Heidi S Phillips

Summary

Affiliation: Genentech Inc
Country: USA

Publications

  1. ncbi Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis
    Heidi S Phillips
    Department of Tumor Biology and Angiogenesis, Genentech, Inc, South San Francisco, California 94080, USA
    Cancer Cell 9:157-73. 2006
  2. ncbi Rescue of NGF-deficient mice I: transgenic expression of NGF in skin rescues mice lacking endogenous NGF
    Susan M W Harrison
    School of Biological Sciences, University of Kentucky, Lexington, KY 40506, USA
    Brain Res Mol Brain Res 122:116-25. 2004
  3. ncbi Rescue of NGF-deficient mice II: basal forebrain cholinergic projections require NGF for target innervation but not guidance
    Heidi S Phillips
    Genentech Incorporated, 1 DNA Way, South San Francisco, CA 94080, USA
    Brain Res Mol Brain Res 124:1-11. 2004
  4. pmc Epigenome scans and cancer genome sequencing converge on WNK2, a kinase-independent suppressor of cell growth
    Chibo Hong
    Department of Neurological Surgery and the Comprehensive Cancer Center, University of California, San Francisco, CA 94143
    Proc Natl Acad Sci U S A 104:10974-9. 2007
  5. pmc Evidence for sequenced molecular evolution of IDH1 mutant glioblastoma from a distinct cell of origin
    Albert Lai
    David Geffen School of Medicine at theUniversity of California at Los Angeles, Los Angeles, CA, USA
    J Clin Oncol 29:4482-90. 2011
  6. pmc Identification of IGF2 signaling through phosphoinositide-3-kinase regulatory subunit 3 as a growth-promoting axis in glioblastoma
    Liliana Soroceanu
    Department of Tumor Biology and Angiogenesis, Molecular Biology, Biostatistics, and Pathology, Genentech, Inc, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 104:3466-71. 2007
  7. doi A hierarchy of self-renewing tumor-initiating cell types in glioblastoma
    Ruihuan Chen
    Department of Tumor Biology and Angiogenesis, Genentech Inc, San Francisco, CA 94080, USA
    Cancer Cell 17:362-75. 2010
  8. pmc TMEFF2 is a PDGF-AA binding protein with methylation-associated gene silencing in multiple cancer types including glioma
    Kui Lin
    Genentech, South San Francisco, California, United States of America
    PLoS ONE 6:e18608. 2011
  9. doi Targeting the PI3K pathway in the brain--efficacy of a PI3K inhibitor optimized to cross the blood-brain barrier
    Laurent Salphati
    Department of Drug Metabolism and Pharmacokinetics, Genentech Inc, South San Francisco, California 94080, USA
    Clin Cancer Res 18:6239-48. 2012
  10. pmc Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent
    Mark Merchant
    Departments of Translational Oncology, Structural Biology, Early Discovery Biochemistry, Antibody Engineering, Biomedical Imaging, Protein Chemistry, Biochemical and Cellular Pharmacology, Purification Development, Pharmacokinetic and Pharmacodynamic Sciences, and Early Stage Cell Culture, Genentech, Inc, South San Francisco, CA 94080
    Proc Natl Acad Sci U S A 110:E2987-96. 2013

