Ira Mellman

Summary

Affiliation: Genentech Inc
Country: USA

Publications

  1. ncbi request reprint Dendritic cell maturation triggers retrograde MHC class II transport from lysosomes to the plasma membrane
    Amy Chow
    Department of Cell Biology and Section of Immunobiology, Ludwig Institute for Cancer Research, Yale University School of Medicine, 333 Cedar Street, PO Box 208002, New Haven, Connecticut 06520 8002, USA
    Nature 418:988-94. 2002
  2. ncbi request reprint Immunotherapy: bewitched, bothered, and bewildered no more
    Ralph M Steinman
    Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, NY 10021 6399, USA
    Science 305:197-200. 2004
  3. ncbi request reprint Old lysosomes, new tricks: MHC II dynamics in DCs
    Amy Y Chow
    Department of Cell Biology and Section of Immunobiology, Ludwig Institute for Cancer Research, Yale University School of Medicine, 333 Cedar Street, PO Box 208002, New Haven, CT 06520 8002, USA
    Trends Immunol 26:72-8. 2005
  4. ncbi request reprint Surface expression of MHC class II in dendritic cells is controlled by regulated ubiquitination
    Jeoung Sook Shin
    Department of Cell Biology and Section of Immunobiology, Ludwig Institute for Cancer Research, Yale University School of Medicine, 333 Cedar Street, PO Box 208002, New Haven, Connecticut 06520 8002, USA
    Nature 444:115-8. 2006
  5. ncbi request reprint Private lives: reflections and challenges in understanding the cell biology of the immune system
    Ira Mellman
    Department of Research Oncology, Genentech, 1 DNA Way, Mail Stop 212, South San Francisco, CA 94080 4990, USA
    Science 317:625-7. 2007
  6. pmc Spinophilin participates in information transfer at immunological synapses
    Ona Bloom
    Department of Cell Biology, Ludwig Institute for Cancer Research, New Haven, CT 06520, USA
    J Cell Biol 181:203-11. 2008
  7. pmc Lkb1 regulates organogenesis and early oncogenesis along AMPK-dependent and -independent pathways
    Bryan Lo
    Genentech, South San Francisco, CA 94080, USA
    J Cell Biol 199:1117-30. 2012
  8. pmc Monocyte-derived dendritic cells exhibit increased levels of lysosomal proteolysis as compared to other human dendritic cell populations
    Nathanael McCurley
    Department of Cell Biology, Ludwig Institute for Cancer Research, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 5:e11949. 2010
  9. pmc Par3 functions in the biogenesis of the primary cilium in polarized epithelial cells
    Jeff Sfakianos
    Department of Cell Biology, Ludwig Institute for Cancer Research, New Haven, CT 06520
    J Cell Biol 179:1133-40. 2007
  10. pmc A hierarchy of signals regulates entry of membrane proteins into the ciliary membrane domain in epithelial cells
    Stephen S Francis
    Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06510, USA
    J Cell Biol 193:219-33. 2011

Detail Information

Publications70

  1. ncbi request reprint Dendritic cell maturation triggers retrograde MHC class II transport from lysosomes to the plasma membrane
    Amy Chow
    Department of Cell Biology and Section of Immunobiology, Ludwig Institute for Cancer Research, Yale University School of Medicine, 333 Cedar Street, PO Box 208002, New Haven, Connecticut 06520 8002, USA
    Nature 418:988-94. 2002
    ..We show that on stimulation, dendritic cells generate tubules from lysosomal compartments that go on to fuse directly with the plasma membrane...
  2. ncbi request reprint Immunotherapy: bewitched, bothered, and bewildered no more
    Ralph M Steinman
    Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, NY 10021 6399, USA
    Science 305:197-200. 2004
    ..We suggest steps to be taken to reinvigorate basic research in human subjects as part of the mainstream of science...
