Yuanxin Xu

Summary

Affiliation: Genzyme Corporation
Country: USA

Publications

  1. pmc Validation of a HLA-A2 tetramer flow cytometric method, IFNgamma real time RT-PCR, and IFNgamma ELISPOT for detection of immunologic response to gp100 and MelanA/MART-1 in melanoma patients
    Yuanxin Xu
    Genzyme Corporation, One Mountain Road, Framingham, Massachusetts, MA 01701, USA
    J Transl Med 6:61. 2008
  2. pmc The anti-CD2 monoclonal antibody BTI-322 generates unresponsiveness by activation-associated T cell depletion
    Y Xu
    BioTransplant Incorporated, Charlestown, MA USA
    Clin Exp Immunol 138:476-83. 2004
  3. ncbi request reprint Effects of specific anti-B and/or anti-plasma cell immunotherapy on antibody production in baboons: depletion of CD20- and CD22-positive B cells does not result in significantly decreased production of anti-alphaGal antibody
    I P Alwayn
    Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, BioTransplant, Inc, Boston 02129, USA
    Xenotransplantation 8:157-71. 2001
  4. ncbi request reprint Rescue of defective T cell development and function in Atm-/- mice by a functional TCR alpha beta transgene
    C Chao
    Department of Biology, University of California, San Diego, La Jolla 92093, USA
    J Immunol 164:345-9. 2000
  5. pmc gammadelta T cells are critical for the induction of anterior chamber-associated immune deviation
    Y Xu
    Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Immunology 104:142-8. 2001
  6. ncbi request reprint Antisense of ATP synthase subunit e inhibits the growth of human hepatocellular carcinoma cells
    H Ying
    Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, P R China
    Oncol Res 12:485-90. 2001
  7. ncbi request reprint [Study of specific targeting cytotoxicity mediated by anti-CD(3)/anti-CD(20) Diabody]
    D Xiong
    State Key Laboratory of Experimental Hematology, Institute of Hematology, CAMS and PUMC, Tianjin 300020, China
    Zhonghua Xue Ye Xue Za Zhi 22:359-62. 2001
  8. ncbi request reprint Systemic lupus erythematosus and B-cell hematologic neoplasm
    Y Xu
    Comprehensive Cancer Center and Department of Medicine, Our Lady of Mercy Medical Center, New York Medical College, Bronx 10466, USA
    Lupus 10:841-50. 2001
  9. ncbi request reprint [A study of the effect of protein kinase C on the expression of nitric oxide synthase mRNA in pulmonary artery smooth muscle in hypoxia]
    Y Ding
    Department of Respiratory Disease, Tongji Hospital, Tongji Medical College, Huazhong Science and Technology University, Wuhan 430030, China
    Zhonghua Jie He He Hu Xi Za Zhi 24:588-91. 2001
  10. ncbi request reprint Effects of dexamethasone on Flt3 receptor expression and proliferation induced by recombinant human Flt3 ligand in malignant hematopoietic cells
    Z X Xu
    Department of Immunology, Medical Biotechnology Institute, School of Life Science, Soochow University, Suzhou 215007, China
    Acta Pharmacol Sin 22:534-40. 2001

Collaborators

Detail Information

Publications55

  1. pmc Validation of a HLA-A2 tetramer flow cytometric method, IFNgamma real time RT-PCR, and IFNgamma ELISPOT for detection of immunologic response to gp100 and MelanA/MART-1 in melanoma patients
    Yuanxin Xu
    Genzyme Corporation, One Mountain Road, Framingham, Massachusetts, MA 01701, USA
    J Transl Med 6:61. 2008
    ..Here we describe a rigorous validation approach for each of these assays prior to their use for clinical sample analysis...
  2. pmc The anti-CD2 monoclonal antibody BTI-322 generates unresponsiveness by activation-associated T cell depletion
    Y Xu
    BioTransplant Incorporated, Charlestown, MA USA
    Clin Exp Immunol 138:476-83. 2004
    ..This unique characteristic of BTI-322 suggests the potential of the antibody for tolerance induction in vivo, besides the potential use as a T cell depleting agent...
