Laurence M Brill

Summary

Affiliation: Genomics Institute of the Novartis Research Foundation
Country: USA

Publications

  1. ncbi request reprint Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry
    Laurence M Brill
    Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, USA
    Anal Chem 76:2763-72. 2004
  2. ncbi request reprint Automated immobilized metal affinity chromatography/nano-liquid chromatography/electrospray ionization mass spectrometry platform for profiling protein phosphorylation sites
    Scott B Ficarro
    Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Rapid Commun Mass Spectrom 19:57-71. 2005
  3. ncbi request reprint An automated noncontact deposition interface for liquid chromatography matrix-assisted laser desorption/ionization mass spectrometry
    Christer Ericson
    Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, USA
    Anal Chem 75:2309-15. 2003
  4. pmc Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry
    Arthur R Salomon
    Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 100:443-8. 2003
  5. pmc Phosphoproteomic analysis of human embryonic stem cells
    Laurence M Brill
    Genomics Institute of the Novartis Research Foundation, San Diego, CA 92109, USA
    Cell Stem Cell 5:204-13. 2009
  6. ncbi request reprint A phosphoproteomic analysis of the ErbB2 receptor tyrosine kinase signaling pathways
    Mridul Mukherji
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Biochemistry 45:15529-40. 2006

Collaborators

Detail Information

Publications6

  1. ncbi request reprint Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry
    Laurence M Brill
    Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, USA
    Anal Chem 76:2763-72. 2004
    ..These proteins had unknown functions or were associated with a plethora of fundamental cellular processes. This robust technology platform should be broadly applicable to profiling the dynamics of tyrosine phosphorylation...
  2. ncbi request reprint Automated immobilized metal affinity chromatography/nano-liquid chromatography/electrospray ionization mass spectrometry platform for profiling protein phosphorylation sites
    Scott B Ficarro
    Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Rapid Commun Mass Spectrom 19:57-71. 2005
    ....
  3. ncbi request reprint An automated noncontact deposition interface for liquid chromatography matrix-assisted laser desorption/ionization mass spectrometry
    Christer Ericson
    Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, USA
    Anal Chem 75:2309-15. 2003
    ..To assess the behavior of the apparatus for complex mixtures, 5 microg of a tryptic digest of the cytosolic proteins of yeast was analyzed by LC/MALDI-MS and more than 13,500 unique analytes were detected in a single LC/MS analysis...
  4. pmc Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry
    Arthur R Salomon
    Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 100:443-8. 2003
    ..This methodology should enable the rapid generation of new insights into signaling pathways as they occur in states of health and disease...
  5. pmc Phosphoproteomic analysis of human embryonic stem cells
    Laurence M Brill
    Genomics Institute of the Novartis Research Foundation, San Diego, CA 92109, USA
    Cell Stem Cell 5:204-13. 2009
    ..These results support the utility of phosphoproteomic data, provide guidance for investigating protein function in hESCs, and complement transcriptomics/epigenetics for broadening our understanding of hESC fate determination...
  6. ncbi request reprint A phosphoproteomic analysis of the ErbB2 receptor tyrosine kinase signaling pathways
    Mridul Mukherji
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Biochemistry 45:15529-40. 2006
    ..Selective depletion of some of these proteins, including RNA binding proteins SRRM2, SFRS1, SFRS9, and SFRS10, by siRNAs reduced the rate of migration of ErbB2-overexpressing ovarian cancer cells...