David Reczek

Summary

Affiliation: Genzyme Corporation
Country: USA

Publications

  1. ncbi request reprint LIMP-2 is a receptor for lysosomal mannose-6-phosphate-independent targeting of beta-glucocerebrosidase
    David Reczek
    Genzyme Corporation, 1 Mountain Road, Framingham, MA 01701, USA
    Cell 131:770-83. 2007
  2. ncbi request reprint Effect of mannose chain length on targeting of glucocerebrosidase for enzyme replacement therapy of Gaucher disease
    Scott M Van Patten
    Cell and Protein Therapeutics, Genzyme Corp, Framingham, MA 01701 9322, USA
    Glycobiology 17:467-78. 2007
  3. doi request reprint Erythrocytes encapsulated with phenylalanine hydroxylase exhibit improved pharmacokinetics and lowered plasma phenylalanine levels in normal mice
    Nelson S Yew
    Genzyme, a Sanofi Company, 49 New York Avenue, Framingham, MA 01701 9322, USA
    Mol Genet Metab 109:339-44. 2013
  4. ncbi request reprint Chemical chaperones and permissive temperatures alter localization of Gaucher disease associated glucocerebrosidase variants
    Anu R Sawkar
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    ACS Chem Biol 1:235-51. 2006

Collaborators

  • Tim Edmunds
  • Huawei Qiu
  • R D'hooge
  • Paul Saftig
  • Nelson S Yew
  • Scott M Van Patten
  • Anu R Sawkar
  • Cristin Crawley
  • Emmanuelle Dufour
  • Yann Godfrin
  • Meta Foster
  • Julie Putelat
  • Aurélien Meyzaud
  • Françoise Horand
  • Malgorzata Przybylska
  • Seng H Cheng
  • Alla Kloss
  • Sarah Gentry
  • Joseph P Kutzko
  • Paul V Ward
  • Peter A Piepenhagen
  • Heather Hughes
  • James Waire
  • Michael R Huff
  • Chandrashekar Ganesa
  • Martina Schmitz
  • Klaus Peter Zimmer
  • William E Balch
  • Jeffery W Kelly

Detail Information

Publications4

  1. ncbi request reprint LIMP-2 is a receptor for lysosomal mannose-6-phosphate-independent targeting of beta-glucocerebrosidase
    David Reczek
    Genzyme Corporation, 1 Mountain Road, Framingham, MA 01701, USA
    Cell 131:770-83. 2007
    ..These data support a role for LIMP-2 as the mannose-6-phosphate-independent trafficking receptor for beta-glucocerebrosidase...
  2. ncbi request reprint Effect of mannose chain length on targeting of glucocerebrosidase for enzyme replacement therapy of Gaucher disease
    Scott M Van Patten
    Cell and Protein Therapeutics, Genzyme Corp, Framingham, MA 01701 9322, USA
    Glycobiology 17:467-78. 2007
    ....
  3. doi request reprint Erythrocytes encapsulated with phenylalanine hydroxylase exhibit improved pharmacokinetics and lowered plasma phenylalanine levels in normal mice
    Nelson S Yew
    Genzyme, a Sanofi Company, 49 New York Avenue, Framingham, MA 01701 9322, USA
    Mol Genet Metab 109:339-44. 2013
    ..These results demonstrate the ability of enzyme-loaded RBCs to metabolize circulating amino acids and highlight the potential to treat disorders of amino acid metabolism. ..
  4. ncbi request reprint Chemical chaperones and permissive temperatures alter localization of Gaucher disease associated glucocerebrosidase variants
    Anu R Sawkar
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    ACS Chem Biol 1:235-51. 2006
    ..These data clearly show manipulating the ER environment with chemical chaperones increases the lysosomal concentration of partially active GC variants and suggest that small molecules could be used to treat Gaucher disease...