R H Barker

Summary

Affiliation: Genzyme Corporation
Country: USA

Publications

  1. ncbi request reprint Review article: tolevamer, a novel toxin-binding polymer: overview of preclinical pharmacology and physicochemical properties
    R H Barker
    Pharmacology and Preclinical Development, Genzyme Drug Discovery and Development, Waltham, MA 02541, USA
    Aliment Pharmacol Ther 24:1525-34. 2006
  2. pmc Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis
    Robert H Barker
    Genzyme Corporation, 153 Second Avenue, Waltham, MA 02451, USA
    Antimicrob Agents Chemother 53:2052-8. 2009
  3. pmc Aminoindoles, a novel scaffold with potent activity against Plasmodium falciparum
    Robert H Barker
    Genzyme Corporation, 153 Second Avenue, Waltham, MA 02451, USA
    Antimicrob Agents Chemother 55:2612-22. 2011
  4. pmc GT160-246, a toxin binding polymer for treatment of Clostridium difficile colitis
    C B Kurtz
    GelTex Pharmaceuticals, Inc, Waltham, Massachusetts 02451, USA
    Antimicrob Agents Chemother 45:2340-7. 2001

Detail Information

Publications4

  1. ncbi request reprint Review article: tolevamer, a novel toxin-binding polymer: overview of preclinical pharmacology and physicochemical properties
    R H Barker
    Pharmacology and Preclinical Development, Genzyme Drug Discovery and Development, Waltham, MA 02541, USA
    Aliment Pharmacol Ther 24:1525-34. 2006
    ..Tolevamer is a novel toxin-binding polymer that is currently being investigated in clinical trials for the treatment of patients who have Clostridium difficile-associated diarrhoea...
  2. pmc Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis
    Robert H Barker
    Genzyme Corporation, 153 Second Avenue, Waltham, MA 02451, USA
    Antimicrob Agents Chemother 53:2052-8. 2009
    ..Taken together, the data strengthen validation of AdoMetDC as an important parasite target, and these studies have shown that analogs of MDL 73811 can be synthesized with improved potency and brain penetration...
  3. pmc Aminoindoles, a novel scaffold with potent activity against Plasmodium falciparum
    Robert H Barker
    Genzyme Corporation, 153 Second Avenue, Waltham, MA 02451, USA
    Antimicrob Agents Chemother 55:2612-22. 2011
    ..These characteristics make Genz-668764 a good candidate for preclinical development...
  4. pmc GT160-246, a toxin binding polymer for treatment of Clostridium difficile colitis
    C B Kurtz
    GelTex Pharmaceuticals, Inc, Waltham, Massachusetts 02451, USA
    Antimicrob Agents Chemother 45:2340-7. 2001
    ..GT160-246 offers a novel, nonantimicrobial treatment of C. difficile disease in humans...