Research Topics
| Peter HotezSummaryAffiliation: George Washington University Country: USA Publications
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Publications
Soil-transmitted helminth infections: updating the global pictureNilanthi R de Silva
Department of Parasitology, Faculty of Medicine, University of Kelaniya, PO Box 6, Ragama, Sri Lanka
Trends Parasitol 19:547-51. 2003- Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookwormJeffrey Bethony
Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University, Washington, DC, 20037, USA
Lancet 367:1521-32. 2006..Concerns about the sustainability of periodic deworming with benzimidazole anthelmintics and the emergence of resistance have prompted efforts to develop and test new control tools... - Incorporating appropriate technology into North American schools of public healthPeter Hotez
Department of Microbiology, George Washington University, Washington, DC, USA
Rev Panam Salud Publica 19:118-23. 2006 - Hookworm and povertyPeter Hotez
Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University, Washington, DC, USA
Ann N Y Acad Sci 1136:38-44. 2008.... 
Helminth infections: the great neglected tropical diseasesPeter J Hotez
Department of Microbiology, Immunology, and Tropical Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA
J Clin Invest 118:1311-21. 2008..Ultimately, these advances in molecular and medical helminth biology should one day translate into a new and robust pipeline of drugs, diagnostics, and vaccines for targeting parasitic worms that infect humans...- Neglected infections of poverty in the United States of AmericaPeter J Hotez
Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University and Sabin Vaccine Institute, Washington, D C, USA
PLoS Negl Trop Dis 2:e256. 2008.... - The antipoverty vaccinesPeter J Hotez
Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University and the Sabin Vaccine Institute, Washington, DC 20037, USA
Vaccine 24:5787-99. 2006..Early development of such antipoverty vaccines will require the establishment of product development public-private partnerships and partnerships with innovative developing countries where these diseases are endemic... 
Neglected diseases amid wealth in the United States and EuropePeter Hotez
Department of Microbiology, Immunology, and Tropical Medicine at George Washington University in Washington, DC, USA
Health Aff (Millwood) 28:1720-5. 2009..Similar infections also occur in Europe. As efforts to control neglected tropical diseases expand throughout Africa, parallel efforts should also target poor and forgotten people in wealthy nations...- Molecular cloning, biochemical characterization, and partial protective immunity of the heme-binding glutathione S-transferases from the human hookworm Necator americanusBin Zhan
Department of Microbiology and Tropical Medicine, The George Washington University and Sabin Vaccine Institute, Ross Hall 736, 2300 Eye St NW, Washington, DC 20037, USA
Infect Immun 78:1552-63. 2010..In contrast, no protection was observed in vaccine trials with Na-GST-2 or Na-GST-3. On the basis of these and other preclinical data, Na-GST-1 is under possible consideration for further vaccine development... - Molecular cloning and characterization of Ac-TMP-2, a tissue inhibitor of metalloproteinase secreted by adult Ancylostoma caninumBin Zhan
Department of Microbiology, Immunology and Tropical Medicine, The George Washington University and the Sabin Vaccine Institute, Washington, DC 20037, USA
Mol Biochem Parasitol 162:142-8. 2008..As an immunodominant protein having a possible role in the parasite-host relationship of canine hookworm infection, recombinant Ac-TMP-2 represents a plausible target for vaccine development... - Reduction of worm fecundity and canine host blood loss mediates protection against hookworm infection elicited by vaccination with recombinant Ac-16Ricardo T Fujiwara
Department of Microbiology, Immunology and Tropical Medicine, The George Washington University, Ross Hall Room 727, 2300 Eye St NW, Washington, DC 20037, USA
Clin Vaccine Immunol 14:281-7. 2007..Our data support the use of Ac-16 as a potential candidate for vaccination against hookworm infection... - Molecular cloning and characterization of Ac-MTP-2, an astacin-like metalloprotease released by adult Ancylostoma caninumJianjun Feng
