical Center, 2300 I Street, NW Washington, DC 20037, USA
    Exp Neurol 192:394-406. 2005
  7. doi request reprint Vascular endothelial growth factor enhances migration of astroglial cells in subventricular zone neurosphere cultures
    Nina Mani
    Department of Anatomy and Regenerative Biology, The George Washington University Medical Center, Washington, DC 20037, USA
    J Neurosci Res 88:248-57. 2010
  8. ncbi request reprint Effect of astroglial degeneration on neonatal blood-brain barrier marker expression
    J M Krum
    Department of Anatomy and Cell Biology, The George Washington University Medical Center, Washington, DC 20037, USA
    Exp Neurol 142:29-35. 1996
  9. ncbi request reprint Age-dependent susceptibility of CNS glial populations in situ to the antimetabolite 6-aminonicotinamide
    J M Krum
    Department of Anatomy, George Washington University Medical Center, Washington, DC 20037, USA
    Mol Chem Neuropathol 26:79-94. 1995
  10. ncbi request reprint Changes in astroglial GLT-1 expression after neural transplantation or stab wounds
    Janette M Krum
    Department of Anatomy and Cell Biology, The George Washington University Medical Center, Washington, DC 20037, USA
    Exp Neurol 174:137-49. 2002

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Angiogenic and astroglial responses to vascular endothelial growth factor administration in adult rat brain
    J M Krum
    Department of Anatomy and Cell Biology, The George Washington University Medical Center, Washington, DC 20037, USA
    Neuroscience 110:589-604. 2002
    ..From these results we suggest that administered VEGF has heretofore unanticipated pleiotrophic effects in the adult CNS...
  2. ncbi request reprint Inhibition of endogenous VEGF impedes revascularization and astroglial proliferation: roles for VEGF in brain repair
    Janette M Krum
    Department of Anatomy and Cell Biology, George Washington University Medical Center, Washington, DC 20037, USA
    Exp Neurol 181:241-57. 2003
    ..VEGF appears to be an integral factor in CNS wound healing that is essential for vascular endothelial proliferation and survival and may also be necessary for astroglial proliferation and maintenance during the repair of brain injury...
  3. ncbi request reprint Experimental gliopathy in the adult rat CNS: effect on the blood-spinal cord barrier
    J M Krum
    Department of Anatomy, George Washington University Medical Center, Washington, D C 20037
    Glia 11:354-66. 1994
    ..Some venous structures were surrounded by hemorrhages and HRP reaction product. Thus, astrocytic injury may alter venous, and possibly microvascular, permeability to macromolecules...
  4. ncbi request reprint Effect of astroglial degeneration on the blood-brain barrier to protein in neonatal rats
    J M Krum
    Department of Anatomy, George Washington University Medical Center, Washington, DC 20037
    Brain Res Dev Brain Res 74:41-50. 1993
    ....
  5. pmc Roles of the endogenous VEGF receptors flt-1 and flk-1 in astroglial and vascular remodeling after brain injury
    Janette M Krum
    Department of Anatomy and Regenerative Biology, The George Washington University Medical Center, 2300 I Street NW, Washington, DC 20037, USA
    Exp Neurol 212:108-17. 2008
    ..It is likely that VEGF plays an important role in aspects of astroglial scar formation...
  6. ncbi request reprint Astrocyte growth effects of vascular endothelial growth factor (VEGF) application to perinatal neocortical explants: receptor mediation and signal transduction pathways
    Nina Mani
    Department of Anatomy and Cell Biology, Ross Hall 205, The George Washington University Medical Center, 2300 I Street, NW Washington, DC 20037, USA
    Exp Neurol 192:394-406. 2005
    ..VEGF, an established angiogenic factor, appears to play a significant role in the growth and differentiation of astrocytes in the CNS...
  7. doi request reprint Vascular endothelial growth factor enhances migration of astroglial cells in subventricular zone neurosphere cultures
    Nina Mani
    Department of Anatomy and Regenerative Biology, The George Washington University Medical Center, Washington, DC 20037, USA
    J Neurosci Res 88:248-57. 2010
    ..VEGF is also an important growth and migratory factor particularly for GFAP(+) cells developing in SVZ-derived NS in culture...
  8. ncbi request reprint Effect of astroglial degeneration on neonatal blood-brain barrier marker expression
    J M Krum
    Department of Anatomy and Cell Biology, The George Washington University Medical Center, Washington, DC 20037, USA
    Exp Neurol 142:29-35. 1996
    ....
  9. ncbi request reprint Age-dependent susceptibility of CNS glial populations in situ to the antimetabolite 6-aminonicotinamide
    J M Krum
    Department of Anatomy, George Washington University Medical Center, Washington, DC 20037, USA
    Mol Chem Neuropathol 26:79-94. 1995
    ..The results suggest the presence of heterogeneous populations of glia whose preferred use of the hexose monophosphate pathway is predicated on both the age of the animal and their location in the CNS...
  10. ncbi request reprint Changes in astroglial GLT-1 expression after neural transplantation or stab wounds
    Janette M Krum
    Department of Anatomy and Cell Biology, The George Washington University Medical Center, Washington, DC 20037, USA
    Exp Neurol 174:137-49. 2002
    ..c)2002 Elsevier Science (USA)...
  11. ncbi request reprint Neurotrophic effects of vascular endothelial growth factor on organotypic cortical explants and primary cortical neurons
    Jeffrey M Rosenstein
    Department of Anatomy and Cell Biology, The George Washington University Medical Center, Washington, DC 20037, USA
    J Neurosci 23:11036-44. 2003
    ..Several studies have now shown that VEGF is neurotrophic and neuroprotective independent of a vascular component; we suggest that VEGF plays seminal pleiotrophic roles in CNS development and repair...
  12. ncbi request reprint Activation of receptor-mediated angiogenesis and signaling pathways after VEGF administration in fetal rat CNS explants
    Nina Mani
    Department of Anatomy and Cell Biology, The George University Medical Center, Washington, DC 20037, USA
    J Cereb Blood Flow Metab 23:1420-9. 2003
    ....
  13. ncbi request reprint Vascular endothelial growth factor promotes neurite maturation in primary CNS neuronal cultures
    Alfia A Khaibullina
    The George Washington University, Medical Center, Department of Anatomy and Cell Biology, 2300 I Street, NW, Washington, DC 20037, USA
    Brain Res Dev Brain Res 148:59-68. 2004
    ..These experiments suggest that VEGF has a direct effect on neuronal growth and maturation under normoxic conditions during CNS development, which is mediated by the VEGFR2 receptor via the MAPK pathway...
  14. ncbi request reprint New roles for VEGF in nervous tissue--beyond blood vessels
    Jeffrey M Rosenstein
    Department of Anatomy and Cell Biology, The George Washington University Medical Center, Washington, DC 20037, USA
    Exp Neurol 187:246-53. 2004
    ..It is now apparent that VEGF's role in nervous tissue is pleiotropic in nature, and further elucidation of its mechanisms of action may serve as a key substrate in understanding aspects of neural repair and development...