Zhong Zhao

Summary

Affiliation: Genzyme Corporation
Country: USA

Publications

  1. ncbi request reprint Synthesis and evaluation of novel pyrazolidinone analogs of PGE2 as EP2 and EP4 receptors agonists
    Zhong Zhao
    Department of Medicinal Chemistry, EMD Serono Research Institute, Inc, Rockland, MA 02370, USA
    Bioorg Med Chem Lett 17:6572-5. 2007
  2. ncbi request reprint Discovery of novel prostaglandin analogs of PGE2 as potent and selective EP2 and EP4 receptor agonists
    Yufang Xiao
    Department of Medicinal Chemistry, EMD Serono Research Institute, Inc, Rockland, MA 02370, USA
    Bioorg Med Chem Lett 17:4323-7. 2007
  3. ncbi request reprint Synthesis and evaluation of a gamma-lactam as a highly selective EP2 and EP4 receptor agonist
    Yufang Xiao
    Department of Medicinal Chemistry, EMD Serono Research Institute, Inc, Rockland, MA 02370, USA
    Bioorg Med Chem Lett 18:821-4. 2008
  4. ncbi request reprint Cyclooxygenase-2 promotes amyloid plaque deposition in a mouse model of Alzheimer's disease neuropathology
    Zhongmin Xiang
    Neuroinflammation Research Laboratories, Department of Psychiatry, and Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Gene Expr 10:271-8. 2002
  5. ncbi request reprint Cyclooxygenase (COX)-2 and COX-1 potentiate beta-amyloid peptide generation through mechanisms that involve gamma-secretase activity
    Weiping Qin
    Neuroinflammation Research Laboratories, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 278:50970-7. 2003

Collaborators

  • Yufang Xiao
  • Zhongmin Xiang
  • Weiping Qin
  • Giulio Maria Pasinetti
  • Lap Ho
  • Yuanzhen Peng
  • Nikolaos K Robakis
  • Junichi Shioi
  • Jason Suh
  • Patrick N Pompl
  • David Teplow
  • Anju Dang
  • Weiping Qing
  • Shrishailam Yemul
  • Patrick Pompl
  • Kevin Kelley
  • Wein Qing

Detail Information

Publications5

  1. ncbi request reprint Synthesis and evaluation of novel pyrazolidinone analogs of PGE2 as EP2 and EP4 receptors agonists
    Zhong Zhao
    Department of Medicinal Chemistry, EMD Serono Research Institute, Inc, Rockland, MA 02370, USA
    Bioorg Med Chem Lett 17:6572-5. 2007
    ..Compound 10f showed the highest potency and selectivity for EP(4) the receptor...
  2. ncbi request reprint Discovery of novel prostaglandin analogs of PGE2 as potent and selective EP2 and EP4 receptor agonists
    Yufang Xiao
    Department of Medicinal Chemistry, EMD Serono Research Institute, Inc, Rockland, MA 02370, USA
    Bioorg Med Chem Lett 17:4323-7. 2007
    ..An optimized analog (compound 9b) showed high potency and selectivity for the EP(4) receptor over other known receptors...
  3. ncbi request reprint Synthesis and evaluation of a gamma-lactam as a highly selective EP2 and EP4 receptor agonist
    Yufang Xiao
    Department of Medicinal Chemistry, EMD Serono Research Institute, Inc, Rockland, MA 02370, USA
    Bioorg Med Chem Lett 18:821-4. 2008
    ..Several compounds (such as 2a, 2h) with high potency, selectivity and acceptable PK profiles were discovered. These were assessed in animal models of ovulation induction and bronchoconstriction...
  4. ncbi request reprint Cyclooxygenase-2 promotes amyloid plaque deposition in a mouse model of Alzheimer's disease neuropathology
    Zhongmin Xiang
    Neuroinflammation Research Laboratories, Department of Psychiatry, and Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Gene Expr 10:271-8. 2002
    ..Collectively these data suggest that COX-2 influences APP processing and promotes amyloidosis in the brain...
  5. ncbi request reprint Cyclooxygenase (COX)-2 and COX-1 potentiate beta-amyloid peptide generation through mechanisms that involve gamma-secretase activity
    Weiping Qin
    Neuroinflammation Research Laboratories, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 278:50970-7. 2003
    ....