J Jurka

Summary

Affiliation: Genetic Information Research Institute
Country: USA

Publications

  1. ncbi request reprint Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae
    James E Galagan
    The Broad Institute of MIT and Harvard, 320 Charles Street, Cambridge, Massachusetts 02142, USA
    Nature 438:1105-15. 2005
  2. ncbi request reprint Evolutionary history of 7SL RNA-derived SINEs in Supraprimates
    Jan Ole Kriegs
    Institute of Experimental Pathology, ZMBE, University of Munster, Von Esmarch Str 56, D 48149 Munster, Germany
    Trends Genet 23:158-61. 2007
  3. pmc A superfamily of DNA transposons targeting multicopy small RNA genes
    Kenji K Kojima
    Genetic Information Research Institute, Mountain View, California, United States of America
    PLoS ONE 8:e68260. 2013
  4. pmc Genomic impact of eukaryotic transposable elements
    Irina R Arkhipova
    Institute of Experimental Pathology, ZMBE, University of Munster, Munster D 48149, Germany
    Mob DNA 3:19. 2012
  5. pmc Homologues of bacterial TnpB_IS605 are widespread in diverse eukaryotic transposable elements
    Weidong Bao
    Genetic Information Research Institute, 1925 Landings Drive, Mountain View, CA, 94043, USA
    Mob DNA 4:12. 2013
  6. pmc Distinct groups of repetitive families preserved in mammals correspond to different periods of regulatory innovations in vertebrates
    Jerzy Jurka
    Genetic Information Research Institute, Mountain View, CA 94043, USA
    Biol Direct 7:36. 2012
  7. pmc Accelerated evolution of the ASPM gene controlling brain size begins prior to human brain expansion
    Natalay Kouprina
    Laboratory of Biosystems and Cancer, National Cancer Institute, Bethesda, Maryland, USA
    PLoS Biol 2:E126. 2004
  8. pmc Analysis of the human Alu Ye lineage
    Abdel Halim Salem
    Department of Biological Sciences, Biological Computation and Visualization Center, Center for Bio Modular Multi Scale Systems, Louisiana State University, 202 Life Sciences Building, Baton Rouge, Louisiana 70803, USA
    BMC Evol Biol 5:18. 2005
  9. pmc VisualRepbase: an interface for the study of occurrences of transposable element families
    Sebastien Tempel
    Genetic Information Research Institute, 1925 Landings Dr, Mountain View, CA 94043, USA
    BMC Bioinformatics 9:345. 2008
  10. pmc Annotation, submission and screening of repetitive elements in Repbase: RepbaseSubmitter and Censor
    Oleksiy Kohany
    Genetic Information Research Institute, 1925 Landings Drive, Mountain View, CA 94043, USA
    BMC Bioinformatics 7:474. 2006

Detail Information

Publications59

  1. ncbi request reprint Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae
    James E Galagan
    The Broad Institute of MIT and Harvard, 320 Charles Street, Cambridge, Massachusetts 02142, USA
    Nature 438:1105-15. 2005
    ..These results enhance our understanding of these widely studied fungi as well as provide new insight into eukaryotic genome evolution and gene regulation...
  2. ncbi request reprint Evolutionary history of 7SL RNA-derived SINEs in Supraprimates
    Jan Ole Kriegs
    Institute of Experimental Pathology, ZMBE, University of Munster, Von Esmarch Str 56, D 48149 Munster, Germany
    Trends Genet 23:158-61. 2007
    ..As well as new elements in Tupaia and primates, we also found that the purported ancestral fossil Alu monomer was restricted to Primates, and provide here the first description of a potential chimeric promoter box region in SINEs...
  3. pmc A superfamily of DNA transposons targeting multicopy small RNA genes
    Kenji K Kojima
    Genetic Information Research Institute, Mountain View, California, United States of America
    PLoS ONE 8:e68260. 2013
    ..Dada also opens a new frontier for target-specific gene delivery application. ..
  4. pmc Genomic impact of eukaryotic transposable elements
    Irina R Arkhipova
    Institute of Experimental Pathology, ZMBE, University of Munster, Munster D 48149, Germany
    Mob DNA 3:19. 2012
    ..The success of the meeting reflects the important role of Repbase in comparative genomic studies, and emphasizes the need for close interactions between experimental and computational biologists in the years to come...
