KIM L contact BLACKWELL

Summary

Affiliation: George Mason University
Country: USA

Publications

  1. ncbi request reprint A comparative voltage and current-clamp analysis of feedback and feedforward synaptic transmission in the striatal microcircuit in vitro
    Nicholas Gustafson
    Unit of Neural Network Physiology, Laboratory of Systems Neuroscience, National Institute of Mental Health, Bethesda, MD 20892, USA
    J Neurophysiol 95:737-52. 2006
  2. ncbi request reprint The effect of white and filtered noise on contrast detection thresholds
    K T Blackwell
    Environmental Research Institute of Michigan, Arlington, VA 22209, USA
    Vision Res 38:267-80. 1998
  3. ncbi request reprint An efficient stochastic diffusion algorithm for modeling second messengers in dendrites and spines
    Kim T Blackwell
    School of Computational Sciences, George Mason University, MS 2A1, Fairfax, VA 22030, USA
    J Neurosci Methods 157:142-53. 2006
  4. pmc Subcellular, cellular, and circuit mechanisms underlying classical conditioning in Hermissenda crassicornis
    Kim T Blackwell
    School of Computational Sciences, and the Krasnow Institute for Advanced Study, George Mason University, Fairfax, VA 22030, USA
    Anat Rec B New Anat 289:25-37. 2006
  5. ncbi request reprint Ionic currents underlying difference in light response between type A and type B photoreceptors
    K T Blackwell
    School of Computational Sciences, and the Krasnow Institute for Advanced Study, George Mason University, MS 2A1, Fairfax, VA 22030, USA
    J Neurophysiol 95:3060-72. 2006
  6. ncbi request reprint A new era in computational neuroscience
    Kim T Blackwell
    School of Computational Sciences, and the Krasnow Institute of Advanced Studies, Rockfish Creek Lane, MS 2A1 George Mason University, Fairfax, VA 22030, USA
    Neuroinformatics 3:163-6. 2005
  7. ncbi request reprint Paired turbulence and light do not produce a supralinear calcium increase in Hermissenda
    Kim T Blackwell
    School of Computational Sciences, and the Krasnow Institute for Advanced Study, George Mason University, MS 2A1, Fairfax, VA 22030, USA
    J Comput Neurosci 17:81-99. 2004
  8. ncbi request reprint Quantitative estimate of synaptic inputs to striatal neurons during up and down states in vitro
    Kim T Blackwell
    Krasnow Institute of Advanced Studies and School of Computational Sciences, George Mason University, Fairfax, Virginia 22030, USA
    J Neurosci 23:9123-32. 2003
  9. ncbi request reprint Evidence for a distinct light-induced calcium-dependent potassium current in Hermissenda crassicornis
    K T Blackwell
    Institute for Computational Sciences and Informatics, and Krasnow Institute for Advanced Study, George Mason University, Fairfax, VA 22030, USA
    J Comput Neurosci 9:149-70. 2000
  10. ncbi request reprint Ryanodine receptor modulation of in vitro associative learning in Hermissenda crassicornis
    K T Blackwell
    Institute for Computational Sciences and Informatics, George Mason University, Krasnow Institute, MS 2A1, Fairfax, VA 22030, USA
    Brain Res 822:114-25. 1999

