Genomes and Genes
Affiliation: Genzyme Corporation
- LIMP-2 is a receptor for lysosomal mannose-6-phosphate-independent targeting of beta-glucocerebrosidaseDavid Reczek
Genzyme Corporation, 1 Mountain Road, Framingham, MA 01701, USA
Cell 131:770-83. 2007..These data support a role for LIMP-2 as the mannose-6-phosphate-independent trafficking receptor for beta-glucocerebrosidase...
- Effect of mannose chain length on targeting of glucocerebrosidase for enzyme replacement therapy of Gaucher diseaseScott M Van Patten
Cell and Protein Therapeutics, Genzyme Corp, Framingham, MA 01701 9322, USA
Glycobiology 17:467-78. 2007....
- Erythrocytes encapsulated with phenylalanine hydroxylase exhibit improved pharmacokinetics and lowered plasma phenylalanine levels in normal miceNelson S Yew
Genzyme, a Sanofi Company, 49 New York Avenue, Framingham, MA 01701 9322, USA
Mol Genet Metab 109:339-44. 2013..These results demonstrate the ability of enzyme-loaded RBCs to metabolize circulating amino acids and highlight the potential to treat disorders of amino acid metabolism. ..
- Chemical chaperones and permissive temperatures alter localization of Gaucher disease associated glucocerebrosidase variantsAnu R Sawkar
Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, USA
ACS Chem Biol 1:235-51. 2006..These data clearly show manipulating the ER environment with chemical chaperones increases the lysosomal concentration of partially active GC variants and suggest that small molecules could be used to treat Gaucher disease...