  3. ncbi request reprint Old lysosomes, new tricks: MHC II dynamics in DCs
    Amy Y Chow
    Department of Cell Biology and Section of Immunobiology, Ludwig Institute for Cancer Research, Yale University School of Medicine, 333 Cedar Street, PO Box 208002, New Haven, CT 06520 8002, USA
    Trends Immunol 26:72-8. 2005
  4. ncbi request reprint Surface expression of MHC class II in dendritic cells is controlled by regulated ubiquitination
    Jeoung Sook Shin
    Department of Cell Biology and Section of Immunobiology, Ludwig Institute for Cancer Research, Yale University School of Medicine, 333 Cedar Street, PO Box 208002, New Haven, Connecticut 06520 8002, USA
    Nature 444:115-8. 2006
    ..Dendritic cells thus exhibit a unique ability to regulate MHC II surface expression by selectively controlling MHC II ubiquitination...
  5. ncbi request reprint Private lives: reflections and challenges in understanding the cell biology of the immune system
    Ira Mellman
    Department of Research Oncology, Genentech, 1 DNA Way, Mail Stop 212, South San Francisco, CA 94080 4990, USA
    Science 317:625-7. 2007
    ..As a result, there are great opportunities, but also great challenges, for new conceptual discoveries by taking a more cell-biological approach to probing the function of the immune system...
  6. pmc Spinophilin participates in information transfer at immunological synapses
    Ona Bloom
    Department of Cell Biology, Ludwig Institute for Cancer Research, New Haven, CT 06520, USA
    J Cell Biol 181:203-11. 2008
    ..Thus, spinophilin may play analogous roles in information transfer at both neuronal and immunological synapses...
  7. pmc Lkb1 regulates organogenesis and early oncogenesis along AMPK-dependent and -independent pathways
    Bryan Lo
    Genentech, South San Francisco, CA 94080, USA
    J Cell Biol 199:1117-30. 2012
    ..Combining culture of embryonic tissues with genetic manipulation and chemical genetics thus provides a powerful approach to unraveling developmental programs and understanding cancer initiation...
  8. pmc Monocyte-derived dendritic cells exhibit increased levels of lysosomal proteolysis as compared to other human dendritic cell populations
    Nathanael McCurley
    Department of Cell Biology, Ludwig Institute for Cancer Research, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 5:e11949. 2010
    ..Combined with the ability to modulate lysosomal pH during phagocytosis and maturation, murine DCs enhance their production of class II MHC-peptide complexes for presentation to T cells...
  9. pmc Par3 functions in the biogenesis of the primary cilium in polarized epithelial cells
    Jeff Sfakianos
    Department of Cell Biology, Ludwig Institute for Cancer Research, New Haven, CT 06520
    J Cell Biol 179:1133-40. 2007
    ..Thus, the Par complex likely serves as an adaptor that couples the vectorial movement of at least a subset of membrane proteins to microtubule-dependent transport during ciliogenesis...
  10. pmc A hierarchy of signals regulates entry of membrane proteins into the ciliary membrane domain in epithelial cells
    Stephen S Francis
    Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06510, USA
    J Cell Biol 193:219-33. 2011
    ..Thus, a hierarchy of interactions controls the composition of the ciliary membrane, including selective retention, selective inclusion, and passive diffusion...
  11. pmc Cancer immunotherapy comes of age
    Ira Mellman
    Genentech, 1 DNA Way, South San Francisco, California 94080, USA
    Nature 480:480-9. 2011
    ....
  12. pmc Bringing science to cancer therapy
    Ira Mellman
    Ludwig Institute for Cancer Research, Yale University School of Medicine, New Haven, Connecticut 06520 8002, USA
    Yale J Biol Med 79:177-8. 2006
  13. pmc Coordinated protein sorting, targeting and distribution in polarized cells
    Ira Mellman
    Genentech, Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nat Rev Mol Cell Biol 9:833-45. 2008
    ..The integration of these mechanisms into a complex and dynamic network is crucial for normal tissue function and is often defective in disease states...
  14. pmc Vectorial insertion of apical and basolateral membrane proteins in polarized epithelial cells revealed by quantitative 3D live cell imaging
    Wei Hua
    Department of Cell Biology, Ludwig Institute for Cancer Research, Yale University School of Medicine, New Haven, CT 06520, USA
    J Cell Biol 172:1035-44. 2006
    ....
