Rama Pai

Summary

Affiliation: Genentech Inc
Country: USA

Publications

  1. pmc Deoxycholic acid activates beta-catenin signaling pathway and increases colon cell cancer growth and invasiveness
    Rama Pai
    Medical Service, Department of Veterans Affairs Medical Center, Long Beach, California, USA
    Mol Biol Cell 15:2156-63. 2004
  2. doi request reprint Antibody-mediated inhibition of fibroblast growth factor 19 results in increased bile acids synthesis and ileal malabsorption of bile acids in cynomolgus monkeys
    Rama Pai
    Department of Safety Assessment, Genentech Incorporated, South San Francisco, California 94080, USA
    Toxicol Sci 126:446-56. 2012
  3. doi request reprint Inhibition of fibroblast growth factor 19 reduces tumor growth by modulating beta-catenin signaling
    Rama Pai
    Department of Pathology, Genentech Incorporated, South San Francisco, California 94080, USA
    Cancer Res 68:5086-95. 2008
  4. doi request reprint Phosphorous dysregulation induced by MEK small molecule inhibitors in the rat involves blockade of FGF-23 signaling in the kidney
    Dolores Diaz
    Safety Assessment, Genentech Inc, South San Francisco, California 94080, USA
    Toxicol Sci 125:187-95. 2012
  5. ncbi request reprint Rebamipide inhibits gastric cancer cell growth
    Tetsuya Tanigawa
    Medical Service, Department of Veterans Affairs Medical Center, Long Beach, California 90822, USA
    Dig Dis Sci 52:240-7. 2007
  6. ncbi request reprint Pharmacological characterization of human and murine neuropeptide s receptor variants
    Rainer K Reinscheid
    Department of Pharmacology, University of California at Irvine, 360 Med Surge II, Irvine, CA 92697 4625, USA
    J Pharmacol Exp Ther 315:1338-45. 2005
  7. ncbi request reprint Leptin activates STAT and ERK2 pathways and induces gastric cancer cell proliferation
    Rama Pai
    Medical Service, Department of Veterans Affairs Medical Center, Long Beach, California, USA
    Biochem Biophys Res Commun 331:984-92. 2005
  8. ncbi request reprint Prostaglandins promote colon cancer cell invasion; signaling by cross-talk between two distinct growth factor receptors
    Rama Pai
    Medical Service, Department of Veterans Affairs Medical Center, Long Beach, California 90822, USA
    FASEB J 17:1640-7. 2003
  9. ncbi request reprint Indomethacin delays gastric restitution: association with the inhibition of focal adhesion kinase and tensin phosphorylation and reduced actin stress fibers
    Imre L Szabo
    Medical Service, Department of Veterans Affairs Medical Center, Long Beach, California 90822, USA
    Exp Biol Med (Maywood) 227:412-24. 2002
  10. ncbi request reprint Prostaglandin E2 transactivates EGF receptor: a novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy
    Rama Pai
    Medical Service, Department of Veterans Affairs Medical Center, Long Beach, California, USA
    Nat Med 8:289-93. 2002

Collaborators

  • Laurent Salphati
  • Jing Qing
  • M K Jones
  • Andrzej S Tarnawski
  • Hirofumi Kawanaka
  • Imre L Szabo
  • Dolores Diaz
  • Dolgor Baatar
  • Tetsuya Tanigawa
  • Rainer K Reinscheid
  • Nghi La
  • Preeti Dhawan
  • Brian J Dean
  • Gary R Cain
  • Sock Cheng Lewin-Koh
  • Jacqueline M Tarrant
  • Hajime Hiraragi
  • Xiao Ding
  • Cleopatra Kozlowski
  • Sheila Bheddah
  • Krishna Allamneni
  • Donna M Dambach
  • Dylan P Hartley
  • Tetsuo Arakawa
  • Olivier Civelli
  • Naoe Okamura
  • Shinjae Chung
  • Yan Ling Xu
  • Zhiwei Wang
  • Joanne Zeng
  • Keizo Sugimachi
  • I James Sarfeh
  • Kouji Tsugawa
  • Seigo Kitano
  • George R Ehring

