Myung Chul Chung

Summary

Affiliation: George Mason University
Country: USA

Publications

  1. pmc Bacillus anthracis interacts with plasmin(ogen) to evade C3b-dependent innate immunity
    Myung Chul Chung
    National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, Virginia, United States of America
    PLoS ONE 6:e18119. 2011
  2. doi request reprint Bacillus anthracis-derived nitric oxide induces protein S-nitrosylation contributing to macrophage death
    Myung Chul Chung
    School of Systems Biology, National Center for Biodefense and Infectious Diseases, George Mason University, 10650 Pyramid Place, Manassas, VA 20110, United States
    Biochem Biophys Res Commun 430:125-30. 2013
  3. pmc Transcriptional and apoptotic responses of THP-1 cells to challenge with toxigenic, and non-toxigenic Bacillus anthracis
    Christopher Bradburne
    Center for Bio Molecular Science and Engineering Code 6900, US Naval Research Laboratory, Washington DC, USA
    BMC Immunol 9:67. 2008
  4. doi request reprint Secreted Bacillus anthracis proteases target the host fibrinolytic system
    Myung Chul Chung
    National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, VA, USA
    FEMS Immunol Med Microbiol 62:173-81. 2011
  5. doi request reprint Degradation of circulating von Willebrand factor and its regulator ADAMTS13 implicates secreted Bacillus anthracis metalloproteases in anthrax consumptive coagulopathy
    Myung Chul Chung
    National Center for Biodefense and Infectious Diseases, College of Sciences, George Mason University, 10900 University Boulevard, Manassas, VA 20110, USA
    J Biol Chem 283:9531-42. 2008
  6. doi request reprint Bacillus anthracis protease InhA regulates BslA-mediated adhesion in human endothelial cells
    Jessica H Tonry
    Department of Biosciences and Biomedical Research Laboratory, George Mason University, 10650 Pyramid Place, Manassas, Virginia 20110, USA
    Cell Microbiol 14:1219-30. 2012
  7. pmc Bacillus anthracis protease InhA increases blood-brain barrier permeability and contributes to cerebral hemorrhages
    Dhritiman V Mukherjee
    National Center for Biodefense and Infectious Diseases, Department of Molecular and Microbiology, George Mason University, Manassas, Virginia, United States of America
    PLoS ONE 6:e17921. 2011
  8. doi request reprint Neutrophil elastase and syndecan shedding contribute to antithrombin depletion in murine anthrax
    Myung Chul Chung
    National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, VA 20110, USA
    FEMS Immunol Med Microbiol 54:309-18. 2008
  9. doi request reprint In vivo murine and in vitro M-like cell models of gastrointestinal anthrax
    Jessica H Tonry
    National Center for Biodefense and Infectious Diseases, George Mason University, 10650 Pyramid Place, Manassas, VA 20110, USA
    Microbes Infect 15:37-44. 2013
  10. pmc Anthrolysin O and fermentation products mediate the toxicity of Bacillus anthracis to lung epithelial cells under microaerobic conditions
    Taissia G Popova
    National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, VA, USA
    FEMS Immunol Med Microbiol 61:15-27. 2011

Collaborators

  • Serguei G Popov
  • Nalini Ramarao
  • Olaf Schneewind
  • Jessica H Tonry
  • Taissia G Popova
  • Charles Bailey
  • Aarthi Narayanan
  • Stephen St John
  • Charles L Bailey
  • Fatah Kashanchi
  • Kwang Sik Kim
  • Dhritiman V Mukherjee
  • Christopher Bradburne
  • Ramin M Hakami
  • Calvin Carpenter
  • Ryan Blower
  • Beth A McNichol
  • Scott Stibitz
  • Daniel S Chertow
  • Bryan Millis
  • Dan Soppet
  • Qin Zong
  • Derong Liu
  • Karen Schlauch
  • Taissia Popova
  • Anna Popova