Department of Microbiology, Immunology and Tropical Medicine, The George Washington University and Sabin Vaccine Institute, Washington, DC 20037, USA
Mol Biochem Parasitol 152:132-8. 2007..It is hypothesized that Ac-MTP-2 functions in the extracorporeal digestion of the intestinal mucosal plug lodged in the buccal capsule of the adult parasite... - Ac-AP-12, a novel factor Xa anticoagulant peptide from the esophageal glands of adult Ancylostoma caninumDesheng Jiang
Department of Microbiology, Immunology and Tropical Medicine, The George Washington University and the Sabin Vaccine Institute, Washington, DC 20037, USA
Mol Biochem Parasitol 177:42-8. 2011..Immunolocalization with specific rabbit antiserum showed that Ac-AP-12 was exclusively located in the esophageal glands of adult hookworm. Ac-AP-12 is hypothesized to facilitate both parasite blood feeding and digestion... - A handful of 'antipoverty' vaccines exist for neglected diseases, but the world's poorest billion people need morePeter Hotez
Sabin Vaccine Institute, Washington, DC, USA
Health Aff (Millwood) 30:1080-7. 2011.... - The neglected tropical diseases: the ancient afflictions of stigma and poverty and the prospects for their control and eliminationPeter Hotez
Department of Microbiology, Immunology and Tropical Medicine, The George Washington University and Sabin Vaccine Institute, Washington, DC 20037, USA
Adv Exp Med Biol 582:23-33. 2006 - Immunogenicity of the hookworm Na-ASP-2 vaccine candidate: characterization of humoral and cellular responses after vaccination in the Sprague Dawley ratRicardo T Fujiwara
Department of Microbiology and Tropical Medicine, The George Washington University Medical Center, Washington, DC 20037, USA
Hum Vaccin 1:123-8. 2005..Host IL-6 levels were also significantly elevated. These data provide evidence that the immune response of the Na-ASP-2 vaccine is robust and durable and therefore suitable for the further clinical development of the Na-ASP-2 vaccine... - New vaccines for developing countries: will it be feast or famine?Jon Kim Andrus
Comprehensive Family Immunization Project, Pan American Health Organization, Washington, D C, USA
Am J Law Med 35:311-22. 2009..The alternative, namely to bypass the Revolving Fund, could severely threaten the health of the region, especially Latin America's poorest people... - Recent progress in integrated neglected tropical disease controlPeter Hotez
Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University and Sabin Vaccine Institute, 2300 I Street NW, Washington, DC 20037, USA
Trends Parasitol 23:511-4. 2007..who.int/dg/speeches/2007). Outlined here is a summary of the recent progress in global efforts to integrate NTD control, with an emphasis on the challenges that lie ahead... - The neglected tropical diseases of Latin America and the Caribbean: a review of disease burden and distribution and a roadmap for control and eliminationPeter J Hotez
Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University and Sabin Vaccine Institute, Washington, DC, USA
PLoS Negl Trop Dis 2:e300. 2008..Ultimately, the roadmap for the control and elimination of the more widespread NTDs will require an inter-sectoral approach that bridges public health, social services, and environmental interventions... - Hookworm: "the great infection of mankind"Peter J Hotez
Department of Microbiology and Tropical Medicine, The George Washington University, Washington, DC, USA
PLoS Med 2:e67. 2005 - Combating tropical infectious diseases: report of the Disease Control Priorities in Developing Countries ProjectPeter J Hotez
George Washington University, Washington, DC, USA
Clin Infect Dis 38:871-8. 2004..Application of technologies must be cost-effective and intensified research is essential if these and other scourges are to be controlled or eliminated in the 21st century... - Expression of the Necator americanus hookworm larval antigen Na-ASP-2 in Pichia pastoris and purification of the recombinant protein for use in human clinical trialsGaddam Narsa Goud
Department of Microbiology and Tropical Medicine, The George Washington University Medical Center, Ross Hall 736, 2300 Eye Street NW, Washington, DC 20037, USA
Vaccine 23:4754-64. 2005..The processes developed and tested for the high yield production of recombinant Na-ASP-2 provide a foundation for clinical vaccine development... - The National Institutes of Health roadmap and the developing worldPeter J Hotez
