Affiliation: Genentech Inc
- Characterization of the drug-to-antibody ratio distribution for antibody-drug conjugates in plasma/serumKeyang Xu
Genentech, 1 DNA Way, South San Francisco, CA 94080, USA
Bioanalysis 5:1057-71. 2013..The objective of this manuscript was to propose and assess the assays that allow for the characterization of the drug deconjugation in plasma/serum...
- Characterization of intact antibody-drug conjugates from plasma/serum in vivo by affinity capture capillary liquid chromatography-mass spectrometryKeyang Xu
Genentech, South San Francisco, CA 94080, USA
Anal Biochem 412:56-66. 2011..Other potential applications of the method may include characterization of posttranslational modifications, protein adducts, and immunogenicity...
- Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugatesBen Quan Shen
Genentech Inc, 1 DNA Way, S San Francisco, California, USA
Nat Biotechnol 30:184-9. 2012..Thus, the chemical and structural dynamics of the conjugation site can influence antibody conjugate performance by modulating the stability of the antibody-linker interface...
- Bioanalytical assay strategies for the development of antibody-drug conjugate biotherapeuticsSurinder Kaur
Genentech, 1 DNA Way, South San Francisco, CA 94080 4990, USA
Bioanalysis 5:201-26. 2013..Our strategy has involved novel protein structural characterization tools to help understand ADC biotransformations in vivo and use of the analyte knowledge gained to guide the development of quantitative bioanalytical assays...