  3. ncbi request reprint Effects of specific anti-B and/or anti-plasma cell immunotherapy on antibody production in baboons: depletion of CD20- and CD22-positive B cells does not result in significantly decreased production of anti-alphaGal antibody
    I P Alwayn
    Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, BioTransplant, Inc, Boston 02129, USA
    Xenotransplantation 8:157-71. 2001
    ..These observations suggest that CD20-and CD22-positive B cells are not the major source of antialphaGal Ab production. Future efforts will be directed towards suppression of plasma cell function...
  4. ncbi request reprint Rescue of defective T cell development and function in Atm-/- mice by a functional TCR alpha beta transgene
    C Chao
    Department of Biology, University of California, San Diego, La Jolla 92093, USA
    J Immunol 164:345-9. 2000
    ..Therefore, the defective T-dependent immune responses in Atm-/- mice must be secondary to greatly reduced T cell numbers in these mutant mice...
  5. pmc gammadelta T cells are critical for the induction of anterior chamber-associated immune deviation
    Y Xu
    Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Immunology 104:142-8. 2001
    ..These findings indicate that gammadelta T cells play a very important role in ocular tolerance...
  6. ncbi request reprint Antisense of ATP synthase subunit e inhibits the growth of human hepatocellular carcinoma cells
    H Ying
    Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, P R China
    Oncol Res 12:485-90. 2001
    ..Together, the results suggest that antisense of hAS-e can inhibit cell proliferation through the MAP kinase pathway. Our data indicate that hAS-e may become a new target in gene therapy...
  7. ncbi request reprint [Study of specific targeting cytotoxicity mediated by anti-CD(3)/anti-CD(20) Diabody]
    D Xiong
    State Key Laboratory of Experimental Hematology, Institute of Hematology, CAMS and PUMC, Tianjin 300020, China
    Zhonghua Xue Ye Xue Za Zhi 22:359-62. 2001
    ..CONCLUSION: The diabody proved to be a potent agent for targeting peripheral blood lymphocytes to lyse CD(20) antigen expressing tumor cells in vitro and in vivo...
  8. ncbi request reprint Systemic lupus erythematosus and B-cell hematologic neoplasm
    Y Xu
    Comprehensive Cancer Center and Department of Medicine, Our Lady of Mercy Medical Center, New York Medical College, Bronx 10466, USA
    Lupus 10:841-50. 2001
    ..Lastly, EBV infection, found to have a high prevalence in SLE patients, may serve as a common etiological factor in both disorders...
  9. ncbi request reprint [A study of the effect of protein kinase C on the expression of nitric oxide synthase mRNA in pulmonary artery smooth muscle in hypoxia]
    Y Ding
    Department of Respiratory Disease, Tongji Hospital, Tongji Medical College, Huazhong Science and Technology University, Wuhan 430030, China
    Zhonghua Jie He He Hu Xi Za Zhi 24:588-91. 2001
    ..The effect of PKC in hypoxic pulmonary hypertension may be made by inhibiting the expression of cNOS mRNA and modulating NO. The site of the effect of PKC may be in upstream of NO. The mechanism of it needs to be studied further...
  10. ncbi request reprint Effects of dexamethasone on Flt3 receptor expression and proliferation induced by recombinant human Flt3 ligand in malignant hematopoietic cells
    Z X Xu
    Department of Immunology, Medical Biotechnology Institute, School of Life Science, Soochow University, Suzhou 215007, China
    Acta Pharmacol Sin 22:534-40. 2001
    ..A combination of rhFL and DXM may serve to control hematopoietic defects in malignant hematopoietic diseases...
  11. ncbi request reprint Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr
    C M Vines
    Department of Pathology and Cancer Research Facility, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    Immunity 15:507-19. 2001
    ..The inhibitory effects of Fgr are independent of its kinase activity, are dose dependent, and can be overcome by chemokines and inflammatory mediators...
  12. ncbi request reprint Cloning and characterization of F-LANa, upregulated in human liver cancer
    H Ying
    Laboratory of Molecular and Cellular Oncology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai, 200031, People s Republic of China
    Biochem Biophys Res Commun 286:394-400. 2001
    ..Together, our data demonstrate that overexpression of evolutionarily conserved F-LANa occurs frequently and may play an important role in proliferation...