  15. pmc Membrane proteins follow multiple pathways to the basolateral cell surface in polarized epithelial cells
    Glen A Farr
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Cell Biol 186:269-82. 2009
    ..Finally, Na,K-ATPase and VSV-G travel in separate post-Golgi transport intermediates, demonstrating directly that multiple routes exist for transport from the Golgi to the basolateral membrane in polarized epithelial cells...
  16. pmc Disruption of E-cadherin-mediated adhesion induces a functionally distinct pathway of dendritic cell maturation
    Aimin Jiang
    Department of Cell Biology, Ludwig Institute for Cancer Research, Yale University School of Medicine, 333 Cedar Street, PO Box 208002, New Haven, CT 06520, USA
    Immunity 27:610-24. 2007
    ..These DCs induced tolerance in vivo and may thus contribute to the elusive steady-state "tolerogenic DCs."..
  17. pmc The AP-1A and AP-1B clathrin adaptor complexes define biochemically and functionally distinct membrane domains
    HEIKE FOLSCH
    Department of Cell Biology, Ludwig Institute for Cancer Research, Yale University School of Medicine, New Haven, CT 06520, USA
    J Cell Biol 163:351-62. 2003
    ..Thus, despite the similarity of the two AP-1 complexes, AP-1A and AP-1B exhibit great specificity for endosomal transport versus cell polarity...
  18. pmc Antigen delivery to early endosomes eliminates the superiority of human blood BDCA3+ dendritic cells at cross presentation
    Lillian Cohn
    Genentech, South San Francisco, CA 94080, USA
    J Exp Med 210:1049-63. 2013
    ..Thus, multiple DC populations may be comparably effective at presenting exogenous antigens to CD8(+) T cells as long as the antigen is delivered to early endocytic compartments...
  19. ncbi request reprint Differential lysosomal proteolysis in antigen-presenting cells determines antigen fate
    Lelia Delamarre
    Department of Cell Biology and Department of Immunobiology, Ludwig Institute for Cancer Research, Yale University School of Medicine, 333 Cedar Street, Post Office Box 208002, New Haven, CT 06520 8002, USA
    Science 307:1630-4. 2005
    ..Limited lysosomal proteolysis also favored antigen presentation. These results help explain why DCs are able to efficiently accumulate, process, and disseminate antigens and microbes systemically for purposes of tolerance and immunity...
  20. pmc Transcytosis of NgCAM in epithelial cells reflects differential signal recognition on the endocytic and secretory pathways
    Eric Anderson
    Department of Cell Biology, Ludwig Institute for Cancer Research, Yale University School of Medicine, New Haven, CT 06520, USA
    J Cell Biol 170:595-605. 2005
    ..Thus, transcytosis of NgCAM and perhaps other membrane proteins may reflect the spatial regulation of recognition by adaptors such as AP-1B...
  21. pmc Recycling endosomes can serve as intermediates during transport from the Golgi to the plasma membrane of MDCK cells
    Agnes Lee Ang
    Department of Cell Biology, Ludwig Institute of Cancer Research, Yale University School of Medicine, New Haven, CT 06520, USA
    J Cell Biol 167:531-43. 2004
    ..Because an apically targeted VSV-G mutant behaved similarly, these results suggest that REs not only serve as an intermediate but also as a common site for polarized sorting on the endocytic and secretory pathways...
  22. pmc CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis
    Jae Hyuck Shim
    Section of Immunobiology, Ludwig Institute for Cancer Research, Yale University School of Medicine, New Haven, CT 06520, USA
    J Cell Biol 172:1045-56. 2006
    ..Therefore, CHMP5 regulates late endosome function downstream of MVB formation, and the loss of CHMP5 enhances signal transduction by inhibiting lysosomal degradation of activated receptors...
  23. pmc The J-domain protein Rme-8 interacts with Hsc70 to control clathrin-dependent endocytosis in Drosophila
    Henry C Chang
    Dept of Cell Biology, Ludwig Institute for Cancer Research, Yale University School of Medicine, 333 Cedar Street, PO Box 208002, New Haven, CT 06520 8002, USA
    J Cell Biol 164:1055-64. 2004
    ....
