Randall D Little

Summary

Affiliation: Genome Therapeutics Corporation
Country: USA

Publications

  1. pmc A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait
    Randall D Little
    Department of Human Genetics, Genome Therapeutics Corporation, Waltham, MA 02453, USA
    Am J Hum Genet 70:11-9. 2002
  2. pmc Mechanistic role of a disease-associated genetic variant within the ADAM33 asthma susceptibility gene
    Richard G Del Mastro
    Molecular Therapeutics Division, AmberGen Incorporated, Waltham, Massachusetts 02453, USA
    BMC Med Genet 8:46. 2007
  3. ncbi request reprint Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness
    Paul Van Eerdewegh
    Genome Therapeutics Corporation, 100 Beaver St, Waltham, Massachusetts 02453, USA
    Nature 418:426-30. 2002
  4. ncbi request reprint High bone density due to a mutation in LDL-receptor-related protein 5
    Randall D Little
    N Engl J Med 347:943-4; author reply 943-4. 2002
  5. pmc Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci
    John V Raelson
    Genizon BioSciences, Inc, St Laurent, QC, Canada H4T 2C7
    Proc Natl Acad Sci U S A 104:14747-52. 2007

Collaborators

  • Richard G Del Mastro
  • Josee Dupuis
  • Gordon Gong
  • Stephen T Holgate
  • John W Holloway
  • MARK LOUIS JOHNSON
  • Robert Roy Recker
  • Hui Huang
  • Paul Van Eerdewegh
  • John V Raelson
  • Tim P Keith
  • John W Hooper
  • Andre Franke
  • Bruno Paquin
  • Helene Fournier
  • Peter Szego
  • Abdelmajid Belouchi
  • Philip Rosenstiel
  • Nathalie Laplante
  • Pascal Croteau
  • René Allard
  • René J Paulussen
  • Susanna Nikolaus
  • W E C Bradley
  • Quynh Nguyen-Huu
  • Jonathan Segal
  • Andreas Ruether
  • Jean Michel Vidal
  • Gunnar Jacobs
  • Stefan Schreiber
  • Hilary F Clark
  • Sophie Debrus
  • JoAnn Dubois
  • Dana Torrey
  • Brooke Hayward
  • Robert W Egan
  • Kathy Falls
  • Francis M Cuss
  • Joanne B Clough
  • Alicia Bawa
  • René Gibson
  • Michelle Thackston
  • Lisa Saracino
  • Susan P Manning
  • Jason Simon
  • Sunil Pandit
  • Neva Capparell
  • Youssef Benchekroun
  • Michael G FitzGerald
  • Melvyn R Danzig
  • Karen Braunschweiger
  • Ziying Liu
  • Mei Wang
  • Yun Feng
  • Steuart Rorke
  • Joyce McKenny
  • Ron Adair
  • Colleen Folz
  • Alex Pedan
  • Kristina M Allen
  • Shelby P Umland
  • Alison Walsh

Detail Information

Publications5

  1. pmc A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait
    Randall D Little
    Department of Human Genetics, Genome Therapeutics Corporation, Waltham, MA 02453, USA
    Am J Hum Genet 70:11-9. 2002
    ..Our findings suggest that the HBM mutation confers a unique osteogenic activity in bone remodeling, and this understanding may facilitate the development of novel therapies for the treatment of osteoporosis...
  2. pmc Mechanistic role of a disease-associated genetic variant within the ADAM33 asthma susceptibility gene
    Richard G Del Mastro
    Molecular Therapeutics Division, AmberGen Incorporated, Waltham, Massachusetts 02453, USA
    BMC Med Genet 8:46. 2007
    ..One disease-associated SNP, BC+1, which resides in intron BC toward the 5' end of ADAM33, is highly associated with the disease...
  3. ncbi request reprint Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness
    Paul Van Eerdewegh
    Genome Therapeutics Corporation, 100 Beaver St, Waltham, Massachusetts 02453, USA
    Nature 418:426-30. 2002
    ..The identification and characterization of ADAM33, a putative asthma susceptibility gene identified by positional cloning in an outbred population, should provide insights into the pathogenesis and natural history of this common disease...
  4. ncbi request reprint High bone density due to a mutation in LDL-receptor-related protein 5
    Randall D Little
    N Engl J Med 347:943-4; author reply 943-4. 2002
  5. pmc Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci
    John V Raelson
    Genizon BioSciences, Inc, St Laurent, QC, Canada H4T 2C7
    Proc Natl Acad Sci U S A 104:14747-52. 2007
    ..Together with previously published loci, the spectrum of CD genes identified to date involves biochemical networks that affect epithelial defense mechanisms, innate and adaptive immune response, and the repair or remodeling of tissue...