  5. pmc Homologues of bacterial TnpB_IS605 are widespread in diverse eukaryotic transposable elements
    Weidong Bao
    Genetic Information Research Institute, 1925 Landings Drive, Mountain View, CA, 94043, USA
    Mob DNA 4:12. 2013
    ..Bacterial insertion sequences (IS) of IS200/IS605 and IS607 family often encode a transposase (TnpA) and a protein of unknown function, TnpB...
  6. pmc Distinct groups of repetitive families preserved in mammals correspond to different periods of regulatory innovations in vertebrates
    Jerzy Jurka
    Genetic Information Research Institute, Mountain View, CA 94043, USA
    Biol Direct 7:36. 2012
    ..Recently, we proposed that families of TEs originate in small populations by genetic drift and that the origin of small subpopulations from larger populations can be fueled by biological innovations...
  7. pmc Accelerated evolution of the ASPM gene controlling brain size begins prior to human brain expansion
    Natalay Kouprina
    Laboratory of Biosystems and Cancer, National Cancer Institute, Bethesda, Maryland, USA
    PLoS Biol 2:E126. 2004
    ..Our data suggest that evolutionary selection of specific segments of the ASPM sequence strongly relates to differences in cerebral cortical size...
  8. pmc Analysis of the human Alu Ye lineage
    Abdel Halim Salem
    Department of Biological Sciences, Biological Computation and Visualization Center, Center for Bio Modular Multi Scale Systems, Louisiana State University, 202 Life Sciences Building, Baton Rouge, Louisiana 70803, USA
    BMC Evol Biol 5:18. 2005
    ..Alu elements are therefore a rich source of inter- and intra-species primate genomic variation...
  9. pmc VisualRepbase: an interface for the study of occurrences of transposable element families
    Sebastien Tempel
    Genetic Information Research Institute, 1925 Landings Dr, Mountain View, CA 94043, USA
    BMC Bioinformatics 9:345. 2008
    ..Repbase already has software for entering new sequence families and for comparing the user's sequence with the database of consensus sequences...
  10. pmc Annotation, submission and screening of repetitive elements in Repbase: RepbaseSubmitter and Censor
    Oleksiy Kohany
    Genetic Information Research Institute, 1925 Landings Drive, Mountain View, CA 94043, USA
    BMC Bioinformatics 7:474. 2006
    ..Updating and maintenance of the database requires specialized tools, which we have created and made available for use with Repbase, and which may be useful as a template for other curated databases...
  11. ncbi request reprint Origin and diversification of minisatellites derived from human Alu sequences
    Jerzy Jurka
    Genetic Information Research Institute, 1925 Landings Drive, Mountain View, CA 94043, USA
    Gene 365:21-6. 2006
    ..Our analysis shows that they can be effectively used in comparative studies of the overall sequence context which may contribute to instability of DNA segments flanked by short direct repeats...
  12. ncbi request reprint Repbase Update, a database of eukaryotic repetitive elements
    J Jurka
    Genetic Information Research Institute, Mountain View, CA 94043, USA
    Cytogenet Genome Res 110:462-7. 2005
    ..Sequences from Repbase Update are used to screen and annotate repetitive elements using programs such as Censor and RepeatMasker. Repbase Update is available on the worldwide web at http://www.girinst.org/Repbase_Update.html...
  13. ncbi request reprint Repetitive sequences in complex genomes: structure and evolution
    Jerzy Jurka
    Genetic Information Research Institute, Mountain View, California 94043, USA
    Annu Rev Genomics Hum Genet 8:241-59. 2007
    ..Remnants of TEs appear to be overrepresented in transcription regulatory modules and other regions conserved among distantly related species, which may have implications for our understanding of their impact on speciation...
  14. ncbi request reprint Evolutionary impact of human Alu repetitive elements
    Jerzy Jurka
    Genetic Information Research Institute, 1925 Landings Drive, Mountain View, CA 94043, USA
    Curr Opin Genet Dev 14:603-8. 2004
    ..Studying the Alu family in a human genomic context is likely to have general significance for our understanding of the evolutionary impact of other repetitive elements in diverse eukaryotic genomes...
