Research Topics
| Frederick K GoodwinSummaryAffiliation: George Washington University Country: USA Publications
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Detail Information
Publications
"Cade's disease" and beyond: misdiagnosis, antidepressant use, and a proposed definition for bipolar spectrum disorderS Nassir Ghaemi
Department of Psychiatry, Cambridge Hospital, 1493 Cambridge Street, Cambridge, MA 02139, USA
Can J Psychiatry 47:125-34. 2002..The role of antidepressants is also controversial. Our review of the evidence leads us to conclude that there should be less emphasis on using antidepressants to treat persons with this illness...- Substance use disorder and other predictors of antidepressant-induced mania: a retrospective chart reviewSumita G Manwani
Bipolar Disorder Research Program, Department of Psychiatry, Cambridge Health Alliance, Cambridge, MA, USA
J Clin Psychiatry 67:1341-5. 2006..Type II illness, female gender, and TCA use also appeared to be predictors of ADM, while bupropion use appeared to predict lower likelihood of ADM... - Long-term lamotrigine plus lithium for bipolar disorder: One year outcomeS Nassir Ghaemi
Department of Psychiatry, School of Medicine, Emory University, GA, USA
J Psychiatr Pract 12:300-5. 2006..To obtain pilot data in an observational setting on the use of lamotrigine plus lithium in the long-term treatment of patients with bipolar disorder, 87% of whom had failed to respond to at least one previous mood stabilizer... - ACNP Task Force report on SSRIs and suicidal behavior in youthJ John Mann
Columbia University New York State Psychiatric Institute, New York, NY 10032, USA
Neuropsychopharmacology 31:473-92. 2006.... - Use of olanzapine in the treatment of bipolar I disorderDaniel Z Lieberman
George Washington University Medical Faculty Associates, 2300 I Street NW, Washington, DC 20037, USA
Expert Rev Neurother 4:759-67. 2004..Weight gain and sedation are prominent adverse effects, and it has been associated with atherogenic dyslipidemia and glucose intolerance... - Rationale for long-term treatment of bipolar disorder and evidence for long-term lithium treatmentFrederick K Goodwin
Psychopharmacology Research Center, George Washington University Medical Center, Washington, DC, USA
J Clin Psychiatry 63:5-12. 2002..Until newer agents have comparable evidence of efficacy, lithium will be considered a first-line long-term treatment for bipolar disorder, either as monotherapy or in combination therapy... - Rationale for using lithium in combination with other mood stabilizers in the management of bipolar disorderFrederick K Goodwin
Psychopharmacology Research Center, George Washington University Medical Center, Washington, D C 20037, USA
J Clin Psychiatry 64:18-24. 2003..Also, each mood stabilizer may be given at lower doses when given in combination, resulting in a reduced side effect burden and improved compliance... - Suicide risk in bipolar disorder during treatment with lithium and divalproexFrederick K Goodwin
Department of Psychiatry, George Washington University Medical Center, Washington, DC 20037, USA
JAMA 290:1467-73. 2003.... - Impact of formularies on clinical innovationFrederick K Goodwin
Psychopharmacology Research Center, George Washington University Medical Center, Washington, DC, 20037, USA
J Clin Psychiatry 64:11-4. 2003..Preserving the climate for innovation in health care requires the management culture to focus on the long-term impact of policies on quality and innovation as well as on the overall health cost in the system... 
