A Dessen

Summary

Affiliation: Genetics Institute
Country: USA

Publications

  1. ncbi Crystal structure of human cytosolic phospholipase A2 reveals a novel topology and catalytic mechanism
    A Dessen
    Biochemistry, Wyeth Research, Cambridge, Massachusetts 02140, USA
    Cell 97:349-60. 1999
  2. ncbi Structural and kinetic analysis of Escherichia coli GDP-mannose 4,6 dehydratase provides insights into the enzyme's catalytic mechanism and regulation by GDP-fucose
    J R Somoza
    Wyeth Research, Cambridge, MA 02140, USA
    Structure 8:123-35. 2000
  3. ncbi Crystal structure and function of the isoniazid target of Mycobacterium tuberculosis
    A Dessen
    Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461
    Science 267:1638-41. 1995
  4. ncbi X-ray crystal structure of HLA-DR4 (DRA*0101, DRB1*0401) complexed with a peptide from human collagen II
    A Dessen
    Laboratory of Molecular Medicine, The Children s Hospital, Boston, Massachusetts 02115, USA
    Immunity 7:473-81. 1997
  5. pmc Crystal structure of the matrix protein VP40 from Ebola virus
    A Dessen
    European Molecular Biology Laboratory Grenoble Outstation, 6 rue Jules Horowitz, 38000 Grenoble, France
    EMBO J 19:4228-36. 2000
  6. pmc The Salmonella typhimurium nadC gene: sequence determination by use of Mud-P22 and purification of quinolinate phosphoribosyltransferase
    K T Hughes
    Department of Microbiology, University of Washington, Seattle 98195
    J Bacteriol 175:479-86. 1993
  7. ncbi Crystal structure of PBP2x from a highly penicillin-resistant Streptococcus pneumoniae clinical isolate: a mosaic framework containing 83 mutations
    A Dessen
    Laboratoire de Cristallographie Macromoléculaire, Institut de Biologie Structurale Jean Pierre Ebel CNRS Commissariat à l Energie Atomique, 41, rue Jules Horowitz, 38027 Grenoble, France
    J Biol Chem 276:45106-12. 2001

Collaborators

Detail Information

Publications7

  1. ncbi Crystal structure of human cytosolic phospholipase A2 reveals a novel topology and catalytic mechanism
    A Dessen
    Biochemistry, Wyeth Research, Cambridge, Massachusetts 02140, USA
    Cell 97:349-60. 1999
    ..The structure reveals a flexible lid that must move to allow substrate access to the active site, thus explaining the interfacial activation of this important lipase...
  2. ncbi Structural and kinetic analysis of Escherichia coli GDP-mannose 4,6 dehydratase provides insights into the enzyme's catalytic mechanism and regulation by GDP-fucose
    J R Somoza
    Wyeth Research, Cambridge, MA 02140, USA
    Structure 8:123-35. 2000
    ..Fucose forms part of a number of glycoconjugates, including the ABO blood groups and the selectin ligand sialyl Lewis X. Defects in GDP-fucose metabolism have been linked to leukocyte adhesion deficiency type II (LADII)...
  3. ncbi Crystal structure and function of the isoniazid target of Mycobacterium tuberculosis
    A Dessen
    Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461
    Science 267:1638-41. 1995
    ..2 and 2.7 angstroms, respectively, revealed that drug resistance is directly related to a perturbation in the hydrogen-bonding network that stabilizes NADH binding...
  4. ncbi X-ray crystal structure of HLA-DR4 (DRA*0101, DRB1*0401) complexed with a peptide from human collagen II
    A Dessen
    Laboratory of Molecular Medicine, The Children s Hospital, Boston, Massachusetts 02115, USA
    Immunity 7:473-81. 1997
    ..A model is proposed for the DR4 recognition of collagen II (261-273), an antigen immunodominant in human-transgenic mouse models of RA...
  5. pmc Crystal structure of the matrix protein VP40 from Ebola virus
    A Dessen
    European Molecular Biology Laboratory Grenoble Outstation, 6 rue Jules Horowitz, 38000 Grenoble, France
    EMBO J 19:4228-36. 2000
    ..The crystal structure reveals how the molecule may be able to switch from a monomeric conformation to a hexameric form, as observed in vitro. Its implications for the assembly process are discussed...
  6. pmc The Salmonella typhimurium nadC gene: sequence determination by use of Mud-P22 and purification of quinolinate phosphoribosyltransferase
    K T Hughes
    Department of Microbiology, University of Washington, Seattle 98195
    J Bacteriol 175:479-86. 1993
    ..Steady-state kinetics on the purified QAPRTase indicated Km values of 32 microM for 5-phosphoribosyl-1-pyrophosphate and 20 microM for quinolinate. Vmax was 0.9 U/mg, similar to values reported for this enzyme by other sources...
  7. ncbi Crystal structure of PBP2x from a highly penicillin-resistant Streptococcus pneumoniae clinical isolate: a mosaic framework containing 83 mutations
    A Dessen
    Laboratoire de Cristallographie Macromoléculaire, Institut de Biologie Structurale Jean Pierre Ebel CNRS Commissariat à l Energie Atomique, 41, rue Jules Horowitz, 38027 Grenoble, France
    J Biol Chem 276:45106-12. 2001
    ..Thus, in vivo, an "open" active site could facilitate the recognition of distinct, branched physiological substrates...