  15. pmc Duplication, coclustering, and selection of human Alu retrotransposons
    Jerzy Jurka
    Genetic Information Research Institute, 2081 Landings Drive, Mountain View, CA 94043 0815, USA
    Proc Natl Acad Sci U S A 101:1268-72. 2004
    ..We also propose that long-term Alu accumulation in GC-rich DNA is associated with DNA duplication initiated by elevated recombinogenic activities in Alu clusters...
  16. ncbi request reprint Clustering, duplication and chromosomal distribution of mouse SINE retrotransposons
    J Jurka
    Genetic Information Research Institute, Mountain View, CA 94043, USA
    Cytogenet Genome Res 110:117-23. 2005
    ..We propose that the accumulation of mouse SINE elements observed in GC-rich regions may be due to the excess of DNA duplications over deletions in gene-rich regions that tend to be GC rich...
  17. ncbi request reprint Conserved eukaryotic transposable elements and the evolution of gene regulation
    J Jurka
    Genetic Information Research Institute, Mountain View, California, 94043, USA
    Cell Mol Life Sci 65:201-4. 2008
    ..Multiple remnants of transposable elements preserved in cis-regulatory modules may represent a record of mutations that were critical to the evolution of gene regulation and speciation...
  18. pmc Ginger DNA transposons in eukaryotes and their evolutionary relationships with long terminal repeat retrotransposons
    Weidong Bao
    Genetic Information Research Institute, Mountain View, CA, USA
    Mob DNA 1:3. 2010
    ..In this paper we analyze a diverse superfamily of eukaryotic cut and paste DNA transposons coding for INT-like transposase and discuss their evolutionary relationship to LTR retrotransposons...
  19. pmc Crypton transposons: identification of new diverse families and ancient domestication events
    Kenji K Kojima
    Genetic Information Research Institute, 1925 Landings Drive, Mountain View, CA 94043, USA
    Mob DNA 2:12. 2011
    ..abstract:..
  20. pmc Families of transposable elements, population structure and the origin of species
    Jerzy Jurka
    Genetic Information Research Institute, 1925 Landings Drive, Mountain View, CA 94043, USA
    Biol Direct 6:44. 2011
    ..We present a new hypothesis to explain the observed correlations based on classical concepts of population genetics...
  21. ncbi request reprint Molecular paleontology of transposable elements from Arabidopsis thaliana
    V V Kapitonov
    Genetic Information Research Institute, Sunnyvale, CA 94089, USA
    Genetica 107:27-37. 1999
    ..thaliana are relatively young, extremely diverse and much smaller than those from mammalian genomes. We discuss the potential factors determining similarities and differences in the evolution of TEs in mammals and A. thaliana...
  22. pmc New superfamilies of eukaryotic DNA transposons and their internal divisions
    Weidong Bao
    Genetic Information Research Institute, Mountain View, CA, USA
    Mol Biol Evol 26:983-93. 2009
    ..These transposons are named TP36 elements (abbreviated from transposase 36)...
  23. ncbi request reprint Repeats in genomic DNA: mining and meaning
    J Jurka
    Genetic Information Research Institute, Sunnyvale, CA 94089, USA
    Curr Opin Struct Biol 8:333-7. 1998
    ..Analysis of these sequences, combined with experimental research, reveals a history of complex 'intracellular ecosystems' of transposable elements that are inseparably associated with genomic evolution...
  24. ncbi request reprint The esterase and PHD domains in CR1-like non-LTR retrotransposons
    Vladimir V Kapitonov
    Genetic Information Research Institute, Mountain View, California, USA
    Mol Biol Evol 20:38-46. 2003
    ..Unexpectedly, ES links together non-LTR retrotransposons and single-stranded RNA viruses like influenza C and coronaviruses, which are known to depend on their own ES...
  25. pmc Sequence patterns indicate an enzymatic involvement in integration of mammalian retroposons
    J Jurka
    Genetic Information Research Institute, Palo Alto, CA 94306, USA
    Proc Natl Acad Sci U S A 94:1872-7. 1997
    ..Moran, J. V., Kazazian, H. H. & Boeke, J. D. (1996) Cell 87, 905-916]. A model for integration of mammalian retroposons based on the presented data is discussed...
