Tim Wiltshire

Summary

Affiliation: Genomics Institute of the Novartis Research Foundation
Country: USA

Publications

  1. pmc Can we find the genes involved in complex traits?
    Mathew Pletcher
    Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Genome Biol 5:347. 2004
  2. pmc Genome-wide single-nucleotide polymorphism analysis defines haplotype patterns in mouse
    Tim Wiltshire
    Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 100:3380-5. 2003
  3. pmc Gene set enrichment in eQTL data identifies novel annotations and pathway regulators
    Chunlei Wu
    Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America
    PLoS Genet 4:e1000070. 2008
  4. pmc Use of a dense single nucleotide polymorphism map for in silico mapping in the mouse
    Mathew T Pletcher
    Genomics Institute of the Novartis Research Foundation, San Diego, California, USA
    PLoS Biol 2:e393. 2004
  5. ncbi request reprint c-Myb and p300 regulate hematopoietic stem cell proliferation and differentiation
    Mark L Sandberg
    Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, USA
    Dev Cell 8:153-66. 2005
  6. pmc Comparative analysis of haplotype association mapping algorithms
    Phillip McClurg
    Genomics Institute of the Novartis Research Foundation, San Diego, USA
    BMC Bioinformatics 7:61. 2006
  7. pmc A conserved salt bridge in the G loop of multiple protein kinases is important for catalysis and for in vivo Lyn function
    Rina Barouch-Bentov
    Genomics Institute of the Novartis Research Foundation, 10675 John J Hopkins Drive, San Diego, CA 92121, USA
    Mol Cell 33:43-52. 2009
  8. pmc Genomewide association analysis in diverse inbred mice: power and population structure
    Phillip McClurg
    Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, USA
    Genetics 176:675-83. 2007
  9. pmc A gene atlas of the mouse and human protein-encoding transcriptomes
    Andrew I Su
    The Genomics Institute of the Novartis Research Foundation, 10675 John J Hopkins Drive, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 101:6062-7. 2004
  10. pmc Inositol (1,4,5) trisphosphate 3 kinase B controls positive selection of T cells and modulates Erk activity
    Ben G Wen
    Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 101:5604-9. 2004

