Melanie C Ruzek

Summary

Affiliation: Genzyme Corporation
Country: USA

Publications

  1. doi request reprint Ultrasound imaging accurately detects skin thickening in a mouse scleroderma model
    Jennifer L Tedstone
    Immunology and Clinical Laboratory Sciences, Biologics R and D, Genzyme Corporation, Framingham, MA, USA
    Ultrasound Med Biol 34:1239-47. 2008
  2. ncbi request reprint Adenoviral vectors stimulate murine natural killer cell responses and demonstrate antitumor activities in the absence of transgene expression
    Melanie C Ruzek
    Immunology Laboratory, Cell and Protein Therapeutics R and D, Genzyme Corporation, Framingham, Massachusetts 01701, USA
    Mol Ther 5:115-24. 2002
  3. ncbi request reprint Minimal effects on immune parameters following chronic anti-TGF-beta monoclonal antibody administration to normal mice
    Melanie C Ruzek
    Cell and Protein Therapeutics R and D, Genzyme Corporation, Framingham, Massachusetts 01701 9322, USA
    Immunopharmacol Immunotoxicol 25:235-57. 2003
  4. ncbi request reprint A modified model of graft-versus-host-induced systemic sclerosis (scleroderma) exhibits all major aspects of the human disease
    Melanie C Ruzek
    Genzyme Corporation, Framingham, Massachusetts 01701, USA
    Arthritis Rheum 50:1319-31. 2004
  5. ncbi request reprint Characterization of in vitro antimurine thymocyte globulin-induced regulatory T cells that inhibit graft-versus-host disease in vivo
    Melanie C Ruzek
    Immunology and Clinical Laboratory Sciences, Biologics R and D, Framingham, MA, USA
    Blood 111:1726-34. 2008
  6. doi request reprint In vivo characterization of rabbit anti-mouse thymocyte globulin: a surrogate for rabbit anti-human thymocyte globulin
    Melanie C Ruzek
    Department of Immunology and Clinical Laboratory Sciences, Biologics R and D, Genzyme Corporation, Framingham, MA 01701, USA
    Transplantation 88:170-9. 2009
  7. doi request reprint Murine antithymocyte globulin T-cell depletion is mediated predominantly by macrophages, but the Fas/FasL pathway selectively targets regulatory T cells
    Kathleen S Neff
    Department Immunology and Clinical Laboratory Sciences, Biologics R and D, Genzyme Corporation, Framingham, MA, USA
    Transplantation 92:523-8. 2011
  8. pmc Homeostatic role of transforming growth factor-beta in the oral cavity and esophagus of mice and its expression by mast cells in these tissues
    Allison Vitsky
    Genzyme Corporation, 1 The Mountain Rd, Framingham, MA 01701 9322, USA
    Am J Pathol 174:2137-49. 2009

Collaborators

  • Jennifer Sullivan
  • Beth L Thurberg
  • Richard D Garman
  • Kathleen S Neff
  • Susan M Richards
  • Allison Vitsky
  • Jennifer L Tedstone
  • John M Williams
  • Michael L Hawes
  • Douglas Matthews
  • Carol Nelson
  • Robert Pawliuk
  • James Waire
  • Steve Ledbetter
  • Laura Andrews
  • Scott Lonning
  • Susan Richards
  • Peter A Piepenhagen
  • Arden Bond
  • Emily Lacasse

Detail Information

Publications8

  1. doi request reprint Ultrasound imaging accurately detects skin thickening in a mouse scleroderma model
    Jennifer L Tedstone
    Immunology and Clinical Laboratory Sciences, Biologics R and D, Genzyme Corporation, Framingham, MA, USA
    Ultrasound Med Biol 34:1239-47. 2008
    ..Thus, these studies demonstrate that ultrasound can accurately detect skin thickening in a mouse model of scleroderma...
  2. ncbi request reprint Adenoviral vectors stimulate murine natural killer cell responses and demonstrate antitumor activities in the absence of transgene expression
    Melanie C Ruzek
    Immunology Laboratory, Cell and Protein Therapeutics R and D, Genzyme Corporation, Framingham, Massachusetts 01701, USA
    Mol Ther 5:115-24. 2002
    ..Collectively, these results demonstrate in a murine system that the adenoviral vector gene delivery system itself stimulates NK cells, and this in turn can nonspecifically enhance antitumor immunity...
  3. ncbi request reprint Minimal effects on immune parameters following chronic anti-TGF-beta monoclonal antibody administration to normal mice
    Melanie C Ruzek
    Cell and Protein Therapeutics R and D, Genzyme Corporation, Framingham, Massachusetts 01701 9322, USA
    Immunopharmacol Immunotoxicol 25:235-57. 2003
    ..Thus, there does not appear to be any significant immune dysregulation detectable after long-term antibody-mediated neutralization of TGF-beta in normal mice...
  4. ncbi request reprint A modified model of graft-versus-host-induced systemic sclerosis (scleroderma) exhibits all major aspects of the human disease
    Melanie C Ruzek
    Genzyme Corporation, Framingham, Massachusetts 01701, USA
    Arthritis Rheum 50:1319-31. 2004
    ..The present studies were undertaken to determine if alteration of the induction of GVH-induced scleroderma could result in a model that more fully represented the human condition...
  5. ncbi request reprint Characterization of in vitro antimurine thymocyte globulin-induced regulatory T cells that inhibit graft-versus-host disease in vivo
    Melanie C Ruzek
    Immunology and Clinical Laboratory Sciences, Biologics R and D, Framingham, MA, USA
    Blood 111:1726-34. 2008
    ..The in vitro generation of regulatory cells by anti-thymocyte globulins could provide ad-ditional therapeutic modalities for immune-mediated disease...
  6. doi request reprint In vivo characterization of rabbit anti-mouse thymocyte globulin: a surrogate for rabbit anti-human thymocyte globulin
    Melanie C Ruzek
    Department of Immunology and Clinical Laboratory Sciences, Biologics R and D, Genzyme Corporation, Framingham, MA 01701, USA
    Transplantation 88:170-9. 2009
    ..Polyclonal rabbit anti-human thymocyte globulin (Thymoglobulin) is used clinically for immunosuppression in solid organ transplantation; however, it is difficult to fully characterize the effects of this agent in humans...
  7. doi request reprint Murine antithymocyte globulin T-cell depletion is mediated predominantly by macrophages, but the Fas/FasL pathway selectively targets regulatory T cells
    Kathleen S Neff
    Department Immunology and Clinical Laboratory Sciences, Biologics R and D, Genzyme Corporation, Framingham, MA, USA
    Transplantation 92:523-8. 2011
    ..The current studies were designed to determine whether different effector mechanisms are involved in differential depletion of T-cell subsets by mATG...
  8. pmc Homeostatic role of transforming growth factor-beta in the oral cavity and esophagus of mice and its expression by mast cells in these tissues
    Allison Vitsky
    Genzyme Corporation, 1 The Mountain Rd, Framingham, MA 01701 9322, USA
    Am J Pathol 174:2137-49. 2009
    ..These studies illustrate a previously unappreciated biological role of TGF-beta in maintaining homeostasis within both oral and esophageal tissues...