  13. ncbi request reprint Immunohistochemical study of Muc1, Muc2 and human gastric mucin in breast carcinoma: relationship with prognostic factors
    Y Xu
    Department of Pathology, Tohoku Rosai Hospital, Sendai, Japan
    Oncol Rep 8:1177-82. 2001
    ..Muc 2 expression correlated with lymph node metastasis. HGM was found in the tumors without lymph node metastasis and lower levels of serum CA153...
  14. ncbi request reprint Lysophosphatidylcholine as a ligand for the immunoregulatory receptor G2A
    J H Kabarowski
    Department of Microbiology, Immunology, and Molecular Genetics, Lerner Research Institute, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Science 293:702-5. 2001
    ..This finding implicates a role for LPC-G2A interaction in the etiology of inflammatory autoimmune disease and atherosclerosis...
  15. ncbi request reprint An investigation of the specificity of induced anti-pig antibodies in baboons
    L Buhler
    The Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, Boston, MA, USA
    Xenotransplantation 10:88-93. 2003
    ..To provide information on the specificity of induced anti-pig antibodies (Abs) in baboons after exposure and sensitization to pig antigens...
  16. ncbi request reprint The effect of Erigeron breviscapus on proliferation of pulmonary artery smooth muscle cells in hypoxic porcines
    Y Ding
    Department of Respiratory Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030
    J Tongji Med Univ 21:206-8. 2001
    ..The EB may be used in treating the pulmonary hypertension by inhibiting the proliferation of PASMC and the pulmonary vascular remodeling...
  17. pmc Thiazolidinedione drugs block cardiac KATP channels and may increase propensity for ischaemic ventricular fibrillation in pigs
    L Lu
    VA Medical Center and University of Colorado Health Sciences Center, Denver, CO 80220, USA
    Diabetologia 51:675-85. 2008
    ..Thiazolidinedione drugs block K(ATP) channels in non-cardiac cells in vitro. This study determined whether thiazolidinedione drugs block cardiac K(ATP) channels in vivo...
  18. ncbi request reprint Altered protein profile of lymphocytes in an antigen-specific model of colitis: a comparative proteomic study
    B G Liu
    Department of Pharmacology, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai, 200433, China
    Inflamm Res 56:377-84. 2007
    ..The aim of this study was to identify the altered protein profiles of lymphocytes from rats with colitis...
  19. ncbi request reprint Tumor-specific dendritic cells generated by genetic redirection of Toll-like receptor signaling against the tumor-associated antigen, erbB2
    Y Xu
    Cancer Immunology Research Program, Peter MacCallum Cancer Centre, Melbourne, VIC 3002, Australia
    Cancer Gene Ther 14:773-80. 2007
    ..This first description of the generation of tumor-reactive DC may lead to the development of new cell-based vaccines that can act at both the tumor site to induce danger and at the lymph node to stimulate a specific T-cell response...
  20. ncbi request reprint Antitumor activity of dual-specific T cells and influenza virus
    A Murphy
    Cancer Immunology Research Program, Peter MacCallum Cancer Centre, Melbourne, Australia
    Cancer Gene Ther 14:499-508. 2007
    ..This is the first demonstration that the potent immunogenic nature of an infectious agent can be utilized to directly impact on T-cell expansion and activity against tumor in vivo...
  21. ncbi request reprint Immunophenotypic identification of acute myeloid leukemia with monocytic differentiation
    Y Xu
    Leukemia 20:1321-4. 2006
  22. pmc Topological characterization of the essential Escherichia coli cell division protein FtsN
    K Dai
    Department of Microbiology, Molecular Genetics, and Immunology, University of Kansas Medical Center, Kansas City 66160, USA
    J Bacteriol 178:1328-34. 1996
    ..It is concluded that the N-terminal, cytoplasmic, and transmembrane domains of FtsN are not required for function of the carboxy domain other than to transport it to the periplasm. FtsQ and FtsI were also analyzed...
  23. ncbi request reprint Detection and in vitro and in vivo characterization of porcine circovirus DNA from a porcine-derived commercial pepsin product
    M Fenaux
    Center for Molecular Medicine and Infectious Diseases, College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 0342, USA
    J Gen Virol 85:3377-82. 2004
    ..Nevertheless, the detection of PCV DNA in a porcine-derived commercial product raises concern for potential human infection through xenotransplantation...