Antidepressant discontinuation in bipolar depression: a Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) randomized clinical trial of long-term effectiveness and safetyS Nassir Ghaemi
Mood Disorders Program, Department of Psychiatry, Tufts Medical Center, 800 Washington St, Box 1007, Boston, MA 02111, USA
J Clin Psychiatry 71:372-80. 2010..To assess long-term effectiveness and safety of randomized antidepressant discontinuation after acute recovery from bipolar depression...- Maintenance treatment study designs in bipolar disorder: do they demonstrate that atypical neuroleptics (antipsychotics) are mood stabilizers?Frederick K Goodwin
Center on Neuroscience, Medical Progress, and Society, The George Washington University School of Medicine, Washington, DC, USA
CNS Drugs 25:819-27. 2011..Future maintenance research studies in bipolar disorder should use the prophylaxis design (i.e. without pre-selection of drug responders), rather than the relapse prevention design... - The role of gender in single vs married individuals with bipolar disorderDaniel Z Lieberman
Department of Psychiatry and Behavioral Sciences, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA
Compr Psychiatry 51:380-5. 2010..Despite the importance of marriage as a source of social support, it has been largely neglected in studies of bipolar disorder; and differential effects on men and women have not been explored... - An automated Internet application to help patients with bipolar disorder track social rhythm stabilizationDaniel Z Lieberman
Department of Psychiatry and Behavioral Sciences, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA
Psychiatr Serv 62:1267-9. 2011..Internet-based programs can enhance access to a best practice in the management of bipolar disorder... - Separate and concomitant use of lamotrigine, lithium, and divalproex in bipolar disordersDaniel Z Lieberman
Department of Psychiatry and Behavioral Sciences, George Washington University, 2150 Pennsylvania Ave, NW, Washington, DC 20037, USA
Curr Psychiatry Rep 6:459-65. 2004..Because no agent is universally effective in all phases of the illness, combination therapy with two or more agents often is the best option... - Rash in multicenter trials of lamotrigine in mood disorders: clinical relevance and managementJoseph R Calabrese
Department of Psychiatry, Case Western Reserve University University Hospitals of Cleveland, Cleveland, Ohio, USA
J Clin Psychiatry 63:1012-9. 2002..The objective of this report was to determine rash rates in clinical trials of lamotrigine in DSM-IV unipolar depression or bipolar disorder... - Bipolar spectrum disorder: a pilot studyS Nassir Ghaemi
Bipolar Disorder Research Program, Department of Psychiatry, Cambridge Health Alliance, Cambridge, MA 02139, USA
Psychopathology 37:222-6. 2004..Further prospective study needs to be conducted comparing BSD with unipolar depression... - Extrapyramidal side effects with atypical neuroleptics in bipolar disorderS Nassir Ghaemi
Bipolar Disorder Research Program, Department of Psychiatry, Emory University, 1365 Clifton Road, Building B, Suite 6100, Atlanta, GA 30322, USA
Prog Neuropsychopharmacol Biol Psychiatry 30:209-13. 2006..This rate is much higher than the 5-15% range reported in clinical trials, suggesting potential problems with clinical trial generalizability... - A randomized comparison of online and paper mood charts for people with bipolar disorderDaniel Z Lieberman
Department of Psychiatry and Behavioral Sciences, George Washington University School of Medicine and Health Sciences, NW Room 8 421, Washington, DC 20037, USA
J Affect Disord 124:85-9. 2010..Adherence to daily rating, however, tends to be low. In this study an online version of the LCM, designed to enhance adherence, was compared to the standard paper version... - Preventing inpatient suicideFrederick K Goodwin
Department of Psychiatry and Behavioral Sciences, The George Washington Universtiy Medical Faculty Associates, Inc, Washington, DC 20037, USA
J Clin Psychiatry 64:12-3. 2003 - Decreased risk of suicides and attempts during long-term lithium treatment: a meta-analytic reviewRoss J Baldessarini
International Consortium for Research on Bipolar Disorders, Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, MA, USA
Bipolar Disord 8:625-39. 2006..To update and extend comparisons of rates of suicides and suicide attempts among patients with major affective disorders with versus without long-term lithium treatment... - Antidepressants in bipolar disorder: the case for cautionS Nassir Ghaemi
Bipolar Disorder Research Program, Cambridge Hospital, Cambridge, MA and Harvard Medical School, Boston, MA 02139, USA
Bipolar Disord 5:421-33. 2003.... - Long-term observational comparison of risperidone and olanzapine in bipolar disorderS Nassir Ghaemi
Bipolar Disorder Research Program, Cambridge Health Alliance, Cambridge, Massachusetts, USA
Ann Clin Psychiatry 16:69-73. 2004..EPS was similar, and tardive dyskinesia did not occur. Risperidone and olanzapine appeared to have similar real-world maintenance effectiveness for bipolar disorder, but differed somewhat in side effects... - Effect of lamotrigine on cognitive complaints in patients with bipolar I disorderArifulla Khan
Northwest Clinical Research Center, Bellevue, Wash 98004, USA
J Clin Psychiatry 65:1483-90. 2004..This analysis describes the effects of bipolar I disorder on self-reported neurocognitive measures and remediation of these deficits with lamotrigine therapy... - Antidepressants for bipolar depressionS Nassir Ghaemi
Am J Psychiatry 162:1545-6; author reply 1547-8. 2005 
The ethics of clinical innovation in psychopharmacology: Challenging traditional bioethicsS Nassir Ghaemi
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA USA
Philos Ethics Humanit Med 2:26. 2007..To assess the scientific and ethical basis for clinical innovation in psychopharmacology...- Brightening depressionAnna Wirz-Justice
Science 303:467-9. 2004 - Introduction to special issue on antidepressant use in bipolar disorderS Nassir Ghaemi
Bipolar Disord 5:385-7. 2003 - Relapse after antidepressant discontinuationFederico Soldani
Am J Psychiatry 161:1312-3; author reply 1313. 2004 - The course of bipolar disorder and the nature of agitated depressionFrederick K Goodwin
Am J Psychiatry 160:2077-9. 2003