Collaborators

Detail Information

Publications10

  1. ncbi Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis
    Heidi S Phillips
    Department of Tumor Biology and Angiogenesis, Genentech, Inc, South San Francisco, California 94080, USA
    Cancer Cell 9:157-73. 2006
    ..A robust two-gene prognostic model utilizing PTEN and DLL3 expression suggests that Akt and Notch signaling are hallmarks of poor prognosis versus better prognosis gliomas, respectively...
  2. ncbi Rescue of NGF-deficient mice I: transgenic expression of NGF in skin rescues mice lacking endogenous NGF
    Susan M W Harrison
    School of Biological Sciences, University of Kentucky, Lexington, KY 40506, USA
    Brain Res Mol Brain Res 122:116-25. 2004
    ..Thus, the most vital functions of NGF are not dependent on faithful recapitulation of the normal spatiotemporal pattern of gene expression...
  3. ncbi Rescue of NGF-deficient mice II: basal forebrain cholinergic projections require NGF for target innervation but not guidance
    Heidi S Phillips
    Genentech Incorporated, 1 DNA Way, South San Francisco, CA 94080, USA
    Brain Res Mol Brain Res 124:1-11. 2004
    ..These results indicate that NGF is required for induction of proper innervation by BFC neurons, but that the cellular pattern of expression of this factor is not critical for specifying the distribution of axon terminals...
  4. pmc Epigenome scans and cancer genome sequencing converge on WNK2, a kinase-independent suppressor of cell growth
    Chibo Hong
    Department of Neurological Surgery and the Comprehensive Cancer Center, University of California, San Francisco, CA 94143
    Proc Natl Acad Sci U S A 104:10974-9. 2007
    ..Thus, our integrated genetic and epigenetic approach might be useful to identify genes that are widely relevant to cancer, even when genetic alterations of the locus are infrequent...
  5. pmc Evidence for sequenced molecular evolution of IDH1 mutant glioblastoma from a distinct cell of origin
    Albert Lai
    David Geffen School of Medicine at theUniversity of California at Los Angeles, Los Angeles, CA, USA
    J Clin Oncol 29:4482-90. 2011
    ..To determine how GBMs arising with IDH1(R132MUT) differ from other GBMs, we undertook a comprehensive comparison of patients presenting clinically with primary GBM as a function of IDH1(R132) mutation status...
  6. pmc Identification of IGF2 signaling through phosphoinositide-3-kinase regulatory subunit 3 as a growth-promoting axis in glioblastoma
    Liliana Soroceanu
    Department of Tumor Biology and Angiogenesis, Molecular Biology, Biostatistics, and Pathology, Genentech, Inc, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 104:3466-71. 2007
    ..Further, these findings highlight the parallels between growth factors or receptors that are overexpressed in GBMs and those that support in vitro growth of tumor-derived stem-like cells...
  7. doi A hierarchy of self-renewing tumor-initiating cell types in glioblastoma
    Ruihuan Chen
    Department of Tumor Biology and Angiogenesis, Genentech Inc, San Francisco, CA 94080, USA
    Cancer Cell 17:362-75. 2010
    ....
  8. pmc TMEFF2 is a PDGF-AA binding protein with methylation-associated gene silencing in multiple cancer types including glioma
    Kui Lin
    Genentech, South San Francisco, California, United States of America
    PLoS ONE 6:e18608. 2011
    ..The biological function of TMEFF2 remains unclear with conflicting reports suggesting both a positive and a negative association between TMEFF2 expression and human cancers...
  9. doi Targeting the PI3K pathway in the brain--efficacy of a PI3K inhibitor optimized to cross the blood-brain barrier
    Laurent Salphati
    Department of Drug Metabolism and Pharmacokinetics, Genentech Inc, South San Francisco, California 94080, USA
    Clin Cancer Res 18:6239-48. 2012
    ..Our objectives were to identify a dual PI3K/mTOR inhibitor optimized to cross the blood-brain barrier (BBB) and characterize its brain penetration, pathway modulation in the brain and efficacy in orthotopic xenograft models of GBM...
  10. pmc Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent
    Mark Merchant
    Departments of Translational Oncology, Structural Biology, Early Discovery Biochemistry, Antibody Engineering, Biomedical Imaging, Protein Chemistry, Biochemical and Cellular Pharmacology, Purification Development, Pharmacokinetic and Pharmacodynamic Sciences, and Early Stage Cell Culture, Genentech, Inc, South San Francisco, CA 94080
    Proc Natl Acad Sci U S A 110:E2987-96. 2013
    ..Onartuzumab, therefore, represents the founding member of a class of therapeutic monovalent antibodies that overcomes limitations of antibody bivalency for targets impacted by antibody crosslinking. ..