  24. ncbi request reprint Efficient inhibition of multidrug-resistant human tumors with a recombinant bispecific anti-P-glycoprotein x anti-CD3 diabody
    Y Gao
    State Key Laboratory of Experimental Hematology, Institute of Hematology, Chinese Academy of Medical Sciences and Peking Tianjin Union Medical College, Tianjin, China
    Leukemia 18:513-20. 2004
    ..Taken together, our results suggest that the anti-Pgp x anti-CD3 diabody may have a great potential in the treatment of various MDR cancers...
  25. ncbi request reprint In vitro and in vivo investigation of a novel monoclonal antibody to plasma cells (W5 mAb)
    D Harper
    Immerge BioTherapeutics, Inc, Cambridge, MA, USA
    Xenotransplantation 11:78-90. 2004
    ..W5 mAb did not cause complete inhibition of anti-Gal Ab production, probably as a result of its inability to completely deplete B and plasma cells from all lymphoid compartments...
  26. ncbi request reprint Radiation-induced apoptosis in developing mouse retina exhibits dose-dependent requirement for ATM phosphorylation of p53
    H L Borges
    Division of Biological Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0322, USA
    Cell Death Differ 11:494-502. 2004
    ..These results suggest that ATM activates the apoptotic function of p53 in vivo through alternative pathways depending on IR dose...
  27. ncbi request reprint Changes in tendon strength after partial cut and effects of running peripheral sutures
    J Tan
    Department of Hand Surgery, Hand Surgery Research Center, Affiliated Hospital of Nantong Medical College, Nantong, Jiangsu, China
    J Hand Surg Br 28:478-82. 2003
    ..Running peripheral sutures increased the gap formation forces and the ultimate strength of all the tendons, though particularly those with 80% and 90% lacerations...
  28. ncbi request reprint Structural and functional characteristics of a dominant-negative isoform of porcine MHC class II transactivator
    G Quinn
    Imutran Limited, A Novartis Pharma AG Co, Cambridge, UK
    Eur J Immunogenet 30:259-70. 2003
    ..Regulation of MHC class II gene expression by manipulation of CIITA isoform expression in humans and pigs may provide a useful strategy for attenuation of T-cell-mediated cellular rejection...
  29. ncbi request reprint Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine
    R R Amara
    Vaccine Research Center and Yerkes Regional Primate Research Center, Emory University, Atlanta, GA 30329, USA
    Science 292:69-74. 2001
    ..These findings provide hope that a relatively simple multiprotein DNA/MVA vaccine can help to control the acquired immune deficiency syndrome epidemic...
  30. pmc Direct toxicity of nonsteroidal antiinflammatory drugs for renal medullary cells
    G M Rocha
    Laboratory of Kidney and Electrolytes Metabolism, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 98:5317-22. 2001
    ..Such effects of APAF might account for renal medullary cell death in vivo and development of uroepithelial tumors from surviving cells that have chromosomal aberrations...
  31. ncbi request reprint A dendritic-cell-derived C-C chemokine that preferentially attracts naive T cells
    G J Adema
    Department of Tumour Immunology, University Hospital Nijmegen, The Netherlands
    Nature 387:713-7. 1997
    ....
  32. ncbi request reprint Lymphotactin is produced by NK cells and attracts both NK cells and T cells in vivo
    J A Hedrick
    DNAX Research Institute, Palo Alto, CA 94304, USA
    J Immunol 158:1533-40. 1997
    ..This observation indicates the presence of structural features in the carboxyl terminus of Lptn that are necessary for its biologic activity...
  33. ncbi request reprint Targeted disruption of TRAF3 leads to postnatal lethality and defective T-dependent immune responses
    Y Xu
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Immunity 5:407-15. 1996
    ..These findings indicate that TRAF3 is required for postnatal development and for a competent immune system...
  34. ncbi request reprint Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma
    Y Xu
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Genes Dev 10:2411-22. 1996
    ..These findings indicate that the ATM gene product plays an essential role in a diverse group of cellular processes, including meiosis, the normal growth of somatic tissues, immune development, and tumor suppression...
  35. ncbi request reprint Dual roles of ATM in the cellular response to radiation and in cell growth control
    Y Xu
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Genes Dev 10:2401-10. 1996
    ..ATM+/- fibroblasts and thymocytes showed intermediately defective responses to irradiation but no growth defect, suggesting that the increased cancer risk of AT heterozygotes could be attributable to poor checkpoint function...