  26. ncbi request reprint Mammalian retroposons integrate at kinkable DNA sites
    J Jurka
    Genetic Information Research Institute, Palo Alto, CA 94306, USA
    J Biomol Struct Dyn 15:717-21. 1998
    ..Nicking at kinkable sites, particularly at TA steps, may also play a role in integration of other insertion elements...
  27. ncbi request reprint The long terminal repeat of an endogenous retrovirus induces alternative splicing and encodes an additional carboxy-terminal sequence in the human leptin receptor
    V V Kapitonov
    Genetic Information Research Institute, 1170 Morse Avenue, Sunnyvale, CA 94089, USA
    J Mol Evol 48:248-51. 1999
    ..We suggest the possibility of transcriptional and posttranscriptional regulation of OBR expression by steroids that bind the LTR...
  28. pmc Rolling-circle transposons in eukaryotes
    V V Kapitonov
    Genetic Information Research Institute, 2081 Landings Drive, Mountain View, CA 94043, USA
    Proc Natl Acad Sci U S A 98:8714-9. 2001
    ..Sequence conservation suggests that Helitrons continue to be transposed...
  29. pmc Evolutionary diversity and potential recombinogenic role of integration targets of Non-LTR retrotransposons
    Andrew J Gentles
    Genetic Information Research Institute, Mountain View, California, USA
    Mol Biol Evol 22:1983-91. 2005
    ..This provides a possible driving force for the continual emergence of new L1 subfamilies which, in turn, may affect selection of L1-dependent SINE subfamilies...
  30. ncbi request reprint Helitrons on a roll: eukaryotic rolling-circle transposons
    Vladimir V Kapitonov
    Genetic Information Research Institute, 1925 Landings Drive, Mountain View, CA 94043, USA
    Trends Genet 23:521-9. 2007
    ..Helitrons seem to have a major role in the evolution of host genomes. They frequently capture diverse host genes, some of which can evolve into novel host genes or become essential for helitron transposition...
  31. pmc Simple and fast classification of non-LTR retrotransposons based on phylogeny of their RT domain protein sequences
    Vladimir V Kapitonov
    Genetic Information Research Institute, 1925 Landings Dr, Mountain View, CA 94041, USA
    Gene 448:207-13. 2009
    ..5% accuracy. RT1class1 works either as a stand-alone program installed locally or as a web-server that can be accessed distantly by uploading sequence data through the internet (http://www.girinst.org/RTphylogeny/RTclass1)...
  32. pmc Origin and evolution of LINE-1 derived "half-L1" retrotransposons (HAL1)
    Weidong Bao
    Genetic Information Research Institute, Mountain View, CA 94043, USA
    Gene 465:9-16. 2010
    ..The implications of HAL1 for the evolution of L1 elements and the host genomes are discussed...
  33. pmc Molecular paleontology of transposable elements in the Drosophila melanogaster genome
    Vladimir V Kapitonov
    Genetic Information Research Institute, 2081 Landings Drive, Mountain View, CA 94043, USA
    Proc Natl Acad Sci U S A 100:6569-74. 2003
    ..The chromosomal and age distributions of TEs in D. melanogaster are very similar to those in Arabidopsis thaliana. Both genomes contain only relatively young TEs (<20 Myr old), constituting a main component of paracentromeric regions...
  34. ncbi request reprint A novel class of SINE elements derived from 5S rRNA
    Vladimir V Kapitonov
    Genetic Information Research Institute, Mountain View, California, USA
    Mol Biol Evol 20:694-702. 2003
    ..Given the common structural features, it is highly likely that the enzymatic machinery encoded by CR1-like elements powers proliferation of SINE3...
  35. ncbi request reprint Active Alu elements are passed primarily through paternal germlines
    Jerzy Jurka
    Genetic Information Research Institute, Mountain View, California 94043, USA
    Theor Popul Biol 61:519-30. 2002
    ..Finally, we propose that the origin of Alu subfamilies in human populations may be related to evolution of chromosome Y...
  36. pmc RAG1 core and V(D)J recombination signal sequences were derived from Transib transposons
    Vladimir V Kapitonov
    Genetic Information Research Institute, Mountain View, California, USA
    PLoS Biol 3:e181. 2005
    ..We also suggest that the RAG2 protein was not encoded by ancient Transib transposons but emerged in jawed vertebrates as a counterpart of RAG1 necessary for the V(D)J recombination reaction...