  24. ncbi request reprint Regulated recruitment of MHC class II and costimulatory molecules to lipid rafts in dendritic cells
    Christian O Meyer zum Bueschenfelde
    Department of Immunobiology, Ludwig Institute for Cancer Research, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 173:6119-24. 2004
    ..This difference may reflect the necessity for DCs to interact with multiple T cells simultaneously and emphasizes that the biochemical and morphological correlates of lipid rafts are not necessarily equivalent...
  25. ncbi request reprint Internalization and endosomal degradation of receptor-bound antigens regulate the efficiency of cross presentation by human dendritic cells
    Bithi Chatterjee
    Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA
    Blood 120:2011-20. 2012
    ....
  26. ncbi request reprint Sorting of H,K-ATPase beta-subunit in MDCK and LLC-PK cells is independent of mu 1B adaptin expression
    Amy Duffield
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510, USA
    Traffic 5:449-61. 2004
    ....
  27. pmc The tetraspanin CD9 mediates lateral association of MHC class II molecules on the dendritic cell surface
    Julia J Unternaehrer
    Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520 8002, USA
    Proc Natl Acad Sci U S A 104:234-9. 2007
    ..CD9 is thus necessary for the association of heterologous MHC II, a specialization that would facilitate the formation of MHC II multimers expected to enhance T cell receptor stimulation by DCs...
  28. pmc Enhancing immunogenicity by limiting susceptibility to lysosomal proteolysis
    Lelia Delamarre
    Department of Cell Biology and Section of Immunobiology, Ludwig Institute for Cancer Research, Yale University School of Medicine, New Haven, CT 06520, USA
    J Exp Med 203:2049-55. 2006
    ..These findings suggest that stability to lysosomal proteolysis may be an important factor in determining immunogenicity, with potential implications for vaccine design...
  29. pmc IFN-gamma enables cross-presentation of exogenous protein antigen in human Langerhans cells by potentiating maturation
    Mitsutoshi Matsuo
    Ludwig Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:14467-72. 2004
    ..This model of conditional cross-presentation establishes an original level of action for IFN-gamma as an effective immune modulator and supports the use of IFN-gamma in protein vaccination strategies targeting LCs...
  30. doi request reprint Differential role of the Ca(2+) sensor synaptotagmin VII in macrophages and dendritic cells
    Steven M Becker
    Section of Microbial Pathogenesis, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    Immunobiology 214:495-505. 2009
    ....
  31. ncbi request reprint Endosomes are specialized platforms for bacterial sensing and NOD2 signalling
    Norihiro Nakamura
    Genentech, 1 DNA Way, South San Francisco, California 94080, USA
    Nature 509:240-4. 2014
    ..Thus, dendritic cell endosomes are specialized platforms for both the lumenal and cytosolic sensing of pathogens. ..
  32. pmc MHC class II distribution in dendritic cells and B cells is determined by ubiquitin chain length
    Jessica K Ma
    Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 109:8820-7. 2012
    ..Thus, Ub chain length plays a crucial role in regulating the intracellular fate and function of MHC II in DCs and B cells...
  33. ncbi request reprint Spatial control of EGF receptor activation by reversible dimerization on living cells
    Inhee Chung
    Genentech, Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nature 464:783-7. 2010
    ..Interestingly, dimers were enriched in the cell periphery in an actin- and receptor-expression-dependent fashion, resulting in a peripheral enhancement of EGF-induced signalling that may enable polarized responses to growth factors...
  34. pmc AMP-activated protein kinase (AMPK) activation and glycogen synthase kinase-3β (GSK-3β) inhibition induce Ca2+-independent deposition of tight junction components at the plasma membrane
    Li Zhang
    Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 286:16879-90. 2011
    ..These data demonstrate that two kinases involved in regulating cell growth and metabolism act through distinct pathways to influence the deposition of the components of epithelial tight junctions...
  35. pmc Presentation of exogenous antigens on major histocompatibility complex (MHC) class I and MHC class II molecules is differentially regulated during dendritic cell maturation
    Lelia Delamarre
    Department of Cell Biology and Section of Immunobiology, Ludwig Institute for Cancer Research, Yale University School of Medicine, New Haven, CT 06520 8002, USA
    J Exp Med 198:111-22. 2003
    ..Thus, the MHC I and MHC II pathways of antigen presentation are differentially regulated during DC maturation...