Department of Microbiology and Tropical Medicine, The George Washington University, Washington, DC 20037, USA
J Investig Med 52:246-7. 2004 - Control of neglected tropical diseasesPeter J Hotez
Sabin Vaccine Institute, and the Department of Microbiology, Immunology, and Tropical Medicine, George Washington University, Washington, DC 20037, USA
N Engl J Med 357:1018-27. 2007 - Vaccination of dogs with a recombinant cysteine protease from the intestine of canine hookworms diminishes the fecundity and growth of wormsAlex Loukas
Department of Microbiology and Tropical Medicine, George Washington University Medical Center, Washington, DC, USA
J Infect Dis 189:1952-61. 2004..These results indicate that cysteine proteases involved in parasite nutrition are promising candidates as vaccines against hookworm disease... - Hookworm vaccinesDavid J Diemert
Sabin Vaccine Institute, George Washington University, Washington, DC 20037, USA
Clin Infect Dis 46:282-8. 2008..Plans call for eventual development of a vaccine that will combine at least 2 hookworm antigens--one targeting the larval stage of the life cycle and another targeting the adult worm living in the gastrointestinal tract... - Effect of vaccination with a recombinant fusion protein encoding an astacinlike metalloprotease (MTP-1) secreted by host-stimulated Ancylostoma caninum third-stage infective larvaePeter J Hotez
Department of Microbiology and Tropical Medicine and Sabin Vaccine Institute, The George Washington University Medical Center, 2300 Eye Street NW, Washington, DC 20037, USA
J Parasitol 89:853-5. 2003..89; P = 0.04), suggesting that this molecule offers promise as a recombinant vaccine... - Multivalent anthelminthic vaccine to prevent hookworm and schistosomiasisPeter J Hotez
Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University and Sabin Vaccine Institute, Washington, DC, USA
Expert Rev Vaccines 7:745-52. 2008..A multivalent anthelminthic vaccine for hookworm infection and schistosomiasis would represent an important new tool for combating disease and poverty... - Escalating the global fight against neglected tropical diseases through interventions in the Asia Pacific regionPeter J Hotez
Department of Microbiology, Immunology, and Tropical Medicine, George Washington University, Washington, District of Columbia, USA
Adv Parasitol 72:31-53. 2010..Through a global network for NTDs, an innovative finance mechanism Is being created to control the most common neglected diseases across Asia... - Developing vaccines to combat hookworm infection and intestinal schistosomiasisPeter J Hotez
Department of Microbiology, Immunology, and Tropical Medicine, George Washington University, Washington, DC 20037, USA
Nat Rev Microbiol 8:814-26. 2010..New genomic, proteomic, immunological and X-ray crystallographic data have led to the discovery of several promising candidate vaccine antigens. Here, we describe recent progress in this field and the rationale for vaccine development... - Effect of vaccinations with recombinant fusion proteins on Ancylostoma caninum habitat selection in the canine intestinePeter J Hotez
Department of Microbiology and Tropical Medicine, Sabin Vaccine Institute, George Washington University Medical Center, 2300 Eye Street NW, Washington, D.C. 20037, USA
J Parasitol 88:684-90. 2002..Female adult hookworms were more likely to migrate into the colon than were males. Anti-enzyme and anti-enzyme inhibitor antibodies correlated with an alteration in adult hookworm habitat selection in the canine gastroinntestinal tract... - The impact of concurrent and treated Ancylostoma ceylanicum hookworm infections on the immunogenicity of a recombinant hookworm vaccine in hamstersKashinath Ghosh
Department of Microbiology and Tropical Medicine, George Washington University Medical Center, Washington, DC 20037, USA
J Infect Dis 193:155-62. 2006..The hookworm-associated immunodepression may have important implications for design of clinical trials of human vaccines and vaccination strategies... - Incorporating a rapid-impact package for neglected tropical diseases with programs for HIV/AIDS, tuberculosis, and malariaPeter J Hotez
Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University, Washington, District of Columbia, USA
PLoS Med 3:e102. 2006 - An ounce of prevention on a budget: a nonprofit approach to developing vaccines against neglected diseasesMaria Elena Bottazzi
