Ioannis Eleftherianos

Summary

Affiliation: George Washington University
Country: USA

Publications

  1. doi request reprint Dissecting the immune response to the entomopathogen Photorhabdus
    Ioannis Eleftherianos
    Department of Biological Sciences, The George Washington University, 336 Lisner Hall, 2023 G Street NW, Washington, DC 20052, USA
    Trends Microbiol 18:552-60. 2010
  2. pmc Hemocyte density increases with developmental stage in an immune-challenged forest caterpillar
    Teresa M Stoepler
    Department of Biological Sciences, George Washington University, Washington, D C, United States of America
    PLoS ONE 8:e70978. 2013
  3. pmc Endosymbiotic bacteria in insects: guardians of the immune system?
    Ioannis Eleftherianos
    Insect Infection and Immunity Lab, Department of Biological Sciences, Columbian College of Arts and Sciences, Institute for Biomedical Sciences, The George Washington University Washington, DC, USA
    Front Physiol 4:46. 2013
  4. ncbi request reprint Drosophila immunity research on the move
    Ioannis Eleftherianos
    Department of Biological Sciences, George Washington University, Washington, DC, USA
    Fly (Austin) 5:247-54. 2011
  5. doi request reprint Role and importance of phenoloxidase in insect hemostasis
    Ioannis Eleftherianos
    Department of Biological Sciences, The George Washington University, Washington, DC 20052, USA
    J Innate Immun 3:28-33. 2011
  6. doi request reprint Probing the tri-trophic interaction between insects, nematodes and Photorhabdus
    I Eleftherianos
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Parasitology 137:1695-706. 2010
  7. ncbi request reprint The immunoglobulin family protein Hemolin mediates cellular immune responses to bacteria in the insect Manduca sexta
    Ioannis Eleftherianos
    Department of Biology and Biochemistry, University of Bath, Claverton Down, UK
    Cell Microbiol 9:1137-47. 2007
  8. ncbi request reprint Prior infection of Manduca sexta with non-pathogenic Escherichia coli elicits immunity to pathogenic Photorhabdus luminescens: roles of immune-related proteins shown by RNA interference
    Ioannis Eleftherianos
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
    Insect Biochem Mol Biol 36:517-25. 2006
  9. doi request reprint The KdpD/KdpE two-component system of Photorhabdus asymbiotica promotes bacterial survival within M. sexta hemocytes
    Isabella Vlisidou
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath, UK
    J Invertebr Pathol 105:352-62. 2010
  10. doi request reprint A single locus from the entomopathogenic bacterium Photorhabdus luminescens inhibits activated Manduca sexta phenoloxidase
    Ioannis Eleftherianos
    Department of Biology and Biochemistry, University of Bath, Bath, UK
    FEMS Microbiol Lett 293:170-6. 2009

