G Pan

Summary

Affiliation: Genentech Inc
Country: USA

Publications

  1. ncbi Forced expression of murine IL-17E induces growth retardation, jaundice, a Th2-biased response, and multiorgan inflammation in mice
    G Pan
    Department of Molecular Oncology, Genentech, Inc, South San Francisco, CA 94080, USA
    J Immunol 167:6559-67. 2001
  2. ncbi Identification and functional characterization of DR6, a novel death domain-containing TNF receptor
    G Pan
    Department of Pathology, University of Michigan Medical School, Ann Arbor 48109, USA
    FEBS Lett 431:351-6. 1998
  3. ncbi IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1Rrp
    G Pan
    Department of Endocrinology, Genentech, Inc, 1 DNA Way, South San Francisco, CA, 94080, USA
    Cytokine 13:1-7. 2001
  4. ncbi Characterization of novel UCP5/BMCP1 isoforms and differential regulation of UCP4 and UCP5 expression through dietary or temperature manipulation
    X X Yu
    Departments of Endocrinology, Molecular Biology, and Bioassay and Bioimage, Genentech, Inc, South San Francisco, California 94080, USA
    FASEB J 14:1611-8. 2000
  5. pmc Overexpression of the human 2-oxoglutarate carrier lowers mitochondrial membrane potential in HEK-293 cells: contrast with the unique cold-induced mitochondrial carrier CGI-69
    X X Yu
    Department of Endocrinology, Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Biochem J 353:369-75. 2001
  6. ncbi TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling
    G Pan
    Department of Pathology, University of Michigan Medical School, Ann Arbor 48109, USA
    FEBS Lett 424:41-5. 1998
  7. ncbi Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex
    G Pan
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Biol Chem 273:5841-5. 1998
  8. ncbi An antagonist decoy receptor and a death domain-containing receptor for TRAIL
    G Pan
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA
    Science 277:815-8. 1997
  9. pmc IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding
    S G Hymowitz
    Department of Protein Engineering, Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    EMBO J 20:5332-41. 2001
  10. ncbi Perspectives on the biology of uncoupling protein (UCP) homologues
    S H Adams
    Department of Endocrinology, Genentech, Inc, South San Francisco, CA 94080, USA
    Biochem Soc Trans 29:798-802. 2001