Collaborators

Detail Information

Publications18

  1. ncbi request reprint A comparative voltage and current-clamp analysis of feedback and feedforward synaptic transmission in the striatal microcircuit in vitro
    Nicholas Gustafson
    Unit of Neural Network Physiology, Laboratory of Systems Neuroscience, National Institute of Mental Health, Bethesda, MD 20892, USA
    J Neurophysiol 95:737-52. 2006
    ..The reversal potential close to the up-state potential, which supports shunting operation with millisecond precision and the strong synaptic depression, should enable both pathways to carry time-critical information...
  2. ncbi request reprint The effect of white and filtered noise on contrast detection thresholds
    K T Blackwell
    Environmental Research Institute of Michigan, Arlington, VA 22209, USA
    Vision Res 38:267-80. 1998
    ..Based on these results, a model of contrast detection thresholds is modified such that the facilitation is attributed to reduced observer uncertainty caused by small amounts of noise...
  3. ncbi request reprint An efficient stochastic diffusion algorithm for modeling second messengers in dendrites and spines
    Kim T Blackwell
    School of Computational Sciences, George Mason University, MS 2A1, Fairfax, VA 22030, USA
    J Neurosci Methods 157:142-53. 2006
    ..The efficiency of the algorithm is sufficient to allow simulation of second messenger pathways in a multitude of spines on an entire neuron...
  4. pmc Subcellular, cellular, and circuit mechanisms underlying classical conditioning in Hermissenda crassicornis
    Kim T Blackwell
    School of Computational Sciences, and the Krasnow Institute for Advanced Study, George Mason University, Fairfax, VA 22030, USA
    Anat Rec B New Anat 289:25-37. 2006
    ..Thus, the knowledge gained from further study of Hermissenda will continue to illuminate mechanisms of mammalian learning...
  5. ncbi request reprint Ionic currents underlying difference in light response between type A and type B photoreceptors
    K T Blackwell
    School of Computational Sciences, and the Krasnow Institute for Advanced Study, George Mason University, MS 2A1, Fairfax, VA 22030, USA
    J Neurophysiol 95:3060-72. 2006
    ..Because these differences between type A and type B photoreceptors have not been confirmed in comparative experiments, they constitute hypotheses to be tested with future experiments...
  6. ncbi request reprint A new era in computational neuroscience
    Kim T Blackwell
    School of Computational Sciences, and the Krasnow Institute of Advanced Studies, Rockfish Creek Lane, MS 2A1 George Mason University, Fairfax, VA 22030, USA
    Neuroinformatics 3:163-6. 2005
  7. ncbi request reprint Paired turbulence and light do not produce a supralinear calcium increase in Hermissenda
    Kim T Blackwell
    School of Computational Sciences, and the Krasnow Institute for Advanced Study, George Mason University, MS 2A1, Fairfax, VA 22030, USA
    J Comput Neurosci 17:81-99. 2004
    ..Thus, the expression of this correlate of classical conditioning may depend on a leak potassium current...
  8. ncbi request reprint Quantitative estimate of synaptic inputs to striatal neurons during up and down states in vitro
    Kim T Blackwell
    Krasnow Institute of Advanced Studies and School of Computational Sciences, George Mason University, Fairfax, Virginia 22030, USA
    J Neurosci 23:9123-32. 2003
    ..The high correlation between up- and down-state reversal potential suggests that despite these drastic changes in synaptic input frequency, the ratio of inhibitory to excitatory currents is similar during both states...
  9. ncbi request reprint Evidence for a distinct light-induced calcium-dependent potassium current in Hermissenda crassicornis
    K T Blackwell
    Institute for Computational Sciences and Informatics, and Krasnow Institute for Advanced Study, George Mason University, Fairfax, VA 22030, USA
    J Comput Neurosci 9:149-70. 2000
    ....
  10. ncbi request reprint Ryanodine receptor modulation of in vitro associative learning in Hermissenda crassicornis
    K T Blackwell
    Institute for Computational Sciences and Informatics, George Mason University, Krasnow Institute, MS 2A1, Fairfax, VA 22030, USA
    Brain Res 822:114-25. 1999
    ..These results suggest a role for the ryanodine receptor in both a cellular correlate of classical conditioning and light adaptation...