Detail Information

Publications12

  1. pmc Deoxycholic acid activates beta-catenin signaling pathway and increases colon cell cancer growth and invasiveness
    Rama Pai
    Medical Service, Department of Veterans Affairs Medical Center, Long Beach, California, USA
    Mol Biol Cell 15:2156-63. 2004
    ..These findings provide evidence for a novel mechanism underlying the oncogenic effects of secondary bile acids...
  2. doi request reprint Antibody-mediated inhibition of fibroblast growth factor 19 results in increased bile acids synthesis and ileal malabsorption of bile acids in cynomolgus monkeys
    Rama Pai
    Department of Safety Assessment, Genentech Incorporated, South San Francisco, California 94080, USA
    Toxicol Sci 126:446-56. 2012
    ..Increased bile acids alter expression of solute transporters in the ileum causing diarrhea and the enhanced enterohepatic recirculation of bile acids leading to liver toxicity...
  3. doi request reprint Inhibition of fibroblast growth factor 19 reduces tumor growth by modulating beta-catenin signaling
    Rama Pai
    Department of Pathology, Genentech Incorporated, South San Francisco, California 94080, USA
    Cancer Res 68:5086-95. 2008
    ..These findings highlight that FGF19/FGFR4 cross-talk with beta-catenin and that pathway intervention reduces tumor growth...
  4. doi request reprint Phosphorous dysregulation induced by MEK small molecule inhibitors in the rat involves blockade of FGF-23 signaling in the kidney
    Dolores Diaz
    Safety Assessment, Genentech Inc, South San Francisco, California 94080, USA
    Toxicol Sci 125:187-95. 2012
    ..These transcriptional changes increase serum vitamin D levels, which in turn drive the increase in serum iP, leading to soft tissue mineralization in the rat...
  5. ncbi request reprint Rebamipide inhibits gastric cancer cell growth
    Tetsuya Tanigawa
    Medical Service, Department of Veterans Affairs Medical Center, Long Beach, California 90822, USA
    Dig Dis Sci 52:240-7. 2007
    ..Inactivation of ERK2 partly inhibited rebamipide-induced p21 expression, indicating a crosstalk between ERK and Smad signaling pathways...
  6. ncbi request reprint Pharmacological characterization of human and murine neuropeptide s receptor variants
    Rainer K Reinscheid
    Department of Pharmacology, University of California at Irvine, 360 Med Surge II, Irvine, CA 92697 4625, USA
    J Pharmacol Exp Ther 315:1338-45. 2005
    ....
  7. ncbi request reprint Leptin activates STAT and ERK2 pathways and induces gastric cancer cell proliferation
    Rama Pai
    Medical Service, Department of Veterans Affairs Medical Center, Long Beach, California, USA
    Biochem Biophys Res Commun 331:984-92. 2005
    ..These findings indicate that leptin promotes cancer growth by activating multiple signaling pathways and therefore blocking its action at the receptor level could be a rational therapeutic strategy...
  8. ncbi request reprint Prostaglandins promote colon cancer cell invasion; signaling by cross-talk between two distinct growth factor receptors
    Rama Pai
    Medical Service, Department of Veterans Affairs Medical Center, Long Beach, California 90822, USA
    FASEB J 17:1640-7. 2003
    ..Our findings explain a functional relationship between prostaglandins, EGFR, and c-Met-R in colon cancer growth and invasion...
  9. ncbi request reprint Indomethacin delays gastric restitution: association with the inhibition of focal adhesion kinase and tensin phosphorylation and reduced actin stress fibers
    Imre L Szabo
    Medical Service, Department of Veterans Affairs Medical Center, Long Beach, California 90822, USA
    Exp Biol Med (Maywood) 227:412-24. 2002
    ..Our study indicates that FAK, tensin, and actin stress fibers are likely mediators of EGF-stimulated cell migration in wounded human gastric monolayers and potential targets for IND-induced inhibition of restitution...
  10. ncbi request reprint Prostaglandin E2 transactivates EGF receptor: a novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy
    Rama Pai
    Medical Service, Department of Veterans Affairs Medical Center, Long Beach, California, USA
    Nat Med 8:289-93. 2002
    ..Our findings that PGE2 transactivates EGFR reveal a previously unknown mechanism by which PGE2 mediates trophic actions resulting in gastric and intestinal hypertrophy as well as growth of colonic polyps and cancers...
  11. ncbi request reprint Esophageal ulceration activates keratinocyte growth factor and its receptor in rats: implications for ulcer healing
    Dolgor Baatar
    Department of Veterans Affairs Medical Center, Long Beach, California 90822, USA
    Gastroenterology 122:458-68. 2002
    ..We studied the sequential cellular events and the expression of keratinocyte growth factor (KGF) and its receptor (KGF-R) during the healing of experimental esophageal ulcers...
  12. ncbi request reprint Activation of eNOS in rat portal hypertensive gastric mucosa is mediated by TNF-alpha via the PI 3-kinase-Akt signaling pathway
    Hirofumi Kawanaka
    Departments of Medicine and Surgery, Department of Veterans Affairs Medical Center, Long Beach, CA 90822, USA
    Hepatology 35:393-402. 2002
    ..In conclusion, these findings show that in PHT gastric mucosa, TNF-alpha stimulates eNOS phosphorylation at serine 1177 (required for its activation) via the PI 3-kinase-Akt signal transduction pathway...