Affiliation: Genentech Inc
Chen Y, Wang Y, Modrusan Z, Sheng M, Kaminker J. Regulation of neuronal gene expression and survival by basal NMDA receptor activity: a role for histone deacetylase 4. J Neurosci. 2014;34:15327-39 pubmed publisher
..These data suggest that basal, but not evoked, NMDAR activity regulates gene expression in part through HDAC4, and, that HDAC4 has neuroprotective functions under conditions of low NMDAR activity. ..
Dejanovic B, Huntley M, De Mazière A, Meilandt W, Wu T, Srinivasan K, et al
. Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies. Neuron. 2018;: pubmed publisher
..Thus, inhibiting complement-mediated synapse removal by microglia could be a potential therapeutic target for Tau-associated neurodegeneration. ..
Yeh F, Hansen D, Sheng M. TREM2, Microglia, and Neurodegenerative Diseases. Trends Mol Med. 2017;23:512-533 pubmed publisher
..Our increased understanding of TREM2 and microglia has opened new avenues for therapeutic intervention to delay or prevent the progression of AD. ..
Chang M, Srinivasan K, Friedman B, Suto E, Modrusan Z, Lee W, et al
. Progranulin deficiency causes impairment of autophagy and TDP-43 accumulation. J Exp Med. 2017;214:2611-2628 pubmed publisher
Hansen D, Hanson J, Sheng M. Microglia in Alzheimer's disease. J Cell Biol. 2018;217:459-472 pubmed publisher
..Gene expression profiles indicate multiple states of microglial activation in neurodegenerative disease settings, which might explain the disparate roles of microglia in the development and progression of AD pathology. ..
Yeh F, Wang Y, Tom I, Gonzalez L, Sheng M. TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia. Neuron. 2016;91:328-40 pubmed publisher
..These data link three genetic risk factors for AD and reveal aÂ possible mechanism by which mutant TREM2 increases risk of AD. VIDEO ABSTRACT. ..