Saikat Mukhopadhyay

Summary

Affiliation: Genentech Inc
Country: USA

Publications

  1. ncbi TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia
    Saikat Mukhopadhyay
    Department of Cell Regulation, Genentech, Inc, South San Francisco, California 94080, USA
    Genes Dev 24:2180-93. 2010
  2. ncbi The tubby family proteins
    Saikat Mukhopadhyay
    Department of Cell Regulation, Genentech Inc, South San Francisco, CA 94080, USA
    Genome Biol 12:225. 2011
  3. ncbi The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling
    Saikat Mukhopadhyay
    Department of Research Oncology, Genentech Inc, South San Francisco, CA 94080, USA
    Cell 152:210-23. 2013
  4. ncbi An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium
    Kevin J Wright
    Genentech Inc, South San Francisco, California 94080, USA
    Genes Dev 25:2347-60. 2011

Collaborators

  • Piali Sengupta
  • Kevin J Wright
  • Weiru Wang
  • Anique Olivier-Mason
  • Peter K Jackson
  • Val C Sheffield
  • Pamela R Pretorius
  • Lisa M Baye
  • Diane C Slusarski
  • Liyun Sang
  • Mandy Kwong

Detail Information

Publications4

  1. ncbi TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia
    Saikat Mukhopadhyay
    Department of Cell Regulation, Genentech, Inc, South San Francisco, California 94080, USA
    Genes Dev 24:2180-93. 2010
    ..TULP3 and IFT-A proteins both negatively regulate Hedgehog signaling in the mouse embryo, and the TULP3-IFT-A interaction suggests how these proteins cooperate during neural tube patterning...
  2. ncbi The tubby family proteins
    Saikat Mukhopadhyay
    Department of Cell Regulation, Genentech Inc, South San Francisco, CA 94080, USA
    Genome Biol 12:225. 2011
    ..Molecular studies on this functionally diverse protein family are beginning to provide us with remarkable insights into the tubby-mouse syndrome and other related diseases...
  3. ncbi The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling
    Saikat Mukhopadhyay
    Department of Research Oncology, Genentech Inc, South San Francisco, CA 94080, USA
    Cell 152:210-23. 2013
    ..Conversely, Shh signaling directs Gpr161 to be internalized from cilia, preventing its activity. Thus, Gpr161 defines a morphogenetic pathway coupling protein kinase A activation to Shh signaling during neural tube development...
  4. ncbi An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium
    Kevin J Wright
    Genentech Inc, South San Francisco, California 94080, USA
    Genes Dev 25:2347-60. 2011
    ..Our results uncover a selective, membrane targeting GTPase cycle that delivers myristoylated proteins to the ciliary membrane and suggest that other myristoylated proteins may be similarly targeted to specialized membrane domains...