The George Washington University, The Human Hookworm Vaccine Initiative, Department of Microbiology, Immunology and Tropical Medicine, 2300 Eye Street NW, Ross Hall Room 733, Washington, DC 20037, USA
Expert Rev Vaccines 5:189-98. 2006..Throughout this perspective, special emphasis is placed on the growing promise that product development public-private partnerships hold for developing vaccines for the world's poorest people... - Antibodies against a secreted protein from hookworm larvae reduce the intensity of hookworm infection in humans and vaccinated laboratory animalsJeffrey Bethony
Department of Microbiology and Tropical Medicine, The George Washington University, Washington, DC 20037, USA
FASEB J 19:1743-5. 2005..These findings provide strong support for the development of an effective recombinant vaccine against hookworm infection in humans... - Vaccination with irradiated Ancylostoma caninum third stage larvae induces a Th2 protective response in dogsRicardo T Fujiwara
Department of Microbiology and Tropical Medicine, The George Washington University, 2300 Eye Street, Ross Hall Room 727, Medical Center, Washington, DC 20037, USA
Vaccine 24:501-9. 2006.... - Helminth infections of children: prospects for controlPeter J Hotez
Department of Microbiology and Tropical Medicine, The George Washington University Medical Center, Washington, DC 20037, USA
Adv Exp Med Biol 568:135-44. 2005 - Biochemical characterization and vaccine potential of a heme-binding glutathione transferase from the adult hookworm Ancylostoma caninumBin Zhan
Department of Microbiology and Tropical Medicine, The George Washington University, Washington, DC 20037, USA
Infect Immun 73:6903-11. 2005..7%) following challenge with heterologous Necator americanus larvae. These studies suggest that Ac-GST-1 is a possible drug and vaccine target for hookworm infection... - Should we establish a North American school of global health sciences?Peter J Hotez
Department of Microbiology and Tropical Medicine, Global Health, Epidemiology and Biostatistics, The George Washington University, Washington, DC 20037, USA
Am J Med Sci 328:71-7. 2004..The North American school, possibly in association with one of the existing schools of medicine or public health, would provide interdisciplinary training to produce a new generation of global health scientists... - Helminth vaccines: from mining genomic information for vaccine targets to systems used for protein expressionJohn P Dalton
School of Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland
Int J Parasitol 33:621-40. 2003.... - Progress in the development of a recombinant vaccine for human hookworm disease: the Human Hookworm Vaccine InitiativePeter J Hotez
Department of Microbiology and Tropical Medicine, The George Washington University, Washington, DC, USA
Int J Parasitol 33:1245-58. 2003..Another challenge will be to produce anti-hookworm vaccine antigens at high yield low cost suitable for immunising large impoverished populations living in the developing nations of the tropics... - "Rapid-impact interventions": how a policy of integrated control for Africa's neglected tropical diseases could benefit the poorDavid H Molyneux
Lymphatic Filariasis Support Centre at the Liverpool School of Tropical Medicine, Liverpool, United Kingdom
PLoS Med 2:e336. 2005 - Erosion of William Henry Welch's concept of the hygienic laboratory in our nation's schools of public health and medicinePeter J Hotez
Department of Microbiology and Tropical Medicine, The George Washington University Medical Center, Washington DC 20037, USA
Public Health Rep 118:184-6. 2003 - Vaccination with recombinant aspartic hemoglobinase reduces parasite load and blood loss after hookworm infection in dogsAlex Loukas
Division of Infectious Diseases and Immunology, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
PLoS Med 2:e295. 2005..The parasites subsequently digest hemoglobin in their intestines using a cascade of proteolysis that begins with the Ancylostoma caninum aspartic protease 1, APR-1... - Randomized, placebo-controlled, double-blind trial of the Na-ASP-2 hookworm vaccine in unexposed adultsJeffrey M Bethony
Department of Microbiology, Immunology and Tropical Medicine, George Washington University Health Center, Washington, DC 20037, United States