Research Grants

Detail Information

Publications24

  1. pmc Can we find the genes involved in complex traits?
    Mathew Pletcher
    Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Genome Biol 5:347. 2004
  2. pmc Genome-wide single-nucleotide polymorphism analysis defines haplotype patterns in mouse
    Tim Wiltshire
    Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 100:3380-5. 2003
    ..These analyses define blocks of high or low diversity, often extending across tens of megabases that are delineated by abrupt transitions. These observations provide a striking contrast to the haplotype structure of the human genome...
  3. pmc Gene set enrichment in eQTL data identifies novel annotations and pathway regulators
    Chunlei Wu
    Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America
    PLoS Genet 4:e1000070. 2008
    ..We believe that the specific molecular hypotheses generated in this study will reveal many additional pathway members and regulators, and that the analysis approaches described herein will be broadly applicable to other eQTL data sets...
  4. pmc Use of a dense single nucleotide polymorphism map for in silico mapping in the mouse
    Mathew T Pletcher
    Genomics Institute of the Novartis Research Foundation, San Diego, California, USA
    PLoS Biol 2:e393. 2004
    ..The inferred haplotype data also facilitates the refinement of QTL regions such that candidate genes can be more easily identified and characterized as shown for adenylate cyclase 7...
  5. ncbi request reprint c-Myb and p300 regulate hematopoietic stem cell proliferation and differentiation
    Mark L Sandberg
    Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, USA
    Dev Cell 8:153-66. 2005
    ..Cell cycle analyses show that twice as many HSCs from c-Myb(M303V/M303V) animals are actively cycling. Thus c-Myb, through interaction with p300, controls the proliferation and differentiation of hematopoietic stem and progenitor cells...
  6. pmc Comparative analysis of haplotype association mapping algorithms
    Phillip McClurg
    Genomics Institute of the Novartis Research Foundation, San Diego, USA
    BMC Bioinformatics 7:61. 2006
    ..As the availability of genotyping data grows in size and density, analysis of these haplotype association mapping methods should be of increasing value to the statistical genetics community...
  7. pmc A conserved salt bridge in the G loop of multiple protein kinases is important for catalysis and for in vivo Lyn function
    Rina Barouch-Bentov
    Genomics Institute of the Novartis Research Foundation, 10675 John J Hopkins Drive, San Diego, CA 92121, USA
    Mol Cell 33:43-52. 2009
    ..This demonstrates the physiological importance of the conserved G loop salt bridge and at the same time distinguishes the in vivo requirement for the Lyn kinase activity from other potential functions of the protein...
  8. pmc Genomewide association analysis in diverse inbred mice: power and population structure
    Phillip McClurg
    Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, USA
    Genetics 176:675-83. 2007
    ..These eQTL data confirmed that the MDP is a suitable mapping population for QTL discovery and that eQTL results can serve as a gold standard for relative measures of statistical power...
  9. pmc A gene atlas of the mouse and human protein-encoding transcriptomes
    Andrew I Su
    The Genomics Institute of the Novartis Research Foundation, 10675 John J Hopkins Drive, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 101:6062-7. 2004
    ..We describe hundreds of regions of correlated transcription and show that some are subject to both tissue and parental allele-specific expression, suggesting a link between spatial expression and imprinting...
  10. pmc Inositol (1,4,5) trisphosphate 3 kinase B controls positive selection of T cells and modulates Erk activity
    Ben G Wen
    Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 101:5604-9. 2004
    ..T-less thymocytes, suggesting a role for Itpkb in linking T cell receptor signaling to efficient and sustained Erk activation...
  11. ncbi request reprint Databases of free expression
    John R Walker
    Genomics Institute of Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, USA
    Mamm Genome 17:1141-6. 2006
    ..This review highlights the current features and describes examples of two broad categories of mammalian microarray databases: tissue gene expression databases and data warehouses...
  12. pmc Genetically based resistance to the antiinflammatory effects of methotrexate in the air-pouch model of acute inflammation
    David L Delano
    New York University Medical Center, NY 10016, USA
    Arthritis Rheum 52:2567-75. 2005
    ..To determine whether genetic factors or the model itself is responsible for the poor response to MTX, we directly compared the responses of 4 inbred mouse strains to MTX in the air-pouch model of acute inflammation...
  13. ncbi request reprint Quantitative trait loci that determine BMD in C57BL/6J and 129S1/SvImJ inbred mice
    Naoki Ishimori
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    J Bone Miner Res 21:105-12. 2006
    ..To identify loci controlling BMD, we conducted a QTL analysis in a (B6 x 129) F2 population of mice. We report on additional QTLs and also narrow one QTL by combining the data from multiple crosses and through haplotype analysis...
  14. pmc Utilization of a whole genome SNP panel for efficient genetic mapping in the mouse
    Jennifer L Moran
    Genetics Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genome Res 16:436-40. 2006
    ..By using this approach, we identified DNA sequence changes in two ethylnitrosourea-induced mutants...
  15. pmc The genetic contribution to heart rate and heart rate variability in quiescent mice
    Reuben Howden
    National Inst of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Am J Physiol Heart Circ Physiol 295:H59-68. 2008
    ..Furthermore, QTLs were found that will provide important insight to the genetic regulation of HR and HRV at rest...
  16. pmc The Modifier of hemostasis (Mh) locus on chromosome 4 controls in vivo hemostasis of Gp6-/- mice
    Yann Cheli
    Roon Research Center for Arteriosclerosis and Thrombosis, Division of Experimental Hemostasis and Thrombosis, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Blood 111:1266-73. 2008
    ..9, P < .0001) that we designate Modifier of hemostasis (Mh). Our results indicate that one or more modifier genes in Mh control the extent to which in vivo platelet thrombus formation is disrupted by the absence of platelet GPVI...
  17. ncbi request reprint A forward genetics screen in mice identifies recessive deafness traits and reveals that pejvakin is essential for outer hair cell function
    Martin Schwander
    Department of Cell Biology, Institute for Childhood and Neglected Disease, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 27:2163-75. 2007
    ....
  18. pmc A mutant mouse with a highly specific contextual fear-conditioning deficit found in an N-ethyl-N-nitrosourea (ENU) mutagenesis screen
    Leon G Reijmers
    Institute for Childhood and Neglected Diseases, Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Learn Mem 13:143-9. 2006
    ..Mapping of Slowlearner found linkage to a region of chromosome 12 (LOD score of 6.5 close to D12Mit171), which suggests that ENU mutants should enable the positional cloning of genes involved in memory formation...
  19. ncbi request reprint An interaction between genetic factors and gender determines the magnitude of the inflammatory response in the mouse air pouch model of acute inflammation
    David L Delano
    New York University Medical Center, New York, New York 10016, USA
    Inflammation 29:1-7. 2005
    ..The loci identified by in silico mapping likely contain genes with differential roles in determining this phenotype between genders...
  20. ncbi request reprint The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9
    Koichi Tabeta
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nat Immunol 7:156-64. 2006
    ..Innate responses to nucleic acids and exogenous antigen presentation, which both initiate in endosomes, thus seem to depend on an endoplasmic reticulum-resident protein, which suggests communication between these organellar systems...
  21. ncbi request reprint Genome-wide linkage identifies novel modifier loci of aganglionosis in the Sox10Dom model of Hirschsprung disease
    Sarah E Owens
    Division of Genetic Medicine, Department of Medicine, Vanderbilt University School of Medicine, 529 Light Hall, 2215 Garland Avenue, Nashville, TN 37232 0275, USA
    Hum Mol Genet 14:1549-58. 2005
    ....
  22. ncbi request reprint Uncovering regulatory pathways that affect hematopoietic stem cell function using 'genetical genomics'
    Leonid Bystrykh
    Department of Stem Cell Biology, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Nat Genet 37:225-32. 2005
    ..Our data are accessible through WebQTL, a web-based interface that allows custom genetic linkage analysis and identification of coregulated transcripts...
  23. ncbi request reprint The Collaborative Cross, a community resource for the genetic analysis of complex traits
    Gary A Churchill
    The Jackson Laboratory, 600 Main Street Bar Harbor, Maine 04609, USA
    Nat Genet 36:1133-7. 2004
    ..The Collaborative Cross will provide a common reference panel specifically designed for the integrative analysis of complex systems and will change the way we approach human health and disease...
  24. pmc Large-scale analysis of the human and mouse transcriptomes
    Andrew I Su
    Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:4465-70. 2002
    ..Finally, to allow the scientific community to use this resource, we have built a free and publicly accessible website (http://expression.gnf.org) that integrates data visualization and curation of current gene annotations...

Research Grants1

  1. Organismal, Cellular, and Genetic Networks in Anxiety and Depression
    Tim Wiltshire; Fiscal Year: 2007
    ..In addition, a drug fluoxetine, will be administered to mice to modulate basal level phenotypic measurements to track perturbations at the biochemical, genetic and organismal level. ..