Genomes and Genes
Affiliation: Genentech Inc
- TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary ciliaSaikat Mukhopadhyay
Department of Cell Regulation, Genentech, Inc, South San Francisco, California 94080, USA
Genes Dev 24:2180-93. 2010..TULP3 and IFT-A proteins both negatively regulate Hedgehog signaling in the mouse embryo, and the TULP3-IFT-A interaction suggests how these proteins cooperate during neural tube patterning...
- The tubby family proteinsSaikat Mukhopadhyay
Department of Cell Regulation, Genentech Inc, South San Francisco, CA 94080, USA
Genome Biol 12:225. 2011..Molecular studies on this functionally diverse protein family are beginning to provide us with remarkable insights into the tubby-mouse syndrome and other related diseases...
- The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signalingSaikat Mukhopadhyay
Department of Research Oncology, Genentech Inc, South San Francisco, CA 94080, USA
Cell 152:210-23. 2013..Conversely, Shh signaling directs Gpr161 to be internalized from cilia, preventing its activity. Thus, Gpr161 defines a morphogenetic pathway coupling protein kinase A activation to Shh signaling during neural tube development...
- An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary ciliumKevin J Wright
Genentech Inc, South San Francisco, California 94080, USA
Genes Dev 25:2347-60. 2011..Our results uncover a selective, membrane targeting GTPase cycle that delivers myristoylated proteins to the ciliary membrane and suggest that other myristoylated proteins may be similarly targeted to specialized membrane domains...