  36. pmc The Rab8 GTPase selectively regulates AP-1B-dependent basolateral transport in polarized Madin-Darby canine kidney cells
    Agnes Lee Ang
    Department of Cell Biology, Ludwig Institute for Cancer Research, Yale University School of Medicine, New Haven, CT 06520 8002, USA
    J Cell Biol 163:339-50. 2003
    ..However, expression of active Rab8 caused a selective dissociation of AP-1B complexes, reflecting the specificity of Rab8 for AP-1B-dependent transport...
  37. pmc A PDZ-binding motif controls basolateral targeting of syndecan-1 along the biosynthetic pathway in polarized epithelial cells
    Sandra Maday
    Department of Cell Biology, Ludwig Institute for Cancer Research, Yale University School of Medicine, New Haven, CT 06520, USA
    Traffic 9:1915-24. 2008
    ....
  38. ncbi request reprint Cell biology of antigen processing in vitro and in vivo
    E Sergio Trombetta
    Department of Cell Biology and Section of Immunobiology, Ludwig Institute for Cancer Research, Yale University School of Medicine, New Haven, Connecticut 06520 8002, USA
    Annu Rev Immunol 23:975-1028. 2005
    ..How dendritic cells handle antigens is likely to be as important a determinant of immunogenicity and tolerance as is the nature of the antigens themselves...
  39. ncbi request reprint Activation of lysosomal function during dendritic cell maturation
    E Sergio Trombetta
    Department of Cell Biology and Department of Immunobiology, Ludwig Institute for Cancer Research, Yale University School of Medicine, 333 Cedar Street, Post Office Box 208002, New Haven, CT 06520 8002, USA
    Science 299:1400-3. 2003
    ..Lysosomal function in DCs thus appears to be specialized for the developmentally regulated processing of internalized antigens...
  40. pmc Differential presentation of a soluble exogenous tumor antigen, NY-ESO-1, by distinct human dendritic cell populations
    Yasuhiro Nagata
    Ludwig Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 99:10629-34. 2002
    ..These results indicate that monocyte-derived DCs will be easier to load by using protein antigen in vitro than CD34-derived DCs, and that the latter population exhibits a restricted ability to crosspresent soluble exogenous antigens...
  41. pmc Hsc70 is required for endocytosis and clathrin function in Drosophila
    Henry C Chang
    Department of Cell Biology, Ludwig Institute for Cancer Research, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8002, USA
    J Cell Biol 159:477-87. 2002
    ..Together, these data provide genetic support for the long-suspected role of Hsc70 in clathrin-mediated endocytosis, at least in part by inhibiting the uncoating of CCVs...
  42. pmc Mature dendritic cells use endocytic receptors to capture and present antigens
    Craig D Platt
    Department of Cell Biology, Ludwig Institute for Cancer Research, and Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 107:4287-92. 2010
    ....
  43. pmc Inflammasome-activating nanoparticles as modular systems for optimizing vaccine efficacy
    Stacey L Demento
    Department of Biomedical Engineering, Yale University, New Haven, CT 06511, USA
    Vaccine 27:3013-21. 2009
    ..The design of such an antigen delivery mechanism with the ability to stimulate two potent innate immune pathways represents a potent new approach to simultaneous antigen and adjuvant delivery...
  44. ncbi request reprint Targeting antigen to CD19 on B cells efficiently activates T cells
    Jun Yan
    Section of Rheumatology, Department of Internal Medicine, Ludwig Institute for Cancer Research, Yale University School of Medicine, 300 Cedar Street, S525, PO Box, 208031 New Haven, CT 06520 8031, USA
    Int Immunol 17:869-77. 2005
    ..This work illustrates an important and previously unrecognized mechanism for targeting proteins to B lymphocytes for antigen presentation and activation of CD4 T cells...
  45. pmc Transferrin receptor recycling in the absence of perinuclear recycling endosomes
    David Sheff
    Department of Cell Biology, Ludwig Institute for Cancer Research, Yale University School of Medicine, New Haven, CT 06520
    J Cell Biol 156:797-804. 2002
    ....
