David Reczek

Summary

Affiliation: Genzyme Corporation
Country: USA

Publications

  1. ncbi request reprint LIMP-2 is a receptor for lysosomal mannose-6-phosphate-independent targeting of beta-glucocerebrosidase
    David Reczek
    Genzyme Corporation, 1 Mountain Road, Framingham, MA 01701, USA
    Cell 131:770-83. 2007
  2. ncbi request reprint Effect of mannose chain length on targeting of glucocerebrosidase for enzyme replacement therapy of Gaucher disease
    Scott M Van Patten
    Cell and Protein Therapeutics, Genzyme Corp, Framingham, MA 01701 9322, USA
    Glycobiology 17:467-78. 2007
  3. ncbi request reprint Chemical chaperones and permissive temperatures alter localization of Gaucher disease associated glucocerebrosidase variants
    Anu R Sawkar
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    ACS Chem Biol 1:235-51. 2006

Collaborators

  • Tim Edmunds
  • Huawei Qiu
  • R D'hooge
  • Paul Saftig
  • Scott M Van Patten
  • Anu R Sawkar
  • Joseph P Kutzko
  • James Waire
  • Michael R Huff
  • Paul V Ward
  • Peter A Piepenhagen
  • Heather Hughes
  • Chandrashekar Ganesa
  • William E Balch
  • Jeffery W Kelly
  • Martina Schmitz
  • Klaus Peter Zimmer

Detail Information

Publications3

  1. ncbi request reprint LIMP-2 is a receptor for lysosomal mannose-6-phosphate-independent targeting of beta-glucocerebrosidase
    David Reczek
    Genzyme Corporation, 1 Mountain Road, Framingham, MA 01701, USA
    Cell 131:770-83. 2007
    ..These data support a role for LIMP-2 as the mannose-6-phosphate-independent trafficking receptor for beta-glucocerebrosidase...
  2. ncbi request reprint Effect of mannose chain length on targeting of glucocerebrosidase for enzyme replacement therapy of Gaucher disease
    Scott M Van Patten
    Cell and Protein Therapeutics, Genzyme Corp, Framingham, MA 01701 9322, USA
    Glycobiology 17:467-78. 2007
    ....
  3. ncbi request reprint Chemical chaperones and permissive temperatures alter localization of Gaucher disease associated glucocerebrosidase variants
    Anu R Sawkar
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    ACS Chem Biol 1:235-51. 2006
    ..These data clearly show manipulating the ER environment with chemical chaperones increases the lysosomal concentration of partially active GC variants and suggest that small molecules could be used to treat Gaucher disease...