Kylene Kehn-Hall

Summary

Affiliation: George Mason University
Country: USA

Publications

  1. Kendra J, de La Fuente C, Brahms A, Woodson C, Bell T, Chen B, et al. Ablation of Programmed -1 Ribosomal Frameshifting in Venezuelan Equine Encephalitis Virus Results in Attenuated Neuropathogenicity. J Virol. 2017;91: pubmed publisher
    ..These findings suggest a new approach to the development of safe and effective live attenuated vaccines directed against VEEV and other related viruses. ..
  2. Lin S, Chen M, Liu S, Callahan V, Bracci N, Woodson C, et al. Phloretin Inhibits Zika Virus Infection by Interfering with the Cellular Glucose Utilization. Int J Antimicrob Agents. 2019;: pubmed publisher
    ..The activity of phloretin and its role in inhibiting glucose uptake could provide a useful foundation for the development of ZIKV antivirals. ..
  3. Carey B, Bakovic A, Callahan V, Narayanan A, Kehn Hall K. New World alphavirus protein interactomes from a therapeutic perspective. Antiviral Res. 2019;163:125-139 pubmed publisher
    ..Non-structural protein 3 (nsP3), capsid, and E2 proteins have garnered attention in recent years, whereas little is known regarding host protein interactions of the other viral proteins and is an important avenue for future study. ..
  4. Sampey G, Guendel I, Das R, Jaworski E, Klase Z, Narayanan A, et al. Transcriptional Gene Silencing (TGS) via the RNAi Machinery in HIV-1 Infections. Biology (Basel). 2012;1:339-69 pubmed publisher
    ..Here we examine the latest findings regarding mammalian TGS, specifically focusing on HIV-1 infected cells, and discuss future avenues of exploration in this field. ..
  5. Pinkham C, Ahmed A, Bracci N, Narayanan A, Kehn Hall K. Host-based processes as therapeutic targets for Rift Valley fever virus. Antiviral Res. 2018;160:64-78 pubmed publisher
    ..Therapeutics targeted towards host processes that are essential for RVFV to thrive as well as their efficacy and importance to viral pathogenesis are highlighted. ..
  6. Madsen C, Hooper I, Lundberg L, Shafagati N, Johnson A, Senina S, et al. Small molecule inhibitors of Ago2 decrease Venezuelan equine encephalitis virus replication. Antiviral Res. 2014;112:26-37 pubmed publisher
    ..These results suggest that inhibition of Ago2 results in decreased replication of encephalitic alphaviruses in vitro and this pathway may be an avenue to explore for future therapeutic development. ..
  7. Bell T, Espina V, Lundberg L, Pinkham C, Brahms A, Carey B, et al. Combination Kinase Inhibitor Treatment Suppresses Rift Valley Fever Virus Replication. Viruses. 2018;10: pubmed publisher
    ..These findings serve as a proof of concept regarding combination kinase inhibitor treatment for RVFV infection. ..
  8. Carey B, Ammosova T, Pinkham C, Lin X, Zhou W, Liotta L, et al. Protein Phosphatase 1α Interacts with Venezuelan Equine Encephalitis Virus Capsid Protein and Regulates Viral Replication through Modulation of Capsid Phosphorylation. J Virol. 2018;92: pubmed publisher
    ..Inhibition of PP1 also inhibited multiple biomedically important alphaviruses, indicating that PP1 may be a potential therapeutic target for alphavirus-induced disease. ..
  9. Lundberg L, Brahms A, Hooper I, Carey B, Lin S, Dahal B, et al. Repurposed FDA-Approved drug sorafenib reduces replication of Venezuelan equine encephalitis virus and other alphaviruses. Antiviral Res. 2018;157:57-67 pubmed publisher

More Information

Publications17

  1. Guendel I, Meltzer B, Baer A, Dever S, Valerie K, Guo J, et al. BRCA1 functions as a novel transcriptional cofactor in HIV-1 infection. Virol J. 2015;12:40 pubmed publisher
    ..The BRCA1 pathway or enzymes that phosphorylate BRCA1 could potentially be used as complementary host-based treatment for combined antiretroviral therapy, as there are multiple potent ATM inhibitors in development as chemotherapeutics. ..
  2. Baer A, Shafagati N, Benedict A, Ammosova T, Ivanov A, Hakami R, et al. Protein Phosphatase-1 regulates Rift Valley fever virus replication. Antiviral Res. 2016;127:79-89 pubmed publisher
    ..These results indicate that PP1 activity is important for RVFV replication early on during the viral life cycle and may prove an attractive therapeutic target. ..
  3. Pinkham C, An S, Lundberg L, Bansal N, Benedict A, Narayanan A, et al. The role of signal transducer and activator of transcription 3 in Rift Valley fever virus infection. Virology. 2016;496:175-185 pubmed publisher
    ..Collectively, these data demonstrate that STAT3 functions in a pro-survival capacity through modulation of NSs localization. ..
  4. Bell T, Espina V, Senina S, Woodson C, Brahms A, Carey B, et al. Rapamycin modulation of p70 S6 kinase signaling inhibits Rift Valley fever virus pathogenesis. Antiviral Res. 2017;143:162-175 pubmed publisher
    ..Additionally, the phosphorylation of p70 S6 kinase was decreased following rapamycin treatment in vivo. Collectively these data demonstrate modulating p70 S6 kinase can be an effective antiviral strategy. ..
  5. Pinkham C, Dahal B, DE LA FUENTE C, Bracci N, Beitzel B, Lindquist M, et al. Alterations in the host transcriptome in vitro following Rift Valley fever virus infection. Sci Rep. 2017;7:14385 pubmed publisher
    ..Overall, this is the first global transcriptomic analysis of the human host response following RVFV infection, which could give insight into novel host responses that have not yet been explored. ..
  6. Brahms A, Mudhasani R, Pinkham C, Kota K, Nasar F, Zamani R, et al. Sorafenib Impedes Rift Valley Fever Virus Egress by Inhibiting Valosin-Containing Protein Function in the Cellular Secretory Pathway. J Virol. 2017;91: pubmed publisher
    ..The significance of our research is in identifying the cellular target of sorafenib that inhibits RVFV propagation, so that this information can be used as a tool for the further development of therapeutics used to treat RVFV infection. ..
  7. Lundberg L, Carey B, Kehn Hall K. Venezuelan Equine Encephalitis Virus Capsid-The Clever Caper. Viruses. 2017;9: pubmed publisher
    ..Herein, the role of VEEV capsid in viral replication and pathogenesis will be discussed including a comparison to proteins of other alphaviruses. ..
  8. Baer A, Kehn Hall K. Viral concentration determination through plaque assays: using traditional and novel overlay systems. J Vis Exp. 2014;:e52065 pubmed publisher
    ..Liquid overlays may also prove more sensitive than traditional overlays for certain heat labile viruses. ..