Randall D Little

Summary

Affiliation: Genome Therapeutics Corporation
Country: USA

Publications

  1. ncbi A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait
    Randall D Little
    Department of Human Genetics, Genome Therapeutics Corporation, Waltham, MA 02453, USA
    Am J Hum Genet 70:11-9. 2002
  2. ncbi Mechanistic role of a disease-associated genetic variant within the ADAM33 asthma susceptibility gene
    Richard G Del Mastro
    Molecular Therapeutics Division, AmberGen Incorporated, Waltham, Massachusetts 02453, USA
    BMC Med Genet 8:46. 2007
  3. ncbi Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness
    Paul Van Eerdewegh
    Genome Therapeutics Corporation, 100 Beaver St, Waltham, Massachusetts 02453, USA
    Nature 418:426-30. 2002
  4. ncbi High bone density due to a mutation in LDL-receptor-related protein 5
    Randall D Little
    N Engl J Med 347:943-4; author reply 943-4. 2002
  5. ncbi Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci
    John V Raelson
    Genizon BioSciences, Inc, St Laurent, QC, Canada H4T 2C7
    Proc Natl Acad Sci U S A 104:14747-52. 2007

Collaborators

  • Richard G Del Mastro
  • Josee Dupuis
  • Gordon Gong
  • Stephen T Holgate
  • Hui Huang
  • John W Holloway
  • MARK LOUIS JOHNSON
  • Robert Roy Recker
  • Paul Van Eerdewegh
  • John V Raelson
  • Tim P Keith
  • Bruno Paquin
  • Pascal Croteau
  • Jean-Michel Vidal
  • Hilary F Clark
  • Sophie Debrus
  • Quynh Nguyen-Huu
  • René J Paulussen
  • Philip Rosenstiel
  • Andreas Ruether
  • Stefan Schreiber
  • Jonathan Segal
  • Nathalie Laplante
  • Andre Franke
  • John W Hooper
  • W E C Bradley
  • Gunnar Jacobs
  • René Allard
  • Abdelmajid Belouchi
  • Peter Szego
  • Jean Michel Vidal
  • Helene Fournier
  • Susanna Nikolaus
  • Joanne B Clough
  • Robert W Egan
  • Brooke Hayward
  • Susan P Manning
  • Neva Capparell
  • Alison Walsh
  • Joyce McKenny
  • Jason Simon
  • Alex Pedan
  • Ziying Liu
  • Michelle Thackston
  • Youssef Benchekroun
  • Colleen Folz
  • Kristina M Allen
  • Steuart Rorke
  • Alicia Bawa
  • Melvyn R Danzig
  • Francis M Cuss
  • Shelby P Umland
  • Karen Braunschweiger
  • Lisa Saracino
  • Dana Torrey
  • Ron Adair
  • Sunil Pandit
  • Yun Feng
  • JoAnn Dubois
  • Michael G FitzGerald
  • Kathy Falls
  • Mei Wang
  • René Gibson

Detail Information

Publications5

  1. ncbi A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait
    Randall D Little
    Department of Human Genetics, Genome Therapeutics Corporation, Waltham, MA 02453, USA
    Am J Hum Genet 70:11-9. 2002
    ..Our findings suggest that the HBM mutation confers a unique osteogenic activity in bone remodeling, and this understanding may facilitate the development of novel therapies for the treatment of osteoporosis...
  2. ncbi Mechanistic role of a disease-associated genetic variant within the ADAM33 asthma susceptibility gene
    Richard G Del Mastro
    Molecular Therapeutics Division, AmberGen Incorporated, Waltham, Massachusetts 02453, USA
    BMC Med Genet 8:46. 2007
    ..One disease-associated SNP, BC+1, which resides in intron BC toward the 5' end of ADAM33, is highly associated with the disease...
  3. ncbi Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness
    Paul Van Eerdewegh
    Genome Therapeutics Corporation, 100 Beaver St, Waltham, Massachusetts 02453, USA
    Nature 418:426-30. 2002
    ..The identification and characterization of ADAM33, a putative asthma susceptibility gene identified by positional cloning in an outbred population, should provide insights into the pathogenesis and natural history of this common disease...
  4. ncbi High bone density due to a mutation in LDL-receptor-related protein 5
    Randall D Little
    N Engl J Med 347:943-4; author reply 943-4. 2002
  5. ncbi Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci
    John V Raelson
    Genizon BioSciences, Inc, St Laurent, QC, Canada H4T 2C7
    Proc Natl Acad Sci U S A 104:14747-52. 2007
    ..Together with previously published loci, the spectrum of CD genes identified to date involves biochemical networks that affect epithelial defense mechanisms, innate and adaptive immune response, and the repair or remodeling of tissue...