  37. ncbi request reprint Harbinger transposons and an ancient HARBI1 gene derived from a transposase
    Vladimir V Kapitonov
    Genetic Information Research Institute, Mountain View, California 94040, USA
    DNA Cell Biol 23:311-24. 2004
    ..Based on this observation, we suggest that the hypothetical HARBI1 nucleases are also characterized by a strong DNA-target specificity...
  38. pmc Self-synthesizing DNA transposons in eukaryotes
    Vladimir V Kapitonov
    Genetic Information Research Institute, 1925 Landings Drive, Mountain View, CA 94043, USA
    Proc Natl Acad Sci U S A 103:4540-5. 2006
    ....
  39. pmc Traffic of genetic information between segmental duplications flanking the typical 22q11.2 deletion in velo-cardio-facial syndrome/DiGeorge syndrome
    Adam Pavlicek
    Genetic Information Research Institute, Mountain View, California 94043, USA
    Genome Res 15:1487-95. 2005
    ..We also found that gaps up to 1.5 kb long can be transferred between LCR22s...
  40. ncbi request reprint Evolution of the tumor suppressor BRCA1 locus in primates: implications for cancer predisposition
    Adam Pavlicek
    Genetic Information Research Institute, Mountain View, CA, USA
    Hum Mol Genet 13:2737-51. 2004
    ..Finally, on the basis of protein sequence conservation, we identified missense changes that are likely to compromise BRCA1 function...
  41. pmc Retroposition of processed pseudogenes: the impact of RNA stability and translational control
    Adam Pavlicek
    Genetic Information Research Institute, 1925 Landings Drive, Mountain View, CA 94043, USA
    Trends Genet 22:69-73. 2006
    ..They are preferentially translated on free cytoplasmic ribosomes and encode soluble proteins. Our results indicate that interactions between mRNAs and L1 proteins seem to occur at free cytoplasmic ribosomes...
  42. ncbi request reprint The amphioxus genome and the evolution of the chordate karyotype
    Nicholas H Putnam
    Department of Energy Joint Genome Institute, Walnut Creek, California 94598, USA
    Nature 453:1064-71. 2008
    ..These genome-scale events shaped the vertebrate genome and provided additional genetic variation for exploitation during vertebrate evolution...
  43. pmc Shuffling of genes within low-copy repeats on 22q11 (LCR22) by Alu-mediated recombination events during evolution
    Melanie Babcock
    Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, New York, New York 10461, USA
    Genome Res 13:2519-32. 2003
    ..Such sites may represent focal points for recombination. Thus, genome shuffling by Alu-mediated rearrangements has contributed to genome architecture during primate evolution...
  44. ncbi request reprint Potential for retroposition by old Alu subfamilies
    Karla Johanning
    Tulane Cancer Center SL 66, Department of Environmental Health Sciences, Tulane University Medical Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    J Mol Evol 56:658-64. 2003
    ..The presence of few conserved Alu Sx elements and the dynamic expansion/contraction of the A-tail suggests that some of these older subfamilies may still be active at very low levels or in a few individuals...
  45. ncbi request reprint Sea anemone genome reveals ancestral eumetazoan gene repertoire and genomic organization
    Nicholas H Putnam
    Department of Energy Joint Genome Institute, Walnut Creek, CA 94598, USA
    Science 317:86-94. 2007
    ..Analysis of diverse pathways suggests that these gene "inventions" along the lineage leading to animals were likely already well integrated with preexisting eukaryotic genes in the eumetazoan progenitor...
  46. pmc Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27
    Natalay Kouprina
    Laboratory of Biosystems and Cancer, National Cancer Institute, Bethesda, Maryland 20892, USA
    Genome Res 15:1477-86. 2005
    ..We speculate that the predisposition to prostate cancer in X-linked families is an example of a genomic disease caused by a specific architecture of the SPANX gene cluster...
  47. ncbi request reprint The genome of the diatom Thalassiosira pseudonana: ecology, evolution, and metabolism
    E Virginia Armbrust
    School of Oceanography, University of Washington, Seattle, WA 98195, USA
    Science 306:79-86. 2004
    ....
