X Kate Zhang

Summary

Affiliation: Genzyme Corporation
Country: USA

Publications

  1. doi request reprint Multiplex enzyme assay screening of dried blood spots for lysosomal storage disorders by using tandem mass spectrometry
    X Kate Zhang
    Genzyme Corporation, Framingham, MA 01701, USA
    Clin Chem 54:1725-8. 2008
  2. doi request reprint The effect of preparation, storage and shipping of dried blood spots on the activity of five lysosomal enzymes
    Carole S Elbin
    Genzyme Corporation, P O Box 9322, Framingham, MA 01701, United States
    Clin Chim Acta 412:1207-12. 2011
  3. doi request reprint Determination of psychosine concentration in dried blood spots from newborns that were identified via newborn screening to be at risk for Krabbe disease
    Wei Lien Chuang
    Genzyme Corporation, Framingham, MA 01701 09322, United States
    Clin Chim Acta 419:73-6. 2013
  4. pmc Multiplex lysosomal enzyme activity assay on dried blood spots using tandem mass spectrometry
    X Kate Zhang
    Genzyme Corporation, Framingham, MA, USA
    Methods Mol Biol 603:339-50. 2010
  5. doi request reprint Lyso-sphingomyelin is elevated in dried blood spots of Niemann-Pick B patients
    Wei Lien Chuang
    Genzyme Corporation, a Sanofi Company, One Mountain Road, Framingham, MA 01701 9322, USA
    Mol Genet Metab 111:209-11. 2014
  6. doi request reprint Newborn screening for Pompe disease by measuring acid alpha-glucosidase activity using tandem mass spectrometry
    Angéla Dajnoki
    Division of Biochemical and Paediatric Genetics, University Children s Hospital Vienna, Austria
    Clin Chem 54:1624-9. 2008

Collaborators

  • Joseph J Orsini
  • O A Bodamer
  • Wei Lien Chuang
  • Joan M Keutzer
  • Carole S Elbin
  • Joan Keutzer
  • Angéla Dajnoki
  • Samantha Cooper
  • Joshua Pacheco
  • Gerald F Cox
  • Margaret M McGovern
  • Chad K Biski
  • Monica M Martin
  • Michele Caggana
  • Josh Pacheco
  • David A Wenger
  • Petra Olivova
  • Samantha K Cooper
  • Carla A Marashio
  • Emmaline Cullen
  • Victor Dejesus
  • Gyorgy Fekete
  • Adolf Muhl

Detail Information

Publications6

  1. doi request reprint Multiplex enzyme assay screening of dried blood spots for lysosomal storage disorders by using tandem mass spectrometry
    X Kate Zhang
    Genzyme Corporation, Framingham, MA 01701, USA
    Clin Chem 54:1725-8. 2008
    ..We modified the assay for high-throughput use in screening laboratories...
  2. doi request reprint The effect of preparation, storage and shipping of dried blood spots on the activity of five lysosomal enzymes
    Carole S Elbin
    Genzyme Corporation, P O Box 9322, Framingham, MA 01701, United States
    Clin Chim Acta 412:1207-12. 2011
    ..The effect of DBS preparation, storage and shipping was evaluated on the activities of acid α-glucosidase, acid α-galactosidase, acid β-glucocerebrosidase, acid sphingomyelinase, and galactocerebrosidase...
  3. doi request reprint Determination of psychosine concentration in dried blood spots from newborns that were identified via newborn screening to be at risk for Krabbe disease
    Wei Lien Chuang
    Genzyme Corporation, Framingham, MA 01701 09322, United States
    Clin Chim Acta 419:73-6. 2013
    ..In addition, 6 other newborns were identified with very low galactosylcerebrosidase (GALC) activity. Because these patients remain asymptomatic, we investigated whether psychosine levels could be a useful marker for disease...
  4. pmc Multiplex lysosomal enzyme activity assay on dried blood spots using tandem mass spectrometry
    X Kate Zhang
    Genzyme Corporation, Framingham, MA, USA
    Methods Mol Biol 603:339-50. 2010
    ..The mixtures of the reaction products are prepared using liquid-liquid and solid-phase extractions and quantified simultaneously using selected ion monitoring on LC-MS-MS system...
  5. doi request reprint Lyso-sphingomyelin is elevated in dried blood spots of Niemann-Pick B patients
    Wei Lien Chuang
    Genzyme Corporation, a Sanofi Company, One Mountain Road, Framingham, MA 01701 9322, USA
    Mol Genet Metab 111:209-11. 2014
    ..Here, we show that the de-acylated form of sphingomyelin, lyso-SPM, is elevated approximately 5-fold in dried blood spots (DBS) from NPD-B patients and has no overlap with normal controls, making it a potentially useful biomarker. ..
  6. doi request reprint Newborn screening for Pompe disease by measuring acid alpha-glucosidase activity using tandem mass spectrometry
    Angéla Dajnoki
    Division of Biochemical and Paediatric Genetics, University Children s Hospital Vienna, Austria
    Clin Chem 54:1624-9. 2008
    ..We evaluated a tandem mass spectrometry (MS/MS) method to measure GAA activity for newborn screening for Pompe disease...