Joseph T Bruder

Summary

Affiliation: GenVec Inc
Country: USA

Publications

  1. ncbi Molecular vaccines for malaria
    Joseph T Bruder
    GenVec, Inc, Gaithersburg, MD, USA
    Hum Vaccin 6:54-77. 2010
  2. pmc Modification of Ad5 hexon hypervariable regions circumvents pre-existing Ad5 neutralizing antibodies and induces protective immune responses
    Joseph T Bruder
    Research, GenVec, Inc, Gaithersburg, Maryland, United States of America
    PLoS ONE 7:e33920. 2012
  3. pmc Identification and localization of minimal MHC-restricted CD8+ T cell epitopes within the Plasmodium falciparum AMA1 protein
    Martha Sedegah
    USMMVP, Malaria Department, NMRC, Silver Spring, MD 20910, USA
    Malar J 9:241. 2010
  4. doi Adenovectors induce functional antibodies capable of potent inhibition of blood stage malaria parasite growth
    Joseph T Bruder
    GenVec, Inc, 65 West Watkins Mill Road, Gaithersburg, MD 20878, USA
    Vaccine 28:3201-10. 2010
  5. doi Persistent expression of PEDF in the eye using high-capacity adenovectors
    Ping Chen
    GenVec, Inc Research Department, Gaithersburg, Maryland 20878, USA
    Mol Ther 16:1986-94. 2008
  6. pmc Identification of a suppressor mutation that improves the yields of hexon-modified adenovirus vectors
    Joseph T Bruder
    GenVec, Inc, Gaithersburg, Maryland, USA
    J Virol 87:9661-71. 2013
  7. pmc Adenovirus-5-vectored P. falciparum vaccine expressing CSP and AMA1. Part B: safety, immunogenicity and protective efficacy of the CSP component
    Cindy Tamminga
    U S Military Malaria Vaccine Program, Naval Medical Research Center, Silver Spring, Maryland, United States of America
    PLoS ONE 6:e25868. 2011
  8. pmc DNA prime/Adenovirus boost malaria vaccine encoding P. falciparum CSP and AMA1 induces sterile protection associated with cell-mediated immunity
    Ilin Chuang
    US Military Malaria Vaccine Program, Naval Medical Research Center, Silver Spring, Maryland, United States of America
    PLoS ONE 8:e55571. 2013
  9. ncbi Promoters influence the kinetics of transgene expression following adenovector gene delivery
    Ping Chen
    GenVec, Inc, 65 West Watkins Mill Road, Gaithersburg, MD 20878, USA
    J Gene Med 10:123-31. 2008
  10. pmc Adenovirus 5-vectored P. falciparum vaccine expressing CSP and AMA1. Part A: safety and immunogenicity in seronegative adults
    Martha Sedegah
    U S Military Malaria Vaccine Program, Naval Medical Research Center, Silver Spring, Maryland, United States of America
    PLoS ONE 6:e24586. 2011

