Flavius Martin

Summary

Affiliation: Genentech Inc
Country: USA

Publications

  1. ncbi request reprint PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells
    Kiminori Hasegawa
    Department of Immunology, Genentech, Inc, One DNA Way, South San Francisco, CA 94080, USA
    Science 303:685-9. 2004
  2. ncbi request reprint B cell immunobiology in disease: evolving concepts from the clinic
    Flavius Martin
    Department of Immunology, Genentech, Inc, South San Francisco, California 94080, USA
    Annu Rev Immunol 24:467-96. 2006
  3. ncbi request reprint Anti-BR3 antibodies: a new class of B-cell immunotherapy combining cellular depletion and survival blockade
    Wei Yu Lin
    Department of Immunology, Genentech, South San Francisco, CA 94080, USA
    Blood 110:3959-67. 2007
  4. doi request reprint Transplantation: it may take two to tango and to treat
    Flavius Martin
    Immunol Cell Biol 86:107-8. 2008
  5. doi request reprint Equilibrative nucleoside transporter 3 deficiency perturbs lysosome function and macrophage homeostasis
    Chia Lin Hsu
    Immunology, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Science 335:89-92. 2012
  6. ncbi request reprint Pathogenic roles of B cells in human autoimmunity; insights from the clinic
    Flavius Martin
    Department of Immunology, One DNA Way, MS 34, South San Francisco, CA 94080 USA
    Immunity 20:517-27. 2004
  7. pmc A soluble BAFF antagonist, BR3-Fc, decreases peripheral blood B cells and lymphoid tissue marginal zone and follicular B cells in cynomolgus monkeys
    Yulia Vugmeyster
    Genentech, Inc, San Francisco, CA 94080, USA
    Am J Pathol 168:476-89. 2006
  8. pmc In vivo blockade of OX40 ligand inhibits thymic stromal lymphopoietin driven atopic inflammation
    Dhaya Seshasayee
    Department of Immunology, Genentech Inc, South San Francisco, California 94080, USA
    J Clin Invest 117:3868-78. 2007
  9. ncbi request reprint Importance of cellular microenvironment and circulatory dynamics in B cell immunotherapy
    Qian Gong
    Department of Immunology, Genentech, South San Francisco, CA 94080, USA
    J Immunol 174:817-26. 2005
  10. doi request reprint Structural basis for the dual recognition of helical cytokines IL-34 and CSF-1 by CSF-1R
    Xiaolei Ma
    Department of Structural Biology, Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Structure 20:676-87. 2012