  11. ncbi request reprint The effect of intensity and duration on the light-induced sodium and potassium currents in the Hermissenda type B photoreceptor
    Kim T Blackwell
    School of Computational Sciences and the Krasnow Institute for Advanced Study, George Mason University, Fairfax, Virginia 22030, USA
    J Neurosci 22:4217-28. 2002
    ..Characteristics of these currents suggest that I(Klgt) is responsible for the long-lasting depolarization seen after light termination, and thus plays a role in classical conditioning...
  12. ncbi request reprint Calcium waves and closure of potassium channels in response to GABA stimulation in Hermissenda type B photoreceptors
    K T Blackwell
    School of Computational Sciences and the Krasnow Institute for Advanced Study, George Mason University, MS 281, Fairfax, Virginia 22030, USA
    J Neurophysiol 87:776-92. 2002
    ..Thus the late depolarization and input resistance elevation can be explained by a closure of calcium-sensitive leak potassium currents but cannot be explained by a transient calcium current and a hyperpolarization-activated current...
  13. ncbi request reprint Comparison of Hermissenda type a and type B photoreceptors: response to light as a function of intensity and duration
    Ji Ling Mo
    School of Computational Sciences and Krasnow Institute for Advanced Study, George Mason University, Fairfax, Virginia 22030, USA
    J Neurosci 23:8020-8. 2003
    ..Although membrane potential is correlated with firing frequency, this correlation is much lower in type A than type B photoreceptors, suggesting that some other conductance influences firing frequency in type A photoreceptors...
  14. ncbi request reprint Subcellular interactions between parallel fibre and climbing fibre signals in Purkinje cells predict sensitivity of classical conditioning to interstimulus interval
    Jeanette Hellgren Kotaleski
    George Mason University, School of Computational Sciences, The Krasnow Institute for Advanced Studies, USA
    Integr Physiol Behav Sci 37:265-92. 2002
    ..1 to 3 s. The sensitivity of IICR to the temporal relation between PF and CF stimulation, together with the buffering system of Purkinje cells, significantly contribute to the temporal sensitivity...
  15. pmc Temporal sensitivity of protein kinase a activation in late-phase long term potentiation
    Myungsook Kim
    George Mason University, The Krasnow Institute for Advanced Studies, Fairfax, Virginia, United States of America
    PLoS Comput Biol 6:e1000691. 2010
    ..In addition to explaining the temporal sensitivity of PKA, these simulations suggest that the use of several kinases for memory storage allows each to respond optimally to different temporal patterns...
  16. pmc Computational models of neuronal biophysics and the characterization of potential neuropharmacological targets
    Michele Ferrante
    Krasnow Institute for Advanced Study, George Mason University, 4400 University Drive, MS 2A1, Fairfax, Virginia 22030 4444, USA
    Curr Med Chem 15:2456-71. 2008
    ....
  17. pmc The role of type 4 phosphodiesterases in generating microdomains of cAMP: large scale stochastic simulations
    Rodrigo F Oliveira
    The Krasnow Institute for Advanced Study, George Mason University, Fairfax, Virginia, United States of America
    PLoS ONE 5:e11725. 2010
    ..The simulations reported here further demonstrate the utility of the new stochastic reaction-diffusion algorithm for exploring signaling pathways in spatially complex structures such as neurons...
  18. pmc Transient calcium and dopamine increase PKA activity and DARPP-32 phosphorylation
    Maria Lindskog
    School of Computer Science and Communication, Royal Institute of Technology, Stockholm, Sweden
    PLoS Comput Biol 2:e119. 2006
    ..This result, which is robust to variation in model parameters, supports reinforcement learning theories in which activity-dependent long-term synaptic plasticity requires paired glutamate and dopamine inputs...

Research Grants7

  1. CRCNS: Spatio-temporal Dynamics of Dopamine Activated 2nd Messenger Pathways
    KIM BLACKWELL; Fiscal Year: 2009
    ..Thus, the results of this research may help in the development of treatments for alcohol addiction. ..
  2. CRCNS: Spatial & Temporal Aspects of cAMP/PKA Signaling Underlying Information
    KIM L contact BLACKWELL; Fiscal Year: 2010
    ..Successful completion of the research will form the basis for investigating how alterations in this pathway contributes to psychiatric disease such as schizophrenia and alcoholism. ..