Collaborators

Detail Information

Publications17

  1. doi request reprint Dissecting the immune response to the entomopathogen Photorhabdus
    Ioannis Eleftherianos
    Department of Biological Sciences, The George Washington University, 336 Lisner Hall, 2023 G Street NW, Washington, DC 20052, USA
    Trends Microbiol 18:552-60. 2010
    ....
  2. pmc Hemocyte density increases with developmental stage in an immune-challenged forest caterpillar
    Teresa M Stoepler
    Department of Biological Sciences, George Washington University, Washington, D C, United States of America
    PLoS ONE 8:e70978. 2013
    ..While the underlying raison d' ĂȘtre for this improvement remains unclear, these findings may be useful in explaining natural patterns of stage-dependent parasitism and pathogen infection. ..
  3. pmc Endosymbiotic bacteria in insects: guardians of the immune system?
    Ioannis Eleftherianos
    Insect Infection and Immunity Lab, Department of Biological Sciences, Columbian College of Arts and Sciences, Institute for Biomedical Sciences, The George Washington University Washington, DC, USA
    Front Physiol 4:46. 2013
    ..We finally point out unresolved questions for future research and speculate how the current knowledge can be employed to design and implement measures for the effective control of agricultural insect pests and vectors of diseases...
  4. ncbi request reprint Drosophila immunity research on the move
    Ioannis Eleftherianos
    Department of Biological Sciences, George Washington University, Washington, DC, USA
    Fly (Austin) 5:247-54. 2011
    ..Here, we give an overview of the presented work and we explain how these findings will open new avenues in Drosophila immunity research...
  5. doi request reprint Role and importance of phenoloxidase in insect hemostasis
    Ioannis Eleftherianos
    Department of Biological Sciences, The George Washington University, Washington, DC 20052, USA
    J Innate Immun 3:28-33. 2011
    ..Here we review our current knowledge of the association between PO and coagulation and discuss the implications of the previous findings on insect innate immunity and hemostasis...
  6. doi request reprint Probing the tri-trophic interaction between insects, nematodes and Photorhabdus
    I Eleftherianos
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Parasitology 137:1695-706. 2010
    ..These results imply that both bacteria and nematodes contribute separately to the pathogenic modulation of host immune responses during natural infections by the mutualistic Heterorhabdus-Photorhabdus complex...
  7. ncbi request reprint The immunoglobulin family protein Hemolin mediates cellular immune responses to bacteria in the insect Manduca sexta
    Ioannis Eleftherianos
    Department of Biology and Biochemistry, University of Bath, Claverton Down, UK
    Cell Microbiol 9:1137-47. 2007
    ..In contrast, RNAi of PGRP had no effect on any of these cellular immune functions. These results demonstrate the vital role of Hemolin in Manduca cellular immune responses...
  8. ncbi request reprint Prior infection of Manduca sexta with non-pathogenic Escherichia coli elicits immunity to pathogenic Photorhabdus luminescens: roles of immune-related proteins shown by RNA interference
    Ioannis Eleftherianos
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
    Insect Biochem Mol Biol 36:517-25. 2006
    ..Given the continuous normal exposure of insects to environmental and symbiotic bacteria, we suggest that prior infection is likely to play a significant and underestimated role in determining the level of insect immunity found in nature...
  9. doi request reprint The KdpD/KdpE two-component system of Photorhabdus asymbiotica promotes bacterial survival within M. sexta hemocytes
    Isabella Vlisidou
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath, UK
    J Invertebr Pathol 105:352-62. 2010
    ....
  10. doi request reprint A single locus from the entomopathogenic bacterium Photorhabdus luminescens inhibits activated Manduca sexta phenoloxidase
    Ioannis Eleftherianos
    Department of Biology and Biochemistry, University of Bath, Bath, UK
    FEMS Microbiol Lett 293:170-6. 2009
    ..5-kb locus, which contained three ORFs and was homologous to the maltodextrin phosphorylase locus of E. coli. The implications of this novel inhibitory factor of insect phenoloxidase for Photorhabdus virulence are discussed...
  11. pmc An antibiotic produced by an insect-pathogenic bacterium suppresses host defenses through phenoloxidase inhibition
    Ioannis Eleftherianos
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, United Kingdom
    Proc Natl Acad Sci U S A 104:2419-24. 2007
    ..Thus, ST has a dual function both as a PO inhibitor to counter host immune reactions and also as an antibiotic to exclude microbial competitors from the insect cadaver...
  12. ncbi request reprint RNAi suppression of recognition protein mediated immune responses in the tobacco hornworm Manduca sexta causes increased susceptibility to the insect pathogen Photorhabdus
    Ioannis Eleftherianos
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
    Dev Comp Immunol 30:1099-107. 2006
    ..These results show not only that Photorhabdus is recognized by the Manduca sexta immune system but also that the insect's immune system plays an active, but ultimately ineffective, role in countering infection...
  13. pmc A novel method for infecting Drosophila adult flies with insect pathogenic nematodes
    Julio Cesar Castillo
    Insect Infection and Immunity Lab, Department of Biological Sciences, The George Washington University, Washington, DC, USA
    Virulence 3:339-47. 2012
    ..The protocol we present can be readily adapted for studying parasitic strategies of other insect nematodes using Drosophila as the host infection model...
  14. pmc Rapid Virulence Annotation (RVA): identification of virulence factors using a bacterial genome library and multiple invertebrate hosts
    Nicholas R Waterfield
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, United Kingdom
    Proc Natl Acad Sci U S A 105:15967-72. 2008
    ..The application of RVA to other pathogen genomes promises to ascribe biological function to otherwise uncharacterized virulence genes...
  15. doi request reprint Insect immune responses to nematode parasites
    Julio Cesar Castillo
    Insect Infection and Immunity Lab, Department of Biological Sciences, The George Washington University, 336 Lisner Hall, 2023 G Street NW, Washington, DC 20052, USA
    Trends Parasitol 27:537-47. 2011
    ..Such information can be used to model diseases caused by human parasitic nematodes and provide clues indicating directions for research into the interplay between vector insects and their invading tropical parasites...
  16. doi request reprint The Yersinia pseudotuberculosis and Yersinia pestis toxin complex is active against cultured mammalian cells
    Michelle C Hares
    University of Bath, Department of Biology and Biochemistry, Claverton Down, Bath, UK
    Microbiology 154:3503-17. 2008
    ..pseudotuberculosis and Y. pestis have been adapted for mammalian pathogenicity. We further conclude that Tc proteins from Y. pseudotuberculosis and Y. pestis display differential mammalian cell specificity in their toxicity...
  17. pmc Molecular mechanisms of aging and immune system regulation in Drosophila
    Ioannis Eleftherianos
    Insect Infection and Immunity Lab, Department of Biological Sciences, Microbiology and Immunology Program, Institute for Biomedical Sciences, The George Washington University, Lisner Hall 336, 2023 G Street NW, Washington, DC 20052, USA E mail
    Int J Mol Sci 13:9826-44. 2012
    ....