  48. doi request reprint A universal classification of eukaryotic transposable elements implemented in Repbase
    Vladimir V Kapitonov
    Nat Rev Genet 9:411-2; author reply 414. 2008
  49. pmc Transposition of a reconstructed Harbinger element in human cells and functional homology with two transposon-derived cellular genes
    Ludivine Sinzelle
    Max Delbruck Center for Molecular Medicine, 13092 Berlin, Germany
    Proc Natl Acad Sci U S A 105:4715-20. 2008
    ..The Harbinger transposon will serve as a useful experimental system for transposon biology and for investigating the enzymatic functions of domesticated, transposon-derived cellular genes...
  50. ncbi request reprint Introduction for the Gene special issue dedicated to the meeting "Genomic impact of eukaryotic transposable elements" at Asilomar
    Mark A Batzer
    Gene 390:1-2. 2007
  51. ncbi request reprint Comprehensive analysis of two Alu Yd subfamilies
    Jinchuan Xing
    Department of Biological Sciences, Biological Computation and Visualization Center, Louisiana State University, 202 Life Sciences Building, Baton Rouge, LA 70803, USA
    J Mol Evol 57:S76-89. 2003
    ..These Alu subfamilies are a source of genomic fossil relics for the study of primate phylogenetics and human population genetics...
  52. ncbi request reprint SINEs, evolution and genome structure in the opossum
    Wanjun Gu
    Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Gene 396:46-58. 2007
    ..Like eutherians, metatherian (marsupial) mammals have evolved high CpG substitution rates, but this is apparently a convergence in process rather than a shared ancestral state...
  53. pmc Evolutionary dynamics of transposable elements in the short-tailed opossum Monodelphis domestica
    Andrew J Gentles
    Department of Radiology, School of Medicine, Stanford University, Stanford, California 94305, USA
    Genome Res 17:992-1004. 2007
    ..Many of these conserved repeats are also present in human, and are highly over-represented in predicted cis-regulatory modules. Seventy-six of the 83 families are present in chicken in addition to mammals...
  54. ncbi request reprint Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences
    Tarjei S Mikkelsen
    Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 447:167-77. 2007
    ..A substantial proportion of these eutherian-specific CNEs arose from sequence inserted by transposable elements, pointing to transposons as a major creative force in the evolution of mammalian gene regulation...
  55. ncbi request reprint Identification of sequence motifs at the breakpoint junctions in three t(1;9)(p36.3;q34) and delineation of mechanisms involved in generating balanced translocations
    Marzena Gajecka
    Health Research and Education Center, Washington State University Spokane, Spokane, WA, 99210 1495, USA
    Hum Genet 120:519-26. 2006
    ..We propose a model for balanced translocation formation in humans similar to transposition in bacteria, in which staggered nicks are repaired resulting in duplications and insertions at the translocation breakpoints...
  56. ncbi request reprint Tracing genetic history of modern humans using X-chromosome lineages
    Vania Yotova
    Centre de Recherche, Hopital Sainte Justine, CHU Mère Enfant, 3175 Cote Sainte Catherine, Montreal, QC, Canada, H3T 1C5
    Hum Genet 122:431-43. 2007
    ..e. before the mitochondrial DNA and well before the Y-chromosome most recent common ancestors...
  57. pmc Genes, pseudogenes, and Alu sequence organization across human chromosomes 21 and 22
    Chingfer Chen
    Department of Mathematics, Stanford University, Stanford, CA 94305 2125, USA
    Proc Natl Acad Sci U S A 99:2930-5. 2002
    ..Other assessments concern comparisons of intergenic lengths, properties of Psig sequences, and correlations between Alu and Psig sequences...
  58. pmc HERVd: the Human Endogenous RetroViruses Database: update
    Jan Paces
    Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Flemingovo 2, CZ 16637 Prague, Czech Republic
    Nucleic Acids Res 32:D50. 2004
    ..This leads to a more precise identification of members with individual families. The second improvement is better accessibility of the database and connection with human genome annotation...
  59. ncbi request reprint Distinct catalytic and non-catalytic roles of ARGONAUTE4 in RNA-directed DNA methylation
    Yijun Qi
    Cold Spring Harbor Laboratory, Watson School of Biological Sciences and Howard Hughes Medical Institute, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nature 443:1008-12. 2006
    ..Second, AGO4 catalytic activity can be crucial for the generation of secondary siRNAs that reinforce its repressive effects...