  36. pmc Function of the pre-T-cell receptor alpha chain in T-cell development and allelic exclusion at the T-cell receptor beta locus
    Y Xu
    Department of Biology, Massachusettes Institute of Technology, Cambridge 02139, USA
    Proc Natl Acad Sci U S A 93:2169-73. 1996
    ....
  37. ncbi request reprint flk2/flt3 ligand is a potent cofactor for the growth of primitive B cell progenitors
    B E Hunte
    Department of Immunology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304, USA
    J Immunol 156:489-96. 1996
    ..Since the CD24- subset was the most immature of the B cell populations studied, our data suggest that FL costimulates the expansion of very primitive B cell progenitors...
  38. pmc Cloning and characterization of ftsN, an essential cell division gene in Escherichia coli isolated as a multicopy suppressor of ftsA12(Ts)
    K Dai
    Department of Microbiology, Molecular Genetics, and Immunology, University of Kansas Medical Center, Kansas City 66103
    J Bacteriol 175:3790-7. 1993
    ..A 36-kDa protein that was localized to the membrane fraction was detected in minicells containing plasmids with the ftsN gene, confirming that FtsN was a membrane protein...
  39. pmc Mutations in ftsZ that confer resistance to SulA affect the interaction of FtsZ with GTP
    K Dai
    Department of Microbiology, Molecular Genetics, and Immunology, University of Kansas Medical Center, Kansas City 66103
    J Bacteriol 176:130-6. 1994
    ..It is likely that mutations in ftsZ that confer sulA resistance alter the conformation of the protein such that it assumes the active form...
  40. ncbi request reprint Retention of unassembled components of integral membrane proteins by calnexin
    S Rajagopalan
    Department of Rheumatology and Immunology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115
    Science 263:387-90. 1994
    ..Since engineered calnexin determined the intracellular localization of the proteins associated with it, it is concluded that calnexin interacts with incompletely assembled TCR components and retains them in the ER...
  41. ncbi request reprint Induction of embryonic major histocompatibility complex antigen expression by gamma-IFN
    C M Warner
    Department of Biology, Northeastern University, Boston, MA 02115
    J Reprod Immunol 24:111-21. 1993
    ..Since rate of preimplantation embryonic development is genetically controlled by the Ped gene, it is suggested that gamma-IFN has a direct effect on the Ped gene phenotype of preimplantation mouse embryos...
  42. ncbi request reprint Predominance of the recurrent mutation R635X in the LAMB3 gene in European patients with Herlitz junctional epidermolysis bullosa has implications for mutation detection strategy
    L Pulkkinen
    Department of Dermatology and Cutaneous Biology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, U S A
    J Invest Dermatol 109:232-7. 1997
    ..This recurrent mutation will facilitate screening of additional JEB patients for the purpose of prenatal testing of fetuses at risk for recurrence...
  43. ncbi request reprint Identification of the cellular source of laminin beta2 in adult and developing vertebrate retinae
    R T Libby
    Department of Biology, Boston College, Chestnut Hill, Massachusetts 02167, USA
    J Comp Neurol 389:655-67. 1997
    ....
  44. ncbi request reprint Prognostic significance of tumour-infiltrating T lymphocytes and T-cell subsets in de novo diffuse large B-cell lymphoma: a multiparameter flow cytometry study
    Y Xu
    Department of Pathology, University of Texas Southwestern Medical Center, 3523 Harry Hines Blvd, Dallas, TX 75390-9072, USA
    Br J Haematol 112:945-9. 2001
    ..06). These results suggest that TIL-T, particularly CD4+ T cells, may play a role in the control of DLBCL, and measurement of T-cell percentage and T-cell subsets using FCI may be useful in predicting the clinical behaviour of DLBCL...
  45. pmc Definition of a divergent epitope that allows differential detection of early protein p41 from human herpesvirus 6 variants A and B
    Y Xu
    Department of Virology, Swedish Institute for Infectious Disease Control, 171 82 Solna, Sweden
    J Clin Microbiol 39:1449-55. 2001
    ..Our findings are of value for the interpretation of previous findings of p41 expression in brains of MS patients and may allow a more detailed analysis of the role of HHV-6 variants in other disorders...