  46. doi request reprint Transcriptional programming of dendritic cells for enhanced MHC class II antigen presentation
    Bryan Vander Lugt
    Department of Discovery Immunology, Genentech, South San Francisco, California, USA
    Nat Immunol 15:161-7. 2014
    ..We propose that the evolutionary divergence of IRF4 and IRF8 facilitated the specialization of DC subsets for distinct modes of antigen presentation and priming of helper T cell versus CTL responses. ..
  47. pmc Influenza A virus infection of human primary dendritic cells impairs their ability to cross-present antigen to CD8 T cells
    Anna Smed-Sorensen
    Genentech, South San Francisco, California, USA
    PLoS Pathog 8:e1002572. 2012
    ..Our results suggest that cross-presentation by uninfected mDCs is a preferred mechanism of antigen-presentation for the activation and expansion of CD8 T cells during IAV infection...
  48. doi request reprint Harnessing dendritic cells for immunotherapy
    Lelia Delamarre
    Genentech, 1 DNA Way, South San Francisco, CA 94080, United States
    Semin Immunol 23:2-11. 2011
    ....
  49. ncbi request reprint Modulation of cell adhesion and motility in the immune system by Myo1f
    Sangwon V Kim
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Science 314:136-9. 2006
    ..In vivo, Myo1f-deficient mice showed increased susceptibility to infection by Listeria monocytogenes and an impaired neutrophil response. Thus, Myo1f directs immune cell motility and innate host defense against infection...
  50. ncbi request reprint Antigen processing and presentation by dendritic cells: cell biological mechanisms
    Ira Mellman
    Department of Cell Biology, Ludwig Institute for Cancer Research, Yale University School of Medicine, 333 Cedar Street, PO Box 208002, New Haven, Connecticut 06520 8002, USA
    Adv Exp Med Biol 560:63-7. 2005
  51. pmc Hepatocyte Growth Factor stimulated cell scattering requires ERK and Cdc42-dependent tight junction disassembly
    Akashi Togawa
    Section of Nephrology, Yale University School of Medicine, New Haven, CT 06520, USA
    Biochem Biophys Res Commun 400:271-7. 2010
    ..Our findings reveal a novel pathway for regulating HGF signaling to the Par proteins through Erk-cdGAP, resulting in TJ disassembly and cell scattering...
  52. pmc Actin dependence of polarized receptor recycling in Madin-Darby canine kidney cell endosomes
    David R Sheff
    Department of Cell Biology, Ludwig Institute for Cancer Research, Yale University School of Medicine, New Haven, Connecticut 06520 8002, USA
    Mol Biol Cell 13:262-75. 2002
    ..Thus, filamentous actin may help to guide receptor traffic from endosomes to the basolateral plasma membrane...
  53. pmc A Nobel Prize for membrane traffic: vesicles find their journey's end
    Ira Mellman
    Genentech, South San Francisco, CA 94080
    J Cell Biol 203:559-61. 2013
    ..In this article, we highlight their achievements and also pay tribute to the pioneering scientists before them who set the stage for their remarkable discoveries...
  54. doi request reprint Antibody therapeutics in cancer
    Mark X Sliwkowski
    Genentech, Incorporated, 1 DNA Way, South San Francisco, CA 94080, USA
    Science 341:1192-8. 2013
    ..With ever more promising results from the clinic, the future will likely see continued growth in the discovery and development of therapeutic antibodies and their derivatives. ..
  55. pmc Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity
    Till Maurer
    Structural Biology, Genentech, Inc, One DNA Way, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 109:5299-304. 2012
    ..The discovery of a small-molecule binding pocket on Ras with functional significance provides a new direction in the search of therapeutically effective inhibitors of the Ras oncoprotein...
  56. ncbi request reprint The immunosuppressive agent 15-deoxyspergualin functions by inhibiting cell cycle progression and cytokine production following naive T cell activation
    Hilda Holcombe
    Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 169:4982-9. 2002
    ....