Collaborators

Detail Information

Publications19

  1. ncbi Forced expression of murine IL-17E induces growth retardation, jaundice, a Th2-biased response, and multiorgan inflammation in mice
    G Pan
    Department of Molecular Oncology, Genentech, Inc, South San Francisco, CA 94080, USA
    J Immunol 167:6559-67. 2001
    ..Taken together, these findings suggest that IL-17E is a unique pleiotropic cytokine and may be an important mediator of inflammatory and immune responses...
  2. ncbi Identification and functional characterization of DR6, a novel death domain-containing TNF receptor
    G Pan
    Department of Pathology, University of Michigan Medical School, Ann Arbor 48109, USA
    FEBS Lett 431:351-6. 1998
    ..DR6 interacts with TRADD, which has previously been shown to associate with TNFR1. Furthermore, ectopic expression of DR6 in mammalian cells induces apoptosis and activation of both NF-kappaB and JNK...
  3. ncbi IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1Rrp
    G Pan
    Department of Endocrinology, Genentech, Inc, 1 DNA Way, South San Francisco, CA, 94080, USA
    Cytokine 13:1-7. 2001
    ..These findings suggest that IL-1H may be another ligand for the IL-18 receptor and a new player in the inflammatory and immune responses mediated by the IL-18/IL-18R axis...
  4. ncbi Characterization of novel UCP5/BMCP1 isoforms and differential regulation of UCP4 and UCP5 expression through dietary or temperature manipulation
    X X Yu
    Departments of Endocrinology, Molecular Biology, and Bioassay and Bioimage, Genentech, Inc, South San Francisco, California 94080, USA
    FASEB J 14:1611-8. 2000
    ..These findings are consistent with the notion that UCP4 and UCP5 may be involved in tissue-specific thermoregulation and metabolic changes associated with nutritional status...
  5. pmc Overexpression of the human 2-oxoglutarate carrier lowers mitochondrial membrane potential in HEK-293 cells: contrast with the unique cold-induced mitochondrial carrier CGI-69
    X X Yu
    Department of Endocrinology, Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Biochem J 353:369-75. 2001
    ....
  6. ncbi TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling
    G Pan
    Department of Pathology, University of Michigan Medical School, Ann Arbor 48109, USA
    FEBS Lett 424:41-5. 1998
    ..Consistent with an inhibitory role, ectopic expression of TRUNDD attenuated TRAIL-induced apoptosis in mammalian cells...
  7. ncbi Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex
    G Pan
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Biol Chem 273:5841-5. 1998
    ..Consistent with a central role for caspase-9, a dominant negative form effectively inhibited cell death initiated by a wide variety of inducers...
  8. ncbi An antagonist decoy receptor and a death domain-containing receptor for TRAIL
    G Pan
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA
    Science 277:815-8. 1997
    ..Another death domain-containing receptor for TRAIL (designated as death receptor-5), which preferentially engaged a FLICE (caspase-8)-related death protease, was also identified...
  9. pmc IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding
    S G Hymowitz
    Department of Protein Engineering, Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    EMBO J 20:5332-41. 2001
    ..Remarkably, this cavity is located in precisely the same position where nerve growth factor binds its high affinity receptor, TrkA, suggesting further parallels between IL-17s and neurotrophins with respect to receptor recognition...
  10. ncbi Perspectives on the biology of uncoupling protein (UCP) homologues
    S H Adams
    Department of Endocrinology, Genentech, Inc, South San Francisco, CA 94080, USA
    Biochem Soc Trans 29:798-802. 2001
    ....
  11. ncbi Requirement of calmodulin binding by HIV-1 gp160 for enhanced FAS-mediated apoptosis
    K J Micoli
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Biol Chem 275:1233-40. 2000
    ..The data indicate that gp160-enhanced apoptosis is dependent upon calmodulin up-regulation, involves the activation of caspase 3, and requires calmodulin binding to the C-terminal binding domain of gp160...
  12. ncbi UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells
    W Mao
    Department of Endocrinology, Genentech, Inc, South San Francisco, CA 94080, USA
    FEBS Lett 443:326-30. 1999
    ..These findings suggest that UCP4 may be involved in thermoregulatory heat production and metabolism in the brain...
  13. ncbi The receptor for the cytotoxic ligand TRAIL
    G Pan
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Science 276:111-3. 1997
    ..Thus, the DR4-TRAIL axis defines another receptor-ligand pair involved in regulating cell suicide and tissue homeostasis...
  14. ncbi Knock-out of the neural death effector domain protein PEA-15 demonstrates that its expression protects astrocytes from TNFalpha-induced apoptosis
    D Kitsberg
    Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 19:8244-51. 1999
    ..After generation of PEA-15 null mutant mice, our results demonstrate that PEA-15 expression increases astrocyte survival after exposure to TNF...
  15. ncbi TRAIL (Apo-2L) and TRAIL receptors in human placentas: implications for immune privilege
    T A Phillips
    Departments ofAnatomy and Cell Biology, Pathology and Laboratory Medicine, and Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    J Immunol 162:6053-9. 1999
    ..Collectively, the results are consistent with a role for the TRAIL/TRAIL-R system in the establishment of placental immune privilege...
  16. ncbi FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO
    J Archambault
    Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada M5G 1L6
    J Biol Chem 273:27593-601. 1998
    ..FCP1 is also a stoichiometric component of a human RNA polymerase II holoenzyme complex...
  17. ncbi Interaction of elongation factors TFIIS and elongin A with a human RNA polymerase II holoenzyme capable of promoter-specific initiation and responsive to transcriptional activators
    G Pan
    Banting and Best Department of Medical Research and Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario M5G 1L6, Canada
    J Biol Chem 272:24563-71. 1997
    ..The transcriptional activators GAL4-VP16 and GAL4-Sp1 activated transcription in vitro by purified holoenzyme in the absence of any additional factors...
  18. ncbi The C-terminal domain of RNA polymerase II couples mRNA processing to transcription
    S McCracken
    Amgen Institute, Toronto, Ontario, Canada
    Nature 385:357-61. 1997
    ....
  19. pmc Characterization of the interaction between the acidic activation domain of VP16 and the RNA polymerase II initiation factor TFIIB
    R Gupta
    Banting and Best Department of Medical Research, University of Toronto, Ontario, Canada
    Nucleic Acids Res 24:2324-30. 1996
    ..Taken together our results suggest more evidence is needed to support the notion that TFIIB is a functionally important target for the activator VP16...