Collaborators

Detail Information

Publications20

  1. ncbi request reprint PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells
    Kiminori Hasegawa
    Department of Immunology, Genentech, Inc, One DNA Way, South San Francisco, CA 94080, USA
    Science 303:685-9. 2004
    ..These results revealed a central role for PEP in negatively regulating specific aspects of T cell development and function...
  2. ncbi request reprint B cell immunobiology in disease: evolving concepts from the clinic
    Flavius Martin
    Department of Immunology, Genentech, Inc, South San Francisco, California 94080, USA
    Annu Rev Immunol 24:467-96. 2006
    ..In this review, we highlight some of these recent findings that provide insights into both murine models of autoimmunity and human autoimmune diseases...
  3. ncbi request reprint Anti-BR3 antibodies: a new class of B-cell immunotherapy combining cellular depletion and survival blockade
    Wei Yu Lin
    Department of Immunology, Genentech, South San Francisco, CA 94080, USA
    Blood 110:3959-67. 2007
    ..This novel class of B-cell-targeted therapies shows species characteristics in mice and primates that will guide translation to treatment of human disease...
  4. doi request reprint Transplantation: it may take two to tango and to treat
    Flavius Martin
    Immunol Cell Biol 86:107-8. 2008
  5. doi request reprint Equilibrative nucleoside transporter 3 deficiency perturbs lysosome function and macrophage homeostasis
    Chia Lin Hsu
    Immunology, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Science 335:89-92. 2012
    ..These studies suggest a cellular and molecular basis for the development of histiocytosis in several human syndromes associated with ENT3 mutations and potentially other LSDs...
  6. ncbi request reprint Pathogenic roles of B cells in human autoimmunity; insights from the clinic
    Flavius Martin
    Department of Immunology, One DNA Way, MS 34, South San Francisco, CA 94080 USA
    Immunity 20:517-27. 2004
    ..In this review, we will highlight some of these studies and discuss how clinical insights parallel murine models of normal immunity and autoimmunity...
  7. pmc A soluble BAFF antagonist, BR3-Fc, decreases peripheral blood B cells and lymphoid tissue marginal zone and follicular B cells in cynomolgus monkeys
    Yulia Vugmeyster
    Genentech, Inc, San Francisco, CA 94080, USA
    Am J Pathol 168:476-89. 2006
    ..These findings should prove very useful in guiding the desired therapeutic use of BR3-Fc for autoimmune diseases in the clinic...
  8. pmc In vivo blockade of OX40 ligand inhibits thymic stromal lymphopoietin driven atopic inflammation
    Dhaya Seshasayee
    Department of Immunology, Genentech Inc, South San Francisco, California 94080, USA
    J Clin Invest 117:3868-78. 2007
    ..The use of a blocking, OX40L-specific mAb thus presents a promising strategy for the treatment of allergic diseases associated with pathologic Th2 immune responses...
  9. ncbi request reprint Importance of cellular microenvironment and circulatory dynamics in B cell immunotherapy
    Qian Gong
    Department of Immunology, Genentech, South San Francisco, CA 94080, USA
    J Immunol 174:817-26. 2005
    ..These findings provide new insights into the mechanisms of immunotherapy and define new opportunities in the treatment of cancers and autoimmune diseases...
  10. doi request reprint Structural basis for the dual recognition of helical cytokines IL-34 and CSF-1 by CSF-1R
    Xiaolei Ma
    Department of Structural Biology, Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Structure 20:676-87. 2012
    ....
  11. pmc Comparative transcriptomic analyses of atopic dermatitis and psoriasis reveal shared neutrophilic inflammation
    David F Choy
    Department of Immunology, Tissue Growth, and Repair Biomarker Discovery, Genentech, South San Francisco, CA, USA
    J Allergy Clin Immunol 130:1335-43.e5. 2012
    ..Despite intensive investigation, these pathways remain incompletely understood in vivo in human subjects...
  12. ncbi request reprint Synthetic anti-BR3 antibodies that mimic BAFF binding and target both human and murine B cells
    Chingwei V Lee
    Department of Protein Engineering, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Blood 108:3103-11. 2006
    ....
  13. doi request reprint A mouse knockout library for secreted and transmembrane proteins
    Tracy Tang
    Department of Molecular Biology, Genentech, Inc, South San Francisco, California, USA
    Nat Biotechnol 28:749-55. 2010
    ..To our knowledge, a comprehensive phenotypic assessment of a large number of mouse mutants generated by a gene-specific approach has not been described previously...
  14. pmc Critical role of activation induced cytidine deaminase in experimental autoimmune encephalomyelitis
    Yonglian Sun
    Department of Immunology, Genentech Inc, San Francisco, CA 94080, USA
    Autoimmunity 46:157-67. 2013
    ..Thus affinity maturation and/or class switching are critical processes in the pathogenesis of EAE...
  15. doi request reprint Chondroitin sulfate synthase 1 (Chsy1) is required for bone development and digit patterning
    Deanna G Wilson
    Genentech, South San Francisco, CA 94080, USA
    Dev Biol 363:413-25. 2012
    ..Our results place Chsy1 as an essential regulator of joint patterning and provide a mouse model of human brachydactylies caused by mutations in CHSY1...
  16. ncbi request reprint Loss of the tumor suppressor BAP1 causes myeloid transformation
    Anwesha Dey
    Department of Physiological Chemistry, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA
    Science 337:1541-6. 2012
    ..A BAP1 catalytic mutation found in a MDS patient implies that BAP1 loss of function has similar consequences in mice and humans...
  17. pmc APRIL-deficient mice have normal immune system development
    Eugene Varfolomeev
    Department of Molecular Oncology, Genentech Inc, South San Francisco, California 94080, USA
    Mol Cell Biol 24:997-1006. 2004
    ..These data indicate that APRIL is dispensable in the mouse for proper development. Thus, BLyS may be capable of fulfilling APRIL's main functions...
  18. ncbi request reprint Control of spontaneous B lymphocyte autoimmunity with adenovirus-encoded soluble TACI
    Weimin Liu
    University of Alabama at Birmingham, and the Birmingham VA Medical Center, 35294, USA
    Arthritis Rheum 50:1884-96. 2004
    ..Serum B lymphocyte stimulator (BLyS) is increased in autoimmune diseases, both in animal models and in humans. This study examined the effect of BLyS blockade in 3 animal models of lupus...
  19. ncbi request reprint Blood dendritic cells interact with splenic marginal zone B cells to initiate T-independent immune responses
    Mercedesz Balazs
    Division of Developmental and Clinical Immunology, Department of Microbiology, University of Alabama, Birmingham, AL 35294, USA
    Immunity 17:341-52. 2002
    ..In the absence of soluble TACI ligands, Ag-activated MZ- and B1-derived blasts lack survival signals and undergo apoptosis, resulting in severely impaired antibody responses...
  20. ncbi request reprint Marginal-zone B cells
    Flavius Martin
    Department of Microbiology, University of Alabama at Birmingham, 35294 3300, USA
    Nat Rev Immunol 2:323-35. 2002
    ..Now that the initial 'infatuation' is over, it is time to reconsider these data and generate some conclusions that can be incorporated into a working model of the B-cell system...