  46. ncbi request reprint A clonal growth model: time-course simulations of liver foci growth following penta- or hexachlorobenzene treatment in a medium-term bioassay
    Y C Ou
    Center for Environmental Toxicology and Technology, Department of Environmental Health, Colorado State University, Fort Collins 80523, USA
    Cancer Res 61:1879-89. 2001
    ..This simulation work is an example of quantitative approaches that could be useful for the analysis of other initiation-promotion studies...
  47. pmc Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development
    J Sekiguchi
    The Center for Blood Research, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 98:3243-8. 2001
    ..Finally, in dramatic contrast to effects on Lig4 deficiency, ATM deficiency causes early embryonic lethality in Ku- or DNA-PKcs-deficient mice, providing evidence for an NHEJ-independent role for the DNA-PK holoenzyme...
  48. pmc A common mechanism for concurrent changes of diastolic muscle length and systolic function in intact hearts
    L Lu
    Cardiology Section, Department of Veterans Affairs Medical Center and University of Colorado Health Sciences Center, Denver, Colorado 80220, USA
    Am J Physiol Heart Circ Physiol 280:H1513-8. 2001
    ..01). We concluded that residual diastolic cross-bridges significantly and reversibly influence end-diastolic mechanics in vivo. Alterations of end-diastolic and systolic cross-bridge interactions occur in parallel...
  49. ncbi request reprint The Drosophila S3 multifunctional DNA repair/ribosomal protein protects Fanconi anemia cells against oxidative DNA damaging agents
    M R Kelley
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, 702 Barnhill Dr, Room 2600, Indianapolis, IN 46202, USA
    Mutat Res 485:107-19. 2001
    ..Based on these findings, we would predict other oxidative repair proteins, or oxidative scavengers, could serve as protective agents against the oxidative DNA damage that occurs in FA...
  50. ncbi request reprint Protection of mammalian cells against chemotherapeutic agents thiotepa, 1,3-N,N'-bis(2-chloroethyl)-N-nitrosourea, and mafosfamide using the DNA base excision repair genes Fpg and alpha-hOgg1: implications for protective gene therapy applications
    Y Xu
    Department of Pediatrics, Section of Hematology/Oncology, Herman B. Wells Center for Pediatric Research and Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    J Pharmacol Exp Ther 296:825-31. 2001
    ....
  51. pmc Severe B cell deficiency in mice lacking the tec kinase family members Tec and Btk
    W Ellmeier
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine
    J Exp Med 192:1611-24. 2000
    ..The ability of Tec to compensate for Btk may also explain phenotypic differences in X-linked immunodeficiency (xid) mice compared with human X-linked agammaglobulinemia (XLA) patients...
  52. pmc Attractin (DPPT-L), a member of the CUB family of cell adhesion and guidance proteins, is secreted by activated human T lymphocytes and modulates immune cell interactions
    J S Duke-Cohan
    Division of Tumor Immunology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 95:11336-41. 1998
    ..1 protein, suggesting that attractin has evolved new domains and functions in parallel with the development of cell-mediated immunity...
  53. pmc A cell surface receptor defined by a mAb mediates a unique type of cell death similar to oncosis
    C Zhang
    Tumor Immunology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 95:6290-5. 1998
    ..The induction of cell death by anti-Porimin may represent a unique cell surface receptor-mediated pathway of cell death in the human lymphoid system...
  54. pmc A specific, nonproliferative role for E2F-5 in choroid plexus function revealed by gene targeting
    G J Lindeman
    The Dana Farber Cancer Institute Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 12:1092-8. 1998
    ..Cell cycle kinetics were not perturbed in homozygous knockout embryo fibroblasts. Thus, E2F-5 is not essential for cell proliferation. Rather, it affects the secretory behavior of a differentiated neural tissue...
  55. ncbi request reprint Removal of Qa-2 antigen alters the Ped gene phenotype of preimplantation mouse embryos
    Z Tian
    Department of Biology, Northeastern University Boston, Massachusetts 02115
    Biol Reprod 47:271-6. 1992
    ..Furthermore, removal of Qa-2 antigen from the embryonic cell surface slows down the rate of development of preimplantation mouse embryos. These results suggest the likelihood that the Qa-2 antigen is the Ped gene product...