  57. pmc Direct proteasome-independent cross-presentation of viral antigen by plasmacytoid dendritic cells on major histocompatibility complex class I
    Tiziana Di Pucchio
    Baylor Institute for Immunology Research and Baylor Research Institute, Dallas, Texas 75204, USA
    Nat Immunol 9:551-7. 2008
    ..Our data demonstrate that pDCs use 'ready-made' stores of MHC class I to rapidly present exogenous antigen to CD8+ T cells...
  58. pmc Maturation modulates caspase-1-independent responses of dendritic cells to Anthrax lethal toxin
    Nuria Reig
    Ecole Polytechnique Federale de Lausanne, Global Health Institute, Station 15, CH 1015 Lausanne, Switzerland
    Cell Microbiol 10:1190-207. 2008
    ..These studies illustrate that the cellular damage inflicted by LT depends not only on the innate responses but also on the maturation stage of the cell, which modulates the more general caspase-1-independent responses...
  59. ncbi request reprint Presentation of self-antigens on MHC class II molecules during dendritic cell maturation
    Heather L Zwickey
    Helfgott Research Institute, National College of Naturopathic Medicine, 049 SW Porter Street, Portland, OR 97201, USA
    Int Immunol 18:199-209. 2006
    ..Thus, DC-endogenous antigens may induce tolerance, but only in the absence of potent maturation stimuli...
  60. doi request reprint Design opportunities for actively targeted nanoparticle vaccines
    Tarek M Fahmy
    Yale University, Department of Biomedical Engineering, USA
    Nanomedicine (Lond) 3:343-55. 2008
    ..Optimization of these variables is important for the development of nanoparticle-based vaccine systems against infectious diseases and cancer...
  61. pmc Differential recognition of tyrosine-based basolateral signals by AP-1B subunit mu1B in polarized epithelial cells
    Hisashi Sugimoto
    Division of Molecular Membrane Biology, Cancer Research Institute, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa 920 0934, Japan
    Mol Biol Cell 13:2374-82. 2002
    ..Our results suggest that mu1B interacts with different classes of basolateral targeting signals in distinct ways...
  62. ncbi request reprint Rab10 is involved in basolateral transport in polarized Madin-Darby canine kidney cells
    Sebastian Schuck
    Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany
    Traffic 8:47-60. 2007
    ..These results indicate that Rab10 functions in trafficking from the Golgi at early stages of epithelial polarization, is involved in biosynthetic transport to the basolateral membrane and may co-operate with Rab8...
  63. pmc Regulation and functional insights in cellular polarity, Madrid, Spain June 3-5, 2002
    Ira Mellman
    J Cell Biol 158:12-6. 2002
  64. ncbi request reprint Incomplete screening?
    Ira Mellman
    Nat Immunol 8:473. 2007
  65. ncbi request reprint Quantitative and dynamic assessment of the contribution of the ER to phagosome formation
    Nicolas Touret
    Programme in Cell Biology, University of Toronto, Ontario M5G 1X8, Canada
    Cell 123:157-70. 2005
    ....
  66. ncbi request reprint The antitumor monoclonal antibody 806 recognizes a high-mannose form of the EGF receptor that reaches the cell surface when cells over-express the receptor
    Terrance G Johns
    Ludwig Institute for Cancer Research, Tumour Targeting Program, Austin Hospital, Heidelberg, Australia
    FASEB J 19:780-2. 2005
    ..As our observations are likely to apply to other receptors overexpressed in cancer, they suggest a strategy for developing antitumor antibodies even when the target receptor is expressed in normal tissue...
  67. pmc Protein kinase D regulates basolateral membrane protein exit from trans-Golgi network
    Charles Yeaman
    Department of Anatomy and Cell Biology, University of Iowa, Iowa City, IA 52242 1109, USA
    Nat Cell Biol 6:106-12. 2004
    ..PKD activity is required only for the transport of proteins containing basolateral sorting information, and seems to be cargo specific...
  68. ncbi request reprint Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide
    Roberto Lande
    Department of Immunology, M D Anderson Cancer Center, University of Texas, Houston, Texas 77030, USA
    Nature 449:564-9. 2007
    ..Thus, our data uncover a fundamental role of an endogenous antimicrobial peptide in breaking innate tolerance to self-DNA and suggest that this pathway may drive autoimmunity in psoriasis...