Detail Information

Publications12

  1. pmc Bacillus anthracis interacts with plasmin(ogen) to evade C3b-dependent innate immunity
    Myung Chul Chung
    National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, Virginia, United States of America
    PLoS ONE 6:e18119. 2011
    ..anthracis through recruitment of PLG resulting in the enhancement of anti-complement and anti-opsonization properties of the pathogen...
  2. doi request reprint Bacillus anthracis-derived nitric oxide induces protein S-nitrosylation contributing to macrophage death
    Myung Chul Chung
    School of Systems Biology, National Center for Biodefense and Infectious Diseases, George Mason University, 10650 Pyramid Place, Manassas, VA 20110, United States
    Biochem Biophys Res Commun 430:125-30. 2013
    ..This novel mechanism of anthrax pathogenesis may offer specific approach to the development of therapeutics...
  3. pmc Transcriptional and apoptotic responses of THP-1 cells to challenge with toxigenic, and non-toxigenic Bacillus anthracis
    Christopher Bradburne
    Center for Bio Molecular Science and Engineering Code 6900, US Naval Research Laboratory, Washington DC, USA
    BMC Immunol 9:67. 2008
    ..In fact, responses brought about by the toxins may be different than each of their individual effects...
  4. doi request reprint Secreted Bacillus anthracis proteases target the host fibrinolytic system
    Myung Chul Chung
    National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, VA, USA
    FEMS Immunol Med Microbiol 62:173-81. 2011
    ..We propose that NprB and InhA may contribute to the activation of the fibrinolytic system in anthrax infection...
  5. doi request reprint Degradation of circulating von Willebrand factor and its regulator ADAMTS13 implicates secreted Bacillus anthracis metalloproteases in anthrax consumptive coagulopathy
    Myung Chul Chung
    National Center for Biodefense and Infectious Diseases, College of Sciences, George Mason University, 10900 University Boulevard, Manassas, VA 20110, USA
    J Biol Chem 283:9531-42. 2008
    ..Our results suggest a new mechanism of anthrax coagulopathy affecting the levels and functional activities of both VWF and its natural regulator ADAMTS13. This mechanism may contribute to hemorrhage and thrombosis typical in anthrax...
  6. doi request reprint Bacillus anthracis protease InhA regulates BslA-mediated adhesion in human endothelial cells
    Jessica H Tonry
    Department of Biosciences and Biomedical Research Laboratory, George Mason University, 10650 Pyramid Place, Manassas, Virginia 20110, USA
    Cell Microbiol 14:1219-30. 2012
    ..BslA was sensitive to purified InhA degradation in a concentration- and time-dependent manner. Taken together these data support the role of InhA regulation of BslA-mediated vegetative cell adhesion and invasion...
  7. pmc Bacillus anthracis protease InhA increases blood-brain barrier permeability and contributes to cerebral hemorrhages
    Dhritiman V Mukherjee
    National Center for Biodefense and Infectious Diseases, Department of Molecular and Microbiology, George Mason University, Manassas, Virginia, United States of America
    PLoS ONE 6:e17921. 2011
    ..Cumulatively, these findings indicate that InhA contributes to BBB disruption associated with anthrax meningitis through proteolytic attack on the endothelial tight junctional protein zonula occluden (ZO)-1...
  8. doi request reprint Neutrophil elastase and syndecan shedding contribute to antithrombin depletion in murine anthrax
    Myung Chul Chung
    National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, VA 20110, USA
    FEMS Immunol Med Microbiol 54:309-18. 2008
    ..We propose that antithrombin depletion proceeding through activation of neutrophils and massive shedding of heparin-like syndecan from the liver into circulation contribute to anthrax coagulopathy...
  9. doi request reprint In vivo murine and in vitro M-like cell models of gastrointestinal anthrax
    Jessica H Tonry
    National Center for Biodefense and Infectious Diseases, George Mason University, 10650 Pyramid Place, Manassas, VA 20110, USA
    Microbes Infect 15:37-44. 2013
    ..Here, we developed an in vivo murine model of GI anthrax and an in vitro M-like cell model that could be used to further our knowledge of GI anthrax pathogenesis...
  10. pmc Anthrolysin O and fermentation products mediate the toxicity of Bacillus anthracis to lung epithelial cells under microaerobic conditions
    Taissia G Popova
    National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, VA, USA
    FEMS Immunol Med Microbiol 61:15-27. 2011
    ..This mechanism of metabolic toxicity is relevant to the late-stage conditions of hypoxia and acidosis found in anthrax patients and might operate at anatomical locations of the host deprived from oxygen supply...
  11. doi request reprint Activation of plasminogen activator inhibitor implicates protease InhA in the acute-phase response to Bacillus anthracis infection
    Myung Chul Chung
    National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, VA 20110, USA
    J Med Microbiol 58:737-44. 2009
    ....
  12. pmc Bacillus anthracis co-opts nitric oxide and host serum albumin for pathogenicity in hypoxic conditions
    Stephen St John
    National Center for Biodefense and Infectious Diseases, School of Systems Biology, George Mason University Manassas, VA, USA
    Front Cell Infect Microbiol 3:16. 2013
    ..Our data suggest that during infection in the hypoxic environment of pre-mortal host the accumulated NO is expected to have a broad toxic impact on host cell functions...