Vaccine 26:2408-17. 2008.... - Cures for the Third World's problems: the application of genomics to the diseases plaguing the developing world may have huge medical and economic benefits for those countries and might even prevent armed conflictSamuel Broder
Clera Genomics, Rockville, MD, USA
EMBO Rep 3:806-12. 2002 - Effect of combining the larval antigens Ancylostoma secreted protein 2 (ASP-2) and metalloprotease 1 (MTP-1) in protecting hamsters against hookworm infection and disease caused by Ancylostoma ceylanicumSusana Mendez
Department of Microbiology and Tropical Medicine and Sabin Vaccine Institute, The George Washington University Medical Center, Rose Hall 736, 2300 Eye Street, NW, Washington, DC 20037, USA
Vaccine 23:3123-30. 2005..Taken together, these data suggest that combination of two or more antigens may present an effective vaccine development strategy to improve protection and/or disease symptoms in affected individuals... - New technologies for the control of human hookworm infectionPeter J Hotez
Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University, 2300 I Street, NW Washington, DC 20037, USA
Trends Parasitol 22:327-31. 2006..g. tribendimidine) and a recombinant hookworm vaccine. It is hoped that, ultimately, anthelmintic vaccination will be linked to deworming as part of an expanded control package... - Health innovation networks to help developing countries address neglected diseasesCarlos M Morel
Center for Technological Development in Health, Oswaldo Cruz Foundation FIOCRUZ, Avenida Brasil 4365, Rio de Janeiro, RJ 21040 900, Brazil
Science 309:401-4. 2005..Here we highlight a complementary and increasingly important means to improve health equity: the growing ability of some developing countries to undertake health innovation... - X-ray structure of Na-ASP-2, a pathogenesis-related-1 protein from the nematode parasite, Necator americanus, and a vaccine antigen for human hookworm infectionOluwatoyin A Asojo
Eppley Institute for Research in Cancer and Allied Diseases, 987696 Nebraska Medical Center, Omaha, NE 68198 7696, USA
J Mol Biol 346:801-14. 2005..From these modeling studies, possible binding modes were predicted. In addition, this first structure of a PR-1 protein from parasitic helminths may shed light on the molecular basis of host-parasite interactions... - Contrasting patterns in the small-scale heterogeneity of human helminth infections in urban and rural environments in BrazilSimon Brooker
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, WCIE 7HT, UK
Int J Parasitol 36:1143-51. 2006..We suggest that such species-specific differences in patterns of infection by environment are primarily due to variation in exposure and parasite life cycle, although host genetic factors cannot be ruled out... - Human hookworm infection in the 21st centurySimon Brooker
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
Adv Parasitol 58:197-288. 2004..There are also on-going efforts to develop novel anthelmintic drugs and anti-hookworm vaccines... - The co-distribution of Plasmodium falciparum and hookworm among African schoolchildrenSimon Brooker
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, UK
Malar J 5:99. 2006..This is despite the potential public health importance of co-infection and synergistic opportunities for control... - Neglected tropical diseases and HIV/AIDSPeter J Hotez
Lancet 368:1865-6. 2006 - Hookworm infectionPeter J Hotez
Department of Microbiology and Tropical Medicine, George Washington University, Washington, DC 20037, USA
N Engl J Med 351:799-807. 2004 - Fighting tropical diseasesJeffrey D Sachs
Science 311:1521. 2006 - Synergistic associations between hookworm and other helminth species in a rural community in BrazilFiona M Fleming
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, UK
Trop Med Int Health 11:56-64. 2006..More research is needed to examine the rates of re-infection and immune responses after chemotherapy, and to what extent the effects of polyparasitism are altered by chemotherapy... - Epidemiology of plasmodium-helminth co-infection in Africa: populations at risk, potential impact on anemia, and prospects for combining controlSimon Brooker
London School of Hygiene and Tropical Medicine, Kepel Street, London, United Kingdom
Am J Trop Med Hyg 77:88-98. 2007..We suggest that both school-age children and pregnant women--groups which have the highest risk of anemia--would benefit from an integrated approach to malaria and helminth control...