Research Topics
Genomes and Genes
| G PanSummaryAffiliation: Genentech Inc Country: USA Publications
| Collaborators
|
Detail Information
Publications
Forced expression of murine IL-17E induces growth retardation, jaundice, a Th2-biased response, and multiorgan inflammation in miceG Pan
Department of Molecular Oncology, Genentech, Inc, South San Francisco, CA 94080, USA
J Immunol 167:6559-67. 2001..Taken together, these findings suggest that IL-17E is a unique pleiotropic cytokine and may be an important mediator of inflammatory and immune responses...- Identification and functional characterization of DR6, a novel death domain-containing TNF receptorG Pan
Department of Pathology, University of Michigan Medical School, Ann Arbor 48109, USA
FEBS Lett 431:351-6. 1998..DR6 interacts with TRADD, which has previously been shown to associate with TNFR1. Furthermore, ectopic expression of DR6 in mammalian cells induces apoptosis and activation of both NF-kappaB and JNK... - IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1RrpG Pan
Department of Endocrinology, Genentech, Inc, 1 DNA Way, South San Francisco, CA, 94080, USA
Cytokine 13:1-7. 2001..These findings suggest that IL-1H may be another ligand for the IL-18 receptor and a new player in the inflammatory and immune responses mediated by the IL-18/IL-18R axis... - Characterization of novel UCP5/BMCP1 isoforms and differential regulation of UCP4 and UCP5 expression through dietary or temperature manipulationX X Yu
Departments of Endocrinology, Molecular Biology, and Bioassay and Bioimage, Genentech, Inc, South San Francisco, California 94080, USA
FASEB J 14:1611-8. 2000..These findings are consistent with the notion that UCP4 and UCP5 may be involved in tissue-specific thermoregulation and metabolic changes associated with nutritional status... 
Overexpression of the human 2-oxoglutarate carrier lowers mitochondrial membrane potential in HEK-293 cells: contrast with the unique cold-induced mitochondrial carrier CGI-69X X Yu
Department of Endocrinology, Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
Biochem J 353:369-75. 2001....- TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signallingG Pan
Department of Pathology, University of Michigan Medical School, Ann Arbor 48109, USA
FEBS Lett 424:41-5. 1998..Consistent with an inhibitory role, ectopic expression of TRUNDD attenuated TRAIL-induced apoptosis in mammalian cells... - Caspase-9, Bcl-XL, and Apaf-1 form a ternary complexG Pan
Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
J Biol Chem 273:5841-5. 1998..Consistent with a central role for caspase-9, a dominant negative form effectively inhibited cell death initiated by a wide variety of inducers... - An antagonist decoy receptor and a death domain-containing receptor for TRAILG Pan
Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA
Science 277:815-8. 1997..Another death domain-containing receptor for TRAIL (designated as death receptor-5), which preferentially engaged a FLICE (caspase-8)-related death protease, was also identified... - IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor bindingS G Hymowitz
Department of Protein Engineering, Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
EMBO J 20:5332-41. 2001..Remarkably, this cavity is located in precisely the same position where nerve growth factor binds its high affinity receptor, TrkA, suggesting further parallels between IL-17s and neurotrophins with respect to receptor recognition... - Perspectives on the biology of uncoupling protein (UCP) homologuesS H Adams
Department of Endocrinology, Genentech, Inc, South San Francisco, CA 94080, USA
Biochem Soc Trans 29:798-802. 2001.... - Requirement of calmodulin binding by HIV-1 gp160 for enhanced FAS-mediated apoptosisK J Micoli
Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
J Biol Chem 275:1233-40. 2000..The data indicate that gp160-enhanced apoptosis is dependent upon calmodulin up-regulation, involves the activation of caspase 3, and requires calmodulin binding to the C-terminal binding domain of gp160... - UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cellsW Mao
Department of Endocrinology, Genentech, Inc, South San Francisco, CA 94080, USA
FEBS Lett 443:326-30. 1999..These findings suggest that UCP4 may be involved in thermoregulatory heat production and metabolism in the brain... - The receptor for the cytotoxic ligand TRAILG Pan
Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Science 276:111-3. 1997..Thus, the DR4-TRAIL axis defines another receptor-ligand pair involved in regulating cell suicide and tissue homeostasis... - Knock-out of the neural death effector domain protein PEA-15 demonstrates that its expression protects astrocytes from TNFalpha-induced apoptosisD Kitsberg
Harvard Medical School, Boston, Massachusetts 02115, USA
J Neurosci 19:8244-51. 1999..After generation of PEA-15 null mutant mice, our results demonstrate that PEA-15 expression increases astrocyte survival after exposure to TNF... - TRAIL (Apo-2L) and TRAIL receptors in human placentas: implications for immune privilegeT A Phillips
Departments ofAnatomy and Cell Biology, Pathology and Laboratory Medicine, and Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USA
J Immunol 162:6053-9. 1999..Collectively, the results are consistent with a role for the TRAIL/TRAIL-R system in the establishment of placental immune privilege... - FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIOJ Archambault
Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada M5G 1L6
J Biol Chem 273:27593-601. 1998..FCP1 is also a stoichiometric component of a human RNA polymerase II holoenzyme complex... - Interaction of elongation factors TFIIS and elongin A with a human RNA polymerase II holoenzyme capable of promoter-specific initiation and responsive to transcriptional activatorsG Pan
Banting and Best Department of Medical Research and Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario M5G 1L6, Canada
J Biol Chem 272:24563-71. 1997..The transcriptional activators GAL4-VP16 and GAL4-Sp1 activated transcription in vitro by purified holoenzyme in the absence of any additional factors... - The C-terminal domain of RNA polymerase II couples mRNA processing to transcriptionS McCracken
Amgen Institute, Toronto, Ontario, Canada
Nature 385:357-61. 1997.... - Characterization of the interaction between the acidic activation domain of VP16 and the RNA polymerase II initiation factor TFIIBR Gupta
Banting and Best Department of Medical Research, University of Toronto, Ontario, Canada
Nucleic Acids Res 24:2324-30. 1996..Taken together our results suggest more evidence is needed to support the notion that TFIIB is a functionally important target for the activator VP16...