Research Grants

Collaborators

Detail Information

Publications13

  1. ncbi Molecular vaccines for malaria
    Joseph T Bruder
    GenVec, Inc, Gaithersburg, MD, USA
    Hum Vaccin 6:54-77. 2010
    ..In this review, we discuss the molecular aspects of antigen design, adjuvant advancement and the development of vaccine delivery systems as they are being applied to malaria vaccines...
  2. pmc Modification of Ad5 hexon hypervariable regions circumvents pre-existing Ad5 neutralizing antibodies and induces protective immune responses
    Joseph T Bruder
    Research, GenVec, Inc, Gaithersburg, Maryland, United States of America
    PLoS ONE 7:e33920. 2012
    ..These hexon-modified adenovectors may have advantages in sub-Saharan Africa where there is a high prevalence of Ad5 neutralizing antibody in the population...
  3. pmc Identification and localization of minimal MHC-restricted CD8+ T cell epitopes within the Plasmodium falciparum AMA1 protein
    Martha Sedegah
    USMMVP, Malaria Department, NMRC, Silver Spring, MD 20910, USA
    Malar J 9:241. 2010
    ..Since CD8+ T cell responses have been implicated in protection against pre-erythrocytic stage malaria, this study was designed to identify MHC class I-restricted epitopes within AMA1...
  4. doi Adenovectors induce functional antibodies capable of potent inhibition of blood stage malaria parasite growth
    Joseph T Bruder
    GenVec, Inc, 65 West Watkins Mill Road, Gaithersburg, MD 20878, USA
    Vaccine 28:3201-10. 2010
    ..These data highlight the importance of rational vaccine design and support the advancement of adenovector delivery technology for a malaria vaccine...
  5. doi Persistent expression of PEDF in the eye using high-capacity adenovectors
    Ping Chen
    GenVec, Inc Research Department, Gaithersburg, Maryland 20878, USA
    Mol Ther 16:1986-94. 2008
    ..These results support the development of the HC adenovector gene delivery system for ocular disease...
  6. pmc Identification of a suppressor mutation that improves the yields of hexon-modified adenovirus vectors
    Joseph T Bruder
    GenVec, Inc, Gaithersburg, Maryland, USA
    J Virol 87:9661-71. 2013
    ....
  7. pmc Adenovirus-5-vectored P. falciparum vaccine expressing CSP and AMA1. Part B: safety, immunogenicity and protective efficacy of the CSP component
    Cindy Tamminga
    U S Military Malaria Vaccine Program, Naval Medical Research Center, Silver Spring, Maryland, United States of America
    PLoS ONE 6:e25868. 2011
    ..As adenovirus vaccine vectors induce both these responses in humans, a Phase 1/2a clinical trial was conducted to evaluate the efficacy of an adenovirus serotype 5-vectored malaria vaccine against sporozoite challenge...
  8. pmc DNA prime/Adenovirus boost malaria vaccine encoding P. falciparum CSP and AMA1 induces sterile protection associated with cell-mediated immunity
    Ilin Chuang
    US Military Malaria Vaccine Program, Naval Medical Research Center, Silver Spring, Maryland, United States of America
    PLoS ONE 8:e55571. 2013
    ..We tested a DNA prime/adenovirus boost malaria vaccine in a Phase 1 clinical trial with controlled human malaria infection...
  9. ncbi Promoters influence the kinetics of transgene expression following adenovector gene delivery
    Ping Chen
    GenVec, Inc, 65 West Watkins Mill Road, Gaithersburg, MD 20878, USA
    J Gene Med 10:123-31. 2008
    ..As different promoters have variable strengths and kinetic profiles, the optimal dose of a therapeutic transgene product over time may be achieved by varying the promoter...
  10. pmc Adenovirus 5-vectored P. falciparum vaccine expressing CSP and AMA1. Part A: safety and immunogenicity in seronegative adults
    Martha Sedegah
    U S Military Malaria Vaccine Program, Naval Medical Research Center, Silver Spring, Maryland, United States of America
    PLoS ONE 6:e24586. 2011
    ....
  11. pmc Sterile protection against Plasmodium knowlesi in rhesus monkeys from a malaria vaccine: comparison of heterologous prime boost strategies
    George Jiang
    Naval Medical Research Center, Malaria Program, Silver Spring, MD, USA
    PLoS ONE 4:e6559. 2009
    ..We discuss the high level but short duration of protection in this experiment and the possible benefits of the long interval between prime and boost...
  12. doi Adenoviruses isolated from wild gorillas are closely related to human species C viruses
    McVey Duncan
    GenVec, Inc, 65W Watkins Mill Rd, Gaithersburg, MD 20878, USA
    Virology 444:119-23. 2013
    ..The human adenovirus 5 fiber knob blocked infection, suggesting use of the Coxsackie and Adenovirus Receptor. These viruses may provide viral vectors with properties distinct from chimpanzee adenovirus and human adenovirus vectors. ..
  13. ncbi Repeated administration of adenovector in the eye results in efficient gene delivery
    Melissa M Hamilton
    GenVec, Inc, Gaithersburg, Maryland 20878, USA
    Invest Ophthalmol Vis Sci 47:299-305. 2006
    ....

Research Grants2

  1. Evaluation of High-Capacity Adenovectors in the Eye
    Joseph Bruder; Fiscal Year: 2006
    ..The long-term goal of this proposal is the clinical testing and commercialization of PEDF expressing HC vector for the treatment of AMD and other ocular neovascular diseases. ..